PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19343784-6	2009	Moreover, arecoline only increased the levels of the p-p53Ser6, p-p53Ser15, and p-p53Ser392 phosphorylated p53 isoforms among the known isoforms.	Arecoline	10-19	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	55-58	
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Arecoline	61-70	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	412-415	
19343784-0	2009	Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells.	Arecoline	0-9	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	33-36	
19343784-1	2009	Betel-quid use is associated with liver cancer whereas its constituent arecoline is cytotoxic, genotoxic, and induces p53-dependent p21(WAF1) protein expression in Clone-9 cells (rat hepatocytes).	Arecoline	71-80	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	118-121	
19343784-3	2009	Thus, we studied the role of ATM/ATR and PI3K in arecoline-induced p53 and p21(WAF1) protein expression in Clone-9 cells.	Arecoline	49-58	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	67-70	
19343784-9	2009	We conclude that arecoline activates the ATM/ATR-p53-p21(WAF1) and the PI3K/Akt-mTOR-p53 pathways in Clone-9 cells.	Arecoline	17-26	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	49-52	
19343784-9	2009	We conclude that arecoline activates the ATM/ATR-p53-p21(WAF1) and the PI3K/Akt-mTOR-p53 pathways in Clone-9 cells.	Arecoline	17-26	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	85-88	
17997002-11	2008	Moreover, arecoline-induced p21(WAF1) is dependent on p53 while arecoline-inhibited growth is dependent on both TGF-beta and p53.	Arecoline	64-73	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	125-128	
17997002-0	2008	Arecoline-induced growth arrest and p21WAF1 expression are dependent on p53 in rat hepatocytes.	Arecoline	0-9	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	72-75	
17997002-7	2008	Moreover, arecoline (0.5mM) time-dependently (8-24h) increased p53 serine 15 phosphorylation.	Arecoline	10-19	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	63-66	
17997002-8	2008	Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h.	Arecoline	119-128	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	17-20	
17997002-8	2008	Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h.	Arecoline	119-128	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	56-59	
17997002-10	2008	We concluded that arecoline induces cytotoxicity, DNA damage, G(0)/G(1) cell cycle arrest, TGF-beta1, p21(WAF1) and activates p53 in Clone-9 cells.	Arecoline	18-27	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	126-129	
17997002-11	2008	Moreover, arecoline-induced p21(WAF1) is dependent on p53 while arecoline-inhibited growth is dependent on both TGF-beta and p53.	Arecoline	10-19	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	54-57