PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23000030-0 2012 Interleukin-1 beta simultaneously affects the stress and reproductive axes by modulating norepinephrine levels in different brain areas. Norepinephrine 89-103 interleukin 1 beta Rattus norvegicus 0-18 29580890-1 2018 Increased proinflammatory cytokines, such as interleukin (IL)-1beta, may play an important role in the etiology of depression because they cause the hypothalamic-pituitary-adrenal axis to release glucocorticoids (GC) and induce dysfunction of serotonin and norepinephrine neurotransmission. Norepinephrine 257-271 interleukin 1 beta Rattus norvegicus 45-67 23808809-2 2013 The aim of the present investigation was to evaluate the effect of noradrenaline (NA) on the release of IL-1beta, IL-6 and TNFalpha by macrophages from ObZ, as well as the effect of habitual exercise (running, 5days/week for 35 min at 35cm/s for 14week); all of them using lean Zucker rats (Fa/fa) (LZ) as reference values. Norepinephrine 67-80 interleukin 1 beta Rattus norvegicus 104-112 22036618-3 2012 Since norepinephrine (NE) is involved in these effects, we hypothesized that IL-1beta acts on brainstem noradrenergic nuclei to affect gene transcription of NE synthesizing enzymes, cytokines and associated transcription factors. Norepinephrine 6-20 interleukin 1 beta Rattus norvegicus 77-85 21542970-12 2011 The level of norepinephrine in BALF was increased at each time interval in the LPS + yohimbine group, and so did the levels of TNF-alpha, IL-1beta and IL-6 at 6 and 48 hours after LPS administration respectively. Norepinephrine 13-27 interleukin 1 beta Rattus norvegicus 138-146 19014915-0 2009 Interaction between GABA and norepinephrine in interleukin-1beta-induced suppression of the luteinizing hormone surge. Norepinephrine 29-43 interleukin 1 beta Rattus norvegicus 47-64 20666638-4 2011 Suppressed responsiveness of parvocellular paraventricular nucleus (pPVN) corticotropin-releasing hormone neurons, and hence the HPA axis, following IL-1beta in late pregnancy is evidently explained by presynaptic inhibition of noradrenaline release in the pPVN, owing to increased endogenous opioid peptide enkephalin production in brainstem nucleus tractus solitarii neurons. Norepinephrine 228-241 interleukin 1 beta Rattus norvegicus 149-157 20361987-0 2010 Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex. Norepinephrine 0-13 interleukin 1 beta Rattus norvegicus 65-73 19818755-0 2010 Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity. Norepinephrine 0-13 interleukin 1 beta Rattus norvegicus 110-118 19818755-9 2010 In parallel with its ability to increase IL-1ra and IL-1RII, noradrenaline prevented neurotoxicity in cortical primary neurons induced by conditioned medium from IL-1beta treated mixed glial cells. Norepinephrine 61-74 interleukin 1 beta Rattus norvegicus 162-170 19046481-9 2009 In contrast, in vitro exposure of cultured glial cells to noradrenaline suppressed IL-1beta, TNF-alpha, iNOS and CD40 expression. Norepinephrine 58-71 interleukin 1 beta Rattus norvegicus 83-91 20004705-2 2010 It has been suggested that endogenous interleukin-1beta (IL-1beta) is involved in norepinephrine (NE)-induced release of corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN). Norepinephrine 82-96 interleukin 1 beta Rattus norvegicus 38-55 20004705-2 2010 It has been suggested that endogenous interleukin-1beta (IL-1beta) is involved in norepinephrine (NE)-induced release of corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN). Norepinephrine 82-96 interleukin 1 beta Rattus norvegicus 57-65 19715517-11 2009 Significantly greater up-regulation of CXC motif chemokine ligand and interleukin-1beta occurred in the livers of rats that received norepinephrine and vasopressin than in those that received no resuscitation. Norepinephrine 133-147 interleukin 1 beta Rattus norvegicus 70-87 19458216-4 2009 In late pregnancy, HPA axis responses to stressors, including IL-1beta, are attenuated by a central opioid mechanism that auto-inhibits noradrenaline release in the PVN. Norepinephrine 136-149 interleukin 1 beta Rattus norvegicus 62-70 19054775-1 2009 BACKGROUND: The cytokine, interleukin-1 beta (IL-1 beta), increases during immune stress and is known to suppress the preovulatory luteinizing hormone (LH) surge in female rats by decreasing hypothalamic norepinephrine (NE). Norepinephrine 204-218 interleukin 1 beta Rattus norvegicus 26-44 19054775-1 2009 BACKGROUND: The cytokine, interleukin-1 beta (IL-1 beta), increases