PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32151742-2 2020 Pharmacological norepinephrine transporter (NET) inhibition increases synaptic norepinephrine reuptake, which may be able to prevent hypotension, bradycardia, and syncope. Norepinephrine 16-30 solute carrier family 6 member 2 Homo sapiens 44-47 32660596-1 2020 BACKGROUND: Currently, the diagnosis and treatment of neuroblastomas-the most frequent solid tumors in children-exploit the norepinephrine transporter (hNET) via radiolabeled norepinephrine analogs. Norepinephrine 124-138 solute carrier family 6 member 2 Homo sapiens 152-156 33315681-2 2021 We identified 2 cases with remarkably changed pulmonary uptake between 2 metaiodobenzylguanidine scintigraphies; pulmonary uptake was reduced when patients were taking selective serotonin reuptake inhibitor/serotonin noradrenaline reuptake inhibitor and preserved during the medication-naive or withdrawal state, suggesting that pulmonary uptake involves not only the noradrenaline transporter, but also the serotonin transporter. Norepinephrine 217-230 solute carrier family 6 member 2 Homo sapiens 368-393 33529804-0 2021 Norepinephrine transporter expressed on mammary epithelial cells incorporates norepinephrine in milk into the cells. Norepinephrine 78-92 solute carrier family 6 member 2 Homo sapiens 0-26 32397701-1 2020 The human norepinephrine transporter (hNET) is a transmembrane protein responsible for reuptake of norepinephrine in presynaptic sympathetic nerve terminals and adrenal chromaffin cells. Norepinephrine 10-24 solute carrier family 6 member 2 Homo sapiens 38-42 32397701-3 2020 Molecular imaging of these tumors can be done using radiolabeled norepinephrine analogs that target hNET. Norepinephrine 65-79 solute carrier family 6 member 2 Homo sapiens 100-104 32339102-1 2020 BACKGROUND: Norepinephrine transporter (NET), which regulates synaptic norepinephrine for noradrenergic signaling, is involved in the pathogenesis of anxiety, while expression of the NET gene differs at different ages. Norepinephrine 71-85 solute carrier family 6 member 2 Homo sapiens 12-38 32339102-1 2020 BACKGROUND: Norepinephrine transporter (NET), which regulates synaptic norepinephrine for noradrenergic signaling, is involved in the pathogenesis of anxiety, while expression of the NET gene differs at different ages. Norepinephrine 71-85 solute carrier family 6 member 2 Homo sapiens 40-43 32339102-1 2020 BACKGROUND: Norepinephrine transporter (NET), which regulates synaptic norepinephrine for noradrenergic signaling, is involved in the pathogenesis of anxiety, while expression of the NET gene differs at different ages. Norepinephrine 71-85 solute carrier family 6 member 2 Homo sapiens 183-186 32274584-7 2020 Most radiotracers targeting cardiac NET-function for the cardiac application consistent of derivatives of either norepinephrine or MIBG with its benzylguanidine core structure, e.g. 11C-HED and 18F-LMI1195. Norepinephrine 113-127 solute carrier family 6 member 2 Homo sapiens 36-39 31931960-7 2019 Metaiodobenzylguanidine (MIBG) is a norepinephrine analog that undergoes active uptake by NET receptors resulting in accumulation in neuroblastoma as well as tissues normally expressing the NET receptor. Norepinephrine 36-50 solute carrier family 6 member 2 Homo sapiens 90-93 31912366-5 2020 Since AMPH is a transported inhibitor of both DAT and the norepinephrine transporter (NET), and EAAT3 is also expressed in norepinephrine (NE) neurons, we explored the possibility that this signaling cascade occurs in NE neurons. Norepinephrine 58-72 solute carrier family 6 member 2 Homo sapiens 86-89 31692668-1 2019 The norepinephrine transporter (NET) is a Na+/Cl- coupled neurotransmitter transporter responsible for reuptake of released norepinephrine (NE) into nerve terminals in the brain, a key therapeutic used in the treatment of psychiatric disorders. Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 29300091-3 2018 Pioneer studies provided valuable information on structure, function, and pharmacology of drugs targeting both hSERT and hNET (serotonin-norepinephrine reuptake inhibitors, SNRIs), and the differential binding mechanism between SNRIs and selective inhibitors of 5-HT (SSRIs) or NE (sNRIs) to their corresponding targets was expected to be able to facilitate the discovery of a privileged drug-like scaffold with improved efficacy. Norepinephrine 137-151 solute carrier family 6 member 2 Homo sapiens 121-125 31075414-2 2019 Recent evidence also indicates that norepinephrine neurotransmission can influence a series of psychophysical and psychobiological parameters related to athletic performance, and the presence of variants in the SLC6A2 (solute carrier family 6 member 2) gene, which encodes the norepinephrine transporter, can be detrimental to an adequate noradrenergic signaling. Norepinephrine 36-50 solute carrier family 6 member 2 Homo sapiens 219-251 31075414-2 2019 Recent evidence also indicates that norepinephrine neurotransmission can influence a series of