PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15130278-5 2004 MnSOD-overexpressing cells showed an increase in sensitivity to the cytotoxicity of buthionine sulfoximine, a glutathione-depleting agent, and vitamin C, but a decrease in sensitivity to sodium selenite. Ascorbic Acid 143-152 superoxide dismutase 2 Homo sapiens 0-5 15130278-6 2004 Treatment with a superoxide dismutase (SOD) mimic MnTMPyP resulted in similar effects of MnSOD overexpression on cell responses to vitamin C and selenium. Ascorbic Acid 131-140 superoxide dismutase 2 Homo sapiens 89-94 14967442-0 2004 Ascorbate as a "redox sensor" and protector against irradiation-induced oxidative stress in 32D CL 3 hematopoietic cells and subclones overexpressing human manganese superoxide dismutase. Ascorbic Acid 0-9 superoxide dismutase 2 Homo sapiens 156-186 14967442-5 2004 RESULTS: Manganese superoxide dismutase-overexpressing 2C6 cells maintained higher levels of ascorbate (5.4 +/- 0.5 and 2.6 +/- 0.5 nmol/10(6) cells, respectively) and thiols (14.0 +/- 0.1 and 11.1 +/- 0.2 nmol/10(6) cells) compared to 32D cl 3 parent cells. Ascorbic Acid 93-102 superoxide dismutase 2 Homo sapiens 9-39 14967442-8 2004 CONCLUSIONS: Manganese superoxide dismutase overexpression protects 2C6 cells from irradiation damage by scavenging ROS that readily interact with major endogenous antioxidants--ascorbate and GSH--in nontransfected hematopoietic 32D cl 3 cells. Ascorbic Acid 178-187 superoxide dismutase 2 Homo sapiens 13-43 12017292-6 2002 Incubation of an intracellular MnSOD-enriched fraction with apoptosis-inducing concentrations of sodium ascorbate, gallic acid or EGCG did not significantly reduce the MnSOD activity, suggesting that their actions might be cell-mediated. Ascorbic Acid 97-113 superoxide dismutase 2 Homo sapiens 31-36 30565018-0 2019 Vitamin C Attenuates Sodium Fluoride-Induced Mitochondrial Oxidative Stress and Apoptosis via Sirt1-SOD2 Pathway in F9 Cells. Ascorbic Acid 0-9 superoxide dismutase 2 Homo sapiens 100-104 9211496-6 1997 Elevated serum MnSOD correlated with peripheral plasma markers of lipid peroxidation (malondialdehyde) and neutrophil activation (myeloperoxidase) and was associated with decreased plasma ascorbic acid concentrations. Ascorbic Acid 188-201 superoxide dismutase 2 Homo sapiens 15-20 33302636-9 2021 CONCLUSIONS: This study showed for the first time that VC can attenuate the VCM induced nephrotoxicity by decreasing lipid peroxidation and expression of inflammatory cytokines, and increasing superoxide dismutase 2 (SOD2) activity, this effect may relate to the regulation of ROS/NF-kappaB pathway. Ascorbic Acid 55-57 superoxide dismutase 2 Homo sapiens 193-215 33302636-9 2021 CONCLUSIONS: This study showed for the first time that VC can attenuate the VCM induced nephrotoxicity by decreasing lipid peroxidation and expression of inflammatory cytokines, and increasing superoxide dismutase 2 (SOD2) activity, this effect may relate to the regulation of ROS/NF-kappaB pathway. Ascorbic Acid 55-57 superoxide dismutase 2 Homo sapiens 217-221 30565018-8 2019 Knockdown of Sirt1 blocked the vitamin C-mediated reduction in mROS and apoptosis via inhibiting Sirt1-SOD2 signaling. Ascorbic Acid 31-40 superoxide dismutase 2 Homo sapiens 103-107 30565018-9 2019 Importantly, sodium-dependent vitamin C transporter 2 (SVCT-2) siRNA was found to partially block the ability of vitamin C to promote Sirt1/SOD2 signaling. Ascorbic Acid 30-39 superoxide dismutase 2 Homo sapiens 140-144 30565018-10 2019 In summary, our data indicate that Sirt1 plays a pivotal role in the ability of vitamin C to stimulate SOD2 activity and attenuate mitochondrial oxidative stress, which partially through vitamin C receptor in NaF-induced F9 cells injury. Ascorbic Acid 80-89 superoxide dismutase 2 Homo sapiens 103-107 20059731-5 2010 Superoxide radicals produced are quickly scavenged by superoxide dismutase (MnSOD), and the resulting H(2)O(2) is detoxified by peroxiredoxin-thioredoxin system or by the enzymes of ascorbate-glutathione cycle, found in the mitochondrial matrix. Ascorbic Acid 182-191 superoxide dismutase 2 Homo sapiens 76-81 26482865-13 2015 However, following training, vitamin C and E supplementation significantly attenuated increased skeletal muscle superoxide dismutase (SOD) activity and protein abundance of SOD2 and TFAM. Ascorbic Acid 29-38 superoxide dismutase 2 Homo sapiens 134-137 26482865-13 2015 However, following training, vitamin C and E supplementation significantly attenuated increased skeletal muscle superoxide dismutase (SOD) activity and protein abundance of SOD2 and TFAM. Ascorbic Acid 29-38 superoxide dismutase 2 Homo sapiens 173-177 22607494-9 2013 Also, MDHAR and DHAR, via ascorbate regeneration, could constitute an essential antioxidant defense together with Mn-SOD, against NO and ONOO(-) stress in plant mitochondria. Ascorbic Acid 26-35 superoxide dismutase 2 Homo sapiens 114-120 19467856-7 2009 In addition, we found that the MnSOD Ala-9Ala genotype contributed to an increased breast cancer risk in premenopausal women who had low consumption of antioxidants (Ala/Ala versus Val/Ala+Val/Val: OR=2.6, 95% CI: 1.0-6.4 with low vitamin C consumption; OR=2.1, 95%CI: 1.3-3.4 with low vitamin E consumption and OR=2.9, 95%CI: 1.5-5.7 with low carotenoid consumption). Ascorbic Acid 231-240 superoxide dismutase 2 Homo sapiens 31-36 19229592-9 2009 Supplementing the animals with vitamin C, a powerful water-soluble antioxidant, increased the mRNA expression of MnSOD, though the protein expression and the activity did not change statistically. Ascorbic Acid 31-40 superoxide dismutase 2 Homo sapiens 113-118 17186424-8 2007 We observed an interaction between total vitamin C intake and the MnSOD polymorphism on melanoma risk. Ascorbic Acid 41-50 superoxide dismutase 2 Homo sapiens 66-71 16160055-7 2005 In contrast, feeding ruminally protected vitamin C was not associated with greater (P = 0.59) mean plasma ascorbate concentration; however, feeding ruminally protected vitamin C was associated with lower (P = 0.03) mean blood total superoxide dismutase (Cu/Zn SOD and Mn SOD) concentration. Ascorbic Acid 168-177 superoxide dismutase 2 Homo sapiens 268-274