PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11028916-10 2000 Since PHM is homologous in sequence and mechanism to dopamine beta-monooxygenase (DBM; EC 1.14.17.1), the enzyme that converts dopamine to norepinephrine during catecholamine biosynthesis, these structural and mechanistic insights are extended to DBM. Norepinephrine 139-153 dopamine beta-hydroxylase Rattus norvegicus 53-80 7525897-1 1994 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine. Norepinephrine 72-86 dopamine beta-hydroxylase Rattus norvegicus 27-30 10573542-1 1999 Dopamine beta-monooxygenase (DBM), a cuproenzyme, converts dopamine to norepinephrine in selected cells. Norepinephrine 71-85 dopamine beta-hydroxylase Rattus norvegicus 0-27 10573542-1 1999 Dopamine beta-monooxygenase (DBM), a cuproenzyme, converts dopamine to norepinephrine in selected cells. Norepinephrine 71-85 dopamine beta-hydroxylase Rattus norvegicus 29-32 9641484-1 1998 Nepicastat (RS-25560-197) is a novel, selective, and potent inhibitor of dopamine beta-hydroxylase, which modulates catecholamine levels (reduces norepinephrine and elevates dopamine) in cardiovascular tissues. Norepinephrine 146-160 dopamine beta-hydroxylase Rattus norvegicus 73-98 9329158-5 1997 Coronal sections of rat brain were processed to visualize immunoreactivity for the norepinephrine synthetic enzyme dopamine beta-hydroxylase (DBH), a specific marker for noradrenergic processes. Norepinephrine 83-97 dopamine beta-hydroxylase Rattus norvegicus 115-140 9329158-5 1997 Coronal sections of rat brain were processed to visualize immunoreactivity for the norepinephrine synthetic enzyme dopamine beta-hydroxylase (DBH), a specific marker for noradrenergic processes. Norepinephrine 83-97 dopamine beta-hydroxylase Rattus norvegicus 142-145 8710209-2 1996 Noradrenaline (NA) neurons in A1, A5, A7 regions, locus coeruleus (LC) and nucleus subcoeruleus (SC) and adrenaline (Ad) neurons in C1 region were double-labeled due to DBH or PNMT and retrogradely transported FluoSpheres, and the ratio of their coexistence was higher in A1, A5, A7 and C1 than in LC and SC. Norepinephrine 0-13 dopamine beta-hydroxylase Rattus norvegicus 169-172 9011768-1 1996 Dopamine beta-hydroxylase catalyzes the final step in noradrenaline synthesis and is expressed exclusively in noradrenergic and adrenergic cells. Norepinephrine 54-67 dopamine beta-hydroxylase Rattus norvegicus 0-25 7798950-1 1995 Dopamine beta-hydroxylase (DBH) catalyzes the synthesis of the neurohormone norepinephrine and is expressed only in noradrenergic and adrenergic cells of the nervous and endocrine systems. Norepinephrine 76-90 dopamine beta-hydroxylase Rattus norvegicus 0-25 7798950-1 1995 Dopamine beta-hydroxylase (DBH) catalyzes the synthesis of the neurohormone norepinephrine and is expressed only in noradrenergic and adrenergic cells of the nervous and endocrine systems. Norepinephrine 76-90 dopamine beta-hydroxylase Rattus norvegicus 27-30 7525897-1 1994 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine. Norepinephrine 72-86 dopamine beta-hydroxylase Rattus norvegicus 0-25 7525897-1 1994 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine. Norepinephrine 167-181 dopamine beta-hydroxylase Rattus norvegicus 0-25 7525897-1 1994 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine. Norepinephrine 167-181 dopamine beta-hydroxylase Rattus norvegicus 27-30 7935259-2 1994 Structurally related dithiocarbamates have been found to decrease norepinephrine (NE) synthesis by suppressing the activity of dopamine-beta-hydroxylase. Norepinephrine 66-80 dopamine beta-hydroxylase Rattus norvegicus 127-152 7906468-2 1993 Diethyldithiocarbamate, a dopamine-beta-hydroxylase inhibitor, reduces norepinephrine synthesis and acutely inhibits growth hormone (GH) secretion. Norepinephrine 71-85 dopamine beta-hydroxylase Rattus norvegicus 26-51 8318751-1 1993 Thiram has been reported to inhibit dopamine-beta-hydroxylase (D beta H), thereby affecting norepinephrine (NE) synthesis. Norepinephrine 92-106 dopamine beta-hydroxylase Rattus norvegicus 36-61 1359011-2 1992 In this study we have found that in PC12 cells, the mRNA levels of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the formation of norepinephrine from dopamine, can be regulated by glucocorticoids and cyclic AMP (cAMP) analogues. Norepinephrine 143-157 dopamine beta-hydroxylase Rattus norvegicus 67-92 1359011-2 1992 In this study we have found that in PC12 cells, the mRNA levels of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the formation of norepinephrine from dopamine, can be regulated by glucocorticoids and cyclic AMP (cAMP) analogues. Norepinephrine 143-157 dopamine beta-hydroxylase Rattus norvegicus 94-97 1861777-2 1991 Treatment with FLA63, an inhibitor of dopamine beta-hydroxylase (10 mg/kg, 2 h before killing), induced depletion of noradrenaline and adrenaline in the preoptic area and median eminence (sites, respectively, inside and outside the blood-brain barrier) but, paradoxically, resulted in a significant increase (+77%) in the pineal content of adrenaline without affecting that of noradrenaline. Norepinephrine 117-130 dopamine beta-hydroxylase Rattus norvegicus 38-63 1382062-1 1992 Dopamine beta-hydroxylase, the enzyme which converts dopamine to norepinephrine, is expressed in a cell type-restricted pattern in neuroendocrine tissue. Norepinephrine 65-79 dopamine beta-hydroxylase Rattus norvegicus 0-25 2002450-1 1991 We have found that (R,S)-1-(phenylthio)-aminopropane (4a), a synthetic alternate substrate for the terminal enzyme of norepinephrine biosynthesis, dopamine beta-monooxygenase (DBM), is both an indirect sympathomimetic and a