PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Norepinephrine 74-88 monoamine oxidase A Homo sapiens 0-19 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Norepinephrine 74-88 monoamine oxidase A Homo sapiens 21-25 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Norepinephrine 118-132 monoamine oxidase A Homo sapiens 0-19 18227761-1 2008 BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. Norepinephrine 123-137 monoamine oxidase A Homo sapiens 16-35 18227761-1 2008 BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. Norepinephrine 123-137 monoamine oxidase A Homo sapiens 37-41 17417058-1 2007 OBJECTIVE: Monoamine oxidase A is a mitochondrial enzyme involved in the degradation of certain neurotransmitter amines: serotonin and norepinephrine. Norepinephrine 135-149 monoamine oxidase A Homo sapiens 11-30 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Norepinephrine 117-131 monoamine oxidase A Homo sapiens 4-23 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Norepinephrine 117-131 monoamine oxidase A Homo sapiens 25-29 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Norepinephrine 117-131 monoamine oxidase A Homo sapiens 195-199 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. Norepinephrine 89-103 monoamine oxidase A Homo sapiens 0-19 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. Norepinephrine 89-103 monoamine oxidase A Homo sapiens 21-26 17884271-5 2008 The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression. Norepinephrine 116-130 monoamine oxidase A Homo sapiens 47-52 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Norepinephrine 113-127 monoamine oxidase A Homo sapiens 0-19 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Norepinephrine 113-127 monoamine oxidase A Homo sapiens 21-26 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Norepinephrine 118-132 monoamine oxidase A Homo sapiens 21-25 16202396-2 2006 The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. Norepinephrine 95-108 monoamine oxidase A Homo sapiens 4-23 16728402-1 2006 Monoamine oxidase (MAO) A is a key enzyme for the degradation of neurotransmitters serotonin, norepinephrine, and dopamine. Norepinephrine 94-108 monoamine oxidase A Homo sapiens 0-25 16829576-1 2006 Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. Norepinephrine 48-62 monoamine oxidase A Homo sapiens 0-19 16829576-1 2006 Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. Norepinephrine 48-62 monoamine oxidase A Homo sapiens 21-26 16725119-2 2006 Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT). Norepinephrine 0-14 monoamine oxidase A Homo sapiens 30-49 16725119-2 2006 Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT). Norepinephrine 0-14 monoamine oxidase A Homo sapiens 51-55 16770335-2 2006 Monoamine oxidase A deaminates the monoamine neurotransmitters serotonin, dopamine (DA), and noradrenaline. Norepinephrine 93-106 monoamine oxidase A Homo sapiens 0-19 16202396-2 2006 The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. Norepinephrine 95-108 monoamine oxidase A Homo sapiens 25-30 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. Norepinephrine 132-145 monoamine oxidase A Homo sapiens 0-19 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. Norepinephrine 162-175 monoamine oxidase A Homo sapiens 0-26 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. Norepinephrine 162-175 monoamine oxidase A Homo sapiens 28-43 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. Norepinephrine 132-145 monoamine oxidase A Homo sapiens 21-26 15539858-2 2004 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine. Norepinephrine 108-122 monoamine oxidase A Homo sapiens 0-19 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Norepinephrine 102-116 monoamine oxidase A Homo sapiens 0-19 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Norepinephrine 102-116 monoamine oxidase A Homo sapiens 21-25 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Norepinephrine 215-228 monoamine oxidase A Homo sapiens 0-19 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Norepinephrine 215-228 monoamine oxidase A Homo sapiens 21-25 14697876-10 2004 MAO-A oxidizes noradrenaline and