PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15344912-1	2004	In all mammalian species investigated, noradrenaline activates a beta-adrenoceptor/cAMP/protein kinase A-dependent mechanism to switch on arylalkylamine N-acetyltransferase and melatonin biosynthesis in the pineal gland.	Norepinephrine	39-52	aralkylamine N-acetyltransferase	Homo sapiens	138-172	
18554250-1	2008	In the mammalian pineal gland, the rhythm in melatonin biosynthesis depends on the norepinephrine (NE)-driven regulation of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme of melatonin biosynthesis.	Norepinephrine	83-97	aralkylamine N-acetyltransferase	Homo sapiens	124-158	
18554250-1	2008	In the mammalian pineal gland, the rhythm in melatonin biosynthesis depends on the norepinephrine (NE)-driven regulation of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme of melatonin biosynthesis.	Norepinephrine	83-97	aralkylamine N-acetyltransferase	Homo sapiens	160-165	
16217122-3	2005	This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	83-97	aralkylamine N-acetyltransferase	Homo sapiens	69-75	
3224030-5	1988	The release of norepinephrine from the postganglionic fiber of the superior cervical ganglia controls the production of melatonin in the pineal by regulating the activity of serotonin-N-acetyltransferase.	Norepinephrine	15-29	aralkylamine N-acetyltransferase	Homo sapiens	174-203	
9949305-11	1999	The activation of SNAT may be due to a stimulation of the sympathetic nervous system (urinary noradrenaline; NA: +243%, p < 0.005) when the cellular immune system responded towards tumor growth (urinary biopterin, +214%, p < 0.005).	Norepinephrine	94-107	aralkylamine N-acetyltransferase	Homo sapiens	18-22	
12065661-2	2002	5-HT is present in organelles distinct from l-glutamate-containing synaptic-like microvesicles as well as in the cytoplasm of pinealocytes, and is secreted upon stimulation by norepinephrine (NE) to enhance serotonin N-acetyltransferase activity via the 5-HT2 receptor.	Norepinephrine	176-190	aralkylamine N-acetyltransferase	Homo sapiens	207-236	
7320735-1	1981	The circadian release of norepinephrine from nerve terminals in the pineal gland drives acetyl-CoA:serotonin N-acetyltransferase (NAT; EC 2.3.1.5) activity in the adult pineal from a daytime low to a nighttime high.	Norepinephrine	25-39	aralkylamine N-acetyltransferase	Homo sapiens	99-128	
31356684-2	2019	The nuclear translocation of nuclear factor kappa-B (NFkappaB) homodimers, lacking transactivation domains, once induced by lipopolysaccharide (LPS) or tumor necrosis factor (TNF), inhibits the expression of Aanat gene and the synthesis of noradrenaline (NA)-induced melatonin.	Norepinephrine	240-253	aralkylamine N-acetyltransferase	Homo sapiens	208-213	
24877149-2	2014	In the rodent, Aanat gene expression displays a marked circadian rhythm; release of norepinephrine in the gland at night causes a cAMP-based induction of Aanat transcription.	Norepinephrine	84-98	aralkylamine N-acetyltransferase	Homo sapiens	154-159