potent antihypertensive agent in spontaneously hypertensive rats. Norepinephrine 118-132 dopamine beta-hydroxylase Rattus norvegicus 147-174 1707425-3 1991 Application of immunocytochemical methods to visualize tachykinins (predominantly substance P magnitude of SP), serotonin (5-HT), and dopamine B-hydroxylase (DBH), the synthesizing enzyme for norepinephrine, permits us to compare the response of SP systems in rat and cat spinal cord and to examine the response of two descending systems, serotoninergic and noradrenergic, to deafferentation. Norepinephrine 192-206 dopamine beta-hydroxylase Rattus norvegicus 134-156 1707425-3 1991 Application of immunocytochemical methods to visualize tachykinins (predominantly substance P magnitude of SP), serotonin (5-HT), and dopamine B-hydroxylase (DBH), the synthesizing enzyme for norepinephrine, permits us to compare the response of SP systems in rat and cat spinal cord and to examine the response of two descending systems, serotoninergic and noradrenergic, to deafferentation. Norepinephrine 192-206 dopamine beta-hydroxylase Rattus norvegicus 158-161 3304727-3 1987 An alternative approach to stimulating dopamine receptors, while at the same time blunting sympathetic nervous system activity, would be by inhibiting the enzyme dopamine beta-hydroxylase (D beta H), thus increasing the cardiovascular and renal ratio of dopamine to norepinephrine. Norepinephrine 266-280 dopamine beta-hydroxylase Rattus norvegicus 162-187 2746226-10 1989 In conclusion, sympathetic nerves in the rat pineal gland contain tyrosine hydroxylase and dopamine beta-hydroxylase, the two enzymes required for the synthesis of noradrenaline. Norepinephrine 164-177 dopamine beta-hydroxylase Rattus norvegicus 91-116 2707360-1 1989 Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline. Norepinephrine 181-194 dopamine beta-hydroxylase Rattus norvegicus 123-148 2707360-1 1989 Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline. Norepinephrine 181-194 dopamine beta-hydroxylase Rattus norvegicus 150-153 3240025-2 1988 In addition, we have shown in vitro that these compounds are facile substrates for dopamine beta-hydroxylase, the terminal enzyme of norepinephrine synthesis. Norepinephrine 133-147 dopamine beta-hydroxylase Rattus norvegicus 83-108 3691657-3 1987 Turnover in the left ventricles, as estimated by the decrease of noradrenaline under dopamine beta-hydroxylase inhibition with bis-(4-methyl-1-homo-piperazinyl-thiocarbonyl)-disulfide (FLA-63), was unaffected by ligation whether in untreated, adrenalectomized, or hexamethonium-treated rats. Norepinephrine 65-78 dopamine beta-hydroxylase Rattus norvegicus 85-110 3805164-5 1987 Sequential immunostaining with antibodies toward dopamine-beta-hydroxylase (DBH) (an enzyme involved in the synthesis of noradrenaline) and NPY revealed an identical localization of DBH and NPY in nerve cell bodies in the superior cervical ganglion and in perivascular fibers of pial blood vessels, suggesting their coexistence. Norepinephrine 121-134 dopamine beta-hydroxylase Rattus norvegicus 49-74 3805164-5 1987 Sequential immunostaining with antibodies toward dopamine-beta-hydroxylase (DBH) (an enzyme involved in the synthesis of noradrenaline) and NPY revealed an identical localization of DBH and NPY in nerve cell bodies in the superior cervical ganglion and in perivascular fibers of pial blood vessels, suggesting their coexistence. Norepinephrine 121-134 dopamine beta-hydroxylase Rattus norvegicus 76-79 2129867-5 1990 We propose that the DBH/NPY/NGF-R-positive adrenal medullary ganglion cells are sympathetic postganglionic neurons producing noradrenaline. Norepinephrine 125-138 dopamine beta-hydroxylase Rattus norvegicus 20-23 1971714-3 1990 These measurements were repeated 2 weeks later, 2 h after the intravenous administration of 12.5 mg/kg of the dopamine-beta-hydroxylase inhibitor diethyldithiocarbamate (DDTC), which has been shown to be an effective norepinephrine synthesis inhibitor in the rat. Norepinephrine 217-231 dopamine beta-hydroxylase Rattus norvegicus 110-135 2612490-2 1989 In this study, the immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthesizing enzyme for norepinephrine, was compared between GEPR-9s and SD rats. Norepinephrine 115-129 dopamine beta-hydroxylase Rattus norvegicus 54-79 2612490-2 1989 In this study, the immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthesizing enzyme for norepinephrine, was compared between GEPR-9s and SD rats. Norepinephrine 115-129 dopamine beta-hydroxylase Rattus norvegicus 81-84 3125948-0 1987 Noradrenaline neuron plasticity in developing rat brain: effects of neonatal 6-hydroxydopamine demonstrated by dopamine-beta-hydroxylase immunocytochemistry. Norepinephrine 0-13 dopamine beta-hydroxylase Rattus norvegicus 111-136 3611599-1 1987 In agreement with the inhibition of dopamine-beta-hydroxylase by exposure to CS2, the extension of exposure time from 4 to 16 h increased dopamine concentrations in the hypothalmus and adrenals, and decreased noradrenaline concentration in the hypothalmus. Norepinephrine 209-222 dopamine beta-hydroxylase Rattus norvegicus 36-61 2993777-0 1985 Dopamine-beta-hydroxylase inhibition acutely stimulates rats hypothalamic noradrenaline and dopamine neuronal activity as assessed from metabolic ratios and circulating glucose and ACTH responses. Norepinephrine 74-87 dopamine beta-hydroxylase Rattus norvegicus 0-25 2884200-8 1987 In addition to vascular noradrenaline-containing fibers as described earlier the study shows parenchymal DBH-immunoreactive fibers in the neural lobe, suggesting a local role for noradrenaline in this lobe. Norepinephrine 179-192 