PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24516579-10 2014 CONCLUSIONS: Selective COX-2 inhibitors including etodolac had an antitumor effect on MPNST cells, and their use holds promise as a novel therapeutic strategy for patients with MPNST to improve their prognoses. Etodolac 50-58 prostaglandin-endoperoxide synthase 2 Homo sapiens 23-28 9481468-8 1998 Two new NSAIDS, etodolac and nabumetone, do not inhibit cyclooxygenase 1 prostaglandins, which occur in the stomach and kidneys, but more selectively block cyclooxygenase 2 prostaglandins, which cause arthritic inflammation. Etodolac 16-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 156-172 28875479-6 2017 In a two-way cross-over study, eight healthy volunteers received 300 and 400 mg racemic etodolac, a preferential COX-2 inhibitor. Etodolac 88-96 prostaglandin-endoperoxide synthase 2 Homo sapiens 113-118 28875479-8 2017 Literature in vitro IC50 data for COX-2 inhibition by S-etodolac were used to fit adjusted pain score profiles from dental patients receiving etodolac. Etodolac 54-64 prostaglandin-endoperoxide synthase 2 Homo sapiens 34-39 28875479-8 2017 Literature in vitro IC50 data for COX-2 inhibition by S-etodolac were used to fit adjusted pain score profiles from dental patients receiving etodolac. Etodolac 56-64 prostaglandin-endoperoxide synthase 2 Homo sapiens 34-39 8566109-0 1995 Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1. Etodolac 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 36-64 8566109-0 1995 Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1. Etodolac 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 66-72 8566109-3 1995 In vitro enzyme results were supported by a human whole blood assay where etodolac also demonstrated a 10-fold selectivity for inhibition of PGHS-2 mediated TxB2 production. Etodolac 74-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 141-147 35132496-3 2022 Etodolac (Et), a cyclooxygenase-2 inhibitor, can be used as an adjuvant agent to sensitize cancer cells to chemotherapy. Etodolac 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-33 35132496-3 2022 Etodolac (Et), a cyclooxygenase-2 inhibitor, can be used as an adjuvant agent to sensitize cancer cells to chemotherapy. Etodolac 10-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-33 32158956-4 2020 However, with NSAIDs, these symptoms usually subside within 24 h. Diclofenac sodium and etodolac are NSAIDs, more selectively cyclooxygenase-2 inhibitors, with good analgesic efficacies. Etodolac 88-96 prostaglandin-endoperoxide synthase 2 Homo sapiens 126-142 30216103-1 2019 Etodolac is a nonsteroidal anti-inflammatory drug with selective cyclooxygenase-2 inhibition to treat pain and inflammation associated with osteoarthritis in humans and dogs. Etodolac 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 65-81 21868535-6 2011 RESULTS: Selective COX-2 inhibitor, etodolac, sensitized UM-SCC-23F/R cells to 5-FU. Etodolac 36-44 prostaglandin-endoperoxide synthase 2 Homo sapiens 19-24 22846758-1 2012 OBJECTIVE: We previously reported that oral administration of the selective cyclooxygenase-2 (COX-2) inhibitor etodolac results in antitumor effects in endometrial cancer tissue. Etodolac 111-119 prostaglandin-endoperoxide synthase 2 Homo sapiens 76-92 22846758-1 2012 OBJECTIVE: We previously reported that oral administration of the selective cyclooxygenase-2 (COX-2) inhibitor etodolac results in antitumor effects in endometrial cancer tissue. Etodolac 111-119 prostaglandin-endoperoxide synthase 2 Homo sapiens 94-99 21868535-7 2011 Expression of COX-2 decreased after etodolac treatment in both cell lines. Etodolac 36-44 prostaglandin-endoperoxide synthase 2 Homo sapiens 14-19 18242386-0 2008 Etodolac, a selective cyclooxygenase-2 inhibitor, induces upregulation of E-cadherin and has antitumor effect on human bladder cancer cells in vitro and in vivo. Etodolac 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-38 18405470-0 2008 Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. Etodolac 66-74 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 18405470-1 2008 OBJECTIVES: To review the clinical effectiveness and cost-effectiveness of cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drugs (NSAIDs) (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis (OA) and rheumatoid arthritis (RA). Etodolac 158-166 prostaglandin-endoperoxide synthase 2 Homo sapiens 75-91 18242386-3 2008 In the present study, we investigated the antitumor effect and E-cadherin induction of etodolac, a