PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8728119-0 1996 Human cytochrome P450"s are pro-oxidants in iron/ascorbate-initiated microsomal lipid peroxidation. Ascorbic Acid 49-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 6-21 9279132-4 1997 Liver microsomal cytochrome P-450 level was found to be low in ascorbate deficient animals. Ascorbic Acid 63-72 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-33 9046019-0 1997 NADPH-initiated cytochrome P450-dependent free iron-independent microsomal lipid peroxidation: specific prevention by ascorbic acid. Ascorbic Acid 118-131 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 16-31 9046019-1 1997 In this paper we demonstrate that ascorbic acid specifically prevents NADPH-initiated cytochrome P450 (P450)-mediated microsomal lipid peroxidation in the absence of free iron. Ascorbic Acid 34-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 86-101 22900324-0 2003 Cytochrome P450-mediated oxidative damage of nuclear membrane proteins and its prevention by vitamin C. Ascorbic Acid 93-102 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 8728119-1 1996 We have examined the effect of human cytochrome P450"s (1A1,1A2,3A4,2A6,2B6,2D6,2E1) on ascorbate/iron-induced lipid peroxidation. Ascorbic Acid 88-97 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-52 8728119-4 1996 It is therefore concluded that cytochrome P450"s play a significant role in ascorbate/iron peroxidation. Ascorbic Acid 76-85 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 31-46 1373902-6 1992 Western blot analysis of liver microsomes with antibodies to rat P-450IA2 (P-448-H), P-450IIB1 (P-450b) and human P-450IIIA4 (P-450NF) showed that ascorbic acid-deficiency resulted in a decrease in the amount of cytochrome P-450 immunochemically related to P-450IA2, but not the amounts of the forms of cytochrome P-450 cross-reactive with antibodies to P-450IIB1 and P-450IIIA4. Ascorbic Acid 147-160 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 303-319 8175769-4 1994 Ascorbate (AH2) specifically inhibits free metal ion-independent cyt P450-mediated protein oxidation and thereby prevents subsequent proteolytic degradation. Ascorbic Acid 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-73 3549274-7 1986 The high content of antioxidant compounds in the adrenal cortex, principally ascorbate, may serve to protect cytochrome P-450 enzymes from the damaging effects of oxygen radical species formed as a result of cytochrome P-450/pseudosubstrate interactions. Ascorbic Acid 77-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 109-125 3549274-7 1986 The high content of antioxidant compounds in the adrenal cortex, principally ascorbate, may serve to protect cytochrome P-450 enzymes from the damaging effects of oxygen radical species formed as a result of cytochrome P-450/pseudosubstrate interactions. Ascorbic Acid 77-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 208-224 3021236-2 1986 Vitamin C and tetramethyl-p-phenylene-diamine (TMPD) were used to increase oxygen consumption at the cytochrome a3 level, thereby decreasing its availability to cytochrome P-450. Ascorbic Acid 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 161-177