serotonin; and MAO-B, mainly beta-phenylethylamine. Norepinephrine 15-28 monoamine oxidase A Homo sapiens 0-5 14697899-5 2004 The cheese reaction is a consequence of inhibition of MAO-A, the enzyme responsible for metabolism of noradrenaline and serotonin, located in peripheral adrenergic neurons. Norepinephrine 102-115 monoamine oxidase A Homo sapiens 54-59 14508509-3 2003 Since monoamine oxidase A metabolises noradrenalin, a positive association with the MAOA gene would be biologically plausible. Norepinephrine 38-50 monoamine oxidase A Homo sapiens 6-25 14508509-3 2003 Since monoamine oxidase A metabolises noradrenalin, a positive association with the MAOA gene would be biologically plausible. Norepinephrine 38-50 monoamine oxidase A Homo sapiens 84-88 15936529-2 2005 Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT). Norepinephrine 0-13 monoamine oxidase A Homo sapiens 37-56 15936529-2 2005 Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT). Norepinephrine 0-13 monoamine oxidase A Homo sapiens 58-62 15671203-4 2005 MAO-A activity was estimated by measuring concentrations of 3,4-dihydroxyphenylglycol (DHPG), a stable metabolite of norepinephrine. Norepinephrine 117-131 monoamine oxidase A Homo sapiens 0-5 15990460-1 2005 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. Norepinephrine 108-122 monoamine oxidase A Homo sapiens 0-19 15990460-1 2005 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. Norepinephrine 108-122 monoamine oxidase A Homo sapiens 21-25 15539858-2 2004 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine. Norepinephrine 108-122 monoamine oxidase A Homo sapiens 21-25 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Norepinephrine 111-125 monoamine oxidase A Homo sapiens 0-19 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Norepinephrine 111-125 monoamine oxidase A Homo sapiens 21-26 9730267-0 1998 The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries. Norepinephrine 60-73 monoamine oxidase A Homo sapiens 12-17 9878889-0 1999 Accumulation of 3,4-dihydroxyphenylglycolaldehyde, the neurotoxic monoamine oxidase A metabolite of norepinephrine, in locus ceruleus cell bodies in Alzheimer"s disease: mechanism of neuron death. Norepinephrine 100-114 monoamine oxidase A Homo sapiens 66-85 9878889-1 1999 3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE). Norepinephrine 104-118 monoamine oxidase A Homo sapiens 62-81 9878889-1 1999 3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE). Norepinephrine 104-118 monoamine oxidase A Homo sapiens 83-88 11081224-2 2000 Results of the biochemical analysis of the MAO A activity with serotonin or noradrenaline as substrates revealed a seasonal dependence of the substrate specific changes of this enzyme activity in hibernating animals. Norepinephrine 76-89 monoamine oxidase A Homo sapiens 43-48 23531135-6 2000 Inhibitors of MAO A are clinically useful to treat anxiety and depression since they are expected to increase both noradrenalin and serotonin levels in the brain. Norepinephrine 115-127 monoamine oxidase A Homo sapiens 14-19 10647887-7 1999 The uVNTR genotype may be a common genetic determinant of significant individual differences in oxidizing capacity for critical MAO-A substrates, which include serotonin, norepinephrine, and tyramine. Norepinephrine 171-185 monoamine oxidase A Homo sapiens 128-133 10050962-5 1999 When available, plasma samples were evaluated first for levels of 3-methoxy, 4-hydroxyphenolglycol (MHPG), a metabolite of norepinephrine which serves as the most sensitive index of MAO-A activity in humans. Norepinephrine 123-137 monoamine oxidase A Homo sapiens 182-187 9730267-12 1998 In conclusion, three major differences distinguish the metabolism of noradrenaline by human arteries from that observed in other species: (1) the large predominance of deamination over O-methylation; (2) the extremely high formation of DOMA; and (3) the relative lack of selectivity of clorgyline and selegiline for MAO-A and B, respectively. Norepinephrine 69-82 monoamine oxidase A Homo sapiens 316-327 7792602-1 1995 Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. Norepinephrine 80-94 monoamine oxidase A Homo