psychophysical and psychobiological parameters related to athletic performance, and the presence of variants in the SLC6A2 (solute carrier family 6 member 2) gene, which encodes the norepinephrine transporter, can be detrimental to an adequate noradrenergic signaling. Norepinephrine 36-50 solute carrier family 6 member 2 Homo sapiens 277-303 29677047-1 2018 OBJECTIVES: Noradrenaline released from sympathetic nerves is rapidly inactivated via the action of the noradrenaline transporter (NET). Norepinephrine 12-25 solute carrier family 6 member 2 Homo sapiens 104-129 29677047-1 2018 OBJECTIVES: Noradrenaline released from sympathetic nerves is rapidly inactivated via the action of the noradrenaline transporter (NET). Norepinephrine 12-25 solute carrier family 6 member 2 Homo sapiens 131-134 29677047-2 2018 We aimed to determine whether a single nucleotide polymorphism (SNP) in the NET gene, rs7194256, was associated with blood pressure and plasma noradrenaline concentration in patients with resistant hypertension. Norepinephrine 143-156 solute carrier family 6 member 2 Homo sapiens 76-79 29677047-10 2018 CONCLUSION: A SNP in the NET gene in patients with resistant hypertension is associated with higher plasma noradrenaline concentration and elevated SBP. Norepinephrine 107-120 solute carrier family 6 member 2 Homo sapiens 25-28 29198060-2 2018 MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of alpha1-adrenergic receptors. Norepinephrine 105-119 solute carrier family 6 member 2 Homo sapiens 133-136 30238915-2 2018 Ketamine modulates several neurotransmitter systems, including norepinephrine via the norepinephrine transporter (NET), both peripherally and centrally. Norepinephrine 63-77 solute carrier family 6 member 2 Homo sapiens 86-112 30238915-2 2018 Ketamine modulates several neurotransmitter systems, including norepinephrine via the norepinephrine transporter (NET), both peripherally and centrally. Norepinephrine 63-77 solute carrier family 6 member 2 Homo sapiens 114-117 27345145-4 2017 Plasma norepinephrine (NE) is often elevated in patients with POTS, resulting in consideration of dysfunction of the norepinephrine transporter (NET) encoded by SLC6A2 gene. Norepinephrine 7-21 solute carrier family 6 member 2 Homo sapiens 117-143 27345145-4 2017 Plasma norepinephrine (NE) is often elevated in patients with POTS, resulting in consideration of dysfunction of the norepinephrine transporter (NET) encoded by SLC6A2 gene. Norepinephrine 7-21 solute carrier family 6 member 2 Homo sapiens 161-167 26508020-1 2016 BACKGROUND: This is a pilot study assessing the impact of polymorphisms of serotonin transporter (5-HTT; 5-HTTLPR (S/L)) and norepinephrine transporter (NET; rs2242446 (T/C)) genes on selective serotonin reuptake inhibitors (SSRIs) and serotonin/norepinephrine reuptake inhibitors (SNRIs) response in Korean panic disorder (PD) patients. Norepinephrine 125-139 solute carrier family 6 member 2 Homo sapiens 153-156 27046647-1 2017 Norepinephrine released from sympathetic nerves is removed from the neuroeffector junction via the action of the norepinephrine transporter (NET). Norepinephrine 0-14 solute carrier family 6 member 2 Homo sapiens 113-139 27755221-1 2016 To assess the primary metabolite of norepinephrine, 3,4-dihydroxyphenylglycol (DHPG), as a sensitive biomarker for norepinephrine transporter (NET) function and the relationship of DHPG measured peripherally and centrally, NET was antagonized with 80 mg/d atomoxetine for 18 days. Norepinephrine 36-50 solute carrier family 6 member 2 Homo sapiens 115-141 26207133-1 2015 OBJECTIVE: Norepinephrine is an important chemical messenger that is involved in mood and stress in humans, and is reabsorbed by the norepinephrine transporter (NET). Norepinephrine 11-25 solute carrier family 6 member 2 Homo sapiens 133-159 26207133-1 2015 OBJECTIVE: Norepinephrine is an important chemical messenger that is involved in mood and stress in humans, and is reabsorbed by the norepinephrine transporter (NET). Norepinephrine 11-25 solute carrier family 6 member 2 Homo sapiens 161-164 25175627-1 2015 Neuroblastoma is unique amongst common pediatric cancers for its expression of the norepinephrine transporter (NET), enabling tumor-selective imaging and therapy with radioactive analogues of norepinephrine. Norepinephrine 83-97 solute carrier family 6 member 2 Homo sapiens 111-114 24263237-14 2014 CONCLUSIONS: The unique molecular pharmacological profile of dezocine as a partial mu-receptor agonist, a kappa-receptor antagonist, and a norepinephrine and serotonin reuptake inhibitor (via norepinephrine transporter and serotonin transporter) was revealed. Norepinephrine 139-153 solute carrier family 6 member 2 Homo sapiens 192-218 25295552-4 2014 Response to venlafaxine was assessed after 4 weeks of treatment and correlated to serum concentration and functional variants in genes encoding the norepinephrine (SLC6A2; rs28386840) and the serotonin transporter (SLC6A4; [5-HTTLPR], rs25531). Norepinephrine 148-162 solute carrier family 6 