PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20510373-1 2010 The functional Val158Met polymorphism in the gene coding for the catechol-O-methyltransferase (COMT), the major enzyme degrading the catecholaminergic neurotransmitters dopamine, norepinephrine, and epinephrine, has been associated with differential reactivity in limbic and prefrontal brain areas in response to aversive stimuli. Norepinephrine 179-193 catechol-O-methyltransferase Homo sapiens 65-93 21154325-1 2010 The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Norepinephrine 194-208 catechol-O-methyltransferase Homo sapiens 11-39 21154325-1 2010 The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Norepinephrine 194-208 catechol-O-methyltransferase Homo sapiens 41-45 20139013-3 2010 Here, we examined the impact of the catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism, involved in dopamine and norepinephrine catabolism, on both emotional brain function and self-reported negativity bias. Norepinephrine 127-141 catechol-O-methyltransferase Homo sapiens 36-64 20139013-3 2010 Here, we examined the impact of the catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism, involved in dopamine and norepinephrine catabolism, on both emotional brain function and self-reported negativity bias. Norepinephrine 127-141 catechol-O-methyltransferase Homo sapiens 66-70 20510373-1 2010 The functional Val158Met polymorphism in the gene coding for the catechol-O-methyltransferase (COMT), the major enzyme degrading the catecholaminergic neurotransmitters dopamine, norepinephrine, and epinephrine, has been associated with differential reactivity in limbic and prefrontal brain areas in response to aversive stimuli. Norepinephrine 179-193 catechol-O-methyltransferase Homo sapiens 95-99 19520435-1 2010 Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity. Norepinephrine 48-62 catechol-O-methyltransferase Homo sapiens 0-28 22371762-1 2010 Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E). Norepinephrine 224-238 catechol-O-methyltransferase Homo sapiens 112-140 22371762-1 2010 Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E). Norepinephrine 224-238 catechol-O-methyltransferase Homo sapiens 142-146 19941049-2 2010 COMT and MAOA each contribute to the enzymatic degradation of dopamine and noradrenaline. Norepinephrine 75-88 catechol-O-methyltransferase Homo sapiens 0-4 19520435-1 2010 Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity. Norepinephrine 48-62 catechol-O-methyltransferase Homo sapiens 30-34 19520435-1 2010 Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity. Norepinephrine 48-62 catechol-O-methyltransferase Homo sapiens 128-132 19690620-1 2009 BACKGROUND: Candidate genes of psychological importance include 5HT2A, 5HT2C, and COMT, implicated in the serotonin, noradrenaline and dopamine pathways, which also may be involved in regulation of energy balance. Norepinephrine 117-130 catechol-O-methyltransferase Homo sapiens 82-86 18023073-2 2008 The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol-O-methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor. Norepinephrine 235-248 catechol-O-methyltransferase Homo sapiens 131-135 19374521-1 2009 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates biologically-active catechols, including the important neurotransmitters dopamine, noradrenaline and adrenaline. Norepinephrine 149-162 catechol-O-methyltransferase Homo sapiens 0-28 19374521-1 2009 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates biologically-active catechols, including the important neurotransmitters dopamine, noradrenaline and adrenaline. Norepinephrine 149-162 catechol-O-methyltransferase Homo sapiens 30-34 19547755-2 2009 The functional polymorphism (val(158)met) of the Catechol-O-methyltransferase (COMT) gene regulates the metabolism of dopamine/noradrenaline. Norepinephrine 127-140 catechol-O-methyltransferase Homo sapiens 49-77 19547755-2 2009 The functional polymorphism (val(158)met) of the Catechol-O-methyltransferase (COMT) gene regulates the metabolism of dopamine/noradrenaline. Norepinephrine 127-140 catechol-O-methyltransferase Homo sapiens 79-83 17547583-4 2007 The catechol-O-methyl transferase (COMT) gene is located on chromosome 22q11 and is involved in the metabolism of dopamine and norepinephrine. Norepinephrine 127-141 catechol-O-methyltransferase Homo sapiens 4-33 19300629-1 2007 A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. Norepinephrine 180-194 catechol-O-methyltransferase Homo sapiens 49-76 19300629-1 2007 A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. Norepinephrine 180-194 catechol-O-methyltransferase Homo sapiens 78-82 17547583-4 2007 The catechol-O-methyl transferase (COMT) gene is located on chromosome 22q11 and is involved in the metabolism of dopamine and norepinephrine. Norepinephrine 127-141 catechol-O-methyltransferase Homo sapiens 35-39 17526059-4 2007 COMT enzyme inactivates dopamine and noradrenaline. Norepinephrine 37-50 catechol-O-methyltransferase Homo sapiens 0-4 17405690-9 2007 Mercury, cadmium, and other heavy metals inactivate COMT, which increases serum and urinary epinephrine, norepinephrine, and dopamine. Norepinephrine 105-119 catechol-O-methyltransferase Homo sapiens 52-56 16897602-1 2007 Catechol-O-methyltransferase (COMT) gene is one of the candidate genes