PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7819598-0 1994 Exogenous CoQ10 preserves plasma ubiquinone levels in patients treated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. coenzyme Q10 10-15 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 76-123 18787645-5 2008 Statin, 3-hydroxy-3- methyl-glutaryl (HMG)-CoA reductase inhibitor therapy inhibits conversion of HMG-CoA to mevalonate and lowers plasma CoQ(10) concentrations. coenzyme Q10 138-141 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 8-56 16048353-3 2005 HMG-CoA reductase is also the first committed rate-limiting step for the synthesis of a range of other compounds including steroid hormones and ubidecarenone (ubiquinone), otherwise known as coenzyme Q(10) (CoQ(10)). coenzyme Q10 144-157 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 0-17 33482334-2 2021 CoQ10 biosynthesis decreases with age in different tissues including skin and its biosynthesis can be modulated by 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors such as statins. coenzyme Q10 0-5 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 155-173