during immune stress and is known to suppress the preovulatory luteinizing hormone (LH) surge in female rats by decreasing hypothalamic norepinephrine (NE). Norepinephrine 204-218 interleukin 1 beta Rattus norvegicus 46-55 19212441-1 2009 Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6). Norepinephrine 173-187 interleukin 1 beta Rattus norvegicus 296-304 19120138-5 2008 HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment. Norepinephrine 203-216 interleukin 1 beta Rattus norvegicus 22-30 12433597-9 2002 administered interleukin-1beta (100 ng/animal) elevated plasma levels of noradrenaline but not adrenaline. Norepinephrine 73-86 interleukin 1 beta Rattus norvegicus 13-30 19120138-3 2008 Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats. Norepinephrine 143-156 interleukin 1 beta Rattus norvegicus 26-43 19120138-3 2008 Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats. Norepinephrine 143-156 interleukin 1 beta Rattus norvegicus 45-53 18821705-8 2008 The positive correlation between hypothalamic IL-1beta expression and noradrenaline content in control groups was not observed in rats in which arthritis developed. Norepinephrine 70-83 interleukin 1 beta Rattus norvegicus 46-54 16386803-0 2006 The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress. Norepinephrine 19-33 interleukin 1 beta Rattus norvegicus 76-84 16386803-3 2006 One goal of the following studies was to assess the role of norepinephrine in stress-elicited increases in IL-1beta. Norepinephrine 60-74 interleukin 1 beta Rattus norvegicus 107-115 15949713-0 2005 Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10. Norepinephrine 12-26 interleukin 1 beta Rattus norvegicus 68-76 15917452-12 2005 IL-1beta increased noradrenaline release in the PVN of virgin, but not pregnant, rats. Norepinephrine 19-32 interleukin 1 beta Rattus norvegicus 0-8 15917452-13 2005 However, naloxone infused directly into the PVN increased noradrenaline release after IL-1beta in pregnant rats. Norepinephrine 58-71 interleukin 1 beta Rattus norvegicus 86-94 12708746-1 2003 The norepinephrine (NE)-induced hypertrophy of the left ventricle (LV) in the rat is associated with increased interleukin (IL)-6 and IL-1beta expression. Norepinephrine 4-18 interleukin 1 beta Rattus norvegicus 134-142 17991694-7 2008 Suppressed responsiveness of the CRH neurones, and hence the HPA axis, following IL-1beta in late pregnancy is explained by presynaptic inhibition of noradrenaline release in the pPVN, due to increased endogenous enkephalin and mu-opioid receptor production in brainstem NTS neurones. Norepinephrine 150-163 interleukin 1 beta Rattus norvegicus 81-89 15833600-0 2005 Systemic Interleukin-1beta stimulates the simultaneous release of norepinephrine in the paraventricular nucleus and the median eminence. Norepinephrine 66-80 interleukin 1 beta Rattus norvegicus 9-26 15285793-0 2004 Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production. Norepinephrine 51-65 interleukin 1 beta Rattus norvegicus 95-112 12183018-5 2002 Norepinephrine release in the MPA of control rats increased significantly at 1530, 1600, and 1630 h paralelling an increase in LH at 1600 h. In contrast, IL-1beta treatment blocked the LH surge and the rise in norepinephrine release in the MPA. Norepinephrine 0-14 interleukin 1 beta Rattus norvegicus 154-162 12271472-3 2002 Stimulation of beta-ARs on microglia by norepinephrine (NE) resulted in an increase in the level of intracellular cAMP and the subsequent expression of interleukin-1beta mRNA. Norepinephrine 40-54 interleukin 1 beta Rattus norvegicus 152-169 12183018-5 2002 Norepinephrine release in the MPA of control rats increased significantly at 1530, 1600, and 1630 h paralelling an increase in LH at 1600 h. In contrast, IL-1beta treatment blocked the LH surge and the rise in norepinephrine release in the MPA. Norepinephrine 210-224 interleukin 1 beta Rattus norvegicus 154-162 10451023-3 1999 IL-1beta was up-regulated in pineal cultures, after treatment with either norepinephrine (NE) or interferon (IFN)/lipopolysaccharide (LPS). Norepinephrine 74-88 interleukin 1 beta Rattus norvegicus 0-8 11594790-3 2001 Our results indicate that thymic stimulation (performed by means of interleukin 1beta) induces substantial changes in the fresh weight of the whole thymus, as well as in the thymic microenvironment, thymic nerve fibres, CNF, neuropeptide Y (NPY)-like positive nerve fibres and total amount of both proteins and norepinephrine in rat thymic tissue