PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20507639-1	2010	BACKGROUND: Our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (IL-6), increases levels of tumor suppressor factor p53, and elicits cell cycle arrest, followed by apoptosis.	Arecoline	75-84	interleukin 6	Homo sapiens	134-147	
25529330-0	2015	Arecoline increases basic fibroblast growth factor but reduces expression of IL-1, IL-6, G-CSF and GM-CSF in human umbilical vein endothelium.	Arecoline	0-9	interleukin 6	Homo sapiens	83-87	
22108589-0	2012	Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells.	Arecoline	0-9	interleukin 6	Homo sapiens	20-33	
22108589-1	2012	Arecoline, the most abundant areca alkaloid, has been reported to decrease interleukin-6 (IL-6) levels in epithelial cancer cells.	Arecoline	0-9	interleukin 6	Homo sapiens	75-88	
22108589-1	2012	Arecoline, the most abundant areca alkaloid, has been reported to decrease interleukin-6 (IL-6) levels in epithelial cancer cells.	Arecoline	0-9	interleukin 6	Homo sapiens	90-94	
22108589-2	2012	Since IL-6 overexpression contributes to the tumorigenic potency of basal cell carcinoma (BCC), this study was designed to investigate whether arecoline altered IL-6 expression and its downstream regulation of apoptosis and the cell cycle in cultured BCC-1/KMC cells.	Arecoline	143-152	interleukin 6	Homo sapiens	161-165	
22108589-4	2012	After 24h exposure, arecoline inhibited BCC-1/KMC cell growth and decreased IL-6 production in terms of mRNA expression and protein secretion, but had no effect on HaCaT cells.	Arecoline	20-29	interleukin 6	Homo sapiens	76-80	
22108589-8	2012	This study demonstrates that arecoline has potential for preventing BCC tumorigenesis by reducing levels of the tumor cell survival factor IL-6, increasing levels of the tumor suppressor factor p53, and eliciting cell cycle arrest, followed by apoptosis.	Arecoline	29-38	interleukin 6	Homo sapiens	139-143	
20507639-1	2010	BACKGROUND: Our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (IL-6), increases levels of tumor suppressor factor p53, and elicits cell cycle arrest, followed by apoptosis.	Arecoline	75-84	interleukin 6	Homo sapiens	149-153	
15533212-0	2004	Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.	Arecoline	42-51	interleukin 6	Homo sapiens	14-27	
15533212-5	2004	The effects of arecoline, the major areca nut alkaloid, on IL-6 expression in normal human buccal mucosa fibroblasts (BMFs) were measured in vitro.	Arecoline	15-24	interleukin 6	Homo sapiens	59-63	
15533212-7	2004	To determine whether glutathione (GSH) levels were important in the induction of IL-6 by arecoline, we pretreated cells with 2-oxothiazolidine-4-carboxylic acid (OTZ) to boost GSH levels or with buthionine sulfoximine (BSO) to deplete GSH.	Arecoline	89-98	interleukin 6	Homo sapiens	81-85	
15533212-9	2004	The exposure of quiescent BMF to arecoline resulted in the elevation of IL-6 mRNA expression in a dose-dependent manner (P < 0.05).	Arecoline	33-42	interleukin 6	Homo sapiens	72-76	
15533212-10	2004	IL-6 gene regulated by arecoline correlated with intracellular GSH levels in BMF.	Arecoline	23-32	interleukin 6	Homo sapiens	0-4	
15533212-11	2004	Arecoline at a concentration of 129 muM induced about 2.7-fold IL-6 mRNA levels over the 6-h incubation period.	Arecoline	0-9	interleukin 6	Homo sapiens	63-67	
15533212-13	2004	In addition, OTZ was found to marginally reduce the arecoline-induced IL-6 expression by about 1.7-fold (P < 0.05).	Arecoline	52-61	interleukin 6	Homo sapiens	70-74	
15533212-14	2004	CONCLUSIONS: Taken together, these results suggest that IL-6 expression is significantly upregulated in OSF fibroblasts in areca quid chewers and arecoline may be responsible for the enhanced IL-6 expression.	Arecoline	146-155	interleukin 6	Homo sapiens	56-60	
15533212-14	2004	CONCLUSIONS: Taken together, these results suggest that IL-6 expression is significantly upregulated in OSF fibroblasts in areca quid chewers and arecoline may be responsible for the enhanced IL-6 expression.	Arecoline	146-155	interleukin 6	Homo sapiens	192-196	
15533212-15	2004	In addition, the regulation of IL-6 expression induced by arecoline is critically dependent on the intracellular GSH concentrations.	Arecoline	58-67	interleukin 6	Homo sapiens	31-35	
7490793-1	1995	This study aimed to assess the possibility of a direct effect of betel-nut alkaloids arecoline and arecaidine on cell proliferation and interleukin-6 (IL-6) production by cultured fibroblasts from human normal gingiva, buccal mucosa and oral submucous fibrosis (OSF) buccal mucosa in vitro.	Arecoline	85-94	interleukin 6	Homo sapiens	136-149	
7490793-9	1995	However, two of six individuals" normal buccal mucosa fibroblasts significantly released less IL-6, and some cases of OSF and healthy gingiva exhibited slightly higher levels of IL-6 when cells were exposed to arecoline or arecaidine in cultures.	Arecoline	210-219	interleukin 6	Homo sapiens	178-182	
7490793-10	1995	Such findings suggests that arecoline and arecaidine can enhance cell proliferation and affect fibroblasts to synthesize IL-6.	Arecoline	28-37	interleukin 6	Homo sapiens	121-125	
31610043-11	2020	RESULTS: We have found that the stimulation of arecoline on FBs increased interleukin-2, interleukin-6, and interleukin-21 (IL-2, IL-6, and IL-21) while decreased transforming growth cytokine-beta (TGF-beta).	Arecoline	47-56	interleukin 6	Homo sapiens	89-102	
31610043-11	2020	RESULTS: We have found that the stimulation of arecoline on FBs increased interleukin-2, interleukin-6, and interleukin-21 (IL-2, IL-6, and IL-21) while decreased transforming growth cytokine-beta (TGF-beta).	Arecoline	47-56	interleukin 6	Homo sapiens	130-134