dopamine beta-hydroxylase Rattus norvegicus 105-108 2426539-5 1986 Hypothalamic levels of norepinephrine were decreased during hypoxia [(inhibition of TH, MAO, and dopamine beta-hydroxylase (DBH)]. Norepinephrine 23-37 dopamine beta-hydroxylase Rattus norvegicus 97-122 2426539-5 1986 Hypothalamic levels of norepinephrine were decreased during hypoxia [(inhibition of TH, MAO, and dopamine beta-hydroxylase (DBH)]. Norepinephrine 23-37 dopamine beta-hydroxylase Rattus norvegicus 124-127 2993777-1 1985 Because central noradrenaline neuronal activity is tonically inhibited by noradrenaline (NA) itself via an action at prejunctional alpha 2-adrenoceptors, it was hypothesised that the blockade of central NA synthesis following acute dopamine-beta -hydroxylase (DBH) inhibition might primarily deplete prejunctional NA levels and result in an increase in central NA neuronal activity through reduced NA autoinhibition. Norepinephrine 74-87 dopamine beta-hydroxylase Rattus norvegicus 232-258 2862963-3 1985 Noradrenaline depletion in the cerebral cortex was obtained by peripheral injections of 6-hydroxydopamine (6-OHDA) at birth or N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4) at various postnatal ages and controlled by the absence of dopamine-beta-hydroxylase-labelled axons. Norepinephrine 0-13 dopamine beta-hydroxylase Rattus norvegicus 236-261 4022136-3 1985 The dopamine-beta-hydroxylase inhibitor FLA-63 swiftly elevated the content of dopamine and it lowered the content of noradrenaline in the two noradrenaline regions, but it was ineffective in the substantia nigra. Norepinephrine 118-131 dopamine beta-hydroxylase Rattus norvegicus 4-29 4022136-3 1985 The dopamine-beta-hydroxylase inhibitor FLA-63 swiftly elevated the content of dopamine and it lowered the content of noradrenaline in the two noradrenaline regions, but it was ineffective in the substantia nigra. Norepinephrine 143-156 dopamine beta-hydroxylase Rattus norvegicus 4-29 3991764-0 1985 Dopamine-beta-hydroxylase inhibitors, feeding and locomotor activity: reinstatement of feeding following central norepinephrine. Norepinephrine 113-127 dopamine beta-hydroxylase Rattus norvegicus 0-25 3925090-1 1985 Immunocytochemical localization of dopamine beta-hydroxylase (DBH) was used to study the synthesis and storage sites of norepinephrine (noradrenaline) in the rat and cat carotid bodies. Norepinephrine 120-134 dopamine beta-hydroxylase Rattus norvegicus 35-60 3925090-1 1985 Immunocytochemical localization of dopamine beta-hydroxylase (DBH) was used to study the synthesis and storage sites of norepinephrine (noradrenaline) in the rat and cat carotid bodies. Norepinephrine 120-134 dopamine beta-hydroxylase Rattus norvegicus 62-65 3925090-1 1985 Immunocytochemical localization of dopamine beta-hydroxylase (DBH) was used to study the synthesis and storage sites of norepinephrine (noradrenaline) in the rat and cat carotid bodies. Norepinephrine 136-149 dopamine beta-hydroxylase Rattus norvegicus 35-60 3925090-1 1985 Immunocytochemical localization of dopamine beta-hydroxylase (DBH) was used to study the synthesis and storage sites of norepinephrine (noradrenaline) in the rat and cat carotid bodies. Norepinephrine 136-149 dopamine beta-hydroxylase Rattus norvegicus 62-65 3925090-11 1985 Our results indicate that some of glomus cells in the rat and most of the glomus cells in the cat contain DBH and therefore may be sites of norepinephrine synthesis. Norepinephrine 140-154 dopamine beta-hydroxylase Rattus norvegicus 106-109 4078568-3 1985 The disappearances of dopamine and noradrenaline after alpha-methyltyrosine and the disappearance of noradrenaline after inhibition of the dopamine-beta-hydroxylase were not changed by decentralization or stimulation. Norepinephrine 101-114 dopamine beta-hydroxylase Rattus norvegicus 139-164 6732851-2 1984 However, alongside this effect, carbon disulphide produces a gradual increase in the adrenal content of dopamine-beta-hydroxylase indicated by the increase of in vitro estimated enzyme activity and by the increased in vivo conversion of dopamine to noradrenaline observed 24 hr after the ninth exposure. Norepinephrine 249-262 dopamine beta-hydroxylase Rattus norvegicus 104-129 3905724-1 1985 The aim of the present investigation was to study the distribution in the rat pineal gland of dopamine-beta-hydroxylase (DBH) which is essential for the formation of the melatonin synthesis-regulating substance noradrenaline (NA). Norepinephrine 211-224 dopamine beta-hydroxylase Rattus norvegicus 94-119 3905724-1 1985 The aim of the present investigation was to study the distribution in the rat pineal gland of dopamine-beta-hydroxylase (DBH) which is essential for the formation of the melatonin synthesis-regulating substance noradrenaline (NA). Norepinephrine 211-224 dopamine beta-hydroxylase Rattus norvegicus 121-124 6146989-7 1984 This theory was further supported by the finding that reduction of endogenous norepinephrine levels, via administration of the dopamine-beta-hydroxylase inhibitor FLA-63, markedly reduced the turning evoked by MK-801 and to a lesser degree that produced by amphetamine. Norepinephrine 78-92 dopamine beta-hydroxylase Rattus norvegicus 127-152 6733355-8 1984 produced profound decreases in dopamine-beta-hydroxylase activity in the frontal cortex and in the concentrations of noradrenaline in various brain regions indicating degeneration of the locus coeruleus noradrenaline system. Norepinephrine 203-216 dopamine beta-hydroxylase Rattus norvegicus 31-56 6707645-6 1984 This divergence of the noradrenaline content appears to be related to differing levels of dopamine beta-monooxygenase