PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19343784-7 2009 ATM shRNA attenuated arecoline-induced p-p53Ser15 and p21(WAF1) at 24 h. Arecoline (0.5 mM) increased phosphorylation levels of p-AktSer473 and p-mTORSer2448 at 30-60 min. Arecoline 21-30 KRAS proto-oncogene, GTPase Rattus norvegicus 54-57 19343784-7 2009 ATM shRNA attenuated arecoline-induced p-p53Ser15 and p21(WAF1) at 24 h. Arecoline (0.5 mM) increased phosphorylation levels of p-AktSer473 and p-mTORSer2448 at 30-60 min. Arecoline 73-82 KRAS proto-oncogene, GTPase Rattus norvegicus 54-57 19343784-8 2009 Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription. Arecoline 43-52 KRAS proto-oncogene, GTPase Rattus norvegicus 61-64 19343784-8 2009 Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription. Arecoline 43-52 KRAS proto-oncogene, GTPase Rattus norvegicus 174-177 19343784-8 2009 Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription. Arecoline 43-52 KRAS proto-oncogene, GTPase Rattus norvegicus 174-177 19343784-8 2009 Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription. Arecoline 122-131 KRAS proto-oncogene, GTPase Rattus norvegicus 174-177 19343784-8 2009 Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription. Arecoline 122-131 KRAS proto-oncogene, GTPase Rattus norvegicus 174-177 19343784-8 2009 Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription. Arecoline 122-131 KRAS proto-oncogene, GTPase Rattus norvegicus 174-177 19343784-8 2009 Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription. Arecoline 122-131 KRAS proto-oncogene, GTPase Rattus norvegicus 174-177 19343784-9 2009 We conclude that arecoline activates the ATM/ATR-p53-p21(WAF1) and the PI3K/Akt-mTOR-p53 pathways in Clone-9 cells. Arecoline 17-26 KRAS proto-oncogene, GTPase Rattus norvegicus 53-56 19343784-10 2009 Arecoline-induced phosphorylated p-p53Ser15 expression is dependent on ATM whereas arecoline-induced p21(WAF1) protein expression is dependent on ATM and PI3K. Arecoline 83-92 KRAS proto-oncogene, GTPase Rattus norvegicus 101-104 19343784-11 2009 Moreover, p21(WAF1) gene is transcriptionally induced by arecoline-activated ATM. Arecoline 57-66 KRAS proto-oncogene, GTPase Rattus norvegicus 10-13 19343784-0 2009 Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells. Arecoline 0-9 KRAS proto-oncogene, GTPase Rattus norvegicus 41-44 19343784-1 2009 Betel-quid use is associated with liver cancer whereas its constituent arecoline is cytotoxic, genotoxic, and induces p53-dependent p21(WAF1) protein expression in Clone-9 cells (rat hepatocytes). Arecoline 71-80 KRAS proto-oncogene, GTPase Rattus norvegicus 132-135 19343784-3 2009 Thus, we studied the role of ATM/ATR and PI3K in arecoline-induced p53 and p21(WAF1) protein expression in Clone-9 cells. Arecoline 49-58 KRAS proto-oncogene, GTPase Rattus norvegicus 75-78 17997002-6 2008 Arecoline (0.5mM) also increased p21(WAF1) protein expression and p21(WAF1) gene transcription. Arecoline 0-9 KRAS proto-oncogene, GTPase Rattus norvegicus 33-36 17997002-6 2008 Arecoline (0.5mM) also increased p21(WAF1) protein expression and p21(WAF1) gene transcription. Arecoline 0-9 KRAS proto-oncogene, GTPase Rattus norvegicus 66-69 17997002-8 2008 Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h. Arecoline 119-128 KRAS proto-oncogene, GTPase Rattus norvegicus 84-87 17997002-8 2008 Pifithrin-alpha (p53 inhibitor) and the loss of the two p53-binding elements in the p21(WAF1) gene promoter attenuated arecoline-induced p21(WAF1) gene transcription at 24h. Arecoline 119-128 KRAS proto-oncogene, GTPase Rattus norvegicus 137-140 17997002-10 2008 We concluded that arecoline induces cytotoxicity, DNA damage, G(0)/G(1) cell cycle arrest, TGF-beta1, p21(WAF1) and activates p53 in Clone-9 cells. Arecoline 18-27 KRAS proto-oncogene, GTPase Rattus norvegicus 102-105 17997002-11 2008 Moreover, arecoline-induced p21(WAF1) is dependent on p53 while arecoline-inhibited growth is dependent on both TGF-beta and p53. Arecoline 10-19 KRAS proto-oncogene, GTPase Rattus norvegicus 28-31