PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31151797-10 2019 In wildtype mice, chronic thyroxine treatment induced a large relative increase in the total amounts of UCP1 in the brown adipose tissue (practically no UCP1 in brite/beige adipose tissue), corresponding to an enhanced thermogenic response to norepinephrine injection. Norepinephrine 243-257 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 104-108 31317231-5 2019 RESULTS: Combined treatment with the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist rosiglitazone, the SMAD3 inhibitor SIS3 and the adrenergic receptor agonist noradrenaline (norepinephrine) synergistically induced Ucp1, Fgf21 and Cited1 expression, triggering brown adipogenesis. Norepinephrine 182-195 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 237-241 31048375-8 2019 Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes. Norepinephrine 148-162 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 175-179 31048375-6 2019 Norepinephrine increases energy expenditure in brown adipose tissue by providing fatty acid substrate through lipolysis and by increasing expression of uncoupled protein-1 (UCP1). Norepinephrine 0-14 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 173-177 31048375-8 2019 Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes. Norepinephrine 148-162 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 175-179 27647490-4 2016 Acute noradrenaline-induced hyperthermia requires UCP1 but not UCP3. Norepinephrine 6-19 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 50-54 27647490-9 2016 By comparison, UCP1 knockout (UCP1KO) mice exhibit blunted methamphetamine and fully inhibited noradrenaline thermogenesis, but an increased febrile response to LPS. Norepinephrine 95-108 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 15-19 31048375-6 2019 Norepinephrine increases energy expenditure in brown adipose tissue by providing fatty acid substrate through lipolysis and by increasing expression of uncoupled protein-1 (UCP1). Norepinephrine 0-14 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 152-171 25085924-8 2014 In T37i cells, corticosterone prevented induction of Ucp1 mRNA and Ucp1 protein by both ACTH and norepinephrine in a glucocorticoid receptor (GR)-dependent fashion. Norepinephrine 97-111 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 53-57 25738783-5 2015 Surprisingly, we found that mice lacking uncoupling protein 1 (UCP1) have fully preserved BAT blood flow response to norepinephrine despite failing to perform thermogenesis. Norepinephrine 117-131 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 41-61 25738783-5 2015 Surprisingly, we found that mice lacking uncoupling protein 1 (UCP1) have fully preserved BAT blood flow response to norepinephrine despite failing to perform thermogenesis. Norepinephrine 117-131 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 63-67 25085924-8 2014 In T37i cells, corticosterone prevented induction of Ucp1 mRNA and Ucp1 protein by both ACTH and norepinephrine in a glucocorticoid receptor (GR)-dependent fashion. Norepinephrine 97-111 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 67-71 19598006-1 2009 Thyroid hormones are known to stimulate thermogenesis in rodents by exerting a permissive effect on norepinephrine that affects uncoupling protein-1 (UCP1) expression in brown adipose tissue (BAT). Norepinephrine 100-114 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 128-154 24386355-6 2013 These brown adipocytes contained large amounts of UCP1 and increased their oxygen consumption when stimulated with norepinephirine. Norepinephrine 115-130 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 50-54 22233932-4 2012 Summit metabolism ( V O2summit) and norepinephrine-induced thermogenesis ( V O2NST) were significantly lower in UCP-dta mice relative to wild-type mice regardless of temperature treatment, but both were significantly higher in cold relative to warm acclimated mice. Norepinephrine 36-50 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 112-115 19187776-3 2009 In wild-type mice, high-fat diet increased norepinephrine-induced thermogenesis; i.e., diet-induced thermogenesis was observed, but no such effect was observed in UCP1-ablated mice, demonstrating that diet-induced thermogenesis fully emanates from UCP1 activity. Norepinephrine 43-57 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 248-252 10499537-11 1999 These studies establish that norepinephrine is required for leptin to regulate its own expression in WAT and UCP1 expression in BAT and indicate that these effects are likely mediated through the centrally expressed long form of the leptin receptor. Norepinephrine 29-43 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 