PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33287214-6 2020 In RWPE-1 cells, arecoline increased the expression of cyclin-dependent kinase (CDK)-1, p21, and cyclins B1 and D3, decreased the expression of CDK2, and had no effects on CDK4 and cyclin D1 expression. Arecoline 17-26 cyclin D1 Homo sapiens 181-190 33287214-8 2020 In LNCaP cells, arecoline decreased CDK2, CDK4, and cyclin D1 expression; increased p21, p27, and cyclin D3 expression; had no effects on CDK1 and cyclin B1 expression. Arecoline 16-25 cyclin D1 Homo sapiens 52-61 23525646-10 2013 In the HaCaT epithelial cells, arecoline downregulated expression of the G1/S phase regulatory proteins cyclin D1, CDK4, CDK2, E2F1 as determined by reverse transcription-PCR analysis and western blotting. Arecoline 31-40 cyclin D1 Homo sapiens 104-113 30910432-4 2019 Furthermore, we found that arecoline reduces the protein level of cyclin D1, but it has no effect on its mRNA level and protein stability, implying that arecoline may modulate the translation of cyclin D1. Arecoline 27-36 cyclin D1 Homo sapiens 66-75 30910432-4 2019 Furthermore, we found that arecoline reduces the protein level of cyclin D1, but it has no effect on its mRNA level and protein stability, implying that arecoline may modulate the translation of cyclin D1. Arecoline 27-36 cyclin D1 Homo sapiens 195-204 30910432-4 2019 Furthermore, we found that arecoline reduces the protein level of cyclin D1, but it has no effect on its mRNA level and protein stability, implying that arecoline may modulate the translation of cyclin D1. Arecoline 153-162 cyclin D1 Homo sapiens 195-204 30910432-5 2019 We also observed the downregulation of the Akt/mTOR signaling pathway after treatment with arecoline, which may be related to the translation of cyclin D1. Arecoline 91-100 cyclin D1 Homo sapiens 145-154