PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29351198-0 2018 Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H2O2-Dependent Manner. Ascorbic Acid 78-87 superoxide dismutase 1 Homo sapiens 0-20 26629876-4 2016 Here, we implement an electrochemical setup and use the specificity of superoxide dismutase-1 (SOD1) to show, for the first time, that H2O2 production by Cu-Abeta in the presence of ascorbate occurs mainly via a free O2 (-) intermediate. Ascorbic Acid 182-191 superoxide dismutase 1 Homo sapiens 71-93 26629876-4 2016 Here, we implement an electrochemical setup and use the specificity of superoxide dismutase-1 (SOD1) to show, for the first time, that H2O2 production by Cu-Abeta in the presence of ascorbate occurs mainly via a free O2 (-) intermediate. Ascorbic Acid 182-191 superoxide dismutase 1 Homo sapiens 95-99 24657197-0 2014 Supplementing culture and vitrification-warming media with l-ascorbic acid enhances survival rates and redox status of IVP porcine blastocysts via induction of GPX1 and SOD1 expression. Ascorbic Acid 59-74 superoxide dismutase 1 Homo sapiens 169-173 25839657-5 2015 When the antioxidant ascorbic acid was used to eliminate excess ROS, the levels of antioxidant enzymes (catalase, SOD1 and 2, p-FOXO1, and p53) were partly restored. Ascorbic Acid 21-34 superoxide dismutase 1 Homo sapiens 114-124 26805894-13 2016 Concurrently, we also found that a prolonged (48 h) exposure to Vitamin C, Vitamin E and Green tea extract reduced the enzymatic activity of SOD in lung cancer cells. Ascorbic Acid 64-73 superoxide dismutase 1 Homo sapiens 141-144 24658925-8 2014 Those who consumed vitamin C/E (>=3 times per week) had a significantly higher SOD activity level than those who did not (mean +- SD: 379.8 +- 93.3 and 332.2 +- 94.9, respectively, P = 0.001). Ascorbic Acid 19-28 superoxide dismutase 1 Homo sapiens 82-85 20714147-4 2010 RESULTS: The data obtained from the study revealed that the levels of TBA and the antioxidant enzymes catalase, SOD, glutathine peroxidase and glutathine-S-transferse were significantly normalized by vitamin C treatment in the RBC hemolysate. Ascorbic Acid 200-209 superoxide dismutase 1 Homo sapiens 112-115 23768398-5 2013 The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation. Ascorbic Acid 144-157 superoxide dismutase 1 Homo sapiens 29-49 23768398-5 2013 The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation. Ascorbic Acid 144-157 superoxide dismutase 1 Homo sapiens 51-54 18544955-0 2008 Oral vitamin C supplementation in hemodialysis patients and its effect on the plasma level of oxidized ascorbic acid and Cu/Zn superoxide dismutase, an oxidative stress marker. Ascorbic Acid 5-14 superoxide dismutase 1 Homo sapiens 121-147 12770950-9 2003 Ascorbate and catalase each attenuated this effect of SOD. Ascorbic Acid 0-9 superoxide dismutase 1 Homo sapiens 54-57 15130278-6 2004 Treatment with a superoxide dismutase (SOD) mimic MnTMPyP resulted in similar effects of MnSOD overexpression on cell responses to vitamin C and selenium. Ascorbic Acid 131-140 superoxide dismutase 1 Homo sapiens 17-37 15130278-6 2004 Treatment with a superoxide dismutase (SOD) mimic MnTMPyP resulted in similar effects of MnSOD overexpression on cell responses to vitamin C and selenium. Ascorbic Acid 131-140 superoxide dismutase 1 Homo sapiens 39-42 18386505-0 2008 Capillary electrophoresis study on the dimeric SOD enzyme in the presence of ascorbic acid. Ascorbic Acid 77-90 superoxide dismutase 1 Homo sapiens 47-50 18386505-1 2008 A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide. Ascorbic Acid 171-184 superoxide dismutase 1 Homo sapiens 94-97 18386505-1 2008 A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide. Ascorbic Acid 171-184 superoxide dismutase 1 Homo sapiens 202-205 18386505-1 2008 A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide. Ascorbic Acid 171-184 superoxide dismutase 1 Homo sapiens 202-205 18386505-1 2008 A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide. Ascorbic Acid 171-184 superoxide dismutase 1 Homo sapiens 202-205 18188416-7 2007 The increase in SOD was statistically more in the patients given vitamin C in addition to amlodipine (0.1717 +/- 0.0150 compared to 0.152 +/- 0.0219 units/100 ml assay). Ascorbic Acid 65-74 superoxide dismutase 1 Homo sapiens 16-19 14644319-2 2003 The immediate products of such