PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6321662-5 1984 Noradrenaline induced serotonin N-acetyltransferase activity with either atmosphere. Norepinephrine 0-13 aralkylamine N-acetyltransferase Rattus norvegicus 22-51 7098494-6 1982 After treating cultured rat pineal glands with l-norepinephrine (10 microM) for 6 hr, the concentration of acetyl coenzyme A was increased significantly from 3.26 +/- 0.37 to 10.24 +/- 0.93 pmol/gland, while the activity of serotonin N-acetyltransferase increased 68-fold. Norepinephrine 47-63 aralkylamine N-acetyltransferase Rattus norvegicus 224-253 7098494-7 1982 This result suggests that acetyl coenzyme A may play an important role in the norepinephrine-induced induction of serotonin N-acetyltransferase. Norepinephrine 78-92 aralkylamine N-acetyltransferase Rattus norvegicus 114-143 6261951-2 1981 Norepinephrine (NE) and dibutyryl cyclic 3",5"-adenosine monophosphate (dBcAMP) treatment of cells that had been in culture for 5 and 21 days produced a stimulation in the enzyme activity of serotonin N-acetyl transferase, an enzyme important in indole synthesis. Norepinephrine 0-14 aralkylamine N-acetyltransferase Rattus norvegicus 191-221 133361-4 1976 The maintenance of a sufficient level of active norepinephrine on beta-receptors, either by displacement of norepinephrine in the nerve endings by dopamine, or by the inhibition of norepinephrine reuptake by imipramine, thus slows down or prevents the decrease in serotonin N-acetyltransferase activity after exposure to light during the night. Norepinephrine 48-62 aralkylamine N-acetyltransferase Rattus norvegicus 264-293 7037365-2 1981 This serotonin N-acetyltransferase inactivating substance enhances the thermal inactivation of the norepinephrine-stimulated serotonin N-acetyltransferase activity in rat pineal homogenate. Norepinephrine 99-113 aralkylamine N-acetyltransferase Rattus norvegicus 5-34 7037365-2 1981 This serotonin N-acetyltransferase inactivating substance enhances the thermal inactivation of the norepinephrine-stimulated serotonin N-acetyltransferase activity in rat pineal homogenate. Norepinephrine 99-113 aralkylamine N-acetyltransferase Rattus norvegicus 125-154 4403307-1 1972 Activity of serotonin N-acetyltransferase (EC 2.3.1.5) in rat pineal organ is rapidly and markedly elevated in vivo after administration of beta-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA), norepinephrine, epinephrine, isoproterenol, monoamine oxidase inhibitors, or theophylline. Norepinephrine 187-201 aralkylamine N-acetyltransferase Rattus norvegicus 12-41 4365377-1 1973 Depletion of neural norepinephrine by reserpine treatment or by denervation resulted in a greater induction of serotonin N-acetyltransferase (EC 2.3.1.5) and a higher elevation of cyclic AMP in postsynaptic pineal cell to small amount of isoproterenol. Norepinephrine 20-34 aralkylamine N-acetyltransferase Rattus norvegicus 111-140 26444903-7 2015 Increases in hnRNP R additionally improved AANAT production in rat pinealocytes under norepinephrine (NE) treatment. Norepinephrine 86-100 aralkylamine N-acetyltransferase Rattus norvegicus 43-48 28502584-6 2017 miR-325-3p blocked norepinephrine (NE) induced Aanat activation in cultured pinealocytes. Norepinephrine 19-33 aralkylamine N-acetyltransferase Rattus norvegicus 47-52 22816096-3 2012 Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB. Norepinephrine 25-39 aralkylamine N-acetyltransferase Rattus norvegicus 100-105 19860854-3 2010 The initiation of Aanat transcription at night is controlled largely by the norepinephrine-stimulated phosphorylation of cAMP response element-binding protein by protein kinase A. Norepinephrine 76-90 aralkylamine N-acetyltransferase Rattus norvegicus 18-23 17082254-2 2007 Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA and protein levels of MKP-1 and AA-NAT, as well as in the AA-NAT activity and melatonin production. Norepinephrine 31-45 aralkylamine