for schizophrenia because it codes an enzyme that participates in the metabolic inactivation of dopamine and noradrenaline and a limiting factor of dopamine metabolism in the prefrontal cortex. Norepinephrine 180-193 catechol-O-methyltransferase Homo sapiens 0-28 16897602-1 2007 Catechol-O-methyltransferase (COMT) gene is one of the candidate genes for schizophrenia because it codes an enzyme that participates in the metabolic inactivation of dopamine and noradrenaline and a limiting factor of dopamine metabolism in the prefrontal cortex. Norepinephrine 180-193 catechol-O-methyltransferase Homo sapiens 30-34 17201629-5 2006 Knowledge about thermogenesis-induced weight loss produced by green tea"s epigallocatechin gallate and its ability to inhibit catechol-O-methyltransferase is important for health benefits and for prolonging the action of norepinephrine in the synaptic cleft. Norepinephrine 221-235 catechol-O-methyltransferase Homo sapiens 126-154 16725119-2 2006 Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT). Norepinephrine 0-14 catechol-O-methyltransferase Homo sapiens 61-90 16725119-2 2006 Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT). Norepinephrine 0-14 catechol-O-methyltransferase Homo sapiens 92-96 16648777-1 2006 OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. Norepinephrine 120-133 catechol-O-methyltransferase Homo sapiens 16-44 16648777-1 2006 OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. Norepinephrine 120-133 catechol-O-methyltransferase Homo sapiens 46-50 16233957-1 2006 Based on their metabolic inactivation of dopamine and norepinephrine, genes encoding the catechol-O-methyltransferase (COMT) enzyme are appropriate candidates to consider in the pathogenesis of schizophrenia. Norepinephrine 54-68 catechol-O-methyltransferase Homo sapiens 89-117 16233957-1 2006 Based on their metabolic inactivation of dopamine and norepinephrine, genes encoding the catechol-O-methyltransferase (COMT) enzyme are appropriate candidates to consider in the pathogenesis of schizophrenia. Norepinephrine 54-68 catechol-O-methyltransferase Homo sapiens 119-123 16564429-5 2006 Noradrenaline, a neurotransmitter believed to play an immunosupressive role in neuroinflammatory disorders, is catabolized by catechol-O-methyl transferase (COMT). Norepinephrine 0-13 catechol-O-methyltransferase Homo sapiens 126-155 16564429-5 2006 Noradrenaline, a neurotransmitter believed to play an immunosupressive role in neuroinflammatory disorders, is catabolized by catechol-O-methyl transferase (COMT). Norepinephrine 0-13 catechol-O-methyltransferase Homo sapiens 157-161 17201629-4 2006 That catechin-polyphenols are known to be capable of inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine) is a possible explanation for why the green tea extract is effective in stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis. Norepinephrine 119-133 catechol-O-methyltransferase Homo sapiens 64-92 14520117-2 2003 Catechol-O-methyltransferase and monoamine oxidase enzymes are important agents in the metabolic inactivation of these neurotransmitters (ie, dopamine, serotonin, and norepinephrine). Norepinephrine 167-181 catechol-O-methyltransferase Homo sapiens 0-28 16878403-1 2006 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 0-28 16878403-1 2006 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 30-34 15900225-1 2005 OBJECTIVES: Catechol-O-methyltransferase plays a central role in the metabolism of biogenic amines such as norepinephrine, dopamine and serotonin. Norepinephrine 107-121 catechol-O-methyltransferase Homo sapiens 12-40 15124004-1 2004 The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Norepinephrine 172-186 catechol-O-methyltransferase Homo sapiens 11-39 15124004-1 2004 The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Norepinephrine 172-186 catechol-O-methyltransferase Homo sapiens 41-45 15936529-2 2005 Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT). Norepinephrine 0-13 catechol-O-methyltransferase Homo sapiens 68-97 15936529-2 2005 Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT). Norepinephrine 0-13 catechol-O-methyltransferase Homo sapiens 99-103 15927391-1 2005 Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system. Norepinephrine 74-88 catechol-O-methyltransferase Homo sapiens 0-28 15927391-1 2005 Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system. Norepinephrine 74-88 catechol-O-methyltransferase Homo sapiens 30-34 15941038-0 2005 Improved assay for catechol-O-methyltransferase activity utilizing norepinephrine as an enzymatic substrate and reversed-phase high-performance liquid chromatography with fluorescence detection. Norepinephrine 67-81 catechol-O-methyltransferase Homo sapiens 19-47 15941038-1 2005 We have previously established a rapid catechol-O-methyltransferase (COMT) assay using norepinephrine (NE) as a natural substrate and flow-injection analysis. Norepinephrine 87-101 catechol-O-methyltransferase Homo sapiens 39-67 15941038-1 2005 We have previously established a rapid catechol-O-methyltransferase (COMT) assay using norepinephrine (NE) as a natural substrate and flow-injection analysis. Norepinephrine 87-101 catechol-O-methyltransferase Homo sapiens 69-73 15673663-1 2005 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 0-28 15673663-1 2005 