reactions, superoxide anion radicals and hydrogen peroxide can be metabolised by enzymes such as superoxide dismutase (SOD) and catalase (CAT), respectively, and depending on its concentration by Vitamin C (Vit C). Ascorbic Acid 227-236 superoxide dismutase 1 Homo sapiens 128-148 14644319-2 2003 The immediate products of such reactions, superoxide anion radicals and hydrogen peroxide can be metabolised by enzymes such as superoxide dismutase (SOD) and catalase (CAT), respectively, and depending on its concentration by Vitamin C (Vit C). Ascorbic Acid 227-236 superoxide dismutase 1 Homo sapiens 150-153 14644319-2 2003 The immediate products of such reactions, superoxide anion radicals and hydrogen peroxide can be metabolised by enzymes such as superoxide dismutase (SOD) and catalase (CAT), respectively, and depending on its concentration by Vitamin C (Vit C). Ascorbic Acid 238-243 superoxide dismutase 1 Homo sapiens 128-148 14644319-2 2003 The immediate products of such reactions, superoxide anion radicals and hydrogen peroxide can be metabolised by enzymes such as superoxide dismutase (SOD) and catalase (CAT), respectively, and depending on its concentration by Vitamin C (Vit C). Ascorbic Acid 238-243 superoxide dismutase 1 Homo sapiens 150-153 14644549-6 2003 Both ascorbate and glutathione were very effective in protecting Cu/Zn superoxide dismutase from ozone-induced inactivation. Ascorbic Acid 5-14 superoxide dismutase 1 Homo sapiens 65-91 11993645-8 2001 By using the multilayer electrodes, one could measure the activity of SOD in the presence of L-ascorbic acid. Ascorbic Acid 93-108 superoxide dismutase 1 Homo sapiens 70-73 12049845-1 2002 Four terpenylnaphthoquinones were found to enhance the rate of superoxide production in the presence of ascorbate as detected from the superoxide dismutase (SOD)-inhibitable initial oxygen consumption rates. Ascorbic Acid 104-113 superoxide dismutase 1 Homo sapiens 135-155 12049845-1 2002 Four terpenylnaphthoquinones were found to enhance the rate of superoxide production in the presence of ascorbate as detected from the superoxide dismutase (SOD)-inhibitable initial oxygen consumption rates. Ascorbic Acid 104-113 superoxide dismutase 1 Homo sapiens 157-160 11264892-9 2001 Physiological concentrations of ascorbic acid yielded SOD-inhibitable lucigenin-chemiluminescence. Ascorbic Acid 32-45 superoxide dismutase 1 Homo sapiens 54-57 12065648-3 2002 The EPR signal corresponding to the DOPAC semiquinone was modulated as follows: (i) it was suppressed by glutathione and ascorbic acid with the formation of new EPR spectra corresponding to the glutathionyl and ascorbyl radical, respectively; (ii) it was enhanced by Cu,Zn-superoxide dismutase; the enzyme also accelerated the decay of the semiquinone species to DOPAC quinone. Ascorbic Acid 121-134 superoxide dismutase 1 Homo sapiens 267-293 10432564-3 1999 It was shown that erythrocyte hemolysate and some studied antioxidants (ascorbate and cysteine) inhibit formation of this substance like SOD. Ascorbic Acid 72-81 superoxide dismutase 1 Homo sapiens 137-140 10823352-4 2000 Unlike H2O2 and pyrogallol, Vitamin C(VitC)/Fe2+ (each 100 microM), a commonly used hydroxyl radical-generating system, triggered a tonic contraction which could be prevented by DMSO/mannitol, but not by SOD or catalase. Ascorbic Acid 28-37 superoxide dismutase 1 Homo sapiens 204-207 10823352-4 2000 Unlike H2O2 and pyrogallol, Vitamin C(VitC)/Fe2+ (each 100 microM), a commonly used hydroxyl radical-generating system, triggered a tonic contraction which could be prevented by DMSO/mannitol, but not by SOD or catalase. Ascorbic Acid 38-42 superoxide dismutase 1 Homo sapiens 204-207 10809906-2 2000 PATIENTS AND METHODS: The activities of the antioxidant enzymes superoxide dismutase (SOD, EC 1.15.1.1) and glutathione peroxidase (GPx, EC 1.11.1.9) of blood plasma and peripheral blood mononuclear cells, as well as the plasma levels of ascorbate, alpha-tocopherol and beta-carotene, were measured in 75 subjects with HIV infection and in 26 controls. Ascorbic Acid 238-247 superoxide dismutase 1 Homo sapiens 64-84 7604223-1 1995 Exposure of cupro-zinc superoxide dismutase (SOD) to hydrogen peroxide or ascorbate-Fe(III) gives rise to the extensively oxidative modification of SOD. Ascorbic Acid 74-83 superoxide dismutase 1 Homo sapiens 45-48 9034244-9 1997 Recent results from