PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16413651-6 2006 Western blot analysis revealed that arecoline induced cyclin Bl, Wee 1, and phosphorylated cdc2 protein levels whereas it declined p21 protein expression in KB cancer cells. Arecoline 36-45 cyclin dependent kinase 1 Homo sapiens 91-95 16413651-7 2006 Nevertheless, arecoline induced p21, but decreased cdc2 and cyclin B1 protein levels in GK. Arecoline 14-23 cyclin dependent kinase 1 Homo sapiens 51-55 30011295-3 2018 Arecoline arrested preadipocyte growth in the G2/M phase of the cell cycle; decreased the total levels of cyclin-dependent kinase 1 (CDK1), p21, and p27 proteins; increased p53 and cyclin B1 protein levels; and had no effect on CDK2 protein levels. Arecoline 0-9 cyclin dependent kinase 1 Homo sapiens 106-131 30011295-6 2018 Pre-treatment with the antioxidant, N-acetylcysteine, prevented the actions of arecoline on cell viability, G2/M growth arrest, reactive oxygen species (ROS) production, and the levels of CDK1, p21, p27, p53, cyclin B1, and phospho-AMPK proteins. Arecoline 79-88 cyclin dependent kinase 1 Homo sapiens 188-192 33287214-6 2020 In RWPE-1 cells, arecoline increased the expression of cyclin-dependent kinase (CDK)-1, p21, and cyclins B1 and D3, decreased the expression of CDK2, and had no effects on CDK4 and cyclin D1 expression. Arecoline 17-26 cyclin dependent kinase 1 Homo sapiens 55-86 30011295-3 2018 Arecoline arrested preadipocyte growth in the G2/M phase of the cell cycle; decreased the total levels of cyclin-dependent kinase 1 (CDK1), p21, and p27 proteins; increased p53 and cyclin B1 protein levels; and had no effect on CDK2 protein levels. Arecoline 0-9 cyclin dependent kinase 1 Homo sapiens 133-137 30011295-4 2018 These results suggested that arecoline selectively affected a particular CDK subfamily. Arecoline 29-38 cyclin dependent kinase 1 Homo sapiens 73-76 22108589-6 2012 In addition, arecoline induced progressive and sustained accumulation of BCC-1/KMC cells in G2/M phase as a result of reducing checkpoint Cdc2 activity by decreasing Cdc25C phosphatase levels and increasing p53 levels. Arecoline 13-22 cyclin dependent kinase 1 Homo sapiens 138-142