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 30-34 15520843-1 2005 The catechol-O-methyltransferase (COMT) is a major degrading enzyme in the metabolic pathways of catecholaminergic neurotransmitters such as dopamine and norepinephrine. Norepinephrine 154-168 catechol-O-methyltransferase Homo sapiens 4-32 15520843-1 2005 The catechol-O-methyltransferase (COMT) is a major degrading enzyme in the metabolic pathways of catecholaminergic neurotransmitters such as dopamine and norepinephrine. Norepinephrine 154-168 catechol-O-methyltransferase Homo sapiens 34-38 12564841-0 2002 Assay of catechol-O-methyltransferase activity in human erythrocytes using norepinephrine as a natural substrate. Norepinephrine 75-89 catechol-O-methyltransferase Homo sapiens 9-37 12729939-1 2003 Angiotensin-converting enzyme (ACE) modulates dopamine turnover in the brain and catechol-O-methyltransferase (COMT) enzyme is an important agent in the metabolic inactivation of dopamine and norepinephrine. Norepinephrine 192-206 catechol-O-methyltransferase Homo sapiens 81-109 12729939-1 2003 Angiotensin-converting enzyme (ACE) modulates dopamine turnover in the brain and catechol-O-methyltransferase (COMT) enzyme is an important agent in the metabolic inactivation of dopamine and norepinephrine. Norepinephrine 192-206 catechol-O-methyltransferase Homo sapiens 111-115 10898900-2 2000 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility. Norepinephrine 143-156 catechol-O-methyltransferase Homo sapiens 11-39 12135946-1 2002 BACKGROUND: Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown. Norepinephrine 99-113 catechol-O-methyltransferase Homo sapiens 20-48 12135946-1 2002 BACKGROUND: Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown. Norepinephrine 99-113 catechol-O-methyltransferase Homo sapiens 50-54 11244495-1 2001 Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. Norepinephrine 138-151 catechol-O-methyltransferase Homo sapiens 0-28 11244495-1 2001 Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. Norepinephrine 138-151 catechol-O-methyltransferase Homo sapiens 30-34 11882582-8 2002 The abrogating effects of quercetin and OR486 on the metabolism and antimitogenic effects of 2-hydroxyestradiol were mimicked by 20 micromol/L norepinephrine and isoproterenol, substrates for COMT. Norepinephrine 143-157 catechol-O-methyltransferase Homo sapiens 192-196 11735324-4 2001 In the human brain model dopamine and noradrenaline were metabolized primarily by MB-COMT. Norepinephrine 38-51 catechol-O-methyltransferase Homo sapiens 85-89 11735324-6 2001 It is suggested that MB-COMT clearly predominates the O-methylation of dopamine and noradrenaline also in vivo. Norepinephrine 84-97 catechol-O-methyltransferase Homo sapiens 24-28 10898900-2 2000 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility. Norepinephrine 143-156 catechol-O-methyltransferase Homo sapiens 41-45 10490706-7 1999 It should be noted that the association between the high-enzyme activity COMT val allele that increases CNS dopamine (and norepinephrine) clearance is consistent with the use of methylphenidate, an agent that increases dopamine (and norepinephrine) turnover, in the treatment of this disorder. Norepinephrine 122-136 catechol-O-methyltransferase Homo sapiens 73-77 10581494-4 1999 The Catechol-O-Methyltransferase (COMT) gene is an interesting candidate for ADHD as it is involved in the breakdown of dopamine and norepinephrine, neurotransmitters strongly implicated in the etiology of ADHD. Norepinephrine 133-147 catechol-O-methyltransferase Homo sapiens 4-32 10581494-4 1999 The Catechol-O-Methyltransferase (COMT) gene is an interesting candidate for ADHD as it is involved in the breakdown of dopamine and norepinephrine, neurotransmitters strongly implicated in the etiology of ADHD. Norepinephrine 133-147 catechol-O-methyltransferase Homo sapiens 34-38 10490706-7 1999 It should be noted that the association between the high-enzyme activity COMT val allele that increases CNS dopamine (and norepinephrine) clearance is consistent with the use of methylphenidate, an agent that increases dopamine (and norepinephrine) turnover, in the treatment of this disorder. Norepinephrine 233-247 catechol-O-methyltransferase Homo sapiens 73-77 9121699-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Norepinephrine 101-114 catechol-O-methyltransferase Homo sapiens 0-28 9702745-10 1998 Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine. Norepinephrine 133-147 catechol-O-methyltransferase Homo sapiens 17-21 9702745-10 1998 Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine. Norepinephrine 133-147 catechol-O-methyltransferase Homo sapiens 113-117 9352569-1 1997 Catechol-O-methyltransferase catalyses the O-methylation of biologically active or toxic catechols and is a major component of the metabolism of drugs and neurotransmitters such as L-dopa, noradrenaline, adrenaline, and dopamine. Norepinephrine 189-202 catechol-O-methyltransferase Homo sapiens 0-28 9861640-1 1998 Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. Norepinephrine 154-167 catechol-O-methyltransferase Homo sapiens 0-28 9861640-1 1998 Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. Norepinephrine 154-167 catechol-O-methyltransferase Homo sapiens 30-34 9432090-11 1997 We speculate that an increase in COMT-catalyzed O-methylation of CE may