PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24556215-0 2014 Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity. Methylene Blue 0-14 microtubule associated protein tau Homo sapiens 55-58 24556215-7 2014 MB improved the behavioral abnormalities and reduced tau pathology, inflammation and oxidative damage in the P301S mice. Methylene Blue 0-2 microtubule associated protein tau Homo sapiens 53-56 24361915-9 2014 Methylthioninium chloride (MTC), the first identified tau aggregation inhibitor (TAI), offers an alternative to the amyloid approach. Methylene Blue 0-25 microtubule associated protein tau Homo sapiens 54-57 24361915-9 2014 Methylthioninium chloride (MTC), the first identified tau aggregation inhibitor (TAI), offers an alternative to the amyloid approach. Methylene Blue 27-30 microtubule associated protein tau Homo sapiens 54-57 8855335-5 1996 We have identified a nonneuroleptic phenothiazine previously used in man (methylene blue, MB), which reverses the proteolytic stability of protease-resistant PHFs by blocking the tau-tau binding interaction through the repeat domain. Methylene Blue 74-88 microtubule associated protein tau Homo sapiens 179-182 20154508-13 2009 NP-12, a promising GSK-3 inhibitor, is being tested in a Phase II study, and methylthioninium chloride, a tau protein aggregation inhibitor, has given initial encouraging results in a 50-week study. Methylene Blue 77-102 microtubule associated protein tau Homo sapiens 106-109 18619417-0 2008 Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain. Methylene Blue 46-60 microtubule associated protein tau Homo sapiens 87-90 18619417-2 2008 Since the three- or four-repeat microtubule-binding domain (MBD) in tau protein plays an essential role in filament formation, the inhibitory behavior of cyanidin (Cy) and methylene blue (MB) with respect to heparin-induced filament formation of MBD in a neutral solution (pH 7.6) was characterized by fluorescence, circular dichroism, and electron microscopy measurements. Methylene Blue 60-62 microtubule associated protein tau Homo sapiens 68-71 23443659-0 2013 Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. Methylene Blue 27-41 microtubule associated protein tau Homo sapiens 49-52 23443659-10 2013 Interestingly, methylene blue, an inhibitor of Tau fibrillization under evaluation in Alzheimer disease clinical trials, caused a similar oxidation of cysteines in Tau and other molecules. Methylene Blue 15-29 microtubule associated protein tau Homo sapiens 47-50 23443659-10 2013 Interestingly, methylene blue, an inhibitor of Tau fibrillization under evaluation in Alzheimer disease clinical trials, caused a similar oxidation of cysteines in Tau and other molecules. Methylene Blue 15-29 microtubule associated protein tau Homo sapiens 164-167 21222635-8 2011 Several approaches have been considered, including mainly Abeta deposition interference by anti- Abeta aggregation agents, vaccination, gamma-secretase inhibition or selective Abeta 42-lowering agents (SALAs), tau deposition interference by methyl thioninium chloride (MTC), and methods for reduction of inflammation and oxidative damage. Methylene Blue 241-267 microtubule associated protein tau Homo sapiens 210-213 20298170-10 2010 In particular, several approaches will be described, including Abeta deposition interference by Anti-Abeta aggregation agents, vaccination, gamma-secretase inhibition or Selective Abeta42-lowering agents (SALAs); tau deposition interference by methyl thioninium chloride (MTC); reduction of inflammation and oxidative damage. Methylene Blue 244-270 microtubule associated protein tau Homo sapiens 213-216 8855335-5 1996 We have identified a nonneuroleptic phenothiazine previously used in man (methylene blue, MB), which reverses the proteolytic stability of protease-resistant PHFs by blocking the tau-tau binding interaction through the repeat domain. Methylene Blue 74-88 microtubule associated protein tau Homo sapiens 183-186 32037892-3 2020 Derived from methylene blue, hydromethylthionine is a tau aggregation inhibitor that recently emerged as a promising disease-modifying treatment for AD. Methylene Blue 13-27 microtubule associated protein tau Homo sapiens 54-57 35532254-9 2022 Epigallocatechin-3- gallate and Methylene Blue were described as tau and TDP-43 inhibitors. Methylene Blue 32-46 microtubule associated protein tau Homo sapiens 65-68 29944336-6 2018 As an example of small molecule binding to monomeric Tau, it was shown that methylene blue (MB) bound to monomeric K18 and full-length Tau selectively with high affinity (Kd = 125.8 nM and 86.6 nM, respectively) with binding modes involving Cys291 and Cys322, previously reported to be oxidized in the presence of MB. Methylene Blue 92-94 microtubule associated protein tau Homo sapiens 53-56 29944336-6 2018 As an example of small molecule binding to monomeric Tau, it was shown that methylene blue (MB) bound to monomeric K18 and full-length Tau selectively with high affinity (Kd = 125.8 nM and 86.6 nM, respectively) with binding modes involving Cys291 and Cys322, previously reported to be oxidized in the presence of MB. Methylene Blue 76-90 microtubule associated protein tau Homo sapiens 53-56 29944336-6 2018 As an example of small molecule binding to monomeric Tau, it was shown that methylene blue (MB) bound to monomeric K18 and full-length Tau selectively with high affinity (Kd = 125.8 nM and 86.6 nM, respectively) with binding modes involving Cys291 and Cys322, previously reported to be oxidized in the presence of MB. Methylene Blue 76-90 microtubule associated protein tau Homo sapiens 135-138 29944336-6 2018 As an example of small molecule binding to monomeric Tau, it was shown that methylene blue (MB) bound to monomeric K18 and full-length Tau selectively with high affinity (Kd = 125.8 nM and 86.6 nM, respectively) with binding modes involving Cys291 and Cys322, previously reported to be oxidized in the presence of MB. Methylene Blue 92-94 microtubule associated protein tau Homo sapiens 135-138 25958115-0 2015 Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Methylene Blue 11-25 microtubule associated protein tau Homo sapiens 107-110 25958115-5 2015 Since methylene blue (MB) is able to inhibit Tau aggregation in vitro, we investigated whether MB can prevent or rescue Tau-induced cognitive impairments in our mouse models. Methylene Blue 6-20 microtubule associated protein tau Homo sapiens 45-48 25958115-5 2015 Since methylene blue (MB) is able to inhibit Tau aggregation in vitro, we investigated whether MB can prevent or rescue Tau-induced cognitive impairments in our mouse models. Methylene Blue 22-24 microtubule associated protein tau Homo sapiens 45-48 28287136-6 2017 We also demonstrate that methylene blue, a reported tau aggregation inhibitor, modulates tau acetylation, a novel mechanism of action for this class of compounds. Methylene Blue 25-39 microtubule associated protein tau Homo sapiens 52-55 28287136-6 2017 We also demonstrate that methylene blue, a reported tau aggregation inhibitor, modulates tau acetylation, a novel mechanism of action for this class of compounds. Methylene Blue 25-39 microtubule associated protein tau Homo sapiens 89-92