homogenates. Norepinephrine 311-325 interleukin 1 beta Rattus norvegicus 68-85 11087233-4 2000 To this end, we first found that administration of IL-1beta in the lateral ventricle of control and CRF rats decreased blood pressure and norepinephrine (NE) secretion from the posterior hypothalamus (PH) and increased NOS mRNA expression. Norepinephrine 138-152 interleukin 1 beta Rattus norvegicus 51-59 10580367-3 1999 administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad). Norepinephrine 116-129 interleukin 1 beta Rattus norvegicus 13-30 10580367-3 1999 administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad). Norepinephrine 116-129 interleukin 1 beta Rattus norvegicus 32-40 12037376-3 2002 administered IL-1beta (100 ng/animal) effectively elevated plasma noradrenaline rather than plasma adrenaline. Norepinephrine 66-79 interleukin 1 beta Rattus norvegicus 13-21 8853359-6 1996 Contrastingly, a large dose-dependent decrease in reactivity to norepinephrine was found immediately after exposure to IL-1 beta and still persisted 100 min after the end of the exposure. Norepinephrine 64-78 interleukin 1 beta Rattus norvegicus 119-128 9728078-0 1998 IL-1beta increases norepinephrine level in rat frontal cortex: involvement of prostanoids, NO, and glutamate. Norepinephrine 19-33 interleukin 1 beta Rattus norvegicus 0-8 9728078-2 1998 A local injection of IL-1beta (3 and 10 ng) induced an elevation of norepinephrine (NE) concentration in the medial prefrontal cortex (mPFC). Norepinephrine 68-82 interleukin 1 beta Rattus norvegicus 21-29 9625457-0 1998 Interleukin-1beta administered intracerebroventricularly stimulates the release of noradrenaline in the hypothalamic paraventricular nucleus via prostaglandin in the rat. Norepinephrine 83-96 interleukin 1 beta Rattus norvegicus 0-17 9625457-2 1998 administration of interleukin (IL)-1beta on the rectal temperature and the release of noradrenaline (NA) in the hypothalamic paraventricular nucleus (PVN) of the rat. Norepinephrine 86-99 interleukin 1 beta Rattus norvegicus 18-40 9058422-0 1997 Effects of area postrema lesion and abdominal vagotomy on interleukin-1 beta-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat. Norepinephrine 85-99 interleukin 1 beta Rattus norvegicus 58-76 9058422-1 1997 Peripherally administered interleukin-1 beta (IL-1 beta) has been shown to increase extracellular norepinephrine (NE) concentration in the paraventricular nucleus (PVN) of the hypothalamus. Norepinephrine 98-112 interleukin 1 beta Rattus norvegicus 26-44 9058422-1 1997 Peripherally administered interleukin-1 beta (IL-1 beta) has been shown to increase extracellular norepinephrine (NE) concentration in the paraventricular nucleus (PVN) of the hypothalamus. Norepinephrine 98-112 interleukin 1 beta Rattus norvegicus 46-55 9307243-1 1997 Systemic administration of endotoxin (LPS) or interleukin-1beta (IL-1) to prepubertal rats induced a marked increase in splenic but not cardiac norepinephrine (NE) turnover, an index of sympathetic neural activity. Norepinephrine 144-158 interleukin 1 beta Rattus norvegicus 46-63 8982720-2 1996 Intracerebroventricular administration of interleukin-1 beta induced a gradually developing elevation of plasma noradrenaline levels in a dose-dependent manner (50, 100 and 200 ng/animal), while the levels of adrenaline were not affected. Norepinephrine 112-125 interleukin 1 beta Rattus norvegicus 42-60 8853359-10 1996 2) Short exposure to IL-1 beta but not to rhTNF or IL-6 diminishes the response of the arterioles to norepinephrine but not to KCl. Norepinephrine 101-115 interleukin 1 beta Rattus norvegicus 21-30 9011616-16 1996 IL-1 beta (10 micrograms kg-1)-induced increases in plasma noradrenaline (NA) were suppressed in intact rats pretreated with DEX (0.5 mg kg-1). Norepinephrine 59-72 interleukin 1 beta Rattus norvegicus 0-9 8779882-6 1996 Plasma norepinephrine and adrenocorticotropic hormone concentrations were increased after IL-1 beta injection. Norepinephrine 7-21 interleukin 1 beta Rattus norvegicus 90-99 7630433-0 1995 Inhibition by interleukin-1 beta of noradrenaline release in rat spleen: involvement of lymphocytes, NO and opioid receptors. Norepinephrine 36-49 interleukin 1 beta Rattus norvegicus 14-32 8741743-0 1995 Noradrenaline release in hypothalamus and ACTH secretion induced by central interleukin-1beta. Norepinephrine 0-13 interleukin 1 beta Rattus norvegicus 76-93 8741743-3 1995 IL-1beta induced an early increase in noradrenaline (NA) release in the paraventricular nucleus (PVN) followed by a second long-lasting enhancement starting from 80 min, with a maximum at 140 min (187 +/- 14%). Norepinephrine 38-51 interleukin 1 beta Rattus norvegicus 0-8 7630433-1 1995 Effects of indomethacin, N omega-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-1 beta induced inhibition of exocytotic noradrenaline release were investigated in the isolated, vascularly perfused spleen of the rat. Norepinephrine 182-195 interleukin 1 beta Rattus norvegicus 125-148 7630433-3 1995 Perfusion of the spleen with Tyrode"s solution containing IL-1 beta (100 pg/ml) for 90 min caused an inhibition of the stimulation-evoked noradrenaline overflow which persisted for at least 20 min after washout of the IL. Norepinephrine 138-151 interleukin 1 beta Rattus norvegicus 58-67 8393485-0 1993 Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. Norepinephrine 39-53 interleukin 1 beta Rattus norvegicus 0-18 8003768-0 1994 An interleukin-1 beta-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor: an in vivo microdialysis study in conscious rats. Norepinephrine 30-43 interleukin 1 beta Rattus norvegicus 3-21 8003768-1 1994 The purpose of this study was to investigate whether an intraperitoneal injection of interleukin-1 beta (IL-1 beta) affects noradrenaline release in the spleen through its action on the brain of conscious rats. Norepinephrine 124-137 interleukin 1 beta Rattus norvegicus 85-103 8003768-1 1994 The purpose of this study was to investigate whether an intraperitoneal injection of interleukin-1 beta (IL-1 beta) affects noradrenaline release in the spleen through its action on the brain of conscious rats. Norepinephrine 124-137 interleukin 1 beta Rattus norvegicus 105-114 8003768-5 1994 The intraperitoneal injection of IL-1 beta (100 ng/kg) produced an immediate and significant increase in the noradrenaline levels in the spleen. Norepinephrine 109-122 interleukin 1 beta Rattus norvegicus 33-42 8003768-7 1994 An intracerebroventricular (ICV) injection of a corticotropin-releasing factor (CRF) antagonist (alpha-helical CRF9-41, 30 micrograms) significantly attenuated the IL-1 beta-induced increase in the noradrenaline release. Norepinephrine 198-211 interleukin 1 beta Rattus norvegicus 164-173 8003768-9 1994 These results suggest that the intraperitoneal injection of IL-1 beta facilitates noradrenaline release in the spleen through activation of the sympathetic nerve, and the increased sympathetic activity is, at least in part, due to the excitation of neurons containing CRF in the brain. Norepinephrine 82-95 interleukin 1 beta Rattus norvegicus 60-69 8376550-0 1993 Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1 beta and TNF alpha. Norepinephrine 0-14 interleukin 1 beta Rattus norvegicus 101-110 8393485-3 1993 IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY. Norepinephrine 68-82 interleukin 1 beta Rattus norvegicus 0-9 8384045-0 1993 Central administration of interleukin-1 beta increases norepinephrine turnover in the spleen. Norepinephrine 55-69 interleukin 1 beta Rattus norvegicus 26-44 8430802-0 1993 Interleukin-1 beta modulation of norepinephrine release from rat myenteric nerves. Norepinephrine 33-47 interleukin 1 beta Rattus norvegicus 0-18 8384045-3 1993 In this study, we have determined whether ICV administration of IL-1 beta has an effect on sympathetic outflow and norepinephrine (NE) turnover in the spleen. Norepinephrine 115-129 interleukin 1 beta Rattus norvegicus 64-73 8505861-1 1993 The purpose of this study was to investigate the effects of circulating interleukin-1 beta (IL-1 beta) on the release of norepinephrine (NE) in the paraventricular nucleus (PVN). Norepinephrine 121-135 interleukin 1 beta Rattus norvegicus 72-90 8505861-1 1993 The purpose of this study was to investigate the effects of circulating interleukin-1 beta (IL-1 beta) on the release of norepinephrine (NE) in the paraventricular nucleus (PVN). Norepinephrine 121-135 interleukin 1 beta Rattus norvegicus 92-101 2171909-15 1990 Thus, the secretion of ACTH stimulated by the action of IL-1 beta at the ME depends, in part, on the local secretion of norepinephrine and epinephrine interacting with both alpha and beta adrenergic receptors. Norepinephrine 120-134 interleukin 1 beta Rattus norvegicus 56-65 2573510-3 1989 The iv or intracerebroventricular injection of either Il-1 alpha or Il-1 beta caused dose-related increases in plasma ACTH, epinephrine, and norepinephrine levels. Norepinephrine 141-155 interleukin 1 beta Rattus norvegicus 68-77