PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27037808-7 2016 Both norepinephrine and dobutamine significantly reduced TNF-alpha and IL-6 production after ex vivo LPS stimulation of whole blood in a dose-dependent manner, and this effect was partially reversed by the presence of metoprolol. Norepinephrine 5-19 interleukin 6 Homo sapiens 71-75 27556306-9 2016 Recipients who required moderate/high levels of noradrenaline for weaning off cardiopulmonary bypass were associated with lower donor concentrations of sTNFR2 (P =0.028) and IL-6 (P =0.001). Norepinephrine 48-61 interleukin 6 Homo sapiens 174-178 26677330-11 2015 CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment. Norepinephrine 239-253 interleukin 6 Homo sapiens 59-72 26741414-16 2016 Norepinephrine aggravated interleukin-6 upregulation in males in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent mechanism but blocked interleukin-6 up-regulation in females after fluid percussion injury. Norepinephrine 0-14 interleukin 6 Homo sapiens 26-39 26741414-16 2016 Norepinephrine aggravated interleukin-6 upregulation in males in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent mechanism but blocked interleukin-6 up-regulation in females after fluid percussion injury. Norepinephrine 0-14 interleukin 6 Homo sapiens 171-184 26741414-17 2016 Norepinephrine augments loss of neurons in CA1 and CA3 hippocampus of male piglets after fluid percussion injury in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent and interleukin-6-dependent manner but prevents loss of neurons in females after fluid percussion injury. Norepinephrine 0-14 interleukin 6 Homo sapiens 204-217 26741414-18 2016 CONCLUSION: Norepinephrine protects autoregulation and limits hippocampal neuronal cell necrosis via modulation of extracellular signal-regulated kinase mitogen-activated protein kinase and interleukin-6 after fluid percussion injury in a sex-dependent manner. Norepinephrine 12-26 interleukin 6 Homo sapiens 190-203 25843793-3 2015 Although Norepinephrine (NE) can stimulate the vascular cells to produce IL-6, it is unknown whether NE induces IL-6 expression in macrophages. Norepinephrine 9-23 interleukin 6 Homo sapiens 73-77 23740369-8 2013 Stress hormones such as norepinephrine have been shown to cause upregulation of cytokines such as Interleukin 6 and 8, which are proangiogenic and support tumour progression. Norepinephrine 24-38 interleukin 6 Homo sapiens 98-117 24519125-0 2014 Stress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells. Norepinephrine 23-37 interleukin 6 Homo sapiens 46-59 24519125-3 2014 However, the precise mechanism of IL-6 induction by the stress-related hormone norepinephrine (NE) is not clear, and, furthermore, there are no reports about the effect of NE on IL-6 expression in gastric epithelial cells. Norepinephrine 79-93 interleukin 6 Homo sapiens 34-38 24519125-8 2014 The results suggest that chronic stress may increase IL-6 secretion of human gastric epithelial cells, at least in part, by the stress-associated hormone norepinephrine, and provides basic data on stress and gastric cancer progression. Norepinephrine 154-168 interleukin 6 Homo sapiens 53-57 24479719-3 2013 Norepinephrine and other adrenoceptor agonists are known to provoke activation of proinflammatory cytokines such as interleukin (IL)-1 and IL-6. Norepinephrine 0-14 interleukin 6 Homo sapiens 139-143 25221588-3 2014 In turn, noradrenaline may act on up-regulated alpha1-adrenoceptors to increase the production of the pro-inflammatory cytokine interleukin-6. Norepinephrine 9-22 interleukin 6 Homo sapiens 128-141 24026137-0 2013 Norepinephrine and adenosine-5"-triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells. Norepinephrine 0-14 interleukin 6 Homo sapiens 67-71 18636164-0 2008 Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane. Norepinephrine 27-41 interleukin 6 Homo sapiens 71-75 18835437-7 2009 In the vaccine/stress group, participants with larger IL-6 responses had heightened systolic blood pressure responses to tasks and elevated post-stress salivary levels of the noradrenaline metabolite 3-methoxy-phenyl glycol (MHPG) and cortisol. Norepinephrine 175-188 interleukin 6 Homo sapiens 54-58 19439970-5 2009 RESULTS: A significant correlation between norepinephrine support and IL-6 plasma concentrations was shown at the separation from CPB (k = 0.742) and 12 h after it (k = 0.801) as well as between norepinephrine support and IL-8 concentrations 12 h after the separation from CPB. Norepinephrine 43-57 interleukin 6 Homo sapiens 70-74 21932058-2 2012 The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group. Norepinephrine 155-169 interleukin 6 Homo sapiens 376-389 18996182-0 2009 Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Norepinephrine 0-14 interleukin 6 Homo sapiens 43-47 18636164-6 2008 