PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16037826-1 2005 BACKGROUND AND PURPOSE: Arecoline, an areca quid (AQ) component, has been shown to inhibit the secretion and activity of matrix metalloproteinase-2 (MMP-2) in fibroblast cultures. Arecoline 24-33 matrix metallopeptidase 2 Homo sapiens 121-147 28693294-3 2017 In the present study, in order to characterize the association between chronic arecoline stimulation and carcinogenesis the expression level of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 mRNA in human gingival epithelial progenitor cells (HGEPs) stimulated with arecoline was assessed. Arecoline 79-88 matrix metallopeptidase 2 Homo sapiens 144-176 28693294-5 2017 The expression levels of the MMPs and TIMPs in the cells stimulated with arecoline were evaluated by reverse transcription-quantitative polymerase chain reaction at 18 and 30 days. Arecoline 73-82 matrix metallopeptidase 2 Homo sapiens 29-33 16037826-1 2005 BACKGROUND AND PURPOSE: Arecoline, an areca quid (AQ) component, has been shown to inhibit the secretion and activity of matrix metalloproteinase-2 (MMP-2) in fibroblast cultures. Arecoline 24-33 matrix metallopeptidase 2 Homo sapiens 149-154 11854068-6 2002 To verify whether arecoline, a major areca nut alkaloid, could affect TIMP or MMP production by human BMFs, Western blots and gelatine zymography were used. Arecoline 18-27 matrix metallopeptidase 2 Homo sapiens 78-81 11854068-10 2002 In addition, arecoline was found to inhibit MMP-2 secretion and production at the concentration level of 40 microg/ml. Arecoline 13-22 matrix metallopeptidase 2 Homo sapiens 44-49 11854068-12 2002 Taken together, it was found that arecoline acted not only as an inhibitor on gelatinolytic activity of MMP-2, but also a stimulator for TIMP-1 activity. Arecoline 34-43 matrix metallopeptidase 2 Homo sapiens 104-109