activity. Norepinephrine 23-36 dopamine beta-hydroxylase Rattus norvegicus 90-117 6143680-2 1984 retarded the disappearance of noradrenaline induced by the dopamine-beta-hydroxylase (DBH) inhibitor FLA 63, in the hypothalamus, nucleus of the solitary tract (A-2/C-2 area), and lateral reticular nucleus (A-1/C-1 area) regions, while propranolol (20 mg/kg i.p.) Norepinephrine 30-43 dopamine beta-hydroxylase Rattus norvegicus 59-84 6143680-2 1984 retarded the disappearance of noradrenaline induced by the dopamine-beta-hydroxylase (DBH) inhibitor FLA 63, in the hypothalamus, nucleus of the solitary tract (A-2/C-2 area), and lateral reticular nucleus (A-1/C-1 area) regions, while propranolol (20 mg/kg i.p.) Norepinephrine 30-43 dopamine beta-hydroxylase Rattus norvegicus 86-89 6150762-4 1984 Dopamine beta-hydroxylase was identified in most paraganglionic cells, indicating that they synthesized norepinephrine. Norepinephrine 104-118 dopamine beta-hydroxylase Rattus norvegicus 0-25 6250208-2 1980 The beta adrenoreceptor mediated desensitization of the hyperpolarization response to norepinephrine observed in pinealocyte membranes was rapidly reversed following the infusion of dopamine-beta-hydroxylase (DBH). Norepinephrine 86-100 dopamine beta-hydroxylase Rattus norvegicus 182-207 6290819-2 1982 After treatment of rats with a dopamine beta-hydroxylase inhibitor, 1-cyclohexyl-2-mercapto-imidazole (CHMI), there was a rapid increase in dopamine concentration even before norepinephrine concentration had decreased perceptibility. Norepinephrine 175-189 dopamine beta-hydroxylase Rattus norvegicus 31-56 6117605-8 1981 In vitro studies showed that the spontaneous outflow of noradrenaline from hypothalamic slices was accelerated by GYKI 11679 in a dose-dependent manner in a concentration range of 10(-5) to 10(-7) M. In a 10-fold higher range, GYKI 11679 produced inhibition of both the hypothalamic and the adrenal tyrosine hydroxylase activity but did not alter DOPA-decarboxylase, dopamine-beta-hydroxylase, or monoamine oxidase activities. Norepinephrine 56-69 dopamine beta-hydroxylase Rattus norvegicus 367-392 6295557-3 1982 This report describes the effects of lithium on the central and peripheral levels of activity of dopamine-beta-hydroxylase (DBH), the enzyme that catalyzes the final step in the biosynthetic pathway to the formation of norepinephrine (NE) from dopamine. Norepinephrine 219-233 dopamine beta-hydroxylase Rattus norvegicus 97-122 6295557-3 1982 This report describes the effects of lithium on the central and peripheral levels of activity of dopamine-beta-hydroxylase (DBH), the enzyme that catalyzes the final step in the biosynthetic pathway to the formation of norepinephrine (NE) from dopamine. Norepinephrine 219-233 dopamine beta-hydroxylase Rattus norvegicus 124-127 6806317-2 1982 When CNS stores of norepinephrine (NE) were selectively reduced by the subcutaneous administration of the dopamine-beta-hydroxylase inhibitor FLA-63, TRH concentrations were significantly reduced throughout the brain. Norepinephrine 19-33 dopamine beta-hydroxylase Rattus norvegicus 106-131 7074998-10 1982 The altered relationship between noradrenaline content and DBH activity observed in young SHR when compared to WKY suggests a change in noradrenergic neurones activity and/or structure which could correspond to a genetically transmitted neurochemical abnormality associated with the initiation of hypertension in the SHR. Norepinephrine 33-46 dopamine beta-hydroxylase Rattus norvegicus 59-62 6127640-3 1982 Blockade of dopamine beta-hydroxylase activity by disulfiram depleted brain noradrenaline (NA) and decreased HPT-SRIF. Norepinephrine 76-89 dopamine beta-hydroxylase Rattus norvegicus 12-37 6250208-2 1980 The beta adrenoreceptor mediated desensitization of the hyperpolarization response to norepinephrine observed in pinealocyte membranes was rapidly reversed following the infusion of dopamine-beta-hydroxylase (DBH). Norepinephrine 86-100 dopamine beta-hydroxylase Rattus norvegicus 209-212 6250208-4 1980 We suggest that the dissociation of the concentrations of norepinephrine and dopamine-beta-hydroxylase released into the synaptic cleft as a result of continuous sympathetic nerve stimulation produces a relative dopamine-beta-hydroxylase deficiency which is associated with the beta receptor desensitization. Norepinephrine 58-72 dopamine beta-hydroxylase Rattus norvegicus 212-237 6101345-3 1980 Adrenal dopamine-beta-hydroxylase was also inhibited by NLCAs [3"O-methylnorlaudanosolinecarboxylic acid (MNLCA) Kj = 1.2 x 10(-4) M] and NLCA is a competitive inhibitor of norepinephrine methylation by hepatic catechol-O-methyltransferase (NLCA Kj = 5.6 x 10(-5) M). Norepinephrine 173-187 dopamine beta-hydroxylase Rattus norvegicus 8-33 6261-4 1976 Placement of bilateral lesions in the ventral norepinephrine bundles resulted in a greater than an 85% fall in the dopamine-beta-hydroxylase activity of the median eminence, arcuate nucleus, and ventromedial nucleus, but had no effect on tyrosine hydroxylase activity measured in those same areas. Norepinephrine 46-60 dopamine beta-hydroxylase Rattus norvegicus 115-140 7464918-5 1981 Recent studies with antiserum to dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to noradrenaline, provided evidence for the existence of noradrenergic cells. Norepinephrine 103-116 dopamine beta-hydroxylase Rattus norvegicus 33-58 7464918-8 1981 We report here the simultaneous localization, in the same histological section, of 3H-oestradiol and the enzyme dopamine-beta-hydroxylase in neurones of the rat lower brain stem with a combined technique of thaw-mount autoradiography and