sapiens 14-33 9452885-3 1997 Cell extracts from epidermal suction blister roofs revealed only half the normal activity of phenylethanolamine-N-methyl transferase (PNMT) together with a threefold induction of the norepinephrine-degrading enzyme monoamine oxidase A (MAO-A). Norepinephrine 183-197 monoamine oxidase A Homo sapiens 215-234 8695909-1 1996 Bacterial cells respond to monoamine compounds, such as tyramine, dopamine, octopamine, or norepinephrine, and induce the syntheses of tyramine oxidase encoded by tynA and monoamine oxidase encoded by maoA. Norepinephrine 91-105 monoamine oxidase A Homo sapiens 201-205 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Norepinephrine 19-33 monoamine oxidase A Homo sapiens 244-263 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Norepinephrine 19-33 monoamine oxidase A Homo sapiens 265-270 8678123-1 1996 The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Norepinephrine 145-159 monoamine oxidase A Homo sapiens 24-29 7792602-1 1995 Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. Norepinephrine 80-94 monoamine oxidase A Homo sapiens 35-39 1609114-5 1992 In the central nervous system of man MAO-A seems to be mainly involved in the metabolism of 5 HT and noradrenaline, whereas 2-phenylethylamine and probably dopamine are predominantly deaminated by MAO-B. Norepinephrine 101-114 monoamine oxidase A Homo sapiens 37-42 8584674-1 1995 Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Norepinephrine 48-62 monoamine oxidase A Homo sapiens 0-25 7519662-1 1994 Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Norepinephrine 48-62 monoamine oxidase A Homo sapiens 0-25 8443037-8 1993 Thus, neurotransmitters in the central nervous system which are substrate for MAO-A (i.e. noradrenaline, 5-HT) may be involved in the control of capsaicin-induced reflex bronchoconstriction. Norepinephrine 90-103 monoamine oxidase A Homo sapiens 78-83 2250565-3 1990 MAO-A inhibition, as evidenced by up to 80% decreases in the plasma concentration of 3,4-dihydroxyphenylglycol, a deaminated metabolite of norepinephrine, was similar after both pretreatments. Norepinephrine 139-153 monoamine oxidase A Homo sapiens 0-5 34923109-2 2022 Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites. Norepinephrine 79-93 monoamine oxidase A Homo sapiens 13-32 34923109-2 2022 Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites. Norepinephrine 79-93 monoamine oxidase A Homo sapiens 34-38 34503991-10 2021 Significance Statement Endogenous catecholamines are metabolized by monoamine oxidase (MAO)-A and -B, yielding the catecholaldehydes 3,4-dihydroxyphenylacetaldehyde (DOPAL) from dopamine (DA) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) from norepinephrine (NE) and epinephrine (EPI). Norepinephrine 245-259 monoamine oxidase A Homo sapiens 68-100 30852703-4 2019 Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD. Norepinephrine 96-110 monoamine oxidase A Homo sapiens 24-43 2817346-1 1989 The monoamine oxidase A metabolite of noradrenaline, 3,4-dihydroxyphenylglycolaldehyde, is the precursor of 3,4-dihydroxymandelic acid, and 3,4-dihydroxyphenylglycol, metabolites of noradrenaline. Norepinephrine 38-51 monoamine oxidase A Homo sapiens 4-23 2817346-1 1989 The monoamine oxidase A metabolite of noradrenaline, 3,4-dihydroxyphenylglycolaldehyde, is the precursor of 3,4-dihydroxymandelic acid, and 3,4-dihydroxyphenylglycol, metabolites of noradrenaline. Norepinephrine 182-195 monoamine oxidase A Homo sapiens 4-23 3480939-2 1987 However, availability of other selective MAO-B inhibitors have clearly shown that this is not the case, since the "cheese effect" is associated with the selective inhibition of MAO-A, the enzyme responsible for intraneuronal oxidation of noradrenaline. Norepinephrine 238-251 monoamine oxidase A Homo sapiens 177-182 3480939-3 1987 Following inhibition of neuronal MAO-A, noradrenaline in the cytoplasmic intraneuronal pool can increase to high levels. Norepinephrine 40-53 monoamine oxidase A Homo sapiens 33-38 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Norepinephrine 22-36 monoamine oxidase A Homo sapiens 71-76 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Norepinephrine 