We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF). Norepinephrine 33-47 interleukin 6 Homo sapiens 58-71 18636164-6 2008 We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF). Norepinephrine 33-47 interleukin 6 Homo sapiens 73-77 18636164-8 2008 We found that norepinephrine can increase the IL-6 and VEGF but not IL-10 levels secreted by human pancreatic duct epithelial cells. Norepinephrine 14-28 interleukin 6 Homo sapiens 46-50 18636164-11 2008 Furthermore, sulforaphane also inhibits norepinephrine-mediated increase of the IL-6 levels but not VEGF levels. Norepinephrine 40-54 interleukin 6 Homo sapiens 80-84 18636164-12 2008 Our study is the first to demonstrate that stress-associated hormone, norepinephrine, can increase the cell proliferation and IL-6 levels of human pancreatic duct epithelial cells, which can be inhibited by sulforaphane, a chemopreventive agent and a natural compound from the Cruciferous vegetables. Norepinephrine 70-84 interleukin 6 Homo sapiens 126-130 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Norepinephrine 40-53 interleukin 6 Homo sapiens 118-131 18328837-7 2008 Increased norepinephrine responses were related to larger CRP and IL-6 increases to mental challenge tasks (p values <0.05). Norepinephrine 10-24 interleukin 6 Homo sapiens 66-70 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Norepinephrine 40-53 interleukin 6 Homo sapiens 133-137 15795476-19 2005 Moreover we believe, that the fasting-induced significant increase in plasma IL-6 concentration at rest, accompanied by higher plasma norepinephrine concentration and lower RQ, belongs to the physiological responses, maintaining energy homeostasis in the fasting state. Norepinephrine 134-148 interleukin 6 Homo sapiens 77-81 17716980-3 2007 Here we show that stress hormones such as norepinephrine lead to increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells. Norepinephrine 42-56 interleukin 6 Homo sapiens 89-93 17716980-4 2007 Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression. Norepinephrine 33-47 interleukin 6 Homo sapiens 136-140 15213629-10 2004 TNF-alpha and IL-6 cytokine responses to LPS were markedly influenced by the specific progenitor cells involved as well as the injury conditions and the status of norepinephrine prior to injury. Norepinephrine 163-177 interleukin 6 Homo sapiens 14-18 15213629-11 2004 In burn sepsis the depletion of norepinephrine resulted in a dramatic decrease in both IL-6 and TNF-alpha production by both progenitor-derived macrophages. Norepinephrine 32-46 interleukin 6 Homo sapiens 87-91 11641355-12 2001 A significant correlation (P = 0.004) between resting IL-6 and urinary norepinephrine excretion rates was found over the course of time while at altitude. Norepinephrine 71-85 interleukin 6 Homo sapiens 54-58 14625484-5 2003 Animals, receiving epinephrine therapy, showed a significantly prolonged upregulation of IL-6 mRNA expression at 4 h after LPS application in liver (P = 0.0014), spleen (P < 0.0001), and mesenteric lymph nodes (P = 0.0078) as compared with animals treated with norepinephrine or fluid resuscitation. Norepinephrine 264-278 interleukin 6 Homo sapiens 89-93 12859859-6 2003 Additionally, circulating IL-6 was also significantly correlated with plasma norepinephrine (r = 0.86, p < 0.001) and right atrial pressure (r = 0.57, p < 0.01). Norepinephrine 77-91 interleukin 6 Homo sapiens 26-30 14523327-12 2003 CONCLUSIONS: The norepinephrine-induced increase in plasma and CSF IL-6 suggests that concomitant norepinephrine administration needs to be considered when interpreting systemic and local changes in IL-6 levels in TBI patients. Norepinephrine 17-31 interleukin 6 Homo sapiens 67-71 14523327-12 2003 CONCLUSIONS: The norepinephrine-induced increase in plasma and CSF IL-6 suggests that concomitant norepinephrine administration needs to be considered when interpreting systemic and local changes in IL-6 levels in TBI patients. Norepinephrine 17-31 interleukin 6 Homo sapiens 199-203 14523327-12 2003 CONCLUSIONS: The norepinephrine-induced increase in plasma and CSF IL-6 suggests that concomitant norepinephrine administration needs to be considered when interpreting systemic and local changes in IL-6 levels in TBI patients. Norepinephrine 98-112 interleukin 6 Homo sapiens 67-71 12906374-5 2003 The interleukin-6 (IL-6) over-production can either be ascribed directly to the tumor (as confirmed by immunohistochemistry) or indirectly accounted for by tumoral production, as a consequence of the high levels of circulating norepinephrine. Norepinephrine 227-241 interleukin 6 Homo sapiens 4-17 12906374-5 2003 The interleukin-6 (IL-6) over-production can either be ascribed directly to the tumor (as confirmed by immunohistochemistry) or indirectly accounted for by tumoral production, as a consequence of the high levels of circulating norepinephrine. Norepinephrine 