indicate that less COMT is available to deactivate norepinephrine. Norepinephrine 123-137 catechol-O-methyltransferase Homo sapiens 33-37 9432090-11 1997 We speculate that an increase in COMT-catalyzed O-methylation of CE may indicate that less COMT is available to deactivate norepinephrine. Norepinephrine 123-137 catechol-O-methyltransferase Homo sapiens 91-95 9121699-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Norepinephrine 101-114 catechol-O-methyltransferase Homo sapiens 30-34 27520516-6 1994 COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers. Norepinephrine 103-116 catechol-O-methyltransferase Homo sapiens 0-4 7704341-4 1995 The results of numerical simulation show that: the addition of drugs that inhibit neuronal uptake and catechol-O-methyltransferase cause the augmentation of noradrenaline action on post-synaptic structures and an increase in the amplitude of the generated inhibitory post-synaptic potential (IPSP); treatment with adrenergic antagonists reduces the amplitude of IPSP; decrease in the concentration of extracellular Ca2+ ions and application of TTX abolish the post-synaptic response. Norepinephrine 157-170 catechol-O-methyltransferase Homo sapiens 102-130 7835624-13 1994 These COMT inhibitors also decrease the amount of COMT dependent metabolites of adrenaline and noradrenaline in plasma. Norepinephrine 95-108 catechol-O-methyltransferase Homo sapiens 6-10 7835624-13 1994 These COMT inhibitors also decrease the amount of COMT dependent metabolites of adrenaline and noradrenaline in plasma. Norepinephrine 95-108 catechol-O-methyltransferase Homo sapiens 50-54 9029240-3 1997 In addition, the strong affinity of CE for the catecholamine-deactivating enzyme catechol-O-methyltransferase (COMT) has led to speculations about their possible role in safeguarding norepinephrine from premature decomposition during exercise. Norepinephrine 183-197 catechol-O-methyltransferase Homo sapiens 81-109 9029240-3 1997 In addition, the strong affinity of CE for the catecholamine-deactivating enzyme catechol-O-methyltransferase (COMT) has led to speculations about their possible role in safeguarding norepinephrine from premature decomposition during exercise. Norepinephrine 183-197 catechol-O-methyltransferase Homo sapiens 111-115 8902889-1 1996 Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline. Norepinephrine 110-123 catechol-O-methyltransferase Homo sapiens 0-29 8902889-1 1996 Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline. Norepinephrine 110-123 catechol-O-methyltransferase Homo sapiens 31-35 8612391-14 1996 Other mechanisms are capable of regulating the concentrations of norepinephrine and epinephrine in circulating blood (and apparently also at receptors in the heart and vascular tissue) when both COMT and MAO-A activity are inhibited to a significant extent. Norepinephrine 65-79 catechol-O-methyltransferase Homo sapiens 195-199 27520516-6 1994 COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers. Norepinephrine 103-116 catechol-O-methyltransferase Homo sapiens 44-48 27520516-6 1994 COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers. Norepinephrine 118-132 catechol-O-methyltransferase Homo sapiens 0-4 27520516-6 1994 COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers. Norepinephrine 118-132 catechol-O-methyltransferase Homo sapiens 44-48 8510765-4 1993 Uptake of noradrenaline was manifested after 30 minutes as a 6-fold increase in the cell content of the amine following inhibition of catechol-O-methyl transferase, either alone or in conjunction with inhibition of monoamine oxidase. Norepinephrine 10-23 catechol-O-methyltransferase Homo sapiens 134-163 8154929-1 1994 Catechol-O-methyltransferase (COMT) is involved in the metabolism of neurotransmitters such as epinephrine, norepinephrine and dopamine. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 0-28 8154929-1 1994 Catechol-O-methyltransferase (COMT) is involved in the metabolism of neurotransmitters such as epinephrine, norepinephrine and dopamine. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 30-34 2089098-2 1990 Three such "metabolizing systems" are involved in the inactivation of noradrenaline: 1) Neuronal uptake (high-affinity uptake1) in association with neuronal MAO (and vesicular uptake), 2) extraneuronal uptake (low affinity uptake2) in association with intracellular COMT and MAO (in smooth muscles, myocardial cells, glands), and 3) uptake1 of non-neuronal cells in association with intracellular COMT and/or MAO (in vascular endothelium of rat lung). Norepinephrine 70-83 catechol-O-methyltransferase Homo sapiens 266-270 1817163-5 1991 Noradrenaline which has been taken up into Caki-1 cells by uptake2 is metabolized by the intracellular enzymes catechol-O-methyltransferase (COMT) and to a lesser extend by monoamineoxidase (MAO). Norepinephrine 0-13 catechol-O-methyltransferase Homo sapiens 111-139 1817163-5 1991 Noradrenaline which has been taken up into Caki-1 cells by uptake2 is metabolized by the intracellular enzymes catechol-O-methyltransferase (COMT) and to a lesser extend by monoamineoxidase (MAO). Norepinephrine 0-13 catechol-O-methyltransferase Homo sapiens 141-145 2089098-2 1990 Three such "metabolizing systems" are involved in the inactivation of noradrenaline: 1) Neuronal uptake (high-affinity uptake1) in