PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22108589-5	2012	Analysis of DNA fragmentation and chromatin condensation showed that arecoline induced apoptosis of BCC-1/KMC cells in a dose-dependent manner, activated caspase-3, and decreased expression of the anti-apoptotic protein Bcl-2.	Arecoline	69-78	BCL2 apoptosis regulator	Homo sapiens	220-225	
29931964-2	2016	METHODS: Human breast cancer MCF-7 cells were treated with arecoline at the concentrations of 0,10,30,50, 100,300,500mumol/L, the cell proliferation were detected by MTT assay, cell apoptosis were analyzed by Hoechst 33342 staining and flow cy-tometry, the protein expression of Bax,Bcl-2 and P53 were detected by Western blot.	Arecoline	59-68	BCL2 apoptosis regulator	Homo sapiens	283-288	
29931964-4	2016	However, high concentration(100,300,500mumol/L) arecoline inhibited proliferation and induced apoptosis of MCF-7 cells in a concentration-dependent manner, arecoline also significantly increased P53 and Bax protein expression and decreased Bcl-2 protein expression.	Arecoline	48-57	BCL2 apoptosis regulator	Homo sapiens	240-245	
29931964-4	2016	However, high concentration(100,300,500mumol/L) arecoline inhibited proliferation and induced apoptosis of MCF-7 cells in a concentration-dependent manner, arecoline also significantly increased P53 and Bax protein expression and decreased Bcl-2 protein expression.	Arecoline	156-165	BCL2 apoptosis regulator	Homo sapiens	240-245	
29931964-5	2016	CONCLUSIONS: High concentration arecoline inhibited the proliferation and induced the apoptosis of MCF-7 cells, the mechanism was probably corrected with increasing P53 and Bax protein expression and decreasing Bcl-2 pro-tein expression.	Arecoline	32-41	BCL2 apoptosis regulator	Homo sapiens	211-216