PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23403306-2 2013 In this study, we introduced the human parental neural stem cells, HB1.F3, with the human interferon beta (IFN-beta) gene which is a typical cytokine gene that has an antitumor effect and the cytosine deaminase (CD) gene from Escherichia coli (E. coli) that could convert the non-toxic prodrug, 5-fluorocytosine (5-FC), to a toxic metabolite, 5-fluorouracil (5-FU). Flucytosine 295-311 interferon beta 1 Homo sapiens 90-105 21769425-5 2011 Treatment of a human non-small cell lung carcinoma cell line (A549, a lung carcinoma derived from human lung epithelial cells) with the pro-drug 5-fluorocytosine (5-FC) in the presence of HB1.F3.CD or HB1.F3.CD.IFN-beta cells resulted in the inhibition of lung cancer cell growth. Flucytosine 145-161 interferon beta 1 Homo sapiens 211-219 27188205-3 2017 MATERIALS AND METHODS: CD can convert a prodrug, 5-fluorocytosine (5-FC), to active 5-fluorouracil, which inhibits tumor growth through the inhibition of DNA synthesis,while IFN-beta also strongly inhibits tumor growth by inducing the apoptotic process. Flucytosine 49-65 interferon beta 1 Homo sapiens 174-182 23403306-2 2013 In this study, we introduced the human parental neural stem cells, HB1.F3, with the human interferon beta (IFN-beta) gene which is a typical cytokine gene that has an antitumor effect and the cytosine deaminase (CD) gene from Escherichia coli (E. coli) that could convert the non-toxic prodrug, 5-fluorocytosine (5-FC), to a toxic metabolite, 5-fluorouracil (5-FU). Flucytosine 295-311 interferon beta 1 Homo sapiens 107-115 22790964-6 2012 Treatment of Hep3B, human liver cancer cells, with the prodrug 5-fluorocytosine (5-FC) in the presence of HB1.F3.CD or HB1.F3.CD.IFN-beta cells resulted in the inhibition of Hep3B cell growth. Flucytosine 63-79 interferon beta 1 Homo sapiens 129-137