PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12907213-8	2003	Arecoline and safrole significantly elevated TIMP-1 protein and mRNA expression.	Arecoline	0-9	TIMP metallopeptidase inhibitor 1	Homo sapiens	45-51	
12907213-9	2003	We concluded that increased mRNA expression of TIMP-1 in buccal mucosal fibroblasts by arecoline and safrole is a possible pathogenesis for oral submucous fibrosis.	Arecoline	87-96	TIMP metallopeptidase inhibitor 1	Homo sapiens	47-53	
11854068-7	2002	Arecoline was found to elevate TIMP-1 expression at the concentration level under 20 microg/ml in a dose-dependent manner.	Arecoline	0-9	TIMP metallopeptidase inhibitor 1	Homo sapiens	31-37	
11854068-12	2002	Taken together, it was found that arecoline acted not only as an inhibitor on gelatinolytic activity of MMP-2, but also a stimulator for TIMP-1 activity.	Arecoline	34-43	TIMP metallopeptidase inhibitor 1	Homo sapiens	137-143