PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7694379-7 1993 Relaxation of the corpus cavernosum is blocked by methylene blue which inhibits cyclic GMP synthesis; so, high flow priapism refractory to medical and surgical treatments can be managed successfully by intracavernous methylene blue. Methylene Blue 50-64 5'-nucleotidase, cytosolic II Homo sapiens 87-90 7521462-4 1994 Methylene blue (MB) prevented UV light-induced relaxation and cyclic GMP formation. Methylene Blue 0-14 5'-nucleotidase, cytosolic II Homo sapiens 69-72 7521462-4 1994 Methylene blue (MB) prevented UV light-induced relaxation and cyclic GMP formation. Methylene Blue 16-18 5'-nucleotidase, cytosolic II Homo sapiens 69-72 7688808-11 1993 Incubation with Methylene Blue, a guanylate cyclase inhibitor, lowered the production of cyclic GMP to a level of 10-12 nmol min-1 (g tissue)-1, and the radiation effect did not occur. Methylene Blue 16-30 5'-nucleotidase, cytosolic II Homo sapiens 96-99 1652035-4 1991 The levels of cyclic GMP and cyclic AMP from the intact arteries were significantly elevated by ET-3; the cyclic GMP elevasion disappeared with methylene blue. Methylene Blue 144-158 5'-nucleotidase, cytosolic II Homo sapiens 113-116 1697805-7 1990 The hypothesis of an inhibitory effect of cyclic GMP on neutrophil function was further supported by the attenuation of SIN-1-induced inhibition of enzyme release by methylene blue (10 microM), an inhibitor of soluble guanylate cyclase. Methylene Blue 166-180 5'-nucleotidase, cytosolic II Homo sapiens 49-52 2175809-4 1990 Treatment of endothelial cells with either hemoglobin or methylene blue reduced significantly both the basal and stimulated level of cyclic GMP. Methylene Blue 57-71 5'-nucleotidase, cytosolic II Homo sapiens 140-143 2165993-3 1990 This factor is quite unstable, is not produced by cyclooxygenase, and is an activator of soluble guanylate cyclase that synthesizes cyclic GMP; its action is suppressed by antioxidants via the superoxide anions produced, potentiated by superoxide dismutase and abolished by methylene blue and oxyhemoglobin. Methylene Blue 274-288 5'-nucleotidase, cytosolic II Homo sapiens 139-142 2156053-8 1990 Methylene blue also reduced kinin-stimulated production of cyclic GMP. Methylene Blue 0-14 5'-nucleotidase, cytosolic II Homo sapiens 66-69 2575830-4 1989 In mammary arteries, acetylcholine, thrombin, adenosine diphosphate, histamine and the calcium ionophore A23187 evoked endothelium-dependent relaxations blocked by hemoglobin or methylene blue, but not by cyclooxygenase inhibitors delineating EDRF as the mediator; in vascular smooth muscle cells, this was associated with a rise in intracellular cyclic GMP. Methylene Blue 178-192 5'-nucleotidase, cytosolic II Homo sapiens 354-357 2546782-5 1989 This anti-aggregatory component and the elevation of cyclic GMP were blocked by the inhibitors of endothelium-derived relaxing factor (EDRF), gossypol, haemoglobin and methylene blue. Methylene Blue 168-182 5'-nucleotidase, cytosolic II Homo sapiens 60-63 2484708-4 1989 The production of cyclic GMP evoked by SIN-1 but not evoked by human alpha-natriuretic polypeptide was inhibited by treatment of the cells with either methylene blue (an inhibitor of soluble guanylate cyclase) and hemoglobin (a scavenger of nitric oxide). Methylene Blue 151-165 5'-nucleotidase, cytosolic II Homo sapiens 25-28 12826268-9 2003 Pretreatment with guanylyl cyclase inhibitors, 1H-(1,2,4)oxadiazolo[4,3-a]quinozalin-1-one (ODQ) and methylene blue, inhibited the YC-1-induced increase of cyclic GMP level, but did not change significantly the magnitude of the YC-1-induced inhibition of thymidine incorporation and cell number in HUVEC. Methylene Blue 101-115 5'-nucleotidase, cytosolic II Homo sapiens 163-166 8789382-6 1996 These cyclic GMP levels were significantly decreased by NG-nitro-L-arginine (100 microM), and completely by methylene blue (10 microM). Methylene Blue 108-122 5'-nucleotidase, cytosolic II Homo sapiens 13-16 8661340-6 1996 However, the attenuation in the cyclic GMP formation by methylene blue, a selective inhibitor of soluble guanylate cyclase, was not accompanied by a corresponding increase in NK cell cytolytic activity. Methylene Blue 56-70 5'-nucleotidase, cytosolic II Homo sapiens 39-42 11564644-18 2001 The increase in cyclic GMP content of KMUP-1 (0.1 - 100 microM) was almost completely abolished in the presence of methylene blue (10 microM), ODQ (10 microM), and L-NAME (100 microM). Methylene Blue 115-129 5'-nucleotidase, cytosolic II Homo sapiens 23-26 8640334-13 1995 Methylene blue, an inhibitor of sGC, blocked the increases of cyclic GMP caused by YC-1, and attenuated markedly the anti-aggregatory effect of YC-1. Methylene Blue 0-14 5'-nucleotidase, cytosolic II Homo sapiens 69-72 8564249-13 1995 S-NO-Glu induced-increase in intracellular cyclic GMP synthesis, but not the increase in ouabain-sensitive Rb-uptake, was completely inhibited by methylene blue in HCCSMC. Methylene Blue 146-160 5'-nucleotidase, cytosolic II Homo sapiens 50-53 7543267-8 1995 Further evidence for mediation via cyclic GMP was provided by the finding that methylene blue (20 microM), an inhibitor of soluble guanylate cyclase, decreased both the inhibition of SIN-1-induced NK cell cytotoxicity as well as cyclic GMP formation. Methylene Blue 79-93 5'-nucleotidase, cytosolic II Homo sapiens 42-45 8564231-4 1995 Both NG-nitro-L-arginine methyl ester (L-NAME) and methylene blue attenuated the trilinolein-induced increase in cyclic GMP. Methylene Blue 51-65 5'-nucleotidase, cytosolic II Homo sapiens 120-123 7543267-8 1995 Further evidence for mediation via cyclic GMP was provided by the finding that methylene blue (20 microM), an inhibitor of soluble guanylate cyclase, decreased both the inhibition of SIN-1-induced NK cell cytotoxicity as well as cyclic GMP formation. Methylene Blue 79-93 5'-nucleotidase, cytosolic II Homo sapiens 236-239