PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32441858-0	2020	Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway.	Arecoline	0-9	mitogen-activated protein kinase 1	Homo sapiens	85-88	
24304567-7	2013	In addition, reduced expression of PHA-induced ERK phosphorylation was observed in Jurkat cells treated with arecoline.	Arecoline	109-118	mitogen-activated protein kinase 1	Homo sapiens	47-50	
24304567-9	2013	These results imply that arecoline inhibits the release of PGE2 and PHA-induced IL-2 secretion by Jurkat cells and that these effects seem to occur, at least in part, either through the attenuation of ERK in conjunction with a decrease of PHA-induced IL-2 mRNA expression.	Arecoline	25-34	mitogen-activated protein kinase 1	Homo sapiens	201-204	
21889036-10	2011	Inhibition of c-jun N-terminal kinase (JNK) by SP600125, p38 by SB 203580, or tyrosine kinase by genistein reduced arecoline-induced HO-1 expression.	Arecoline	115-124	mitogen-activated protein kinase 1	Homo sapiens	57-60	
23163860-8	2013	Moreover, 10 muM curcumin and 4 mM NAC significantly inhibited arecoline-induced ERK activation.	Arecoline	63-72	mitogen-activated protein kinase 1	Homo sapiens	81-84	
23163860-10	2013	CONCLUSION: Arecoline-induced PlGF synthesis is probably mediated by reactive oxygen species/ERK pathways, and curcumin may be an useful agent in controlling oral carcinogenesis.	Arecoline	12-21	mitogen-activated protein kinase 1	Homo sapiens	93-96	
21809341-5	2012	Arecoline-elicited increase in intracellular Ca(2+) concentration was responsible for JNK/c-Jun pathway activation and ERK inactivation.	Arecoline	0-9	mitogen-activated protein kinase 1	Homo sapiens	119-122