immunohistochemistry, demonstrating that noradrenaline- or adrenaline-containing neurones are oestradiol target cells. Norepinephrine 279-292 dopamine beta-hydroxylase Rattus norvegicus 112-137 458440-2 1979 The present study represents an effort to evaluate and to place in proper perspective data based on the DbetaH activity found in the region of the light vesicle peak of noradrenaline (NA), which is used as a quantitative measure of a population of small terminal vesicles. Norepinephrine 169-182 dopamine beta-hydroxylase Rattus norvegicus 104-110 367530-1 1979 Dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been localized in light and electron microscopic preparations of rat brain by an immunocytochemical method using a peroxidase--anti-peroxidase Fab complex. Norepinephrine 70-84 dopamine beta-hydroxylase Rattus norvegicus 27-30 367530-1 1979 Dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been localized in light and electron microscopic preparations of rat brain by an immunocytochemical method using a peroxidase--anti-peroxidase Fab complex. Norepinephrine 70-84 dopamine beta-hydroxylase Rattus norvegicus 0-25 24033-5 1978 A32390A inhibits dopamine-beta-hydroxylase reduces heart and adrenal norepinephrine levels, lowers blood pressure in hypertensive rats, and possesses antibiotic activity vs. Gram-positive bacteria and fungi, including Candida albicans. Norepinephrine 69-83 dopamine beta-hydroxylase Rattus norvegicus 17-42 201940-0 1977 Possible role of dopamine-beta-hydroxylase in the regulation of norepinephrine biosynthesis in rat brain. Norepinephrine 64-78 dopamine beta-hydroxylase Rattus norvegicus 17-42 201940-1 1977 In Experiment 1, the dose-response effects of three dopamine-beta-hydroxylase (DBH) inhibitors (diethyldithiocarbamate, FLA-63 and U-14, 624) on the endogenous levels of norepinephrine and dopamine in pons-medulla of rat brain were determined. Norepinephrine 170-184 dopamine beta-hydroxylase Rattus norvegicus 52-77 201940-1 1977 In Experiment 1, the dose-response effects of three dopamine-beta-hydroxylase (DBH) inhibitors (diethyldithiocarbamate, FLA-63 and U-14, 624) on the endogenous levels of norepinephrine and dopamine in pons-medulla of rat brain were determined. Norepinephrine 170-184 dopamine beta-hydroxylase Rattus norvegicus 79-82 201940-5 1977 The results from the three experiments are consistent with the idea that DBH is involved in the regulation of norepinephrine biosynthesis. Norepinephrine 110-124 dopamine beta-hydroxylase Rattus norvegicus 73-76 988175-0 1976 Effect of dopamine-beta-hydroxylase inhibitors on blood pressure and cardiac norepinephrine levels in rats subjected to immobilization stress. Norepinephrine 77-91 dopamine beta-hydroxylase Rattus norvegicus 10-35 988175-11 1976 The present data support the hypothesis that the hypotensive action of picolinic acid derivatives may be attributable to the decrease in sympathetic nerve norepinephrine release caused by dopamine-beta-hydroxylase inhibition. Norepinephrine 155-169 dopamine beta-hydroxylase Rattus norvegicus 188-213 1233385-5 1975 A dopamine-beta-hydroxylase inhibitor, U-14, 624, depleted norepinephrine an additional 70% yet failed to alter self-stimulation in any of the groups. Norepinephrine 59-73 dopamine beta-hydroxylase Rattus norvegicus 2-27 1100685-3 1975 DBH is the enzyme that catalyzes the conversion of dopamine to noradrenaline, and as such is useful as an anatomical marker for noradrenaline and possibly adrenaline neurons. Norepinephrine 63-76 dopamine beta-hydroxylase Rattus norvegicus 0-3 1100685-3 1975 DBH is the enzyme that catalyzes the conversion of dopamine to noradrenaline, and as such is useful as an anatomical marker for noradrenaline and possibly adrenaline neurons. Norepinephrine 128-141 dopamine beta-hydroxylase Rattus norvegicus 0-3 5762612-2 1969 Both drugs inhibit dopamine-beta-hydroxylase, the enzyme responsible for the final step in the biosynthesis of norepinephrine. Norepinephrine 111-125 dopamine beta-hydroxylase Rattus norvegicus 19-44 4197-3 1976 The ratio between tyrosine hydroxylase and dopamine-beta-hydroxylase activities showed a significant correlation when compared with the ratio of dopamine and norepinephrine concentrations for the areas studied. Norepinephrine 158-172 dopamine beta-hydroxylase Rattus norvegicus 43-68 1151368-1 1975 The activity of dopamine-beta-hydroxylase, the enzyme that catalyzes the conversion of dopamine to norepinephrine, was measured in the serum of a strain of Wistar rats homozygous and heterozygous for a genetic form of hypothalamic diabetes insipidus and in Wistar control rats. Norepinephrine 99-113 dopamine beta-hydroxylase Rattus norvegicus 16-41 33746717-7 2021 Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated. Norepinephrine 143-157 dopamine beta-hydroxylase Rattus norvegicus 19-44 33746717-7 2021 Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated. Norepinephrine 143-157 dopamine beta-hydroxylase Rattus norvegicus 46-49 31891756-4 2019 It was hypothesised that NAT would be expressed exclusively on nerve fibres labelled by dopamine beta hydroxylase (DbetaH), an enzyme involved in the conversion of dopamine to noradrenaline. Norepinephrine 176-189 dopamine beta-hydroxylase Rattus norvegicus 88-113 32894465-2 2020 The activity of noradrenaline synthesis enzymes tyrosine hydroxylase and dopamine-beta-hydroxylase was measured in the brain and adrenal glands 48 and 72 h after the injection of immunotoxin (anti-dopamine-beta-hydroxylase-saporin) into the rat brain ventricles. Norepinephrine 16-29 dopamine beta-hydroxylase Rattus norvegicus 73-98 32894465-2 2020 The activity of noradrenaline