PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20004705-11 2010 Moreover, we found that application of L-NNA attenuated IL-1beta-induced CRH release, indicating that NO likely mediates this process. Nitroarginine 39-44 interleukin 1 beta Rattus norvegicus 56-64 19416632-11 2009 Moreover, the expression of several genes involved in inflammation and pain, as IL-1beta, TNFalpha, COX2 and iNOS, was up-regulated in colonic tissue from post-colitis rats and NO2-Arg-Trim, but not trimebutine, effectively reversed this effect. Nitroarginine 177-184 interleukin 1 beta Rattus norvegicus 80-88 11032727-8 2000 Pretreatment with gamma-tocopherol (but not alpha-tocopherol) afforded a partial protection against the inhibitory effects of NO, whereas specifically inhibiting inducible NO synthase with N-nitro-L-arginine completely reversed the IL-1beta effects. Nitroarginine 189-207 interleukin 1 beta Rattus norvegicus 232-240 11733865-7 2001 The suppressive effects of IL-1 beta on proinsulin synthesis and conversion were prevented by addition of NMA. Nitroarginine 106-109 interleukin 1 beta Rattus norvegicus 27-36 11078448-4 2000 IL-1beta-induced NO production was prevented by incubation of islets in arginine-free medium supplemented with the arginine analog NG-nitro-L-arginine. Nitroarginine 131-150 interleukin 1 beta Rattus norvegicus 0-8 7538649-6 1995 The NO synthase inhibitors NG-nitro-L-arginine or NG-monomethyl-L-arginine, or the NO scavenger oxyhaemoglobin prevented the IL-1 beta-induced increase of cGMP. Nitroarginine 27-46 interleukin 1 beta Rattus norvegicus 125-134 10963751-5 2000 Finally, increased IL-1 beta gene expression in the PVN of LPS-treated rats receiving N(G)-nitro-L-arginine showed that NO regulates brain IL-1 beta gene expression. Nitroarginine 86-107 interleukin 1 beta Rattus norvegicus 19-28 10963751-5 2000 Finally, increased IL-1 beta gene expression in the PVN of LPS-treated rats receiving N(G)-nitro-L-arginine showed that NO regulates brain IL-1 beta gene expression. Nitroarginine 86-107 interleukin 1 beta Rattus norvegicus 139-148 9528932-11 1998 Exposure to IL-1beta resulted in 10-fold higher medium nitrite levels in both subpopulations; this effect was prevented by the iNOS blocker, N(G)-methyl-L-arginine, which also prevented the IL-1beta-induced suppression in the glucose-responsive subpopulation. Nitroarginine 141-163 interleukin 1 beta Rattus norvegicus 12-20 9528932-11 1998 Exposure to IL-1beta resulted in 10-fold higher medium nitrite levels in both subpopulations; this effect was prevented by the iNOS blocker, N(G)-methyl-L-arginine, which also prevented the IL-1beta-induced suppression in the glucose-responsive subpopulation. Nitroarginine 141-163 interleukin 1 beta Rattus norvegicus 190-198 9227638-10 1997 IL-1 beta-induced protection was reversed with L-NNA. Nitroarginine 47-52 interleukin 1 beta Rattus norvegicus 0-9 7630433-1 1995 Effects of indomethacin, N omega-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-1 beta induced inhibition of exocytotic noradrenaline release were investigated in the isolated, vascularly perfused spleen of the rat. Nitroarginine 25-49 interleukin 1 beta Rattus norvegicus 125-148 7630433-6 1995 The inhibition of evoked overflow by IL-1 beta was not affected by indomethacin but was reduced or even prevented in the presence of NNA or naloxone, or after lymphocyte depletion of spleens by CY. Nitroarginine 133-136 interleukin 1 beta Rattus norvegicus 37-46 7505207-7 1994 Under bioassay conditions, the perfusates from columns containing IL-1 beta-treated smooth muscle cells relaxed rings of rat aorta without endothelium that had been contracted with phenylephrine; these relaxations were reversed by nitro-L-arginine. Nitroarginine 231-247 interleukin 1 beta Rattus norvegicus 66-75 1378360-9 1992 The effects of interleukin-1 beta were inhibited by nitro-L-arginine. Nitroarginine 52-68 interleukin 1 beta Rattus norvegicus 15-33 8398001-7 1993 Nitro-L-arginine prevented the inhibitory effect of interleukin-1 beta. Nitroarginine 0-16 interleukin 1 beta Rattus norvegicus 52-70 8398001-11 1993 Interleukin-1 beta elicited greater concentration-dependent productions of cyclic GMP and nitrite in rings from spontaneously hypertensive than from Wistar-Kyoto rats, and these were inhibited by methylene blue and nitro-L-arginine, respectively. Nitroarginine 215-231 interleukin 1 beta Rattus norvegicus 0-18 7690108-1 1993 NG-Nitro-L-arginine, an inhibitor of nitric oxide synthase, does not influence CRH basal release but is able to modify ACTH basal secretion and to block interleukin-1 beta-induced CRH and ACTH release from rat hypothalamic and anterior pituitary cell cultures in vitro. Nitroarginine 0-19 interleukin 1 beta Rattus norvegicus 153-171 1661096-4 1991 This effect was potentiated by superoxide dismutase and reversed by incubating the IL-1 beta-treated smooth muscle cells with NG-nitro-L-arginine (L-NNA) or by treating the platelets with methylene blue. Nitroarginine 126-145 interleukin 1 beta Rattus norvegicus 83-92 1374468-8 1992 The production of cyclic GMP evoked by interleukin-1 beta in rings without endothelium was inhibited by nitro L-arginine but not by calmidazolium. Nitroarginine 104-120 interleukin 1 beta Rattus norvegicus 39-57 1661096-4 1991 This effect was potentiated by superoxide dismutase and reversed by incubating the IL-1 beta-treated smooth muscle cells with NG-nitro-L-arginine (L-NNA) or by treating the platelets with methylene blue. Nitroarginine 147-152 interleukin 1 beta Rattus norvegicus 83-92 1661096-7 1991 The elevation of platelet cGMP induced by the IL-1 beta-treated smooth muscle cells was prevented by exposing the cytokine-treated cells to L-NNA or by treating platelets with methylene blue. Nitroarginine 140-145 interleukin 1 beta Rattus norvegicus 46-55 1661096-8 1991 Treatment of smooth muscle cells with IL-1 beta also resulted in an eightfold increase in nitrite production, which was blocked when the cells were incubated with L-NNA. Nitroarginine 163-168 interleukin 1 beta Rattus norvegicus 38-47 24425765-12 2014 N(omega)-nitro-l-arginine and copper prevented the deleterious effect of interleukin-1beta on COX activity and GSIS. Nitroarginine 0-25 interleukin 1 beta Rattus norvegicus 73-90