association with neuronal MAO (and vesicular uptake), 2) extraneuronal uptake (low affinity uptake2) in association with intracellular COMT and MAO (in smooth muscles, myocardial cells, glands), and 3) uptake1 of non-neuronal cells in association with intracellular COMT and/or MAO (in vascular endothelium of rat lung). Norepinephrine 70-83 catechol-O-methyltransferase Homo sapiens 397-401 2089098-7 1990 Hence, membrane-bound COMT appears to be responsible for the extraneuronal O-methylation of noradrenaline. Norepinephrine 92-105 catechol-O-methyltransferase Homo sapiens 22-26 35533359-1 2022 Catechol O-methyltransferase (COMT) plays a vital role in deactivating neurotransmitters like dopamine, norepinephrine, etc., by methylating those compounds. Norepinephrine 104-118 catechol-O-methyltransferase Homo sapiens 0-28 2266783-1 1990 This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT. Norepinephrine 92-106 catechol-O-methyltransferase Homo sapiens 25-53 2266783-1 1990 This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT. Norepinephrine 92-106 catechol-O-methyltransferase Homo sapiens 55-59 2266783-1 1990 This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT. Norepinephrine 92-106 catechol-O-methyltransferase Homo sapiens 200-204 34889236-4 2021 There were the significant differences in the levels of dopamine and noradrenalin between the 2 groups (dopamine: t = 4.30, P < .01; noradrenalin: t = 2.24, P < .05).Our study suggested that the Val158Met polymorphisms of the COMT gene and serum concentrations of catecholaminergic neurotransmitters were associated with ADHD children and adolescents. Norepinephrine 69-81 catechol-O-methyltransferase Homo sapiens 226-230 34889236-4 2021 There were the significant differences in the levels of dopamine and noradrenalin between the 2 groups (dopamine: t = 4.30, P < .01; noradrenalin: t = 2.24, P < .05).Our study suggested that the Val158Met polymorphisms of the COMT gene and serum concentrations of catecholaminergic neurotransmitters were associated with ADHD children and adolescents. Norepinephrine 133-145 catechol-O-methyltransferase Homo sapiens 226-230 35533359-1 2022 Catechol O-methyltransferase (COMT) plays a vital role in deactivating neurotransmitters like dopamine, norepinephrine, etc., by methylating those compounds. Norepinephrine 104-118 catechol-O-methyltransferase Homo sapiens 30-34 3753600-2 1986 Selectivity of catechol O-methyltransferase has been examined for the three ring-fluorinated norepinephrines to elucidate the role of acidity of the phenolic groups in their methylation. Norepinephrine 93-108 catechol-O-methyltransferase Homo sapiens 15-43 3517539-1 1986 Radioenzymatic assays have been developed for norepinephrine (NE) using either catechol O-methyltransferase (COMT) or phenylethanolamine N-methyltransferase (PNMT). Norepinephrine 46-60 catechol-O-methyltransferase Homo sapiens 79-107 3517539-1 1986 Radioenzymatic assays have been developed for norepinephrine (NE) using either catechol O-methyltransferase (COMT) or phenylethanolamine N-methyltransferase (PNMT). Norepinephrine 46-60 catechol-O-methyltransferase Homo sapiens 109-113 3753600-3 1986 Substitution of fluorine at the 5-position of norepinephrine reverses the selectivity of catechol O-methyltransferase so that p-O-methylation predominates. Norepinephrine 46-60 catechol-O-methyltransferase Homo sapiens 89-117 444301-0 1979 Re-evaluation of the relationship between catechol-O-methyl transferase and the binding of norepinephrine to brown adipocyte membranes. Norepinephrine 91-105 catechol-O-methyltransferase Homo sapiens 42-71 4085156-5 1985 It is conceivable that the higher luteal phase noradrenaline is causally related to the higher oestradiol levels, leading to incomplete inactivation by reducing tissue uptake or competitive inhibition of catechol-O-methyl transferase. Norepinephrine 47-60 catechol-O-methyltransferase Homo sapiens 204-233 7172441-0 1982 Radioenzymatic assay of plasma adrenaline and noradrenaline: evidence for a catechol-O-methyltransferase (COMT) inhibiting factor associated with essential hypertension. Norepinephrine 46-59 catechol-O-methyltransferase Homo sapiens 76-104 7172441-0 1982 Radioenzymatic assay of plasma adrenaline and noradrenaline: evidence for a catechol-O-methyltransferase (COMT) inhibiting factor associated with essential hypertension. Norepinephrine 46-59 catechol-O-methyltransferase Homo sapiens 106-110 487592-2 1979 Noradrenaline and adrenaline are converted to their O-methylated analogues, normethanephrine and metanephrine, by the enzyme catechol O-methyltransferase in the presence of tritiated S-adenosyl-L-methionine. Norepinephrine 0-13 catechol-O-methyltransferase Homo sapiens 125-153 6742189-6 1984 Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT). Norepinephrine 35-49 catechol-O-methyltransferase Homo sapiens 110-139 6742189-6 1984 Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT). Norepinephrine 35-49 catechol-O-methyltransferase Homo sapiens 141-145 6826683-1 1983 A radioenzymatic assay is described in which norepinephrine, epinephrine and dopamine are converted to their tritiated 3-O-methyl derivatives by reaction with S-[methyl-3H]adenosyl-L-methionine in the presence of catechol-O-methyltransferase. Norepinephrine 45-59 catechol-O-methyltransferase Homo sapiens 