PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Norepinephrine 43-57 tumor necrosis factor Homo sapiens 107-134 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 22-35 tumor necrosis factor Homo sapiens 186-195 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 22-35 tumor necrosis factor Homo sapiens 261-270 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 96-109 tumor necrosis factor Homo sapiens 186-195 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 96-109 tumor necrosis factor Homo sapiens 261-270 11084220-5 2000 It is concluded that (1) noradrenaline has significant negative immunoregulatory effects in humans through suppression of the production of (monocytic) proinflammatory cytokines, e.g. IL-6 and TNF alpha, and (2) the suppression of the production of TNF alpha may be related to alpha(2)-adrenoceptor-related mechanisms. Norepinephrine 25-38 tumor necrosis factor Homo sapiens 193-202 11084220-5 2000 It is concluded that (1) noradrenaline has significant negative immunoregulatory effects in humans through suppression of the production of (monocytic) proinflammatory cytokines, e.g. IL-6 and TNF alpha, and (2) the suppression of the production of TNF alpha may be related to alpha(2)-adrenoceptor-related mechanisms. Norepinephrine 25-38 tumor necrosis factor Homo sapiens 249-258 10910482-7 2000 Similarly, incubation of PBMCs (T1) with plasma obtained after CPB (T2) as well as addition of IL-10 or norepinephrine in concentrations present in plasma after CPB led to a reduced lipopolysaccharide-stimulated TNF-alpha and an increased IL-10 response. Norepinephrine 104-118 tumor necrosis factor Homo sapiens 212-221 10910482-11 2000 Although norepinephrine fails to induce a cytokine response in the absence of other stimuli, its administration seems to augment the antiinflammatory IL-10 response while attenuating the TNF-alpha response. Norepinephrine 9-23 tumor necrosis factor Homo sapiens 187-196 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Norepinephrine 43-57 tumor necrosis factor Homo sapiens 136-139 11268424-3 2000 Recent evidence indicates that glucocorticoids, norepinephrine, epinephrine, histamine, and adenosine inhibit the production of human IL-12 and TNF-alpha, whereas they do not affect or even stimulate the production of IL-10. Norepinephrine 48-62 tumor necrosis factor Homo sapiens 144-153 8168970-3 1994 The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood. Norepinephrine 52-65 tumor necrosis factor Homo sapiens 92-119 9389931-3 1997 Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta. Norepinephrine 18-31 tumor necrosis factor Homo sapiens 84-93 10970992-4 2000 TNF concentrations were significantly correlated with the 24-hour excretion of epinephrine and norepinephrine (r = 0.64 and 0.69; each p < 0.01). Norepinephrine 95-109 tumor necrosis factor Homo sapiens 0-3 11995034-12 1998 Alternatively TNF alpha production may represent the result of the neuroendocrine response such as cortisol and norepinephrine, to the surgical/anaesthetic trauma which could be blocked by subarachnoid anaesthesia. Norepinephrine 112-126 tumor necrosis factor Homo sapiens 14-23 8168970-3 1994 The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood. Norepinephrine 52-65 tumor necrosis factor Homo sapiens 121-124 8168970-5 1994 Noradrenaline caused a dose-dependent inhibition of LPS-induced TNF and IL-6 production. Norepinephrine 0-13 tumor necrosis factor Homo sapiens 64-67 8168970-9 1994 In acute sepsis, enhanced release of noradrenaline may be part of a negative feedback mechanism meant to inhibit ongoing TNF and IL-6 production. Norepinephrine 37-50 tumor necrosis factor Homo sapiens 121-124 8038024-7 1993 MAIN OUTCOME MEASURES: Changes in TNF alpha and the correlation with changes in plasma noradrenaline, plasma renin activity, and weight during optimal medical