PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27325446-2 2016 Here, we describe our medicinal chemistry approach to discover a novel series of highly potent, peripheral-selective, and orally available noradrenaline reuptake inhibitors with a low multidrug resistance protein 1 (MDR1) efflux ratio by cyclization of an amide moiety and introduction of an acidic group. Norepinephrine 139-152 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 184-214 27325446-2 2016 Here, we describe our medicinal chemistry approach to discover a novel series of highly potent, peripheral-selective, and orally available noradrenaline reuptake inhibitors with a low multidrug resistance protein 1 (MDR1) efflux ratio by cyclization of an amide moiety and introduction of an acidic group. Norepinephrine 139-152 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 216-220