109-113 16160864-10 2005 Using adipocytes from Ucp1(+/+) and Ucp1(-/-) mice, we showed that noradrenaline-mediated phosphorylation of AMPK does not require the presence or activity of UCP1. Norepinephrine 67-80 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 22-26 16160864-10 2005 Using adipocytes from Ucp1(+/+) and Ucp1(-/-) mice, we showed that noradrenaline-mediated phosphorylation of AMPK does not require the presence or activity of UCP1. Norepinephrine 67-80 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 36-40 12023879-0 2002 Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels. Norepinephrine 9-22 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 61-65 11696583-4 2001 In Dio2(-/-) brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O(2) consumption are all reduced due to impaired cAMP generation. Norepinephrine 41-55 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 115-119 11239487-5 2001 Norepinephrine-induced thermogenesis in brown-fat cells is absolutely dependent on UCP1, as is the uncoupled state and the recoupling by purine nucleotides in isolated brown-fat mitochondria. Norepinephrine 0-14 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 83-87 10825155-5 2000 Ucp1(-/-) cells were as potent as wild-type in norepinephrine-induced cAMP accumulation and lipolysis and had a similar mitochondrial respiratory complement. Norepinephrine 47-61 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 0-4 10749798-5 2000 Administration of norepinephrine to rats and isoproterenol to mice stimulated MT and UCP1 expression in BAT, implying a sympathetically mediated pathway for MT induction. Norepinephrine 18-32 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 85-89 15924571-4 2005 Likewise, the increased levels of UCP3 and cAMP-dependent protein kinase in the brown adipose tissue of Ucp1-/- mice given the standard diet were decreased significantly in that of Ucp1-/- mice fed the HF diet, which animals showed impaired norepinephrine-induced lipolysis in their adipose tissues. Norepinephrine 241-255 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 104-108 15924571-4 2005 Likewise, the increased levels of UCP3 and cAMP-dependent protein kinase in the brown adipose tissue of Ucp1-/- mice given the standard diet were decreased significantly in that of Ucp1-/- mice fed the HF diet, which animals showed impaired norepinephrine-induced lipolysis in their adipose tissues. Norepinephrine 241-255 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 181-185 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 61-65 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 93-97 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 134-138 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 134-138 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 260-273 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 61-65 9717772-3 1998 In contrast, an injection of norepinephrine (NE) induced a comparable increase in UCP mRNA levels in control and MSG-obese mice. Norepinephrine 29-43 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 82-85 10555559-5 1999 Treatment of mouse brown adipocytes in primary culture with noradrenaline also triggered a dose-dependent increase of the levels of UCP1 mRNA and UCP2 mRNA. Norepinephrine 60-73 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 132-136 8068027-0 1994 Stabilization of the mRNA for the uncoupling protein thermogenin by transcriptional/translational blockade and by noradrenaline in brown adipocytes differentiated in culture: a degradation factor induced by cessation of stimulation? Norepinephrine 114-127 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 53-64 8765467-7 1996 Cells treated with pioglitazone for 48 hr, with norepinephrine added during the last 7 hr, demonstrated a 59-fold increase in UCP mRNA. Norepinephrine 48-62 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 126-129 8765467-8 1996 However, simultaneous treatment with pioglitazone and repeated treatment norepinephrine for 48 hr yielded a greater than 200-fold increase in UCP mRNA. Norepinephrine 73-87 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 142-145 8765467-9 1996 Examination of UCP protein levels demonstrated a similar time-dependent increase with pioglitazone and/or norepinephrine treatment, as well as a synergistic increase with concurrent pioglitazone and norepinephrine treatment. Norepinephrine 106-120 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 15-18 8765467-9 1996 Examination of UCP protein levels demonstrated a similar time-dependent increase with pioglitazone and/or norepinephrine treatment, as well as a synergistic increase with concurrent pioglitazone and norepinephrine treatment. Norepinephrine 