PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31067439-7 2019 As noradrenaline has high potency at alpha1D-adrenceptors, these receptors mediate the fastest response and seem to be targets for neurally released noradrenaline especially to low frequency stimulation, with alpha1A-adrenoceptors being more important at high frequencies of stimulation. Norepinephrine 3-16 calcium voltage-gated channel subunit alpha1 A Homo sapiens 209-216 31067439-7 2019 As noradrenaline has high potency at alpha1D-adrenceptors, these receptors mediate the fastest response and seem to be targets for neurally released noradrenaline especially to low frequency stimulation, with alpha1A-adrenoceptors being more important at high frequencies of stimulation. Norepinephrine 149-162 calcium voltage-gated channel subunit alpha1 A Homo sapiens 209-216 30619611-1 2019 alpha1A- and alpha1B-adrenoceptors (ARs) are G protein-coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (CNS). Norepinephrine 118-131 calcium voltage-gated channel subunit alpha1 A Homo sapiens 0-7 31503242-2 2019 On smooth muscle cells of pulmonary vessels there are postsynaptic alpha1A-, alpha1B-, alpha1D- and alpha2A-, alpha2B-, alpha2C-adrenoreceptors whose activation by norepinephrine induces vasoconstriction. Norepinephrine 164-178 calcium voltage-gated channel subunit alpha1 A Homo sapiens 67-74 23364786-0 2013 Differential phosphorylation, desensitization, and internalization of alpha1A-adrenoceptors activated by norepinephrine and oxymetazoline. Norepinephrine 105-119 calcium voltage-gated channel subunit alpha1 A Homo sapiens 70-77 30139713-5 2018 The alpha1A- and alpha1D-adrenoceptor antagonist tamsulosin antagonized noradrenaline responses with high affinity (pKD = 9.7 +- 0.3), whilst BMY7378 (100 nM) (alpha1D-adrenoceptor antagonist) failed to antagonize responses. Norepinephrine 72-85 calcium voltage-gated channel subunit alpha1 A Homo sapiens 4-11 28888989-0 2017 Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of alpha1A-adrenergic receptors. Norepinephrine 0-13 calcium voltage-gated channel subunit alpha1 A Homo sapiens 126-133 28569366-15 2017 Since BPS/IC patients present high levels of noradrenaline, alpha 1A stimulation may be an additional trigger for bladder dysfunction presented by these patients. Norepinephrine 45-58 calcium voltage-gated channel subunit alpha1 A Homo sapiens 60-68 23364786-3 2013 It is well established that alpha1A-ARs are less phosphorylated, desensitized, and internalized on exposure to the phenethylamines norepinephrine (NE), epinephrine, or phenylephrine (PE) than are the alpha1B and alpha1D subtypes. Norepinephrine 131-145 calcium voltage-gated channel subunit alpha1 A Homo sapiens 28-35 20363235-5 2010 In addition, amitriptyline, nortriptyline and imipramine were substantially more potent in the inhibition of noradrenaline-induced intracellular Ca(2+) increases in HEK-293 cells expressing alpha(1A)- or a truncated version of alpha(1D)-adrenoceptors which traffics more efficiently towards the cell membrane than in cells expressing alpha(1B)-adrenoceptors. Norepinephrine 109-122 calcium voltage-gated channel subunit alpha1 A Homo sapiens 190-198 22371491-3 2012 By utilizing the G protein-coupled receptor (GPCR) heteromer identification technology on the live cell-based bioluminescence resonance energy transfer (BRET) assay platform, our studies in human embryonic kidney 293 cells have identified norepinephrine-dependent beta-arrestin recruitment that was in turn dependent upon co-expression of alpha(1A)AR with CXCR2. Norepinephrine 239-253 calcium voltage-gated channel subunit alpha1 A Homo sapiens 339-347 12866809-4 2002 In some tissues alpha1A- or alpha1D-adrenoceptors were "protected" from inactivation by incubation in the presence of the selective alpha1A- or 1D-adrenoceptor antagonists 5-methylurapidil and BMY 7378 before recording further responses to noradrenaline. Norepinephrine 240-253 calcium voltage-gated channel subunit alpha1 A Homo sapiens 16-23 17827867-1 2007 The mechanism for noradrenaline (NA)-induced increases in intracellular Ca(2+) concentration ([Ca(2+)](i)) and physiological significance of Na(+) influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese hamster ovary (CHO) cells stably expressing