PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19343784-0	2009	Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells.	Arecoline	0-9	KRAS proto-oncogene, GTPase	Rattus norvegicus	41-44	
19343784-7	2009	ATM shRNA attenuated arecoline-induced p-p53Ser15 and p21(WAF1) at 24 h. Arecoline (0.5 mM) increased phosphorylation levels of p-AktSer473 and p-mTORSer2448 at 30-60 min.	Arecoline	21-30	KRAS proto-oncogene, GTPase	Rattus norvegicus	54-57	
19343784-7	2009	ATM shRNA attenuated arecoline-induced p-p53Ser15 and p21(WAF1) at 24 h. Arecoline (0.5 mM) increased phosphorylation levels of p-AktSer473 and p-mTORSer2448 at 30-60 min.	Arecoline	73-82	KRAS proto-oncogene, GTPase	Rattus norvegicus	54-57	
19343784-8	2009	Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription.	Arecoline	43-52	KRAS proto-oncogene, GTPase	Rattus norvegicus	61-64	
19343784-8	2009	Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription.	Arecoline	43-52	KRAS proto-oncogene, GTPase	Rattus norvegicus	174-177	
19343784-8	2009	Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription.	Arecoline	43-52	KRAS proto-oncogene, GTPase	Rattus norvegicus	174-177	
19343784-8	2009	Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription.	Arecoline	122-131	KRAS proto-oncogene, GTPase	Rattus norvegicus	174-177	
19343784-8	2009	Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription.	Arecoline	122-131	KRAS proto-oncogene, GTPase	Rattus norvegicus	174-177	
19343784-8	2009	Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription.	Arecoline	122-131	KRAS proto-oncogene, GTPase	Rattus norvegicus	174-177	
19343784-8	2009	Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription.	Arecoline	122-131	KRAS proto-oncogene, GTPase	Rattus norvegicus	174-177	
19343784-9	2009	We conclude that arecoline activates the ATM/ATR-p53-p21(WAF1) and the PI3K/Akt-mTOR-p53 pathways in Clone-9 cells.	Arecoline	17-26	KRAS proto-oncogene, GTPase	Rattus norvegicus	53-56	
19343784-10	2009	Arecoline-induced phosphorylated p-p53Ser15 expression is dependent on ATM whereas arecoline-induced p21(WAF1) protein expression is dependent on ATM and PI3K.	Arecoline	83-92	KRAS proto-oncogene, GTPase	Rattus norvegicus	101-104	
19343784-11	2009	Moreover, p21(WAF1) gene is transcriptionally induced by arecoline-activated ATM.	Arecoline	57-66	KRAS proto-oncogene, GTPase	Rattus norvegicus	10-13	
19343784-1	2009	Betel-quid use is associated with liver cancer whereas its constituent arecoline is cytotoxic, genotoxic, and induces p53-dependent p21(WAF1) protein expression in Clone-9 cells (rat hepatocytes).	Arecoline	71-80	KRAS proto-oncogene, GTPase	Rattus norvegicus	132-135	
19343784-3	2009	Thus, we studied the role of ATM/ATR and PI3K in arecoline-induced p53 and p21(WAF1) protein expression in Clone-9 cells.	Arecoline	49-58	KRAS proto-oncogene, GTPase	Rattus norvegicus	75-78	
17997002-6	2008	Arecoline (0.5mM) also increased p21(WAF1) protein expression and p21(WAF1) gene transcription.	Arecoline	0-9	KRAS proto-oncogene, GTPase	Rattus norvegicus	33-36	
17997002-6	2008	Arecoline (0.5mM) also increased p21(WAF1) protein expression and p21(WAF1) gene transcription.	Arecoline	0-9	KRAS proto-oncogene, GTPase	Rattus norvegicus	66-69	
17997002-8	2008	Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h.	Arecoline	119-128	KRAS proto-oncogene, GTPase	Rattus norvegicus	84-87	
17997002-8	2008	Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h.	Arecoline	119-128	KRAS proto-oncogene, GTPase	Rattus norvegicus	137-140	
17997002-10	2008	We concluded that arecoline induces cytotoxicity, DNA damage, G(0)/G(1) cell cycle arrest, TGF-beta1, p21(WAF1) and activates p53 in Clone-9 cells.	Arecoline	18-27	KRAS proto-oncogene, GTPase	Rattus norvegicus	102-105	
17997002-11	2008	Moreover, arecoline-induced p21(WAF1) is dependent on p53 while arecoline-inhibited growth is dependent on both TGF-beta and p53.	Arecoline	10-19	KRAS proto-oncogene, GTPase	Rattus norvegicus	28-31