22-36 monoamine oxidase A Homo sapiens 254-259 7159481-0 1982 Monoamine oxidase type A: differences in selectivity towards l-norepinephrine compared to serotonin. Norepinephrine 61-77 monoamine oxidase A Homo sapiens 0-24 7159481-3 1982 Serotonin was a more selective substrate for MAO-A, being inhibited by low concentrations (less than 10(-7) M) of the irreversible MAO-A inhibitor, clorgyline, more consistently and to a greater extent (80-100%) than was l-norepinephrine (30-85%). Norepinephrine 221-237 monoamine oxidase A Homo sapiens 45-50 7159481-7 1982 Thus, l-norepinephrine, like dopamine, should be regarded as a substrate for both MAO-A and MAO-B in vitro. Norepinephrine 6-22 monoamine oxidase A Homo sapiens 82-87 7327272-1 1981 One--day cold exposure decreases the monoamine oxidase type A activity by 52--54% (serotonin and noradrenaline substrates); the monoamine oxidase type B activity by 14%. Norepinephrine 97-110 monoamine oxidase A Homo sapiens 37-61 33855088-4 2021 Results: The norepinephrine levels were markedly high in gastric cancer tissue, while the norepinephrine-degrading enzymes MAOA and MAOB showed low expression. Norepinephrine 90-104 monoamine oxidase A Homo sapiens 123-127 33855088-8 2021 The norepinephrine-degrading enzymes MAOA and MAOB have significant expression differences in cancer and normal tissue, and their missing or low expression may predict immune therapy outcomes for gastric cancer patients. Norepinephrine 4-18 monoamine oxidase A Homo sapiens 37-41 32942081-1 2020 Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines. Norepinephrine 139-153 monoamine oxidase A Homo sapiens 20-25 31793911-3 2020 Here, we show that 3,4-dihydroxyphenylglycolaldehyde, which is produced exclusively in noradrenergic neurons by monoamine oxidase A metabolism of norepinephrine, activated asparagine endopeptidase that cleaved Tau at residue N368 into aggregation- and propagation-prone forms, thus leading to LC degeneration and the spread of Tau pathology. Norepinephrine 146-160 monoamine oxidase A Homo sapiens 112-131 32342809-3 2020 MAO-A is a flavoenzyme, which binds to the outer mitochondrial membrane and catalyzes the oxidative transformations of neurotransmitters like serotonin, norepinephrine, and dopamine. Norepinephrine 153-167 monoamine oxidase A Homo sapiens 0-5 30456877-1 2019 The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. Norepinephrine 110-124 monoamine oxidase A Homo sapiens 4-23 30456877-1 2019 The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. Norepinephrine 110-124 monoamine oxidase A Homo sapiens 25-29 30852703-4 2019 Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD. Norepinephrine 96-110 monoamine oxidase A Homo sapiens 45-50 29186431-2 2018 Monoamine oxidase A is one of the key enzymes mediating the turnover of noradrenaline. Norepinephrine 72-85 monoamine oxidase A Homo sapiens 0-19 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. Norepinephrine 118-131 monoamine oxidase A Homo sapiens 0-19 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. Norepinephrine 118-131 monoamine oxidase A Homo sapiens 21-26 30043181-2 2018 After the demonstrations that both cardiac neuronal and extraneuronal MAO-A contribute to the degradation of norepinephrine and serotonin, several studies attempted to determine the impact of MAO-A activity in the control of local concentration of the two biogenic amines and in their receptor-mediated effects. Norepinephrine 109-123 monoamine oxidase A Homo sapiens 70-75 30003648-4 2018 The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin. Norepinephrine 178-192 monoamine oxidase A Homo sapiens 25-44 30003648-4 2018 The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin. Norepinephrine 178-192 monoamine oxidase A Homo sapiens 46-51 29478144-7 2018 The MAOA gene encodes an enzyme which is involved in the catabolism of dopamine, norepinephrine, serotonin, and other monoaminergic neurotransmitters. Norepinephrine 81-95 monoamine oxidase A Homo sapiens 4-8 28293733-1 2018 Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. Norepinephrine 79-93 monoamine oxidase A Homo sapiens 7-24 28293733-1 2018 Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. Norepinephrine 79-93 monoamine oxidase A Homo sapiens 26-30 28294055-6 2017 Selective inhibition of MAO-A results in the elevated level of serotonin and noradrenaline. Norepinephrine 77-90 monoamine oxidase A Homo sapiens 24-29 27734680-0 2016 Empirical Valence Bond Simulations of the Hydride-Transfer Step in the Monoamine Oxidase A Catalyzed Metabolism of Noradrenaline. Norepinephrine 115-128 monoamine oxidase A Homo sapiens 71-90 27734680-1 2016 Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines, such as dopamine, serotonin, and noradrenaline (NA), which is why they have been extensively implicated in the etiology and course of various neurodegenerative disorders and, accordingly, used as primary pharmacological targets to treat these debilitating cognitive diseases. Norepinephrine 135-148 monoamine oxidase A Homo sapiens 0-33 27734680-3 2016 In this work, we present atomistic empirical valence bond simulations of the rate-limiting step of the MAO-A-catalyzed NA (norepinephrine) degradation, involving hydride transfer from the substrate alpha-methylene group to the flavin moiety of the flavin adenine dinucleotide prosthetic group, employing the full dimensionality and thermal fluctuations of the hydrated enzyme, with extensive configurational sampling. Norepinephrine 123-137 monoamine oxidase A Homo sapiens 103-108 24809685-10 2015 However, the presently observed trend towards CpG-specific MAO-A gene hypomethylation-possibly via increased gene expression and consecutively decreased serotonin and/or norepinephrine availability-to potentially drive impaired antidepressant treatment response in female patients might be worthwhile to be followed up in larger pharmacoepigenetic studies. Norepinephrine 170-184 monoamine oxidase A Homo sapiens 59-64 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Norepinephrine 127-141 monoamine oxidase A Homo sapiens 0-19 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Norepinephrine 127-141 monoamine oxidase A Homo sapiens 21-25 26776902-2 2016 In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. Norepinephrine 220-234 monoamine oxidase A Homo sapiens 130-149 26776902-2 2016 In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. Norepinephrine 220-234 monoamine oxidase A Homo sapiens 151-155 21761555-1 2011 Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Norepinephrine 126-140 monoamine oxidase A Homo sapiens 0-19 25220264-1 2014 Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines such as dopamine, serotonin and noradrenaline. Norepinephrine 133-146 monoamine oxidase A Homo sapiens 0-33 24607627-7 2014 We then demonstrated that MAOA suppressed norepinephrine/epinephrine (NE/E)-induced HCC invasion and anoikis inhibition, and uncovered that the effects of NE/E on HCC behaviors were primarily mediated through alpha 1A (ADRA1A) and beta 2 adrenergic receptors (ADRB2). Norepinephrine 42-56 monoamine oxidase A Homo sapiens 26-30 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Norepinephrine 128-142 monoamine oxidase A Homo sapiens 21-25 23858446-2 2013 The combined deficiency of MAO A and B results in significantly elevated levels of serotonin (5-hydroxytryptamine), norepinephrine, dopamine, and beta-phenylethylamine; in humans and mice, these neurochemical changes are accompanied by neurodevelopmental perturbations as well as autistic-like responses. Norepinephrine 116-130 monoamine oxidase A Homo sapiens 27-38 26593027-1 2012 Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Norepinephrine 197-211 monoamine oxidase A Homo sapiens 61-66 20641293-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Norepinephrine 44-57 monoamine oxidase A Homo sapiens 0-5 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Norepinephrine 128-142 monoamine oxidase A Homo sapiens 0-19 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Norepinephrine 156-170 monoamine oxidase A Homo sapiens 5-24 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Norepinephrine 156-170 monoamine oxidase A Homo sapiens 26-31 21761555-1 2011 Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Norepinephrine 126-140 monoamine oxidase