PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22108589-6	2012	In addition, arecoline induced progressive and sustained accumulation of BCC-1/KMC cells in G2/M phase as a result of reducing checkpoint Cdc2 activity by decreasing Cdc25C phosphatase levels and increasing p53 levels.	Arecoline	13-22	cyclin dependent kinase 1	Homo sapiens	138-142	
30011295-6	2018	Pre-treatment with the antioxidant, N-acetylcysteine, prevented the actions of arecoline on cell viability, G2/M growth arrest, reactive oxygen species (ROS) production, and the levels of CDK1, p21, p27, p53, cyclin B1, and phospho-AMPK proteins.	Arecoline	79-88	cyclin dependent kinase 1	Homo sapiens	188-192	
16413651-6	2006	Western blot analysis revealed that arecoline induced cyclin Bl, Wee 1, and phosphorylated cdc2 protein levels whereas it declined p21 protein expression in KB cancer cells.	Arecoline	36-45	cyclin dependent kinase 1	Homo sapiens	91-95	
16413651-7	2006	Nevertheless, arecoline induced p21, but decreased cdc2 and cyclin B1 protein levels in GK.	Arecoline	14-23	cyclin dependent kinase 1	Homo sapiens	51-55	
33287214-6	2020	In RWPE-1 cells, arecoline increased the expression of cyclin-dependent kinase (CDK)-1, p21, and cyclins B1 and D3, decreased the expression of CDK2, and had no effects on CDK4 and cyclin D1 expression.	Arecoline	17-26	cyclin dependent kinase 1	Homo sapiens	55-86	
30011295-3	2018	Arecoline arrested preadipocyte growth in the G2/M phase of the cell cycle; decreased the total levels of cyclin-dependent kinase 1 (CDK1), p21, and p27 proteins; increased p53 and cyclin B1 protein levels; and had no effect on CDK2 protein levels.	Arecoline	0-9	cyclin dependent kinase 1	Homo sapiens	106-131	
30011295-3	2018	Arecoline arrested preadipocyte growth in the G2/M phase of the cell cycle; decreased the total levels of cyclin-dependent kinase 1 (CDK1), p21, and p27 proteins; increased p53 and cyclin B1 protein levels; and had no effect on CDK2 protein levels.	Arecoline	0-9	cyclin dependent kinase 1	Homo sapiens	133-137	
30011295-4	2018	These results suggested that arecoline selectively affected a particular CDK subfamily.	Arecoline	29-38	cyclin dependent kinase 1	Homo sapiens	73-76