PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34316331-8 2021 Consequently, silencing NEAT1 in arecoline-exposed cells not only downregulated the expression of JunD and stabilized expression of ZO-1, but also reduced expression of the EMT markers, Slug and Snail, indicating its direct regulatory role in arecoline-mediated TJ disruption and disease progression. Arecoline 33-42 snail family transcriptional repressor 1 Homo sapiens 195-200 23874481-3 2013 Therefore, we hypothesize that the major areca nut alkaloid arecoline may induce Snail via ROS and involve in the pathogenesis of areca quid chewing-associated OSCC. Arecoline 60-69 snail family transcriptional repressor 1 Homo sapiens 81-86 23874481-10 2013 Arecoline was also found to induced Snail expression in a dose- and time-dependent manner (p<0.05). Arecoline 0-9 snail family transcriptional repressor 1 Homo sapiens 36-41 23874481-11 2013 Treatment with NAC, curcumin, and EGCG markedly inhibited arecoline induced Snail expression (p<0.05). Arecoline 58-67 snail family transcriptional repressor 1 Homo sapiens 76-81 23874481-13 2013 Arecoline-upregulated Snail expression may be mediated by ROS generation. Arecoline 0-9 snail family transcriptional repressor 1 Homo sapiens 22-27 23874481-14 2013 In addition, arecoline induced Snail expression was downregulated by NAC, curcumin, and EGCG. Arecoline 13-22 snail family transcriptional repressor 1 Homo sapiens 31-36