PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25978392-2 2015 MAO, catalyzing the reaction of oxidative deamination of major neurotransmitter monoamines, exists in two highly homologous forms, MAO A and MAO B, distinguished by substrate specificity and inhibitor selectivity. monoamines 80-90 monoamine oxidase A Homo sapiens 131-136 26561069-2 2016 1.4.3.4) is a flavin-adenine type of enzyme with two isoforms referred to MAO-A and MAO-B that function for oxidation of monoamines. monoamines 121-131 monoamine oxidase A Homo sapiens 74-79 27341797-3 2016 Monoamine oxidase A (MAOA) and B (MAOB), two isoenzymes bound to the outer membrane of mitochondria, are involved in the degradation of monoamines and were explored for association with ADHD in different ethnic groups. monoamines 136-146 monoamine oxidase A Homo sapiens 0-19 27341797-3 2016 Monoamine oxidase A (MAOA) and B (MAOB), two isoenzymes bound to the outer membrane of mitochondria, are involved in the degradation of monoamines and were explored for association with ADHD in different ethnic groups. monoamines 136-146 monoamine oxidase A Homo sapiens 21-25 25585152-2 2015 Monoamine oxidase A (MAOA), a mitochondria-bound enzyme, degrades monoamine neurotransmitters and dietary monoamines. monoamines 106-116 monoamine oxidase A Homo sapiens 0-19 25585152-2 2015 Monoamine oxidase A (MAOA), a mitochondria-bound enzyme, degrades monoamine neurotransmitters and dietary monoamines. monoamines 106-116 monoamine oxidase A Homo sapiens 21-25 24898155-3 2014 Monoamine oxidase A (MAO-A) is an important brain enzyme that creates oxidative stress, influences apoptosis, and metabolizes monoamines. monoamines 126-136 monoamine oxidase A Homo sapiens 0-19 25253656-1 2014 The membrane bound enzyme monoamine oxidase exist in two splice variants designated A and B (MAO-A and MAO-B) and are key players in the oxidative metabolism of monoamines in mammalians. monoamines 161-171 monoamine oxidase A Homo sapiens 93-98 24898155-3 2014 Monoamine oxidase A (MAO-A) is an important brain enzyme that creates oxidative stress, influences apoptosis, and metabolizes monoamines. monoamines 126-136 monoamine oxidase A Homo sapiens 21-26 23018753-3 2013 MAO-A metabolises monoamines, and greater metabolism of monoamines occurs when MAO-A is elevated in brain. monoamines 18-28 monoamine oxidase A Homo sapiens 0-5 24154665-8 2014 As MAO-A creates oxidative stress, facilitates apoptosis, and metabolizes monoamines, therapeutics opposing these processes are predicted to best treat MDE with greater severity and reversed neurovegetative symptoms. monoamines 74-84 monoamine oxidase A Homo sapiens 3-8 24169519-7 2014 This novel missense mutation decreases MAOA enzymatic activity, leading to abnormal levels of urinary monoamines. monoamines 102-112 monoamine oxidase A Homo sapiens 39-43 23018753-3 2013 MAO-A metabolises monoamines, and greater metabolism of monoamines occurs when MAO-A is elevated in brain. monoamines 56-66 monoamine oxidase A Homo sapiens 79-84 19691856-1 2009 BACKGROUND: Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). monoamines 78-88 monoamine oxidase A Homo sapiens 12-31 22499122-6 2012 Moreover, we have newly identified the two genes that are down-regulated in ESCC: monoamine oxidase A, an enzyme that catalyzes monoamines oxidation and 15-hydroxyprostaglandin dehydrogenase [NAD+], a prostaglandin-synthesizing enzyme that physiologically antagonizes COX-2. monoamines 128-138 monoamine oxidase A Homo sapiens 82-101 22162429-1 2012 Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. monoamines 80-90 monoamine oxidase A Homo sapiens 0-19 22162429-1 2012 Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. monoamines 80-90 monoamine oxidase A Homo sapiens 21-25 21463543-1 2011 BACKGROUND: Monoamine oxidase A (MAO-A) inhibitor antidepressants raise levels of multiple monoamines, whereas the selective serotonin reuptake inhibitors (SSRIs) only raise extracellular serotonin. monoamines 91-101 monoamine oxidase A Homo sapiens 12-31 21463543-1 2011 BACKGROUND: Monoamine oxidase A (MAO-A) inhibitor antidepressants raise levels of multiple monoamines, whereas the selective serotonin reuptake inhibitors (SSRIs) only raise extracellular serotonin. monoamines 91-101 monoamine oxidase A Homo sapiens 33-38 21851116-1 2011 Monoamine oxidase (MAO) A is a flavoenzyme that catalyzes the oxidation of biologically important monoamines and is thought to be associated with psychiatric disorders. monoamines 98-108 monoamine oxidase A Homo sapiens 0-25 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. monoamines 79-89 monoamine oxidase A Homo sapiens 12-31 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. monoamines 79-89 monoamine oxidase A Homo sapiens 33-37 21079379-2 2011 Because monoamine oxidase-A (MAO-A) is a potent degrading enzyme of these monoamines, we hypothesized that orexin-A may mediate its arousal-inducing effects through MAO-A. monoamines 74-84 monoamine oxidase A Homo sapiens 8-27 21079379-2 2011 Because monoamine oxidase-A (MAO-A) is a potent degrading enzyme of these monoamines, we hypothesized that orexin-A may mediate its arousal-inducing effects through MAO-A. monoamines 74-84 monoamine oxidase A Homo sapiens 29-34 23197705-1 2012 Monoamine oxidase-A (MAO-A), a key brain enzyme which metabolizes monoamines, is implicated in the pathophysiology of stress-related illnesses, including major depressive disorder, addiction, and violent behavior. monoamines 66-76 monoamine oxidase A Homo sapiens 0-19 