A Homo sapiens 21-25 20642018-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Norepinephrine 44-57 monoamine oxidase A Homo sapiens 0-5 20204405-1 2010 PURPOSE: Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression. Norepinephrine 130-144 monoamine oxidase A Homo sapiens 23-42 20204405-1 2010 PURPOSE: Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression. Norepinephrine 130-144 monoamine oxidase A Homo sapiens 44-48 20485326-1 2010 Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin. Norepinephrine 118-132 monoamine oxidase A Homo sapiens 20-25 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. Norepinephrine 109-123 monoamine oxidase A Homo sapiens 12-31 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. Norepinephrine 109-123 monoamine oxidase A Homo sapiens 33-37 21302344-2 2011 Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. Norepinephrine 183-196 monoamine oxidase A Homo sapiens 64-68 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Norepinephrine 290-304 monoamine oxidase A Homo sapiens 157-176 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Norepinephrine 290-304 monoamine oxidase A Homo sapiens 178-183 19615672-5 2009 Plasma MAOA dependent metabolites of norepinephrine: dihydroxyphenylglycol; dopamine: homovanillic and dihydroxyphenylacetic acid; and serotonin: 5-hydroxy-indol acetic acid were measured at the end of the second trimester, at delivery, and in arterial cord blood along with plasma cotinine. Norepinephrine 37-51 monoamine oxidase A Homo sapiens 7-11 19941049-2 2010 COMT and MAOA each contribute to the enzymatic degradation of dopamine and noradrenaline. Norepinephrine 75-88 monoamine oxidase A Homo sapiens 9-13 19890267-1 2010 Reversible inhibitors of monoamine oxidase-A (RIMA) inhibit the breakdown of three major neurotransmitters, serotonin, norepinephrine and dopamine, offering a multi-neurotransmitter strategy for the treatment of depression. Norepinephrine 119-133 monoamine oxidase A Homo sapiens 25-44 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. Norepinephrine 74-88 monoamine oxidase A Homo sapiens 0-19 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. Norepinephrine 74-88 monoamine oxidase A Homo sapiens 21-25 19223155-7 2009 According to our results, the higher serotonergic symptom score and cord blood DHPG concentration in rapid MAO-A metabolizers suggest that norepinephrine may modify the severity of perinatal serotonergic symptoms. Norepinephrine 139-153 monoamine oxidase A Homo sapiens 107-112 19506905-5 2009 Indeed, a series of recent studies, particularly concentrating on the serotonin and norepinephrine metabolising enzyme, monoamine oxidase A, has emphasised the necessity of examining gene by environmental interactions if the contributions of individual loci are to be understood. Norepinephrine 84-98 monoamine oxidase A Homo sapiens 120-139 19194374-10 2009 Monoamines such as noradrenalin and serotonin may modulate these relationships, given that their metabolism varies according to MAOA variants, and that they modulate both emotional brain systems and antisocial aggression. Norepinephrine 19-31 monoamine oxidase A Homo sapiens 128-132 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Norepinephrine 199-213 monoamine oxidase A Homo sapiens 0-19 18361446-1 2008 Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin. Norepinephrine 90-104 monoamine oxidase A Homo sapiens 0-19 18361446-1 2008 Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin. Norepinephrine 90-104 monoamine oxidase A Homo sapiens 21-25 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Norepinephrine 199-213 monoamine oxidase A Homo sapiens 21-25 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Norepinephrine 199-213 monoamine oxidase A Homo sapiens 124-128 20641420-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Norepinephrine 44-57 monoamine oxidase A Homo sapiens 0-5 18463263-1 2008 The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Norepinephrine 112-126 monoamine oxidase A Homo sapiens 24-43 18463263-1 2008 The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Norepinephrine 112-126 monoamine oxidase A Homo sapiens 45-50