human alpha(1A)-adrenoceptor (alpha(1A)-AR). Norepinephrine 18-31 calcium voltage-gated channel subunit alpha1 A Homo sapiens 305-313 16254819-7 2005 A close relationship was found between affinities obtained for cloned alpha (1A)-AR and inhibitory potencies on noradrenaline-induced contraction or inositol phosphate accumulation in tail artery, confirming that there is a homogeneous functional population of alpha(1A)-AR in this vessel. Norepinephrine 112-125 calcium voltage-gated channel subunit alpha1 A Homo sapiens 70-79 14678390-3 2004 The potency and intrinsic activity of amidephrine and Ro 115-1240 relative to noradrenaline were determined in native and cell-based assays using human recombinant alpha1-ARs; they acted as selective alpha1A/1L-AR full and partial agonists, respectively. Norepinephrine 78-91 calcium voltage-gated channel subunit alpha1 A Homo sapiens 200-207 12904082-3 2003 Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their alpha(1A)-antagonist and their NO-donor properties. Norepinephrine 95-112 calcium voltage-gated channel subunit alpha1 A Homo sapiens 135-143 12618215-1 2003 Noradrenaline-stimulated phosphoinositide breakdown in cultured glia was found to be mediated by alpha(1A)-adrenoceptors. Norepinephrine 0-13 calcium voltage-gated channel subunit alpha1 A Homo sapiens 97-105 12618215-2 2003 The alpha(1A)-selective agonist A61603 was as effective as noradrenaline in eliciting 3H-inositol phosphate (IP) accumulation but was approximately 50-fold more potent. Norepinephrine 59-72 calcium voltage-gated channel subunit alpha1 A Homo sapiens 4-12 12618215-3 2003 In addition, the use of selective antagonists revealed a clear rank order of potency in the ability of these drugs to reverse the effect of noradrenaline on phosphoinositide breakdown: RS17053 (alpha(1A)-selective) >>AH11110A (alpha(1B)-selective)>BMY7378 (alpha(1D)-selective). Norepinephrine 140-153 calcium voltage-gated channel subunit alpha1 A Homo sapiens 194-202 16039007-1 2005 Alpha1-adrenoreceptors (AR), of which three subtypes exist (alpha1A-, alpha1B- and alpha1D-AR) are G-protein-coupled receptors that mediate the actions of norepinephrine and epinephrine both peripherally and centrally. Norepinephrine 155-169 calcium voltage-gated channel subunit alpha1 A Homo sapiens 60-67 12866809-4 2002 In some tissues alpha1A- or alpha1D-adrenoceptors were "protected" from inactivation by incubation in the presence of the selective alpha1A- or 1D-adrenoceptor antagonists 5-methylurapidil and BMY 7378 before recording further responses to noradrenaline. Norepinephrine 240-253 calcium voltage-gated channel subunit alpha1 A Homo sapiens 132-139 11429392-4 2001 5-Methyl-urapidil competitively antagonized responses to noradrenaline with a pK(B) value of 8.48 and a Schild slope of 0.99, consistent with the presence of alpha(1A)-adrenoceptors. Norepinephrine 57-70 calcium voltage-gated channel subunit alpha1 A Homo sapiens 158-166 11940765-16 2002 Noradrenaline increased intracellular Ca2+ concentration ([Ca2+]i) concentration-dependently, which was inhibited by ONOO-1 in alpha1a- and alpha1d-adrenoceptors. Norepinephrine 0-13 calcium voltage-gated channel subunit alpha1 A Homo sapiens 127-134 11940765-20 2002 Treatment with ONOO-1 attenuates noradrenaline-stimulated increase in [Ca2+]i in alpha1a- and alpha1d-adrenoceptors but not in alpha1b-adrenoceptor. Norepinephrine 33-46 calcium voltage-gated channel subunit alpha1 A Homo sapiens 81-88 11940765-21 2002 ONOO-1 also weakens noradrenaline-induced contractions in rat aorta that has alpha1a- and alpha1d-adrenoceptors. Norepinephrine 20-33 calcium voltage-gated channel subunit alpha1 A Homo sapiens 77-84 11602687-8 2001 Prazosin, 5-methyl-urapidil, and 2-[2,6-dimethoxyphenoxyethyl]aminomethyl)-1,4-benzodioxane (WB 4101) shifted the potency of norepinephrine concentration dependently giving pA2 values of 9.4, 8.9, and 10.1, respectively, showing the presence of the alpha1A-subtype in these arteries. Norepinephrine 125-139 calcium voltage-gated channel subunit alpha1 A Homo sapiens 249-256 11429392-11 2001 These results show that contractile responses to noradrenaline in human skeletal muscle resistance arteries are predominantly mediated by the alpha(1A)-adrenoceptor subtype with a