227-241 interleukin 6 Homo sapiens 19-23 9462584-8 1998 Among the hemodynamic variables and the various neurohumoral factors, the plasma norepinephrine (NE) level showed an independent and significant positive relation with the plasma IL-6 level in patients with CHF. Norepinephrine 81-95 interleukin 6 Homo sapiens 179-183 11268388-6 2000 LPC 18:0 synergistically increases IL-6 release in the presence of norepinephrine, and IL-1 beta transiently increases LPC 18:0 formation in C6 cells. Norepinephrine 67-81 interleukin 6 Homo sapiens 35-39 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 22-35 interleukin 6 Homo sapiens 90-94 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 96-109 interleukin 6 Homo sapiens 90-94 11084220-5 2000 It is concluded that (1) noradrenaline has significant negative immunoregulatory effects in humans through suppression of the production of (monocytic) proinflammatory cytokines, e.g. IL-6 and TNF alpha, and (2) the suppression of the production of TNF alpha may be related to alpha(2)-adrenoceptor-related mechanisms. Norepinephrine 25-38 interleukin 6 Homo sapiens 184-188 10834930-3 2000 We now demonstrate that epinephrine as well as norepinephrine can induce IL-6 in an endothelial cell line (HMEC-1). Norepinephrine 47-61 interleukin 6 Homo sapiens 73-77 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Norepinephrine 43-57 interleukin 6 Homo sapiens 168-181 9114781-1 1997 In a group of patients with New York Heart Association class IV heart failure, significant relations between interleukin-6 and tumor necrosis factor-alpha, and between levels of both interleukin-6 and tumor necrosis factor-alpha and plasma levels of norepinephrine were observed. Norepinephrine 250-264 interleukin 6 Homo sapiens 109-154 9114781-1 1997 In a group of patients with New York Heart Association class IV heart failure, significant relations between interleukin-6 and tumor necrosis factor-alpha, and between levels of both interleukin-6 and tumor necrosis factor-alpha and plasma levels of norepinephrine were observed. Norepinephrine 250-264 interleukin 6 Homo sapiens 183-228 9132617-12 1997 The finding that norepinephrine stimulates activated astrocytes to produce IL-6 implies that the cytokine cascade may be activated by neuronal processes under certain conditions. Norepinephrine 17-31 interleukin 6 Homo sapiens 75-79 8843757-5 1996 A positive correlation was observed between peak plasma epinephrine or norepinephrine and IL-6 levels at 15 min. Norepinephrine 71-85 interleukin 6 Homo sapiens 90-94 8678641-7 1996 Interleukin-6 correlated with duration of extracorporeal circulation, dose of norepinephrine and epinephrine support, pulmonary capillary wedge pressure, mean pulmonary arterial pressure, right atrial pressure, heart rate, cardiac index, and inversely with systemic vascular resistance. Norepinephrine 78-92 interleukin 6 Homo sapiens 0-13 8973087-9 1996 CONCLUSIONS: Initial elevation of IL-6 concentration might induce stress hormones such as norepinephrine and glucagon, but not insulin after surgical trauma. Norepinephrine 90-104 interleukin 6 Homo sapiens 34-38 7926489-3 1994 Therefore, we investigated the effects of IL-6 alone and in combination with IL-1 beta on norepinephrine release. Norepinephrine 90-104 interleukin 6 Homo sapiens 42-46 7926489-7 1994 CONCLUSIONS: Because 3H release reflects [3H]norepinephrine release, our results show that IL-6 exerts a dual effect on norepinephrine release. Norepinephrine 45-59 interleukin 6 Homo sapiens 91-95 7926489-8 1994 Furthermore, there is synergism between IL-1 beta and IL-6 resulting in suppression of norepinephrine release. Norepinephrine 87-101 interleukin 6 Homo sapiens 54-58 8973087-6 1996 Initial elevation and steady decline of IL-6 concentrations were seen after surgical injury, and this response related significantly to post-operative norepinephrine and glucagon levels throughout the study period, and to insulin levels only at the end of surgery. Norepinephrine 151-165 interleukin 6 Homo sapiens 40-44 8168970-0 1994 Noradrenaline inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin 6 production in human whole blood. Norepinephrine 0-13 interleukin 6 Homo sapiens 76-89 8168970-3 1994 The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood. Norepinephrine 52-65 interleukin 6 Homo sapiens 130-143 8168970-3 1994 The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood. Norepinephrine 52-65 interleukin 6 Homo sapiens 145-149 8168970-5 1994 Noradrenaline caused a dose-dependent inhibition of LPS-induced TNF and IL-6 production. Norepinephrine 0-13 interleukin 6 Homo sapiens 72-76 8168970-9 1994 In acute sepsis, enhanced release of noradrenaline may be part of a negative feedback mechanism meant to inhibit ongoing TNF and IL-6 production. Norepinephrine 37-50 interleukin 6 Homo sapiens 129-133