199-213 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 15-18 8760369-3 1996 The two RA isomers displayed similar effectiveness as UCP inducers, their effect being comparable with that triggered by noradrenaline, so far considered to be the main modulator of UCP gene expression. Norepinephrine 121-134 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 182-185 8068027-2 1994 After 7 days in culture, the cells were stimulated for 24 h with noradrenaline, and a high level of thermogenin mRNA was then observed. Norepinephrine 65-78 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 100-111 8068027-4 1994 The presence of noradrenaline during transcriptional blockade led to a further stabilization of thermogenin mRNA. Norepinephrine 16-29 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 96-107 7905411-2 1994 In tissue culture, these tumor cells expressed the brown fat-specific mitochondrial uncoupling protein (Ucp) gene when stimulated by norepinephrine. Norepinephrine 133-147 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 104-107 7905411-4 1994 We found that the addition of 10(-7)-10(-6) M norepinephrine was critical for establishing cells with high Ucp expression, mitochondrial content, and adipogenesis. Norepinephrine 46-60 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 107-110 8264627-1 1994 Previous studies on the regulation of a Ucp minigene in transgenic mice demonstrated that the sequences necessary for brown-fat-specific expression and inducibility by norepinephrine were located in the 5" flanking region between 1 and 2.8 kb from the transcriptional start site. Norepinephrine 168-182 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 40-43 8175918-6 1994 Upon transfection of HIB 1B cells with a reporter gene containing the UCP promoter, the activity of the transgene was regulatable by cAMP and norepinephrine. Norepinephrine 142-156 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 70-73 1323843-6 1992 The cultured adipocytes express mRNA for UCP upon stimulation with N6,O2"-dibutyryladenosine 3",5"-cyclic monophosphate, norepinephrine, isoproterenol or D7114, a beta 3 adrenergic agonist. Norepinephrine 121-135 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 41-44 1603085-5 1992 Addition of 10(-7) M norepinephrine resulted in approximately a 30-fold induction of Ucp mRNA within 4 h. The induction by norepinephrine was independent of cell density and also independent of thyroid hormone and insulin during the first 5 days in culture. Norepinephrine 21-35 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 85-88 1599423-4 1992 High levels of thermogenin could be induced by noradrenaline treatment in cells grown for more than 5 days in culture, and in such cell cultures continuously stimulated with noradrenaline, the thermogenin level continued to increase for at least a further 5 days. Norepinephrine 47-60 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 15-26 1599423-4 1992 High levels of thermogenin could be induced by noradrenaline treatment in cells grown for more than 5 days in culture, and in such cell cultures continuously stimulated with noradrenaline, the thermogenin level continued to increase for at least a further 5 days. Norepinephrine 174-187 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 193-204 1599423-6 1992 In cell cultures continuously stimulated with noradrenaline for 5 days, the induced thermogenin was degraded much more slowly after noradrenaline removal, with a half-life of 70 h. This half-life was unchanged by cycloheximide treatment, and the degradation after cycloheximide was in parallel with the degradation of protein in general, and was therefore non-specific. Norepinephrine 46-59 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 84-95 1599423-6 1992 In cell cultures continuously stimulated with noradrenaline for 5 days, the induced thermogenin was degraded much more slowly after noradrenaline removal, with a half-life of 70 h. This half-life was unchanged by cycloheximide treatment, and the degradation after cycloheximide was in parallel with the degradation of protein in general, and was therefore non-specific. Norepinephrine 132-145 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 84-95 1603085-5 1992 Addition of 10(-7) M norepinephrine resulted in approximately a 30-fold induction of Ucp mRNA within 4 h. The induction by norepinephrine was independent of cell density and also independent of thyroid hormone and insulin during the first 5 days in culture. Norepinephrine 123-137 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 85-88 2176208-5 1990 In these cells, it was possible, by using norepinephrine, to induce specifically the synthesis of the UCP but not of F1-ATPase or cytochrome