213-241 7000971-2 1980 The assay consists basically of 1. conversion of epinephrine, norepinephrine, and dopamine into their respective methyl-derivates in the presence of catechol-O-methyltransferase and S-adenosylmethionine-[3H]methyl, 2. extraction of the methylated 3H labelled amines with diethyl ether, 3. separation by thin-layer chromatography, 4. measurement in a beta radiation scintillation counter. Norepinephrine 62-76 catechol-O-methyltransferase Homo sapiens 149-177 444302-0 1979 Control of the brown fat respiratory response to noradrenaline by catechol-O-methyltransferase. Norepinephrine 49-62 catechol-O-methyltransferase Homo sapiens 66-94 1276880-0 1976 Metabolism of centrally released noradrenaline by extraneuronal monoamine oxidase and catechol-O-methyltransferase. Norepinephrine 33-46 catechol-O-methyltransferase Homo sapiens 86-114 546488-1 1979 Catechol O-methyltransferase (COMT) obtained from human liver (HL) and human placenta (HP) was found to be much less active than rat liver (RL) COMT when norepinephrine, epinephrine, dopamine, and isoproterenol are used as substrates. Norepinephrine 154-168 catechol-O-methyltransferase Homo sapiens 0-28 546488-1 1979 Catechol O-methyltransferase (COMT) obtained from human liver (HL) and human placenta (HP) was found to be much less active than rat liver (RL) COMT when norepinephrine, epinephrine, dopamine, and isoproterenol are used as substrates. Norepinephrine 154-168 catechol-O-methyltransferase Homo sapiens 30-34 17955643-3 1979 It is concluded that desoxycorticosterone potentiates the effects of noradrenaline by inhibiting its inactivation by Catechol-O-methyltransferase. Norepinephrine 69-82 catechol-O-methyltransferase Homo sapiens 117-145 27458023-1 2017 OBJECTIVES: The enzyme catechol-O-methyltransferase (COMT), which catalyses the degradation of dopamine and norepinephrine, is posited to participate in the pathophysiology of bipolar disorder (BD) and schizophrenia. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 23-51 31771069-3 2020 Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline. Norepinephrine 188-201 catechol-O-methyltransferase Homo sapiens 0-28 31771069-3 2020 Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline. Norepinephrine 188-201 catechol-O-methyltransferase Homo sapiens 30-34 13882415-0 1961 Effect of inhibiting both catechol-O-methyl transferase and monoamine oxidase on cardiovascular responses to norepinephrine. Norepinephrine 109-123 catechol-O-methyltransferase Homo sapiens 26-55 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Norepinephrine 172-186 catechol-O-methyltransferase Homo sapiens 0-28 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Norepinephrine 172-186 catechol-O-methyltransferase Homo sapiens 30-34 29472953-1 2017 Objective: Several studies have shown that some polymorphisms of genes encoding catechol-O-methyltransferase (COMT), the key enzyme in degrading dopamine, and norepinephrine and the human brain-derived neurotropic factor (BDNF), a nerve growth factor, are strong candidates for risk of schizophrenia (SCZ). Norepinephrine 159-173 catechol-O-methyltransferase Homo sapiens 80-108 29472953-1 2017 Objective: Several studies have shown that some polymorphisms of genes encoding catechol-O-methyltransferase (COMT), the key enzyme in degrading dopamine, and norepinephrine and the human brain-derived neurotropic factor (BDNF), a nerve growth factor, are strong candidates for risk of schizophrenia (SCZ). Norepinephrine 159-173 catechol-O-methyltransferase Homo sapiens 110-114 28522796-8 2017 We found that the Gly49-variant, the Gly389-variant, and the Val158-COMT-variant were associated with higher postoperative norepinephrine consumption. Norepinephrine 123-137 catechol-O-methyltransferase Homo sapiens 68-72 28522796-9 2017 All patients carrying the Val158-COMT allele exhibited higher preoperative norepinephrine concentrations. Norepinephrine 75-89 catechol-O-methyltransferase Homo sapiens 33-37 28522796-11 2017 CONCLUSIONS These data show that the beta1-adrenoceptor polymorphisms, together with the COMT polymorphism, affect norepinephrine consumption and stay in hospital in a situation of enhanced cardiovascular stress, reflected here by the postoperative period after cardiac surgery. Norepinephrine 115-129 catechol-O-methyltransferase Homo sapiens 89-93 28522796-12 2017 Moreover, we conclude that patients with the Val158-COMT genotype exhibit higher endogenous resting plasma norepinephrine levels. Norepinephrine 107-121 catechol-O-methyltransferase Homo sapiens 52-56 27458023-1 2017 OBJECTIVES: The enzyme catechol-O-methyltransferase (COMT), which catalyses the degradation of dopamine and norepinephrine, is posited to participate in the pathophysiology of bipolar disorder (BD) and schizophrenia. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 53-57 26773917-1 2016 BACKGROUND: Catechol-O-methyltransferase (COMT) is a catabolic enzyme involved in the degradation of bioactive molecules including the neurotransmitters epinephrine, norepinephrine, and dopamine. Norepinephrine 166-180 catechol-O-methyltransferase Homo sapiens 12-40 28032000-3 2016 The enzyme catechol O-methyltransferase (COMT) catabolizes dopamine and norepinephrine in the prefrontal cortex and striatum, brain regions involved in behavioral control. Norepinephrine 72-86 catechol-O-methyltransferase Homo sapiens 11-39 28032000-3 2016 The enzyme catechol O-methyltransferase (COMT) catabolizes dopamine and norepinephrine in the prefrontal cortex and striatum, brain regions involved in behavioral control. Norepinephrine 72-86 catechol-O-methyltransferase Homo sapiens 41-45 27057952-1 2016 AIM: 22q11.2 deletion syndrome (22q11.2DS) affects catechol-O-methyl-transferase (COMT), which involves the degradation of norepinephrine (NE). Norepinephrine 123-137 catechol-O-methyltransferase Homo sapiens 51-80 27057952-1 2016 AIM: 22q11.2 deletion syndrome (22q11.2DS) affects catechol-O-methyl-transferase (COMT), which involves the degradation of norepinephrine (NE). Norepinephrine 123-137 catechol-O-methyltransferase Homo sapiens 82-86 26773917-1 2016 BACKGROUND: Catechol-O-methyltransferase (COMT) is a catabolic enzyme involved in the degradation of bioactive molecules including the neurotransmitters epinephrine, norepinephrine, and dopamine. Norepinephrine 166-180 catechol-O-methyltransferase Homo sapiens 42-46 26253436-1 2015 Catechol-O-methyltransferase (COMT) is a methylation enzyme engaged in the degradation of dopamine and noradrenaline by catalyzing the transfer of a methyl group from S-adenosylmethionine. Norepinephrine 103-116 catechol-O-methyltransferase Homo sapiens 0-28 26010653-1 2015 OBJECTIVE: Catechol-O-methyltransferase (COMT) is an enzyme that participates in the metabolic inactivation of dopamine and norepinephrine, and the Met allele of the COMT Val158Met polymorphism is associated with lower enzymatic activity. Norepinephrine 124-138 catechol-O-methyltransferase Homo sapiens 11-39 26010653-1 2015 OBJECTIVE: Catechol-O-methyltransferase (COMT) is an enzyme that participates in the metabolic inactivation of dopamine and norepinephrine, and the Met allele of the COMT Val158Met polymorphism is associated with lower enzymatic activity. Norepinephrine 124-138 catechol-O-methyltransferase Homo sapiens 41-45 26010653-1 2015 OBJECTIVE: Catechol-O-methyltransferase (COMT) is an enzyme that participates in the metabolic inactivation of dopamine and norepinephrine, and the Met allele of the COMT Val158Met polymorphism is associated with lower enzymatic activity. Norepinephrine 124-138 catechol-O-methyltransferase Homo sapiens 166-170 26253436-1 2015 Catechol-O-methyltransferase (COMT) is a methylation enzyme engaged in the degradation of dopamine and noradrenaline by catalyzing the transfer of a methyl group from S-adenosylmethionine. Norepinephrine 103-116 catechol-O-methyltransferase Homo sapiens 30-34 25242632-1 2014 Reduced levels of noradrenaline (NA) in CNS of multiple sclerosis patients could be due to metabolism by catechol-O-methyltransferase (COMT). Norepinephrine 18-31 catechol-O-methyltransferase Homo sapiens 105-133 26346727-4 2015 COMT has an important role in regulating the embryonic levels of catecholamine neurotransmitters (such as dopamine, norepinephrine, and epinephrine) and estrogens. Norepinephrine 116-130 catechol-O-methyltransferase Homo sapiens 0-4 25242632-1 2014 Reduced levels of noradrenaline (NA) in CNS of multiple sclerosis patients could be due to metabolism by catechol-O-methyltransferase (COMT). Norepinephrine 18-31 catechol-O-methyltransferase Homo sapiens 135-139 22831878-2 2013 A functional variation in the gene coding for the catechol-O-methyltransferase (COMT) enzyme, which metabolizes dopamine and noradrenaline, has been related to executive and emotional functions, and to sex dimorphism. Norepinephrine 125-138 catechol-O-methyltransferase Homo sapiens 50-78 24354565-2 2014 Methylation of the meta-hydroxyl is much more common than that of the para-hydroxyl in many COMT substrates, such as dopamine and norepinephrine. Norepinephrine 130-144 catechol-O-methyltransferase Homo sapiens 92-96 23774690-1 2013 Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine. Norepinephrine 79-92 catechol-O-methyltransferase Homo sapiens 0-28 23774690-1 2013 Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine. Norepinephrine 79-92 catechol-O-methyltransferase Homo sapiens 30-34 22831878-2 2013 A functional variation in the gene coding for the catechol-O-methyltransferase (COMT) enzyme, which metabolizes dopamine and noradrenaline, has been related to executive and emotional functions, and to sex dimorphism. Norepinephrine 125-138 catechol-O-methyltransferase Homo sapiens 80-84 23280413-1 2013 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. Norepinephrine 140-154 catechol-O-methyltransferase Homo sapiens 0-28 23643763-1 2013 Catechol-O-methyltransferase (COMT) plays an important role in the catabolism of brain dopamine and norepinephrine, which have been implicated in the pathogenesis of Autism spectrum disorder (ASD) as well as in other neuropsychatric disorders. Norepinephrine 100-114 catechol-O-methyltransferase Homo sapiens 0-28 23643763-1 2013 Catechol-O-methyltransferase (COMT) plays an important role in the catabolism of brain dopamine and norepinephrine, which have been implicated in the pathogenesis of Autism spectrum disorder (ASD) as well as in other neuropsychatric disorders. Norepinephrine 100-114 catechol-O-methyltransferase Homo sapiens 30-34 23280413-1 2013 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. Norepinephrine 140-154 catechol-O-methyltransferase Homo