treatment for one year. Norepinephrine 87-100 tumor necrosis factor Homo sapiens 34-43 2166759-2 1990 In our study we have determined that UK-14304 (UK) and norepinephrine (NE), both alpha 2-adrenergic agonists, can augment LPS-stimulated TNF from elicited macrophages (MO). Norepinephrine 55-69 tumor necrosis factor Homo sapiens 137-140 8335573-10 1993 The effect of TNF-alpha was specific for release of NO from the endothelium of BPA because TNF-alpha did not affect 1) EDR of BPV to ACh, BK, or ATP; 2) EIR of BPA or BPV to nitroprusside; and 3) contraction of either BPA or BPV to KCl, U-46619, histamine, norepinephrine, or serotonin. Norepinephrine 257-271 tumor necrosis factor Homo sapiens 14-23 35079095-3 2022 Here we show that norepinephrine (NE) secretion from ICA cells is increased through activation of Toll-like receptor 4 (TLR4) to aggravate myocardial TNF-alpha production and dysfunction by lipopolysaccharide (LPS). Norepinephrine 18-32 tumor necrosis factor Homo sapiens 150-159 2550484-5 1989 Pretreatment with tumor necrosis factor synergistically enhanced prostaglandin synthesis in response to bradykinin, bombesin, thrombin, norepinephrine, and platelet-activating factor. Norepinephrine 136-150 tumor necrosis factor Homo sapiens 18-39 3262452-4 1988 Incubation of rat aortas with human monocyte-derived interleukin 1 or recombinant human tumor necrosis factor resulted in diminished aortic contraction and sensitivity to norepinephrine, and gel filtration of medium conditioned by endotoxin-stimulated macrophages yielded suppressive activity at a molecular weight equivalent to interleukin 1 and tumor necrosis factor. Norepinephrine 171-185 tumor necrosis factor Homo sapiens 88-109 32429680-13 2020 Although EA and pharmacological treatment did not differ in terms of pain relief, in vitro epinephrine and norepinephrine reduced TNF-alpha production in response to LPS stimuli. Norepinephrine 107-121 tumor necrosis factor Homo sapiens 130-139 33459706-5 2021 Another insufficiently considered aspect of cerebral proinflammatory cytokines is the fitness of the endogenous cerebral anti-TNF system provided by norepinephrine (NE), generated and distributed throughout the brain from the locus coeruleus (LC). Norepinephrine 149-163 tumor necrosis factor Homo sapiens 126-129 29941879-5 2018 Compared to untreated controls in both OA and RA, TNF-treated iTH+ cells demonstrated a weaker staining of catecholaminergic markers in cell cultures of RA/OA patients, and the amount of produced noradrenaline was markedly lower. Norepinephrine 196-209 tumor necrosis factor Homo sapiens 50-53 31356684-2 2019 The nuclear translocation of nuclear factor kappa-B (NFkappaB) homodimers, lacking transactivation domains, once induced by lipopolysaccharide (LPS) or tumor necrosis factor (TNF), inhibits the expression of Aanat gene and the synthesis of noradrenaline (NA)-induced melatonin. Norepinephrine 240-253 tumor necrosis factor Homo sapiens 175-178 30106035-2 2018 Noradrenaline inhibits microglial activation and suppresses pro-inflammatory mediator production (e.g., tumor necrosis factor-alpha, interleukin-1beta & inducible nitric oxide synthase activity), thus limiting the cytotoxicity of midbrain dopaminergic neurons in response to an inflammatory stimulus. Norepinephrine 0-13 tumor necrosis factor Homo sapiens 104-131 29941879-9 2018 This study shows that TNF inhibits iTH+ synovial cells leading to the decrease of secreted noradrenaline. Norepinephrine 91-104 tumor necrosis factor Homo sapiens 22-25 28011264-7 2017 This inhibitory response in TNF production by exercise was mirrored by beta-AR agonists in an agonist-specific and dose-dependent manner in vitro: similar isoproterenol (EC50=2.1-4.7x10-10M) and epinephrine (EC50=4.4-10x10-10M) potency and higher norepinephrine concentrations (EC50=2.6-4.3x10-8M) needed for the