synthesis enzymes tyrosine hydroxylase and dopamine-beta-hydroxylase was measured in the brain and adrenal glands 48 and 72 h after the injection of immunotoxin (anti-dopamine-beta-hydroxylase-saporin) into the rat brain ventricles. Norepinephrine 16-29 dopamine beta-hydroxylase Rattus norvegicus 197-222 32009887-5 2019 Furthermore, we measured the expression of the noradrenaline biosynthetic enzyme dopamine-beta-hydroxylase (DBH) and of alpha2 -AR in the spinal dorsal horn. Norepinephrine 47-60 dopamine beta-hydroxylase Rattus norvegicus 81-106 32009887-5 2019 Furthermore, we measured the expression of the noradrenaline biosynthetic enzyme dopamine-beta-hydroxylase (DBH) and of alpha2 -AR in the spinal dorsal horn. Norepinephrine 47-60 dopamine beta-hydroxylase Rattus norvegicus 108-111 32259069-2 2019 One strategy to mitigate the SNS overdrive is by restricting the biosynthesis of norepinephrine via the inhibition of dopamine beta-hydroxylase (DBH). Norepinephrine 81-95 dopamine beta-hydroxylase Rattus norvegicus 118-143 32259069-2 2019 One strategy to mitigate the SNS overdrive is by restricting the biosynthesis of norepinephrine via the inhibition of dopamine beta-hydroxylase (DBH). Norepinephrine 81-95 dopamine beta-hydroxylase Rattus norvegicus 145-148 32259069-3 2019 Zamicastat is a new DBH inhibitor that decreases norepinephrine and increases dopamine levels in peripherally sympathetic-innervated tissues. Norepinephrine 49-63 dopamine beta-hydroxylase Rattus norvegicus 20-23 32259069-13 2019 In conclusion, DBH inhibition decreased norepinephrine levels, reduced end-organ damage, and improved cardiometabolic and inflammatory biomarkers in aged male SHRs. Norepinephrine 40-54 dopamine beta-hydroxylase Rattus norvegicus 15-18 25854989-3 2015 An alternative strategy for the modulation of sympathetic nerve function is to reduce the biosynthesis of noradrenaline (NA) by inhibiting dopamine beta-hydroxylase (DbetaH), the enzyme that catalyzes the conversion of dopamine (DA) to NA in the sympathetic nerves. Norepinephrine 106-119 dopamine beta-hydroxylase Rattus norvegicus 139-164 30651588-6 2019 In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001). Norepinephrine 159-172 dopamine beta-hydroxylase Rattus norvegicus 98-101 31367831-2 2019 In this study, we used a rat model that allowed blocking the synthesis of noradrenalin in the brain and evaluated gene expression and protein levels of noradrenaline key synthesis enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in peripheral noradrenaline-producing organs. Norepinephrine 152-165 dopamine beta-hydroxylase Rattus norvegicus 226-251 30510101-3 2019 In the study described here, the noradrenergic system was found to be suppressed with decreased levels of norepinephrine (NE) in brains of infected animals and in infected human and rat neural cells in vitro The mechanism responsible for the NE suppression was found to be downregulation of dopamine beta-hydroxylase (DBH) gene expression, encoding the enzyme that synthesizes norepinephrine from dopamine, with downregulation observed in vitro and in infected brain tissue, particularly in the dorsal locus coeruleus/pons region. Norepinephrine 106-120 dopamine beta-hydroxylase Rattus norvegicus 291-316 30510101-3 2019 In the study described here, the noradrenergic system was found to be suppressed with decreased levels of norepinephrine (NE) in brains of infected animals and in infected human and rat neural cells in vitro The mechanism responsible for the NE suppression was found to be downregulation of dopamine beta-hydroxylase (DBH) gene expression, encoding the enzyme that synthesizes norepinephrine from dopamine, with downregulation observed in vitro and in infected brain tissue, particularly in the dorsal locus coeruleus/pons region. Norepinephrine 106-120 dopamine beta-hydroxylase Rattus norvegicus 318-321 30401628-2 2019 An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline via inhibition of the enzyme dopamine beta-hydroxylase (DbetaH), that catalyzes the hydroxylation of dopamine to noradrenaline in sympathetic nerves. Norepinephrine 105-118 dopamine beta-hydroxylase Rattus norvegicus 148-173 30401628-2 2019 An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline via inhibition of the enzyme dopamine beta-hydroxylase (DbetaH), that catalyzes the hydroxylation of dopamine to noradrenaline in sympathetic nerves. Norepinephrine 105-118 dopamine beta-hydroxylase Rattus norvegicus 175-181 30401628-2 2019 An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline via inhibition of the enzyme dopamine beta-hydroxylase (DbetaH), that catalyzes the hydroxylation of dopamine to noradrenaline in sympathetic nerves. Norepinephrine 232-245 dopamine beta-hydroxylase Rattus norvegicus 148-173 30401628-2 2019 An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline via inhibition of the enzyme dopamine beta-hydroxylase (DbetaH), that catalyzes the hydroxylation of dopamine to noradrenaline in sympathetic nerves. Norepinephrine 232-245 dopamine beta-hydroxylase Rattus norvegicus 175-181 28392265-2 2017 Cocaine-primed reinstatement can also be attenuated by systemic administration of dopamine beta-hydroxylase (DBH) inhibitors, which prevent norepinephrine (NE) synthesis, or by alpha1-adrenergic receptor (alpha1AR) antagonists, indicating functional modulation by the noradrenergic system. Norepinephrine 140-154 dopamine beta-hydroxylase Rattus norvegicus 82-107 28392265-2 2017 Cocaine-primed reinstatement can also be attenuated by systemic administration of dopamine beta-hydroxylase (DBH) inhibitors, which prevent norepinephrine (NE) synthesis, or by alpha1-adrenergic receptor (alpha1AR) antagonists, indicating functional modulation by the noradrenergic system. Norepinephrine 140-154 dopamine beta-hydroxylase Rattus norvegicus 109-112 27959576-6 2016 We found modestly increased adrenal expression of Dbh in transgenic rats versus SHR non-transgenic controls that was associated with reduced adrenal levels of dopamine and increased plasma levels of norepinephrine and epinephrine. Norepinephrine 199-213 dopamine beta-hydroxylase Rattus norvegicus 50-53 28746816-2 2017 Choline acetyltransferase (ChAT), enzyme forming acetylcholine, tyrosine hydroxylase (TH), and dopamine-beta-hydroxylase (DBH), enzymes participating in noradrenaline synthesis, are responsible for the production of classical neurotransmitters, and atrial natriuretic peptide (ANP) is produced by cardiomyocytes. Norepinephrine 153-166 dopamine beta-hydroxylase Rattus norvegicus 122-125 25854989-3 2015 An alternative strategy for the modulation of sympathetic nerve function is to reduce the biosynthesis of noradrenaline (NA) by inhibiting dopamine beta-hydroxylase (DbetaH), the enzyme that catalyzes the conversion of dopamine (DA) to NA in the sympathetic nerves. Norepinephrine 106-119 dopamine beta-hydroxylase Rattus norvegicus 166-172 25581910-8 2015 CPM induced the release of norepinephrine in the spinal cord and was partially blocked by intrathecal idazoxan or dopamine beta-hydroxylase-saporin. Norepinephrine 27-41 dopamine beta-hydroxylase Rattus norvegicus 114-139 25793511-10 2015 Central GLP-1R activation also increased NTS expression of dopamine-beta-hydroxylase, a key enzyme in noradrenaline synthesis, indicating a biological link between these two systems. Norepinephrine 102-115 dopamine beta-hydroxylase Rattus norvegicus 59-84 24817036-2 2014 One of many biochemical actions of disulfiram is inhibition of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons. Norepinephrine 138-152 dopamine beta-hydroxylase Rattus norvegicus 63-88 25131562-8 2014 Triple-labeling immunocytochemistry revealed that alpha2A-AR and CB1R were localised to processes that contained dopamine-beta-hydroxylase, a marker of norepinephrine. Norepinephrine 152-166 dopamine beta-hydroxylase Rattus norvegicus 113-138 24817036-2 2014 One of many biochemical actions of disulfiram is inhibition of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons. Norepinephrine 138-152 dopamine beta-hydroxylase Rattus norvegicus 90-93 22015761-5 2011 Brainstem sections were immunohistochemically processed for dopamine-beta-hydroxylase, a marker for norepinephrine. Norepinephrine 100-114 dopamine beta-hydroxylase Rattus norvegicus 60-85 23389997-7 2013 Furthermore, treatment with desipramine, an antidepressant with specific inhibitory effects on norepinephrine transport, prevented an increased dopamine beta-hydroxylase expression by chronic social defeat in the locus coeruleus and its main terminal regions such as the hippocampus, frontal cortex and amygdala. Norepinephrine 95-109 dopamine beta-hydroxylase Rattus norvegicus 144-169 23389997-9 2013 The present findings indicate that chronic social defeat activates the locus coeruleus-norepinephrine system by upregulating the expression of dopamine beta-hydroxylase, which may increase norepinephrine synthesis. Norepinephrine 87-101 dopamine beta-hydroxylase Rattus norvegicus 143-168 23389997-9 2013 The present findings indicate that chronic social defeat activates the locus coeruleus-norepinephrine system by upregulating the expression of dopamine beta-hydroxylase, which may increase norepinephrine synthesis. Norepinephrine 189-203 dopamine beta-hydroxylase Rattus norvegicus 143-168 24068832-1 2013 Inhibitors of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic cells, have shown promise for the treatment of cocaine abuse disorders. Norepinephrine 89-103 dopamine beta-hydroxylase Rattus norvegicus 14-39 24068832-1 2013 Inhibitors of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic cells, have shown promise for the treatment of cocaine abuse disorders. Norepinephrine 89-103 dopamine beta-hydroxylase Rattus norvegicus 41-44 23675273-1 2012 Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Norepinephrine 105-119 dopamine beta-hydroxylase Rattus norvegicus 0-26 23675273-1 2012 Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Norepinephrine 105-119 dopamine beta-hydroxylase Rattus norvegicus 28-31 20728435-5 2010 A small number of HSD2 immunoreactive neurons was also labeled for dopamine-beta-hydroxylase (DBH), an enzyme involved in norepinephrine biosynthesis. Norepinephrine 122-136 dopamine beta-hydroxylase Rattus norvegicus 94-97 20650329-7 2010 We found that DSP-4 treatment depleted the expression of the norepinephrine marker dopamine -hydroxylase (DBH) in the locus coeruleus and its projection area, the basolateral nucleus of the amygdala, confirming locus coeruleus noradrenergic lesion in the experimental animals. Norepinephrine 61-75 dopamine beta-hydroxylase Rattus norvegicus 106-109 20736996-3 2010 We hypothesized that disulfiram"s inhibition of dopamine beta-hydroxylase (DBH), the catecholamine biosynthetic enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons, underlies the drug"s ability to treat cocaine dependence. Norepinephrine 150-164 dopamine beta-hydroxylase Rattus norvegicus 48-73 20736996-3 2010 We hypothesized that disulfiram"s inhibition of dopamine beta-hydroxylase (DBH), the catecholamine biosynthetic enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons, underlies the drug"s ability to treat cocaine dependence. Norepinephrine 150-164 dopamine beta-hydroxylase Rattus norvegicus 75-78 19079842-1 2009 Cu is an essential cofactor for at least