PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23085230-0 2012 5-Fluorocytosine combined with Fcy-hEGF fusion protein targets EGFR-expressing cancer cells. Flucytosine 0-16 epidermal growth factor receptor Homo sapiens 63-67 33672989-2 2021 Fcy-hEGF fusion protein, composed of yeast cytosine deaminase (Fcy) and human EGF (hEGF), is capable of binding to EGFR and enzymatically convert 5-fluorocytosine (5-FC) to 1000-fold toxic 5-fluorocuracil (5-FU), thereby inhibiting the growth of EGFR-expressing tumor cells. Flucytosine 146-162 epidermal growth factor receptor Homo sapiens 246-250 33672989-2 2021 Fcy-hEGF fusion protein, composed of yeast cytosine deaminase (Fcy) and human EGF (hEGF), is capable of binding to EGFR and enzymatically convert 5-fluorocytosine (5-FC) to 1000-fold toxic 5-fluorocuracil (5-FU), thereby inhibiting the growth of EGFR-expressing tumor cells. Flucytosine 164-168 epidermal growth factor receptor Homo sapiens 246-250 31840981-2 2020 Here, a fusion protein was designed with both an antiepidermal growth factor receptor (EGFR) affibody and the prodrug enzyme cytosine deaminase, which can convert prodrug 5-fluorocytosine to the anticancer drug 5-fluorouracil. Flucytosine 171-187 epidermal growth factor receptor Homo sapiens 87-91 23085230-6 2012 Here, we adopted a prodrug system that uses 5-fluorocytosine (5-FC) and human EGF (hEGF) fused with yeast cytosine deaminase (Fcy) to target EGFR-overexpressing cancer cells and to convert 5-FC to a significantly more toxic chemotherapeutic, 5-fluorouracil (5-FU). Flucytosine 44-60 epidermal growth factor receptor Homo sapiens 141-145 23085230-6 2012 Here, we adopted a prodrug system that uses 5-fluorocytosine (5-FC) and human EGF (hEGF) fused with yeast cytosine deaminase (Fcy) to target EGFR-overexpressing cancer cells and to convert 5-FC to a significantly more toxic chemotherapeutic, 5-fluorouracil (5-FU). Flucytosine 189-193 epidermal growth factor receptor Homo sapiens 141-145