23197705-1 2012 Monoamine oxidase-A (MAO-A), a key brain enzyme which metabolizes monoamines, is implicated in the pathophysiology of stress-related illnesses, including major depressive disorder, addiction, and violent behavior. monoamines 66-76 monoamine oxidase A Homo sapiens 21-26 23197705-10 2012 Since MAO-A metabolizes monoamines, this phenomenon may explain why acute stressors benefit healthy animals even though chronic stress is associated with illness. monoamines 24-34 monoamine oxidase A Homo sapiens 6-11 19691856-1 2009 BACKGROUND: Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). monoamines 78-88 monoamine oxidase A Homo sapiens 33-38 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. monoamines 58-68 monoamine oxidase A Homo sapiens 0-19 19194374-10 2009 Monoamines such as noradrenalin and serotonin may modulate these relationships, given that their metabolism varies according to MAOA variants, and that they modulate both emotional brain systems and antisocial aggression. monoamines 0-10 monoamine oxidase A Homo sapiens 128-132 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. monoamines 166-176 monoamine oxidase A Homo sapiens 0-19 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. monoamines 166-176 monoamine oxidase A Homo sapiens 21-25 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. monoamines 166-176 monoamine oxidase A Homo sapiens 124-128 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. monoamines 58-68 monoamine oxidase A Homo sapiens 21-26 31291696-1 2019 The two human monoamine oxidase isoforms (namely MAO A and MAO B) are enzymes involved in the catabolism of monoamines, including neurotransmitters, and for this reason are well-known and attractive pharmacological targets in neuropsychiatric and neurodegenerative diseases, for which novel pharmacological approaches are necessary. monoamines 108-118 monoamine oxidase A Homo sapiens 49-54 8860658-1 1996 Monoamine oxidases (MAO-A and MAO-B) are enzymes that play a key role in the degradation of endogenous and dietary monoamines. monoamines 115-125 monoamine oxidase A Homo sapiens 20-25 34782122-4 2022 Monoamine oxidase A (MAOA) (X p11.23) plays a crucial role in the metabolism of monoamines. monoamines 80-90 monoamine oxidase A Homo sapiens 0-19 34782122-4 2022 Monoamine oxidase A (MAOA) (X p11.23) plays a crucial role in the metabolism of monoamines. monoamines 80-90 monoamine oxidase A Homo sapiens 21-25 12855685-1 2003 Monoamine oxidase (MAO) A and B catalyze the oxidative deamination of neuroactive and dietary monoamines such as serotonin, tyramine, and phenylethylamine. monoamines 94-104 monoamine oxidase A Homo sapiens 0-25 33262691-7 2020 Following a prenatal exposure to molecules that significantly elicit the MAOA gene expression, a daily treatment with the same metabolic impact would tend to recreate the fetal environment and contribute to rebalance monoamines, thus allowing proper neural circuits to gradually develop, provided behavioral re-education. monoamines 217-227 monoamine oxidase A Homo sapiens 73-77 31322459-7 2020 Glucocorticoids and glucocorticoid-metabolizing enzymes interact closely with other biomolecules such as inflammatory cytokines, monoamines, and some monoamine-metabolizing enzymes, namely the monoamine oxidase type A (MAO-A) and B (MAO-B). monoamines 129-139 monoamine oxidase A Homo sapiens 193-217 31322459-7 2020 Glucocorticoids and glucocorticoid-metabolizing enzymes interact closely with other biomolecules such as inflammatory cytokines, monoamines, and some monoamine-metabolizing enzymes, namely the monoamine oxidase type A (MAO-A) and B (MAO-B). monoamines 129-139 monoamine oxidase A Homo sapiens 219-231 29667298-1 2019 Monoamine oxidase-A (MAOA) metabolises monoamines and is implicated in the pathophysiology of psychiatric disorders. monoamines 39-49 monoamine oxidase A Homo sapiens 0-19 29667298-1 2019 Monoamine oxidase-A (MAOA) metabolises monoamines and is implicated in the pathophysiology of psychiatric disorders. monoamines 39-49 monoamine oxidase A Homo sapiens 21-25 30774343-3 2019 During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood. monoamines 116-126 monoamine oxidase A Homo sapiens 73-92 30774343-3 2019 During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood. monoamines 116-126 monoamine oxidase A Homo sapiens 94-99 30558545-3 2018 A prenatal transient excess of "monoamine oxidase A" enzyme is assumed here to trigger persistent epigenetic regulations that would induce imbalanced metabolisms of synaptic monoamines. monoamines 174-184 monoamine oxidase A Homo sapiens 32-51 30242487-2 2018 The monoamine oxidases A and B (MAOA/MAOB) are prime candidates for the investigation into the role of DNA methylation in mental disorders, given their pivotal role in the metabolism of monoamines and as pharmacological targets of potent antidepressant drugs such as tranylcypromine, phenelzine or moclobemide. monoamines 186-196 monoamine oxidase A Homo sapiens 32-36 27836462-3 2018 Clock genes can regulate the transcription of monoamine oxidase A, which is involved in the degradation of monoamines. monoamines 107-117 monoamine oxidase A Homo sapiens 46-65 29549852-2 2018 Monoamine oxidase A (MAO-A) is an important enzyme that metabolizes monoamines and creates oxidative stress. monoamines 68-78 monoamine oxidase A Homo sapiens 0-19 29549852-2 2018 Monoamine oxidase A (MAO-A) is an important enzyme that metabolizes monoamines and creates oxidative stress. monoamines 68-78 monoamine oxidase A Homo sapiens 21-26