PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25249323-4	2014	DNA damage caused by ultraviolet light or the alkylating agent methyl methanesulphonate strongly activates Chk1, leading to phosphorylation of Smurf1 that enhances its self-degradation, hence resulting in a RhoB accumulation to promote apoptosis.	Methyl Methanesulfonate	63-87	checkpoint kinase 1	Homo sapiens	107-111	
15381075-5	2004	We also found that methyl methanesulfonate induces phosphorylation of Ser-317 in protein kinase Chk1 and Ser-139 in histone H2AX and stimulates formation of single-stranded DNA at replication foci.	Methyl Methanesulfonate	19-42	checkpoint kinase 1	Homo sapiens	96-100	
29092815-5	2017	The chk1-S173A allele is uniquely sensitive to high MMS concentrations where it displays a partial checkpoint defect.	Methyl Methanesulfonate	52-55	checkpoint kinase 1	Homo sapiens	4-8	
21130714-1	2011	Treatment of PARP-1-expressing cells with the combination of a DNA methylating agent (MMS) and the PARP inhibitor 4-amino-1,8-naphthalimide (4-AN) leads to an ATR/Chk1-dependent S phase checkpoint and cell death by apoptosis.	Methyl Methanesulfonate	86-89	checkpoint kinase 1	Homo sapiens	163-167	
30297842-3	2018	DNA damage caused by ultraviolet light (UV) or alkylating agent methyl methanesulphonate (MMS) results in phosphorylation of small GTPase RhoB by Chk1.	Methyl Methanesulfonate	64-88	checkpoint kinase 1	Homo sapiens	146-150	
30297842-3	2018	DNA damage caused by ultraviolet light (UV) or alkylating agent methyl methanesulphonate (MMS) results in phosphorylation of small GTPase RhoB by Chk1.	Methyl Methanesulfonate	90-93	checkpoint kinase 1	Homo sapiens	146-150