twelve mammalian enzymes including dopamine beta-mono-oxygenase (DBM), which converts dopamine (DA) to noradrenaline (NA). Norepinephrine 144-157 dopamine beta-hydroxylase Rattus norvegicus 76-104 20728435-5 2010 A small number of HSD2 immunoreactive neurons was also labeled for dopamine-beta-hydroxylase (DBH), an enzyme involved in norepinephrine biosynthesis. Norepinephrine 122-136 dopamine beta-hydroxylase Rattus norvegicus 67-92 20554938-3 2010 Expression of c-Fos protein was used as a marker for neuronal activation and dopamine-beta-hydroxylase (DBH), the enzyme-catalyzing noradrenaline synthesis, as a marker for noradrenergic neurons. Norepinephrine 132-145 dopamine beta-hydroxylase Rattus norvegicus 104-107 19482560-1 2009 In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Norepinephrine 45-59 dopamine beta-hydroxylase Rattus norvegicus 108-133 19482560-1 2009 In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Norepinephrine 45-59 dopamine beta-hydroxylase Rattus norvegicus 135-138 19212441-3 2009 Phagocytes isolated from adrenalectomized rats displayed enhanced expression of tyrosine-hydroxylase and dopamine-beta-hydroxylase, two key enzymes for catecholamine production and exhibited higher baseline secretion of norepinephrine and epinephrine. Norepinephrine 220-234 dopamine beta-hydroxylase Rattus norvegicus 105-130 17868372-6 2007 Dopamine beta hydroxylase staining was used to confirm N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine-depleted terminal norepinephrine levels. Norepinephrine 118-132 dopamine beta-hydroxylase Rattus norvegicus 0-25 17074321-8 2007 Decreased expression of DBH with age in the retina could lead to reduced production of norepinephrine, potentially resulting in an increase of beta1-adrenergic receptor expression due to denervation supersensitivity. Norepinephrine 87-101 dopamine beta-hydroxylase Rattus norvegicus 24-27 16451083-1 2006 A novel series of dopamine beta-hydroxylase (DBH) inhibitors was designed and synthesized incorporating modifications to the core structure of nepicastat 3, with the principal aim of discovering potent DBH inhibitors exerting minimal effects on dopamine (DA) and noradrenaline (NA) levels in the central nervous system. Norepinephrine 263-276 dopamine beta-hydroxylase Rattus norvegicus 45-48 16931444-1 2006 Dopamine-beta-hydroxylase (DbetaH), the enzyme that synthesizes noradrenaline from dopamine, was studied in the locus coeruleus (LC) of neonate rats exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through lactation for 14 days (from PND 9 to 22). Norepinephrine 64-77 dopamine beta-hydroxylase Rattus norvegicus 0-25 16931444-1 2006 Dopamine-beta-hydroxylase (DbetaH), the enzyme that synthesizes noradrenaline from dopamine, was studied in the locus coeruleus (LC) of neonate rats exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through lactation for 14 days (from PND 9 to 22). Norepinephrine 64-77 dopamine beta-hydroxylase Rattus norvegicus 27-33 15662096-1 2004 Dopamine beta-hydroxylase (DBH) which catalyzes conversion of dopamine into noradrenaline, may be a good blood marker of unipolar depression. Norepinephrine 76-89 dopamine beta-hydroxylase Rattus norvegicus 0-25 15662096-1 2004 Dopamine beta-hydroxylase (DBH) which catalyzes conversion of dopamine into noradrenaline, may be a good blood marker of unipolar depression. Norepinephrine 76-89 dopamine beta-hydroxylase Rattus norvegicus 27-30 12802890-4 2003 Correlations among dopamine-beta-hydroxylase measures and behavior reinforced these tonic norepinephrine/behavior associations. Norepinephrine 90-104 dopamine beta-hydroxylase Rattus norvegicus 19-44 12383975-3 2002 To this aim, we carried out the present immunohistochemistry study using two antibodies raised against dopamine beta-hydroxylase (DBH), the enzyme responsible for the conversion of dopamine into noradrenaline, and against the dopamine transporter (DAT), as markers for noradrenergic and dopaminergic fibers, respectively. Norepinephrine 195-208 dopamine beta-hydroxylase Rattus norvegicus 103-128 12383975-3 2002 To this aim, we carried out the present immunohistochemistry study using two antibodies raised against dopamine beta-hydroxylase (DBH), the enzyme responsible for the conversion of dopamine into noradrenaline, and against the dopamine transporter (DAT), as markers for noradrenergic and dopaminergic fibers, respectively. Norepinephrine 195-208 dopamine beta-hydroxylase Rattus norvegicus 130-133 17287146-1 2007 Limiting dopamine beta-monooxygenase results in lower norepinephrine (NE) and higher dopamine (DA) concentrations in copper-deficient Cu- tissues compared to copper-adequate Cu+ tissues. Norepinephrine 54-68 dopamine beta-hydroxylase Rattus norvegicus 9-36 15276785-1 2004 Previous work using the retrogradely transported immunotoxin, saporin (SAP) conjugated to a monoclonal antibody against dopamine-beta-hydroxylase (DBH; DSAP), to selectively lesion norepinephrine (NE) and epinephrine (E) neurons projecting to the medial hypothalamus, demonstrated the essential role of these neurons for appetitive ingestive responses to glucoprivation. Norepinephrine 181-195 dopamine beta-hydroxylase Rattus norvegicus 120-145 15276785-1 2004 Previous work using the retrogradely transported immunotoxin, saporin (SAP) conjugated to a monoclonal antibody against dopamine-beta-hydroxylase (DBH; DSAP), to selectively lesion norepinephrine (NE) and epinephrine (E) neurons projecting to the medial hypothalamus, demonstrated the essential role of these neurons for appetitive ingestive responses to glucoprivation. Norepinephrine 181-195 dopamine beta-hydroxylase Rattus norvegicus 147-150