effects. Norepinephrine 247-261 tumor necrosis factor Homo sapiens 28-31 21347606-9 2012 Dopamine doses were positively associated with IL-6, and norepinephrine was inversely associated with IL-8 and TNF-alpha levels. Norepinephrine 57-71 tumor necrosis factor Homo sapiens 111-120 27847559-7 2016 Norepinephrine"s effect on TNFalpha production was reduced in HF (-41% +- 17% HF vs -57% +- 9% healthy, P = 0.01), and proportionately with NYHA FC. Norepinephrine 0-14 tumor necrosis factor Homo sapiens 27-35 27037808-7 2016 Both norepinephrine and dobutamine significantly reduced TNF-alpha and IL-6 production after ex vivo LPS stimulation of whole blood in a dose-dependent manner, and this effect was partially reversed by the presence of metoprolol. Norepinephrine 5-19 tumor necrosis factor Homo sapiens 57-66 15770879-8 2005 Variables associated with higher concentrations of TNFalpha were; lower ejection fraction (P=0.04), worse functional class (P=0.007), coronary artery disease (P=0.05), chronic renal failure (P=0.02), arterial hypertension (P=0.05), higher concentrations of epinephrine (P=0.03) and norepinephrine (P=0.05). Norepinephrine 282-296 tumor necrosis factor Homo sapiens 51-59 15781025-0 2005 Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors. Norepinephrine 10-23 tumor necrosis factor Homo sapiens 72-99 15781025-2 2005 This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion. Norepinephrine 29-42 tumor necrosis factor Homo sapiens 69-78 15756641-4 2005 beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration. Norepinephrine 35-49 tumor necrosis factor Homo sapiens 147-156 15212408-0 2004 Norepinephrine is a more potent inhibitor of tumor necrosis factor over a range of doses than dopamine. Norepinephrine 0-14 tumor necrosis factor Homo sapiens 45-66 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Norepinephrine 42-56 tumor necrosis factor Homo sapiens 149-182 15213629-10 2004 TNF-alpha and IL-6 cytokine responses to LPS were markedly influenced by the specific progenitor cells involved as well as the injury conditions and the status of norepinephrine prior to injury. Norepinephrine 163-177 tumor necrosis factor Homo sapiens 0-9 15213629-11 2004 In burn sepsis the depletion of norepinephrine resulted in a dramatic decrease in both IL-6 and TNF-alpha production by both progenitor-derived macrophages. Norepinephrine 32-46 tumor necrosis factor Homo sapiens 96-105 15212408-5 2004 Both norepinephrine and dopamine were able to suppress the production of tumor necrosis factor (TNF) in a dose-dependent fashion. Norepinephrine 5-19 tumor necrosis factor Homo sapiens 96-99 15212408-6 2004 Over the range of doses, norepinephrine is a more potent inhibitor of TNF production than dopamine. Norepinephrine 25-39 tumor necrosis factor Homo sapiens 70-73 15212408-9 2004 Norepinephrine is a more potent inhibitor of TNF than dopamine. Norepinephrine 0-14 tumor necrosis factor Homo sapiens 45-48 15212408-5 2004 Both norepinephrine and dopamine were able to suppress the production of tumor necrosis factor (TNF) in a dose-dependent fashion. Norepinephrine 5-19 tumor necrosis factor Homo sapiens 73-94 12628868-6 2003 RESULTS: There was a significant inverse linear correlation between increased circulating levels of TNF, TNF receptors, and norepinephrine for time-domain and frequency-domain indexes of heart rate variability among patients with heart failure and control subjects. Norepinephrine 124-138 tumor necrosis factor Homo sapiens 100-103 11600565-8 2001 We suggest that a cortisol-, norepinephrine-, and 1,25-dihydroxyvitamin-induced inhibition and subsequent rebound of IL-12 and TNF-alpha production may represent a major mechanism by which pregnancy and postpartum alter the course of or susceptibility to various autoimmune disorders. Norepinephrine 29-43 tumor necrosis factor Homo sapiens 127-136