PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26275128-6	2015	The detoxifying/antioxidant genes activated by t-CA, especially heme oxygenase-1 (HO-1), were found to be involved in its cytoprotective effects against oxidative stress and cell injuries elicited by carcinogens tert-butylhydroperoxide and arecoline.	Arecoline	240-249	heme oxygenase 1	Homo sapiens	64-80	
26275128-6	2015	The detoxifying/antioxidant genes activated by t-CA, especially heme oxygenase-1 (HO-1), were found to be involved in its cytoprotective effects against oxidative stress and cell injuries elicited by carcinogens tert-butylhydroperoxide and arecoline.	Arecoline	240-249	heme oxygenase 1	Homo sapiens	82-86	
19364390-8	2009	Sublethal concentrations of arecoline upregulated the expression of the following stress-responsive genes: heme oxygenase-1; ferritin light chain; glucose-6-phosphate dehydrogenase; glutamate-cysteine ligase catalytic subunit; and glutathione reductase.	Arecoline	28-37	heme oxygenase 1	Homo sapiens	107-123	
19388153-9	2009	Arecoline was also found to elevate HO-1 mRNA and protein expression in a dose-dependent manner (P < 0.05).	Arecoline	0-9	heme oxygenase 1	Homo sapiens	36-40	
19388153-10	2009	CONCLUSIONS: Taken together, the data presented here demonstrated that HO-1 expression is significantly upregulated in OSF from areca quid chewers, and arecoline may be responsible for the enhanced HO-1 expression in vivo.	Arecoline	152-161	heme oxygenase 1	Homo sapiens	198-202	
18492619-11	2008	In addition, arecoline was found to elevate HO-1 mRNA in a dose-dependent manner (p < 0.05).	Arecoline	13-22	heme oxygenase 1	Homo sapiens	44-48	
18492619-13	2008	Moreover, addition of NAC markedly inhibited arecoline-induced HO-1 expression (p < 0.05).	Arecoline	45-54	heme oxygenase 1	Homo sapiens	63-67	
18492619-14	2008	CONCLUSION: Taken together, these results suggest that HO-1 expression is significantly upregulated in OSCC from areca quid chewers, and arecoline may be responsible for enhanced HO-1 expression in vivo.	Arecoline	137-146	heme oxygenase 1	Homo sapiens	179-183	
18492619-16	2008	The regulation of HO-1 expression induced by arecoline is critically dependent on intracellular GSH concentration.	Arecoline	45-54	heme oxygenase 1	Homo sapiens	18-22