sapiens 30-34 24450388-1 2013 Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine. Norepinephrine 209-223 catechol-O-methyltransferase Homo sapiens 0-28 24450388-1 2013 Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine. Norepinephrine 209-223 catechol-O-methyltransferase Homo sapiens 30-34 22483297-1 2012 The enzyme catechol-O-methyltransferase (COMT) has been shown to play a critical role in pain perception by regulating levels of epinephrine (Epi) and norepinephrine (NE). Norepinephrine 151-165 catechol-O-methyltransferase Homo sapiens 11-39 22765285-2 2012 We have typed 2 functional polymorphisms of relevance for both biosynthesis and catabolism of noradrenalin: The Val158Met single-nucleotide polymorphism (SNP) of the Catechol-O-methyl transferase gene (COMT) and the 1021C/T SNP of the dopamine dehydroxylase gene (DBH). Norepinephrine 94-106 catechol-O-methyltransferase Homo sapiens 166-195 22765285-2 2012 We have typed 2 functional polymorphisms of relevance for both biosynthesis and catabolism of noradrenalin: The Val158Met single-nucleotide polymorphism (SNP) of the Catechol-O-methyl transferase gene (COMT) and the 1021C/T SNP of the dopamine dehydroxylase gene (DBH). Norepinephrine 94-106 catechol-O-methyltransferase Homo sapiens 202-206 22483291-1 2012 One of the most important enzymes in the catecholamine cycle, catecholamine-O-methyltransferase (COMT), plays a critical role in the extracellular metabolism of dopamine and norepinephrine both in the periphery and the central nervous system. Norepinephrine 174-188 catechol-O-methyltransferase Homo sapiens 62-95 22483291-1 2012 One of the most important enzymes in the catecholamine cycle, catecholamine-O-methyltransferase (COMT), plays a critical role in the extracellular metabolism of dopamine and norepinephrine both in the periphery and the central nervous system. Norepinephrine 174-188 catechol-O-methyltransferase Homo sapiens 97-101 22371619-7 2012 The effect of the gene polymorphism of catechol-O-methyltransferase (COMT) on individual variations in switching frequency suggests that the balance of exploration and stabilization is modulated by catecholamines such as dopamine and noradrenalin. Norepinephrine 234-246 catechol-O-methyltransferase Homo sapiens 39-67 22371619-7 2012 The effect of the gene polymorphism of catechol-O-methyltransferase (COMT) on individual variations in switching frequency suggests that the balance of exploration and stabilization is modulated by catecholamines such as dopamine and noradrenalin. Norepinephrine 234-246 catechol-O-methyltransferase Homo sapiens 69-73 22483297-1 2012 The enzyme catechol-O-methyltransferase (COMT) has been shown to play a critical role in pain perception by regulating levels of epinephrine (Epi) and norepinephrine (NE). Norepinephrine 151-165 catechol-O-methyltransferase Homo sapiens 41-45 21846718-1 2011 Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens. Norepinephrine 118-132 catechol-O-methyltransferase Homo sapiens 0-28 21846718-1 2011 Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens. Norepinephrine 118-132 catechol-O-methyltransferase Homo sapiens 30-34 21344643-2 2011 COMT involves in the degradation of dopamine and norepinephrin. Norepinephrine 49-62 catechol-O-methyltransferase Homo sapiens 0-4 21414668-1 2011 The catechol-O-methyltransferase (COMT) gene is a candidate gene for schizophrenia as its encoded enzyme is involved in the metabolic inactivation of dopamine and noradrenaline. Norepinephrine 163-176 catechol-O-methyltransferase Homo sapiens 4-32 21414668-1 2011 The catechol-O-methyltransferase (COMT) gene is a candidate gene for schizophrenia as its encoded enzyme is involved in the metabolic inactivation of dopamine and noradrenaline. Norepinephrine 163-176 catechol-O-methyltransferase Homo sapiens 34-38 21656904-14 2011 Based on our robust family-controlled and unrelated-affected analyses, we conclude that COMT is associated with CIP, possibly as a result of its role in the metabolism of dopamine and norepinephrine. Norepinephrine 184-198 catechol-O-methyltransferase Homo sapiens 88-92 21695287-1 2011 Catechol-O-methyltransferase (COMT) metabolizes catechol neurotransmitters dopamine, noradrenaline and adrenaline that are involved in various physiological functions including mood, cognition and stress response. Norepinephrine 85-98 catechol-O-methyltransferase Homo sapiens 0-28 21695287-1 2011 Catechol-O-methyltransferase (COMT) metabolizes catechol neurotransmitters dopamine, noradrenaline and adrenaline that are involved in various physiological functions including mood, cognition and stress response. Norepinephrine 85-98 catechol-O-methyltransferase Homo sapiens 30-34 21402125-7 2011 The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia because norepinephrine is less effectively inactivated. Norepinephrine 97-111 catechol-O-methyltransferase Homo sapiens 24-28 20860878-4 2011 The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine. Norepinephrine 83-97 catechol-O-methyltransferase Homo sapiens 11-40 20860878-4 2011 The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine. Norepinephrine 83-97 catechol-O-methyltransferase Homo sapiens 42-46 21302344-2 2011 Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. Norepinephrine 183-196 catechol-O-methyltransferase Homo sapiens 70-74