PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20507639-1	2010	BACKGROUND: Our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (IL-6), increases levels of tumor suppressor factor p53, and elicits cell cycle arrest, followed by apoptosis.	Arecoline	75-84	tumor protein p53	Homo sapiens	200-203	
22108589-6	2012	In addition, arecoline induced progressive and sustained accumulation of BCC-1/KMC cells in G2/M phase as a result of reducing checkpoint Cdc2 activity by decreasing Cdc25C phosphatase levels and increasing p53 levels.	Arecoline	13-22	tumor protein p53	Homo sapiens	207-210	
22108589-8	2012	This study demonstrates that arecoline has potential for preventing BCC tumorigenesis by reducing levels of the tumor cell survival factor IL-6, increasing levels of the tumor suppressor factor p53, and eliciting cell cycle arrest, followed by apoptosis.	Arecoline	29-38	tumor protein p53	Homo sapiens	194-197	
32722430-6	2020	Mechanistically, arecoline inhibited p53-induced DDB2 promoter activity through the DNA-binding but not the transactivation domain of p53.	Arecoline	17-26	tumor protein p53	Homo sapiens	37-40	
32722430-9	2020	These data uncover one of mechanisms underlying arecoline-mediated carcinogenicity through inhibiting p53-regulated DDB2 expression and DNA repair.	Arecoline	48-57	tumor protein p53	Homo sapiens	102-105	
30011295-6	2018	Pre-treatment with the antioxidant, N-acetylcysteine, prevented the actions of arecoline on cell viability, G2/M growth arrest, reactive oxygen species (ROS) production, and the levels of CDK1, p21, p27, p53, cyclin B1, and phospho-AMPK proteins.	Arecoline	79-88	tumor protein p53	Homo sapiens	204-207	
32722430-0	2020	Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53"s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.	Arecoline	46-55	tumor protein p53	Homo sapiens	67-70	
32722430-3	2020	Previously, we have reported that arecoline (0.3 mM) is able to inhibit DNA repair in a p53-dependent pathway, but the underlying mechanism is unclear.	Arecoline	34-43	tumor protein p53	Homo sapiens	88-91	
32722430-4	2020	Here we demonstrated that arecoline suppressed the expression of DDB2, which is transcriptionally regulated by p53 and is required for nucleotide excision repair (NER).	Arecoline	26-35	tumor protein p53	Homo sapiens	111-114	
30011295-3	2018	Arecoline arrested preadipocyte growth in the G2/M phase of the cell cycle; decreased the total levels of cyclin-dependent kinase 1 (CDK1), p21, and p27 proteins; increased p53 and cyclin B1 protein levels; and had no effect on CDK2 protein levels.	Arecoline	0-9	tumor protein p53	Homo sapiens	173-176	
28550687-0	2018	Tanshinone Suppresses Arecoline-Induced Epithelial-Mesenchymal Transition in Oral Submucous Fibrosis by Epigenetically Reactivating the p53 Pathway.	Arecoline	22-31	tumor protein p53	Homo sapiens	136-139	
28550687-7	2018	In addition, p53 and its downstream molecules were decreased by arecoline treatment in oral mucosal fibroblasts, which was reversed by treatment with TSN in a dose-dependent manner.	Arecoline	64-73	tumor protein p53	Homo sapiens	13-16	
28550687-8	2018	Our results also revealed that arecoline stimulation resulted in hypermethylation of the promoter of TP53 and subsequent downregulation of p53 levels, which was reversed by TSN.	Arecoline	31-40	tumor protein p53	Homo sapiens	101-105	
28550687-8	2018	Our results also revealed that arecoline stimulation resulted in hypermethylation of the promoter of TP53 and subsequent downregulation of p53 levels, which was reversed by TSN.	Arecoline	31-40	tumor protein p53	Homo sapiens	139-142	
29931964-2	2016	METHODS: Human breast cancer MCF-7 cells were treated with arecoline at the concentrations of 0,10,30,50, 100,300,500mumol/L, the cell proliferation were detected by MTT assay, cell apoptosis were analyzed by Hoechst 33342 staining and flow cy-tometry, the protein expression of Bax,Bcl-2 and P53 were detected by Western blot.	Arecoline	59-68	tumor protein p53	Homo sapiens	293-296	
29931964-4	2016	However, high concentration(100,300,500mumol/L) arecoline inhibited proliferation and induced apoptosis of MCF-7 cells in a concentration-dependent manner, arecoline also significantly increased P53 and Bax protein expression and decreased Bcl-2 protein expression.	Arecoline	156-165	tumor protein p53	Homo sapiens	195-198	
29931964-5	2016	CONCLUSIONS: High concentration arecoline inhibited the proliferation and induced the apoptosis of MCF-7 cells, the mechanism was probably corrected with increasing P53 and Bax protein expression and decreasing Bcl-2 pro-tein expression.	Arecoline	32-41	tumor protein p53	Homo sapiens	165-168