PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12581384-0	2003	The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis.	Arecoline	88-97	prostaglandin-endoperoxide synthase 2	Homo sapiens	21-37	
18922923-1	2008	Because the mRNA expression of cyclooxygenase-2 (COX-2) is up-regulated by arecoline in human gingival fibroblasts, as shown in our previous study, we further investigated the mRNA expression level of COX-2 and its upstream effectors in three oral epithelial carcinoma cell lines (KB, SAS, and Ca9-22) by using areca nut extract (ANE) and saliva-reacted ANE (sANE).	Arecoline	75-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	31-47	
18922923-1	2008	Because the mRNA expression of cyclooxygenase-2 (COX-2) is up-regulated by arecoline in human gingival fibroblasts, as shown in our previous study, we further investigated the mRNA expression level of COX-2 and its upstream effectors in three oral epithelial carcinoma cell lines (KB, SAS, and Ca9-22) by using areca nut extract (ANE) and saliva-reacted ANE (sANE).	Arecoline	75-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	49-54	
16538046-0	2006	In vitro effects of arecoline on sperm motility and cyclooxygenase-2 expression.	Arecoline	20-29	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-68	
28365254-5	2017	Moreover, arecoline-induced HIF-1alpha expression was downregulated by mitogen-activated protein kinase inhibitor U0126, phosphatidylinositol 3-kinase inhibitor LY294002, p38 inhibitor SB203580, cyclooxygenase-2 inhibitor NS-398, and glutathione precursor N-acetyl-L-cysteine (p<0.05).	Arecoline	10-19	prostaglandin-endoperoxide synthase 2	Homo sapiens	195-211