PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23525646-10	2013	In the HaCaT epithelial cells, arecoline downregulated expression of the G1/S phase regulatory proteins cyclin D1, CDK4, CDK2, E2F1 as determined by reverse transcription-PCR analysis and western blotting.	Arecoline	31-40	cyclin D1	Homo sapiens	104-113	
33287214-6	2020	In RWPE-1 cells, arecoline increased the expression of cyclin-dependent kinase (CDK)-1, p21, and cyclins B1 and D3, decreased the expression of CDK2, and had no effects on CDK4 and cyclin D1 expression.	Arecoline	17-26	cyclin D1	Homo sapiens	181-190	
33287214-8	2020	In LNCaP cells, arecoline decreased CDK2, CDK4, and cyclin D1 expression; increased p21, p27, and cyclin D3 expression; had no effects on CDK1 and cyclin B1 expression.	Arecoline	16-25	cyclin D1	Homo sapiens	52-61	
30910432-4	2019	Furthermore, we found that arecoline reduces the protein level of cyclin D1, but it has no effect on its mRNA level and protein stability, implying that arecoline may modulate the translation of cyclin D1.	Arecoline	27-36	cyclin D1	Homo sapiens	66-75	
30910432-4	2019	Furthermore, we found that arecoline reduces the protein level of cyclin D1, but it has no effect on its mRNA level and protein stability, implying that arecoline may modulate the translation of cyclin D1.	Arecoline	27-36	cyclin D1	Homo sapiens	195-204	
30910432-4	2019	Furthermore, we found that arecoline reduces the protein level of cyclin D1, but it has no effect on its mRNA level and protein stability, implying that arecoline may modulate the translation of cyclin D1.	Arecoline	153-162	cyclin D1	Homo sapiens	195-204	
30910432-5	2019	We also observed the downregulation of the Akt/mTOR signaling pathway after treatment with arecoline, which may be related to the translation of cyclin D1.	Arecoline	91-100	cyclin D1	Homo sapiens	145-154