N-acetyltransferase Rattus norvegicus 114-120 17437549-1 2007 We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs. Norepinephrine 35-49 aralkylamine N-acetyltransferase Rattus norvegicus 240-274 17437549-1 2007 We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs. Norepinephrine 35-49 aralkylamine N-acetyltransferase Rattus norvegicus 276-282 17082254-2 2007 Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA and protein levels of MKP-1 and AA-NAT, as well as in the AA-NAT activity and melatonin production. Norepinephrine 31-45 aralkylamine N-acetyltransferase Rattus norvegicus 140-146 17014691-8 2006 In addition, corticosterone induced a potentiation of norepinephrine-induced Aa-nat transcription even after 48 hr of incubation. Norepinephrine 54-68 aralkylamine N-acetyltransferase Rattus norvegicus 77-83 16805813-0 2006 Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors. Norepinephrine 23-37 aralkylamine N-acetyltransferase Rattus norvegicus 105-139 17014691-4 2006 Here we analyzed the effect of tumor necrosis factor-alpha (TNF-alpha) and corticosterone on the transcription of the Aa-nat, hiomt and 14-3-3 protein genes in denervated pineal glands of rats stimulated for 5 hr with norepinephrine, using real-time reverse transcription-polymerase chain reaction. Norepinephrine 218-232 aralkylamine N-acetyltransferase Rattus norvegicus 118-142 16805813-4 2006 We demonstrated that treatment of cultured rat pineals with 9-carboxy-11-nor-delta-9-tetrahydrocannabinol (THC), cannabidiol or cannabinol significantly reduced norepinephrine-induced arylalkylamine N-acetyltransferase (AANAT) activity and melatonin biosynthesis. Norepinephrine 161-175 aralkylamine N-acetyltransferase Rattus norvegicus 184-218 16805813-4 2006 We demonstrated that treatment of cultured rat pineals with 9-carboxy-11-nor-delta-9-tetrahydrocannabinol (THC), cannabidiol or cannabinol significantly reduced norepinephrine-induced arylalkylamine N-acetyltransferase (AANAT) activity and melatonin biosynthesis. Norepinephrine 161-175 aralkylamine N-acetyltransferase Rattus norvegicus 220-225 12641739-1 2003 The rat pineal gland is a suitable model to investigate neurotransmitter-controlled gene expression, because it is well established that the stimulation of melatonin biosynthesis by norepinephrine (NE) depends on the activation of the gene that encodes arylalkylamine N-acetyltransferase (AANAT), the melatonin rhythm enzyme. Norepinephrine 182-196 aralkylamine N-acetyltransferase Rattus norvegicus 253-287 16687309-2 2006 Studies with proteasome inhibitors, MG132 and clasto-lactacystin beta-lactone (c-lact), show two opposite effects of proteasomal inhibition on norepinephrine (NE)-induction of Aanat. Norepinephrine 143-157 aralkylamine N-acetyltransferase Rattus norvegicus 176-181 16166080-2 2005 Norepinephrine binds to the beta-adrenergic receptor and stimulates an increase in intracellular cAMP levels, leading to the transcriptional activation of serotonin N-acetyltransferase, which in turn promotes melatonin production. Norepinephrine 0-14 aralkylamine N-acetyltransferase Rattus norvegicus 155-184 16099857-2 2005 Addition of c-lact or MG132 3 h after norepinephrine (NE) stimulation produced a significant increase in AA-NAT protein level and enzyme activity. Norepinephrine 38-52 aralkylamine N-acetyltransferase Rattus norvegicus 105-111 15527789-1 2004 The norepinephrine-driven increase in mitogen-activated protein kinase (MAPK) activity is part of the mechanism that regulates arylalkylamine N-acetyltransferase (AA-NAT) activity in the rat pineal gland. Norepinephrine 4-18 aralkylamine N-acetyltransferase Rattus norvegicus 127-161 15527789-1 2004 The norepinephrine-driven increase in mitogen-activated protein kinase (MAPK) activity is part of the mechanism that regulates arylalkylamine N-acetyltransferase (AA-NAT) activity in the rat pineal gland. Norepinephrine 4-18 aralkylamine N-acetyltransferase Rattus