PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30297842-3 2018 DNA damage caused by ultraviolet light (UV) or alkylating agent methyl methanesulphonate (MMS) results in phosphorylation of small GTPase RhoB by Chk1. Methyl Methanesulfonate 64-88 checkpoint kinase 1 Homo sapiens 146-150 21130714-1 2011 Treatment of PARP-1-expressing cells with the combination of a DNA methylating agent (MMS) and the PARP inhibitor 4-amino-1,8-naphthalimide (4-AN) leads to an ATR/Chk1-dependent S phase checkpoint and cell death by apoptosis. Methyl Methanesulfonate 86-89 checkpoint kinase 1 Homo sapiens 163-167 15381075-5 2004 We also found that methyl methanesulfonate induces phosphorylation of Ser-317 in protein kinase Chk1 and Ser-139 in histone H2AX and stimulates formation of single-stranded DNA at replication foci. Methyl Methanesulfonate 19-42 checkpoint kinase 1 Homo sapiens 96-100 30297842-3 2018 DNA damage caused by ultraviolet light (UV) or alkylating agent methyl methanesulphonate (MMS) results in phosphorylation of small GTPase RhoB by Chk1. Methyl Methanesulfonate 90-93 checkpoint kinase 1 Homo sapiens 146-150 29092815-5 2017 The chk1-S173A allele is uniquely sensitive to high MMS concentrations where it displays a partial checkpoint defect. Methyl Methanesulfonate 52-55 checkpoint kinase 1 Homo sapiens 4-8 25249323-4 2014 DNA damage caused by ultraviolet light or the alkylating agent methyl methanesulphonate strongly activates Chk1, leading to phosphorylation of Smurf1 that enhances its self-degradation, hence resulting in a RhoB accumulation to promote apoptosis. Methyl Methanesulfonate 63-87 checkpoint kinase 1 Homo sapiens 107-111