highly selective COX-2 inhibitor, on human bladder cancer cells in vitro and in vivo. Etodolac 87-95 prostaglandin-endoperoxide synthase 2 Homo sapiens 116-121 18242386-5 2008 RESULTS: Etodolac showed significant cytotoxicity only to T24 cells, which expressed the greatest level of COX-2 mRNA and the lowest level of E-cadherin mRNA among the three cell lines. Etodolac 9-17 prostaglandin-endoperoxide synthase 2 Homo sapiens 107-112 18242386-8 2008 CONCLUSIONS: Etodolac exhibited antitumor activity and induced E-cadherin expression in bladder cancer cells and might be useful for the clinical treatment and prevention of bladder cancer, especially in poorly differentiated bladder cancer with high COX-2 and low E-cadherin expression. Etodolac 13-21 prostaglandin-endoperoxide synthase 2 Homo sapiens 251-256 15598589-4 2005 In this study, we show that etodolac, a selective cyclo-oxygenase-2 inhibitor, enhanced CBDCA-induced apoptosis of SCC-25, although etodolac alone did not induce the apoptosis. Etodolac 28-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 50-67 17186240-1 2007 OBJECTIVE: SDX-101 is the non-cyclooxygenase 2-inhibiting R-enantiomer of the non-steroid anti-inflammatory drug etodolac, and has anti-tumour activity in chronic lymphocytic leukaemia (CLL). Etodolac 11-18 prostaglandin-endoperoxide synthase 2 Homo sapiens 30-46 17603251-0 2007 Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis. Etodolac 92-100 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-80 17603251-2 2007 This is the first case report of membranous nephropathy in a patient with early-stage rheumatoid arthritis treated with the relatively selective cyclooxygenase-2 inhibitor, etodolac. Etodolac 173-181 prostaglandin-endoperoxide synthase 2 Homo sapiens 145-161 17143495-0 2007 Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1). Etodolac 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-38 16360450-1 2005 OBJECTIVES: To investigate the effects of the selective cyclooxygenase-2 (COX-2) inhibitor etodolac on prostate cancer cell lines in vitro and in vivo and on E-cadherin expression in prostate cancer cells. Etodolac 91-99 prostaglandin-endoperoxide synthase 2 Homo sapiens 56-72 16360450-1 2005 OBJECTIVES: To investigate the effects of the selective cyclooxygenase-2 (COX-2) inhibitor etodolac on prostate cancer cell lines in vitro and in vivo and on E-cadherin expression in prostate cancer cells. Etodolac 91-99 prostaglandin-endoperoxide synthase 2 Homo sapiens 74-79 16360450-3 2005 We also performed quantitative real-time polymerase chain reaction to measure the mRNA expression of COX-2, Bcl-2, and E-cadherin in these cell lines after etodolac treatment. Etodolac 156-164 prostaglandin-endoperoxide synthase 2 Homo sapiens 101-106 16360450-9 2005 CONCLUSIONS: The COX-2 inhibitor etodolac exhibited an antitumor effect on prostate cancer cell lines in vitro and in vivo, and it might be useful for the treatment of hormone-resistant prostate cancer. Etodolac 33-41 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-22 16004971-2 2005 Non-steroidal anti-inflammatory drugs such as etodolac and celecoxib have been shown to inhibit COX-2 activity and may play a role in the chemoprevention of cancer. Etodolac 46-54 prostaglandin-endoperoxide synthase 2 Homo sapiens 96-101 16104877-3 2005 In this study, we showed that etodolac, COX-2 inhibitor, induced apoptosis via COX-2 independent pathway, and investigated the molecular details of etodolac-induced apoptosis in Burkitt"s lymphoma cells. Etodolac 30-38 prostaglandin-endoperoxide synthase 2 Homo sapiens 40-45 16104877-3 2005 In this study, we showed that etodolac, COX-2 inhibitor, induced apoptosis via COX-2 independent pathway, and investigated the molecular details of etodolac-induced apoptosis in Burkitt"s lymphoma cells. Etodolac 30-38 prostaglandin-endoperoxide synthase 2 Homo sapiens 79-84 15598589-0 2005 Etodolac, a selective cyclo-oxygenase-2 inhibitor, enhances carboplatin-induced apoptosis of human tongue carcinoma cells by down-regulation of FAP-1 expression. Etodolac 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-39 16046235-7 2006 CONCLUSIONS: Etodolac induced loss of mitochondrial membrane potential and apoptosis via a COX-2-independent pathway, suppressed the expression of adhesion molecules, and inhibited myeloma cell adhesion to BMSCs compared with thalidomide or meloxicam. Etodolac 13-21 prostaglandin-endoperoxide synthase 2 Homo sapiens 91-96 15809736-10 2005 Study of COX-2 inhibition of TMG-L cells showed that