norvegicus 163-169 14617573-3 2004 Treatment of pinealocytes with norepinephrine (NE) caused a time-dependent increase in the levels of AA-NAT mRNA, AA-NAT protein, and enzymatic activity as well as MT production. Norepinephrine 31-45 aralkylamine N-acetyltransferase Rattus norvegicus 101-107 14617573-3 2004 Treatment of pinealocytes with norepinephrine (NE) caused a time-dependent increase in the levels of AA-NAT mRNA, AA-NAT protein, and enzymatic activity as well as MT production. Norepinephrine 31-45 aralkylamine N-acetyltransferase Rattus norvegicus 114-120 12641739-1 2003 The rat pineal gland is a suitable model to investigate neurotransmitter-controlled gene expression, because it is well established that the stimulation of melatonin biosynthesis by norepinephrine (NE) depends on the activation of the gene that encodes arylalkylamine N-acetyltransferase (AANAT), the melatonin rhythm enzyme. Norepinephrine 182-196 aralkylamine N-acetyltransferase Rattus norvegicus 289-294 12077484-3 2002 Norepinephrine (NE) induced AA-NAT and Per1, whereas its effect on Per2 was negligible. Norepinephrine 0-14 aralkylamine N-acetyltransferase Rattus norvegicus 28-34 9054387-4 1997 The increase in AA-NAT mRNA is generated by norepinephrine acting through a cAMP mechanism. Norepinephrine 44-58 aralkylamine N-acetyltransferase Rattus norvegicus 16-22 11516836-10 2001 These results indicate that arylalkylamine N-acetyltransferase mRNA in ganglionectomized rats is not induced by circulating catecholamines and may be caused by both a centrally originated norepinephrine, as already suggested, and other non-adrenergic transmitter(s). Norepinephrine 188-202 aralkylamine N-acetyltransferase Rattus norvegicus 28-62 11516836-11 2001 In conclusion, this work shows that norepinephrine drives the nocturnal increase of arylalkylamine N-acetyltransferase gene expression both in the superficial and deep pineal and strongly suggests that other neurotransmitters are involved in day-time inhibition and night-time stimulation of pineal metabolism. Norepinephrine 36-50 aralkylamine N-acetyltransferase Rattus norvegicus 84-118 11854096-2 2002 In this study, the accumulation of AA-NAT mRNA induced by norepinephrine (NE) and peptides of the secretin superfamily (pituitary adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), growth hormone releasing factor (GRF), secretin) was investigated by a new quantitative reverse transcription-PCR (RT-PCR) assay. Norepinephrine 58-72 aralkylamine N-acetyltransferase Rattus norvegicus 35-41 10629750-2 1999 Upon binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output. Norepinephrine 77-91 aralkylamine N-acetyltransferase Rattus norvegicus 163-192 10629750-2 1999 Upon binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output. Norepinephrine 77-91 aralkylamine N-acetyltransferase Rattus norvegicus 194-197 2984573-2 1985 Noradrenaline, released from sympathetic nerve terminals in the pineal gland, regulates a large nocturnal increase in melatonin synthesis by stimulating the activity of arylalkylamine N-acetyltransferase (NAT, EC 2.3.1.87) 30-70-fold. Norepinephrine 0-13 aralkylamine N-acetyltransferase Rattus norvegicus 169-203 7789743-1 1995 The activity of serotonin N-acetyltransferase in the rat pineal is regulated through a synergistic action of norepinephrine on alpha 1- and beta 1-adrenoceptors. Norepinephrine 109-123 aralkylamine N-acetyltransferase Rattus norvegicus 16-45 20501291-3 1988 The role of this glutamate receptor site was investigated by studying the effects of select glutamate receptor agonists and antagonists and of ?-aminobutyric acid on the basal- and on the norepinephrine-stimulated activity of arylalkylamine N-acetyltransferase in rat pineal glands that were incubated in Dulbecco"s Modified Eagle Medium at 37 degrees C for 20 min in an atmosphere of 5% CO(2)/95% O(2). Norepinephrine 188-202 aralkylamine N-acetyltransferase Rattus norvegicus 226-260