minor population of an unknown alpha(1)-adrenoceptor subtype. Norepinephrine 49-62 calcium voltage-gated channel subunit alpha1 A Homo sapiens 142-150 9892008-3 1999 Norepinephrine activated PI 3-kinase in cells expressing human alpha1A and alpha1B via pertussis toxin-insensitive G proteins; alpha1D-receptors did not detectably activate this kinase. Norepinephrine 0-14 calcium voltage-gated channel subunit alpha1 A Homo sapiens 63-70 10714892-6 2000 In the functional study, concentration-response curves to noradrenaline pretreated with KMD-3213, an alpha1A/L-adrenoceptor selective antagonist, seemed to be biphasic in nature. Norepinephrine 58-71 calcium voltage-gated channel subunit alpha1 A Homo sapiens 101-108 10079004-7 1999 The results suggest that contractions evoked by noradrenaline in both muscle types of human vas deferens is mediated via activation of alpha1-adrenoceptors with pharmacological profile of the alpha1A-subtype. Norepinephrine 48-61 calcium voltage-gated channel subunit alpha1 A Homo sapiens 192-199 10437163-7 1999 CONCLUSION: Only alpha 1A-adrenoceptors mediate the norepinephrine-induced vasopressor response in perfused rat mesenteric vascular bed. Norepinephrine 52-66 calcium voltage-gated channel subunit alpha1 A Homo sapiens 17-25 10820200-2 2000 In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP response element), NFkappaB) (nuclear factor-kappaB), and NFAT (nuclear factor of activated T cells)], whereas nerve growth factor (NGF) and epidermal growth factor activated only AP1 and SRE. Norepinephrine 59-73 calcium voltage-gated channel subunit alpha1 A Homo sapiens 27-35 11263248-7 2000 Treatment with norepinephrine (NE) in the presence of propranolol for 24 h increased DNA synthesis in HEK293/alpha 1A- or HEK293/alpha 1B-AR cells concentration-dependently, with EC50 values of 48.8 nmol.L-1 (95% confidence limits 9.7-246 nmol.L-1) and 8.4 nmol.L-1 (95% confidence limits 2.1-32.9 nmol.L-1), respectively. Norepinephrine 15-29 calcium voltage-gated channel subunit alpha1 A Homo sapiens 109-117 10714892-8 2000 These data suggest that the alpha1A/L-adrenoceptor mediates primarily those responses to noradrenaline in this artery. Norepinephrine 89-102 calcium voltage-gated channel subunit alpha1 A Homo sapiens 28-35 9927621-2 1999 In PC12 cells stably transfected with the human alpha-1A AR, norepinephrine (NE) strongly activated both extracellular signal regulated kinases (ERKs) and c-jun-NH2-terminal kinases (JNK). Norepinephrine 61-75 calcium voltage-gated channel subunit alpha1 A Homo sapiens 48-56 9792725-3 1998 Using Rat1 cells stably transfected with each of the three cloned human alpha1 adrenergic receptor subtypes, norepinephrine strongly stimulated CREB phosphorylation in alpha1A and alpha1B but more weakly in alpha1D-transfected cells. Norepinephrine 109-123 calcium voltage-gated channel subunit alpha1 A Homo sapiens 168-175 9218684-6 1997 The results suggest that only alpha1A-adrenoceptors mediate the noradrenaline-induced vasopressor response in perfused rat hind limb. Norepinephrine 64-77 calcium voltage-gated channel subunit alpha1 A Homo sapiens 30-37 9066089-3 1997 Recent investigations have demonstrated the presence of several subtypes of alpha 1-adrenoceptors (alpha(1A), alpha(1B), and alpha(1D)) in the human corpus cavernosum and also that the noradrenaline-induced contraction in this tissue is probably mediated by two or, possibly, three receptor subtypes. Norepinephrine 185-198 calcium voltage-gated channel subunit alpha1 A Homo sapiens 99-107 8106008-0 1993 Norepinephrine-stimulated PI hydrolysis in oligodendrocytes is mediated by alpha 1A-adrenoceptors. Norepinephrine 0-14 calcium voltage-gated channel subunit alpha1 A Homo sapiens 75-83 7651358-4 1995 KMD-3213 inhibited norepinephrine-induced increases in intracellular Ca2+ concentrations in alpha 1a-AR-expressing Chinese hamster ovary cells with an IC50 of 0.32 nM but had a much weaker inhibitory effect on the alpha 1b- and alpha 1d-ARs. Norepinephrine 19-33 calcium voltage-gated channel subunit alpha1 A Homo sapiens 92-100 8548177-0 1995 Noradrenaline contractions of human prostate mediated by alpha 1A-(alpha 1c-) adrenoceptor subtype. Norepinephrine 0-13 calcium voltage-gated channel subunit alpha1 A Homo sapiens 57-90