oxidase. Norepinephrine 42-56 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 102-105 1346138-8 1992 In contrast, both norepinephrine and CGP-12177 were able to induce the expression of the uncoupling protein thermogenin in the confluent cultured cells. Norepinephrine 18-32 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 108-119 2176208-6 1990 The maximal response was observed at 0.1 microM norepinephrine and the synthesis of UCP remained activated for at least 24 h. Detailed analysis revealed a major role of the beta-adrenergic receptors and elevated intracellular concentration of cAMP in stimulation of UCP synthesis. Norepinephrine 48-62 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 266-269 1697859-2 1990 In these cells, it was possible by norepinephrine (NE) addition to induce specifically the expression of the UCP gene. Norepinephrine 35-49 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 109-112 34485365-6 2021 In white adipocytes, green tea compounds decreased both basal and norepinephrine-induced UCP1 mRNA levels, and this was associated with the suppression of cell differentiation, indicated by reduced lipogenic gene expression and lipid accumulation. Norepinephrine 66-80 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 89-93 2497023-0 1989 Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine. Norepinephrine 132-146 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 89-100 3022838-2 1986 It was found that a 4 hr cold stress led to a 7-fold increase in the amount of thermogenin mRNA; injection of norepinephrine had a significant but smaller effect. Norepinephrine 110-124 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 79-90 3121388-2 1987 As expected, cold exposure or norepinephrine injection caused an increase in the amount of thermogenin mRNA. Norepinephrine 30-44 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 91-102 2497023-4 1989 However, in cells derived from hypothyroid (methimazole-treated) mice there was a higher expression of thermogenin, and norepinephrine had a marked augmenting effect on the thermogenin mRNA level in these cells. Norepinephrine 120-134 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 173-184 2497023-6 1989 It was concluded that brown-fat cells in culture can reach a differentiated state, sufficiently advanced that the unique properties of these cells can be expressed, and that thermogenin gene expression (i.e., the level of thermogenin mRNA) is under direct control of norepinephrine. Norepinephrine 267-281 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 174-185 2497023-6 1989 It was concluded that brown-fat cells in culture can reach a differentiated state, sufficiently advanced that the unique properties of these cells can be expressed, and that thermogenin gene expression (i.e., the level of thermogenin mRNA) is under direct control of norepinephrine. Norepinephrine 267-281 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 222-233 33691909-1 2021 Cold-induced norepinephrine activates beta3-adrenergic receptors (beta3-AR) to stimulate the kinase cascade and cAMP-response element-binding protein, leading to the induction of thermogenic gene expression including uncoupling protein 1 (Ucp1). Norepinephrine 13-27 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 217-237 33691909-1 2021 Cold-induced norepinephrine activates beta3-adrenergic receptors (beta3-AR) to stimulate the kinase cascade and cAMP-response element-binding protein, leading to the induction of thermogenic gene expression including uncoupling protein 1 (Ucp1). Norepinephrine 13-27 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 239-243 32473155-12 2020 Ectopic expression of GATA3 enhanced the expression of UCP-1 and thermogenic genes upon treatment with norepinephrine whereas GATA3 knockdown had the opposite effect. Norepinephrine 103-117 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 55-60 32730300-9 2020 At the cellular level, cultured cells from brown adipose tissue (BAT) of Pdgfralpha-Cre Ahrfl/fl mice were more responsive than cells from controls to transcriptional activation of the thermogenic uncoupling protein 1 (Ucp1) gene by norepinephrine, suggesting an ability to burn more energy under certain conditions. Norepinephrine 233-247 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 197-217 32730300-9 2020 At the cellular level, cultured cells from brown adipose tissue (BAT) of Pdgfralpha-Cre Ahrfl/fl mice were more responsive than cells from controls to transcriptional activation of the thermogenic uncoupling protein 1 (Ucp1) gene by norepinephrine, suggesting an ability to burn more energy under certain conditions. Norepinephrine 233-247 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 219-223