etodolac produced dose-dependent inhibition of cell proliferation through G1 phase cell-cycle arrest. Etodolac 53-61 prostaglandin-endoperoxide synthase 2 Homo sapiens 9-14 15892673-5 2005 Selective cyclooxygenase-2 (COX-2) inhibitors represent a new group of pharmaceutical products termed "coxibs" that include meloxicam, nimesulide, etodolac and celecoxib. Etodolac 147-155 prostaglandin-endoperoxide synthase 2 Homo sapiens 10-26 12483244-0 2002 Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines. Etodolac 11-19 prostaglandin-endoperoxide synthase 2 Homo sapiens 33-49 15298730-0 2004 Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase 2 inhibitor, etodolac, in human hepatocellular carcinoma cell lines. Etodolac 165-173 prostaglandin-endoperoxide synthase 2 Homo sapiens 137-153 15298730-3 2004 In this study, we investigated the mechanisms of growth inhibition and cell cycle arrest by etodolac, a selective COX-2 inhibitor, in HCC cell lines, HepG2 and PLC/PRF/5, by studying cell cycle regulatory proteins, and the MAP kinase and PDK1-PKB/AKT signaling pathways. Etodolac 92-100 prostaglandin-endoperoxide synthase 2 Homo sapiens 114-119 12824918-2 2003 To further investigate this positive correlation and its possible therapeutic implications, a selective COX-2 inhibitor, etodolac, was tested on three variants of HT-29 colon cancer cell lines, HT-29/Inv1, HT-29/Inv2 and HT-29/Inv3, with graded increases of in vitro Matrigel invasive potential and COX-2 expression levels. Etodolac 121-129 prostaglandin-endoperoxide synthase 2 Homo sapiens 104-109 12607659-3 2003 METHODS: We compared a cyclooxygenase-2 inhibitor (etodolac) with two traditional drugs: a nonselective cyclooxygenase inhibitor (diclofenac) and a weak opioid (tramadol) on postoperative pain and renal function in patients undergoing coronary artery bypass operations. Etodolac 51-59 prostaglandin-endoperoxide synthase 2 Homo sapiens 23-39 12126649-7 2002 Etodolac, a selective cyclooxygenase-2 inhibitor, suppressed the increase in PGE(2) levels. Etodolac 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-38 11251697-5 2001 The electron spin resonance study also demonstrated that the formation of superoxide-DMPO spin adduct was strongly inhibited by a selective cyclooxygenase-2 inhibitor, etodolac, in a concentration-dependent manner. Etodolac 168-176 prostaglandin-endoperoxide synthase 2 Homo sapiens 140-156 11525777-12 2001 Plasma from etodolac-treated subjects demonstrated a slight selectivity towards the inhibition of cyclooxygenase-2. Etodolac 12-20 prostaglandin-endoperoxide synthase 2 Homo sapiens 98-114 11275997-0 2001 Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. Etodolac 160-168 prostaglandin-endoperoxide synthase 2 Homo sapiens 78-94 11275997-0 2001 Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. Etodolac 160-168 prostaglandin-endoperoxide synthase 2 Homo sapiens 96-101 11275997-0 2001 Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. Etodolac 160-168 prostaglandin-endoperoxide synthase 2 Homo sapiens 133-138 11275997-6 2001 The effects of a COX-2-selective inhibitor, etodolac, on cell proliferation and invasive activity were also determined. Etodolac 44-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-22 11275997-10 2001 The selective COX-2 inhibitor, etodolac, could especially exert cytotoxicity and markedly suppress the invasive property and PGE(2) production, although not the COX-2 protein level, in HT-29/Inv3 cells. Etodolac 31-39 prostaglandin-endoperoxide synthase 2 Homo sapiens 14-19 11275997-10 2001 The selective COX-2 inhibitor, etodolac, could especially exert cytotoxicity and markedly suppress the invasive property and PGE(2) production, although not the COX-2 protein level, in HT-29/Inv3 cells. Etodolac 31-39 prostaglandin-endoperoxide synthase 2 Homo sapiens 161-166 11160644-3 2001 Using the ratio of IC(50) values (COX-1/COX-2), the selectivity ratio for the inhibition of COX-2 by etoricoxib in the human whole blood assay was 106, compared with values of 35, 30, 7.6, 7.3, 2.4, and 2.0 for rofecoxib, valdecoxib, celecoxib, nimesulide, etodolac, and meloxicam, respectively. Etodolac 257-265 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-97 10594327-3 1999 Indomethacin, sodium diclofenac, flurbiprofen, zaltoprofen, etodolac, but not mofezolac, enhanced apoptotic DNA fragmentation and mRNA expression for cyclooxygenase-2 in AGS cells, a cell line derived from human gastric epithelium. Etodolac 60-68 prostaglandin-endoperoxide synthase 2 Homo sapiens 150-166