our laboratory indicate that ascorbic acid is specifically needed for protection of microsomal membranes against cytochrome P450-mediated lipid peroxidation and protein oxidation, where SOD is ineffective. Ascorbic Acid 49-62 superoxide dismutase 1 Homo sapiens 206-209 9853803-2 1998 In this study the impact of vitamin C supplementation on oxidative damage as assessed by thiobarbituric acid reactive substances and markers of antioxidant status: namely Cu/Zn superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione were investigated in 24 hyperthyroid patients under propylthiouracil therapy (3x100 mg/day) for five days and in 15 healthy controls. Ascorbic Acid 28-37 superoxide dismutase 1 Homo sapiens 171-197 9853803-6 1998 Vitamin C supplementation to hyperthyroid patients caused significant increases in glutathione concentration (p<0.001) and glutathione peroxidase activity (p<0.001), whereas there were significant decreases in glutathione reductase (p<0.001) and Cu/Zn superoxide dismutase activities (p<0.01). Ascorbic Acid 0-9 superoxide dismutase 1 Homo sapiens 255-281 9853803-8 1998 Vitamin C supplementation to euthyroid controls caused significant increases in glutathione concentration (p<0.001) and glutathione peroxidase and Cu/Zn superoxide dismutase activities (p<0.001), whereas there was a significant decrease in glutathione reductase (p<0.001). Ascorbic Acid 0-9 superoxide dismutase 1 Homo sapiens 150-176 9493173-5 1998 We have found that some parameters of ascorbate-stimulated lipid peroxidation are altered in AD and that the effects of superoxide dismutase (SOD) on ascorbate-stimulated lipid peroxidation are significantly different in AD as compared to aged. Ascorbic Acid 150-159 superoxide dismutase 1 Homo sapiens 120-140 9493173-5 1998 We have found that some parameters of ascorbate-stimulated lipid peroxidation are altered in AD and that the effects of superoxide dismutase (SOD) on ascorbate-stimulated lipid peroxidation are significantly different in AD as compared to aged. Ascorbic Acid 150-159 superoxide dismutase 1 Homo sapiens 142-145 7604223-1 1995 Exposure of cupro-zinc superoxide dismutase (SOD) to hydrogen peroxide or ascorbate-Fe(III) gives rise to the extensively oxidative modification of SOD. Ascorbic Acid 74-83 superoxide dismutase 1 Homo sapiens 148-151 33365206-5 2020 Cotton seedlings under salt stress exhibited an inhibition of growth, excessive hydrogen peroxide (H2O2), superoxide anion (O2 -), and malondialdehyde (MDA) accumulations in leaves, increased activity levels of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APX), and elevated ascorbic acid (AsA) and glutathione (GSH) content in leaves. Ascorbic Acid 318-331 superoxide dismutase 1 Homo sapiens 211-231 35334451-7 2022 Vitamin C decreased the gene expression of apoptosis (BAX) and increased the expression of genes associated with nuclear reprogramming (NANOG, POU5F1, SOX2, c-Myc, Klf4, and TEAD4), antioxidation (SOD1), anti-apoptotic (Bcl2), and trophectoderm (CDX2). Ascorbic Acid 0-9 superoxide dismutase 1 Homo sapiens 197-201 33365206-5 2020 Cotton seedlings under salt stress exhibited an inhibition of growth, excessive hydrogen peroxide (H2O2), superoxide anion (O2 -), and malondialdehyde (MDA) accumulations in leaves, increased activity levels of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APX), and elevated ascorbic acid (AsA) and glutathione (GSH) content in leaves. Ascorbic Acid 333-336 superoxide dismutase 1 Homo sapiens 211-231 31199767-8 2019 Conclusions Zinc and vitamin C oral supplementation for 1 month had an ameliorative effect on the hepatotoxicity of AFB1 in wheat miller workers, through decreasing MDA, SOD, and GST levels that in turn led to an improvement in their liver enzymes. Ascorbic Acid 21-30 superoxide dismutase 1 Homo sapiens 170-173 30606264-9 2019 The hematological findings were not significantly different between those with and without MS except the white blood cell (WBC) count which was significantly higher in those with MS. SOD and CAT levels were significantly positively associated with HDL-C levels and negatively associated with components of MS. After adjusting for potential covariates, we found lower SOD and vitamin C levels and higher WBC counts were significantly associated with MS (p < 0.05). Ascorbic Acid 375-384 superoxide dismutase 1 Homo sapiens 183-186