PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28894751-0 2017 Peripheral Inhibitor of AChE, Neostigmine, Prevents the Inflammatory Dependent Suppression of GnRH/LH Secretion during the Follicular Phase of the Estrous Cycle. Neostigmine 30-41 gonadotropin releasing hormone 1 Homo sapiens 94-98 28894751-4 2017 Moreover, Donepezil completely abolished (P < 0.05) the suppressory effect of inflammation on GnRH synthesis in the preoptic area, when pretreatment with Neostigmine reduced (P < 0.05) the decrease in GnRH content in this hypothalamic structure. Neostigmine 157-168 gonadotropin releasing hormone 1 Homo sapiens 97-101 28894751-4 2017 Moreover, Donepezil completely abolished (P < 0.05) the suppressory effect of inflammation on GnRH synthesis in the preoptic area, when pretreatment with Neostigmine reduced (P < 0.05) the decrease in GnRH content in this hypothalamic structure. Neostigmine 157-168 gonadotropin releasing hormone 1 Homo sapiens 207-211 28894751-6 2017 Our study shows that inflammatory dependent changes in the GnRH/LH secretion may be eliminated or reduced by AChE inhibitors suppressing inflammatory reaction only at the periphery such as Neostigmine, without the need for interfering in the central nervous system. Neostigmine 189-200 gonadotropin releasing hormone 1 Homo sapiens 59-63