PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30246378-9	2019	In vitro, arecoline increased ROS along with upregulation of the angiotensin-converting enzyme (ACE)/Ang-II/AT1R axis and NLRP3 inflammasome/interleukin-1beta axis in human oral myofibroblasts, which were reduced by NOX4 inhibitor VAS2870, ROS scavenger N-acetylcysteine, and NOX4 small interfering RNA (siRNA).	Arecoline	10-19	interleukin 1 beta	Homo sapiens	141-158	
10530917-4	1999	IL-1 beta concentrations increased by 2.6, 2.7 and 7.5 times those of the control in groups treated with 1 microM nicotine, arecoline or with both, respectively.	Arecoline	124-133	interleukin 1 beta	Homo sapiens	0-9	
25529330-0	2015	Arecoline increases basic fibroblast growth factor but reduces expression of IL-1, IL-6, G-CSF and GM-CSF in human umbilical vein endothelium.	Arecoline	0-9	interleukin 1 beta	Homo sapiens	77-81	
25204733-3	2015	In this study, we showed that increased pro-IL-1beta expression was associated with the severity of oral malignant transformation in a mouse OSCC model induced by 4-Nitroquinolin-1-oxide (4-NQO) and arecoline, two carcinogens related to tobacco and betel quid, respectively.	Arecoline	199-208	interleukin 1 beta	Homo sapiens	44-52	
25204733-5	2015	In a human OSCC cell line TW2.6, we demonstrated nicotine-derived nitrosamine ketone (NNK) and arecoline stimulated IL-1beta secretion in an inflammasome-dependent manner.	Arecoline	95-104	interleukin 1 beta	Homo sapiens	116-124