PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24304567-5	2013	Arecoline, in a dose-dependent manner, significantly decreased IL-2 and PGE2 secretion by Jurkat cells incubated with 0 or 5 mug/ml 5 mug/ml PHA.	Arecoline	0-9	interleukin 2	Homo sapiens	63-67	
24304567-0	2013	Arecoline inhibits interleukin-2 secretion in Jurkat cells by decreasing the expression of alpha7-nicotinic acetylcholine receptors and prostaglandin E2.	Arecoline	0-9	interleukin 2	Homo sapiens	19-32	
31610043-11	2020	RESULTS: We have found that the stimulation of arecoline on FBs increased interleukin-2, interleukin-6, and interleukin-21 (IL-2, IL-6, and IL-21) while decreased transforming growth cytokine-beta (TGF-beta).	Arecoline	47-56	interleukin 2	Homo sapiens	74-87	
24304567-8	2013	PHA-enhanced IL-2 mRNA expression was also inhibited by arecoline.	Arecoline	56-65	interleukin 2	Homo sapiens	13-17	
24304567-9	2013	These results imply that arecoline inhibits the release of PGE2 and PHA-induced IL-2 secretion by Jurkat cells and that these effects seem to occur, at least in part, either through the attenuation of ERK in conjunction with a decrease of PHA-induced IL-2 mRNA expression.	Arecoline	25-34	interleukin 2	Homo sapiens	80-84	
24304567-9	2013	These results imply that arecoline inhibits the release of PGE2 and PHA-induced IL-2 secretion by Jurkat cells and that these effects seem to occur, at least in part, either through the attenuation of ERK in conjunction with a decrease of PHA-induced IL-2 mRNA expression.	Arecoline	25-34	interleukin 2	Homo sapiens	251-255	
24304567-10	2013	These results imply that arecoline inhibits the protein expression of alpha7-nAChRs , the release of PGE2 and PHA-induced IL-2 secretion by Jurkat cells.	Arecoline	25-34	interleukin 2	Homo sapiens	122-126	
11482128-7	2001	The results showed that IL-2, TNF-alpha, and TGF-beta were significantly lower in mononuclear cells of normal persons as stimulated by arecoline.	Arecoline	135-144	interleukin 2	Homo sapiens	24-28