PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28693294-3	2017	In the present study, in order to characterize the association between chronic arecoline stimulation and carcinogenesis the expression level of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 mRNA in human gingival epithelial progenitor cells (HGEPs) stimulated with arecoline was assessed.	Arecoline	79-88	matrix metallopeptidase 2	Homo sapiens	144-176	
16037826-1	2005	BACKGROUND AND PURPOSE: Arecoline, an areca quid (AQ) component, has been shown to inhibit the secretion and activity of matrix metalloproteinase-2 (MMP-2) in fibroblast cultures.	Arecoline	24-33	matrix metallopeptidase 2	Homo sapiens	121-147	
16037826-1	2005	BACKGROUND AND PURPOSE: Arecoline, an areca quid (AQ) component, has been shown to inhibit the secretion and activity of matrix metalloproteinase-2 (MMP-2) in fibroblast cultures.	Arecoline	24-33	matrix metallopeptidase 2	Homo sapiens	149-154	
11854068-6	2002	To verify whether arecoline, a major areca nut alkaloid, could affect TIMP or MMP production by human BMFs, Western blots and gelatine zymography were used.	Arecoline	18-27	matrix metallopeptidase 2	Homo sapiens	78-81	
11854068-10	2002	In addition, arecoline was found to inhibit MMP-2 secretion and production at the concentration level of 40 microg/ml.	Arecoline	13-22	matrix metallopeptidase 2	Homo sapiens	44-49	
11854068-12	2002	Taken together, it was found that arecoline acted not only as an inhibitor on gelatinolytic activity of MMP-2, but also a stimulator for TIMP-1 activity.	Arecoline	34-43	matrix metallopeptidase 2	Homo sapiens	104-109	
28693294-5	2017	The expression levels of the MMPs and TIMPs in the cells stimulated with arecoline were evaluated by reverse transcription-quantitative polymerase chain reaction at 18 and 30 days.	Arecoline	73-82	matrix metallopeptidase 2	Homo sapiens	29-33