PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17234337-3	2007	Our results indicated that arecoline attenuated the TCDD-induced CYP1A1 enzyme activation with an inhibitory effect on cell proliferation.	Arecoline	27-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	65-71	
17707585-0	2007	Differential effect of arecoline on the endogenous dioxin-responsive cytochrome P450 1A1 and on a stably transfected dioxin-responsive element-driven reporter in human hepatoma cells.	Arecoline	23-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	69-88	
17707585-3	2007	It was also shown that arecoline, a major areca nut alkaloid, inhibited the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cytochrome P450 1A1 (CYP1A1) activation in Huh-7 cells.	Arecoline	23-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	127-146	
17707585-3	2007	It was also shown that arecoline, a major areca nut alkaloid, inhibited the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cytochrome P450 1A1 (CYP1A1) activation in Huh-7 cells.	Arecoline	23-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	148-154	
17707585-5	2007	In the present study, the effect of arecoline on the TCDD-induced activation of DRE-CALUX and CYP1A1 enzyme in Huh7-DRE-Luc and Huh-7 cells, respectively, was examined.	Arecoline	36-45	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	94-100	
17707585-6	2007	It was found that arecoline inhibited TCDD-induced CYP1A1 activation and however enhanced TCDD-induced DRE-CALUX activation.	Arecoline	18-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-57	
17707585-7	2007	This finding indicates the differential effect of arecoline on the endogenous dioxin-responsive CYP1A1 and on a stably transfected DRE-driven reporter in human hepatoma cells.	Arecoline	50-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-102	
17234337-0	2007	Arecoline inhibits the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1A1 activation in human hepatoma cells.	Arecoline	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	67-86	
17234337-1	2007	In the present study, we investigated the effect of arecoline, a major areca nut alkaloid, on the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced activation of cytochrome P4501A1 (CYP1A1) in a human hepatoma cell line Huh-7.	Arecoline	52-61	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	183-189	
17234337-4	2007	By using real-time RT-PCR, we demonstrated that arecoline inhibited the TCDD-induced activations of CYP1A1 and AhR repressor (AhRR) mRNA expression in a similar pattern.	Arecoline	48-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-106	
17234337-6	2007	Therefore, in our present study, the observed inhibitory effect of arecoline on CYP1A1 activation was not due to the up-regulation of AhRR or direct inhibitory effect on CYP1A1.	Arecoline	67-76	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-86	
17234337-7	2007	Taken together, here we have demonstrated that arecoline attenuates the TCDD-induced CYP1A1 activation mainly via down-regulation of AhR expression in human hepatoma cells, suggesting the possible involvement of arecoline in the AhR-mediated metabolism of environmental toxicants in liver.	Arecoline	47-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	85-91