member 2 Homo sapiens 164-170 24573553-2 2014 Although the norepinephrine analog, meta-iodobenzylguanidine (MIBG), is an established substrate for NET, (123)I/(131)I-MIBG has several clinical limitations for diagnostic imaging. Norepinephrine 13-27 solute carrier family 6 member 2 Homo sapiens 101-104 24900709-1 2013 The objective of the described research effort was to identify a novel serotonin and norepinephrine reuptake inhibitor (SNRI) with improved norepinephrine transporter activity and acceptable metabolic stability and exhibiting minimal drug-drug interaction. Norepinephrine 85-99 solute carrier family 6 member 2 Homo sapiens 140-166 23583454-4 2013 3,4-Methylenedioxypyrovalerone and naphyrone had high affinity for radioligand binding sites on recombinant human dopamine (hDAT), serotonin (hSERT) and norepinephrine (hNET) transporters, potently inhibited [3H]neurotransmitter uptake, and, like cocaine, did not induce transporter-mediated release. Norepinephrine 153-167 solute carrier family 6 member 2 Homo sapiens 169-173 24121204-2 2014 The norepinephrine transporter (NET) regulates the synaptic availability of norepinephrine. Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 21983350-3 2011 Because serotonin and norepinephrine systems have been shown to be structurally and functionally highly interrelated, we also examined a novel polymorphism in the promoter region of the norepinephrine transporter gene (NET -3081) in anticipation of epistatic effects. Norepinephrine 22-36 solute carrier family 6 member 2 Homo sapiens 186-212 23086945-1 2012 The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain. Norepinephrine 41-55 solute carrier family 6 member 2 Homo sapiens 69-72 23023867-1 2012 Approximately 80-90% of the norepinephrine released in the brain or in peripheral tissues is taken up again through the neuronal norepinephrine transporter (NET). Norepinephrine 28-42 solute carrier family 6 member 2 Homo sapiens 129-155 23023867-1 2012 Approximately 80-90% of the norepinephrine released in the brain or in peripheral tissues is taken up again through the neuronal norepinephrine transporter (NET). Norepinephrine 28-42 solute carrier family 6 member 2 Homo sapiens 157-160 22480387-8 2012 CONCLUSIONS: Our findings further support the hypothesis that the synergistic effect of olanzapine and fluoxetine on prefrontal cortical levels of norepinephrine and dopamine might be an underlying mechanism for the efficacy of olanzapine-fluoxetine combination in the treatment of treatment-resistant depression and, if replicated, may form a basis on which response to olanzapine-fluoxetine combination versus continued fluoxetine can be predicted based on variants in SLC6A2. Norepinephrine 147-161 solute carrier family 6 member 2 Homo sapiens 471-477 22311903-11 2012 In conclusion, the combination of yohimbine and atomoxetine had a synergistic effect on blood pressure and orthostatic tolerance in peripheral autonomic failure, which may be explained by an increased release of norepinephrine in peripheral sympathetic neurons by alpha-2 antagonism combined with a reduced norepinephrine clearance by norepinephrine transporter blockade. Norepinephrine 212-226 solute carrier family 6 member 2 Homo sapiens 335-361 22155208-7 2012 Similar to amphetamine, amantadine was inactive at alpha(2A)-adrenergic receptors and induced reverse noradrenaline transport by NAT albeit with smaller effect size. Norepinephrine 102-115 solute carrier family 6 member 2 Homo sapiens 129-132 23421681-4 2013 The 6-position of serotonin and the para-hydroxyl groups of dopamine and norepinephrine were found to face Ala173 in hSERT, Gly153 in hDAT, and Gly149 in hNET. Norepinephrine 73-87 solute carrier family 6 member 2 Homo sapiens 154-158 23421681-7 2013 Uptake experiments support that the 5-hydroxyl group of serotonin and the meta-hydroxyl group norepinephrine and dopamine are placed in the hydrophilic pocket around Ala173, Ser438, and Thr439 in hSERT corresponding to Gly149, Ser419, Ser420 in hNET and Gly153 Ser422 and Ala423 in hDAT. Norepinephrine 94-108 solute carrier family 6 member 2 Homo sapiens 245-249 22874414-0 2012 A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter. Norepinephrine 44-58 solute carrier family 6 member 2 Homo sapiens 82-108 22566195-1 2012 Tumor-specific uptake of the radiolabeled nor-epinephrine analogue meta-iodobenzylguanidine via norepinephrine transporter or radiolabeled somatostatin analogues octreotide/octreotate via somatostatin receptors offers possibilities to diagnose and treat metastatic pheochromocytoma/paraganglioma. Norepinephrine 42-57 solute carrier family 6 member 2 Homo sapiens 96-122 22414636-6 2012 To enhance its therapeutic potential, we have engineered HSV1716 to convey the noradrenaline transporter (NAT) gene (HSV1716/NAT), whose expression endows infected cells with the capacity to accumulate the noradrenaline analog metaiodobenzylguanidine (MIBG). Norepinephrine 79-92 solute carrier family 6 member 2 Homo sapiens 106-109 22414636-6 2012 To enhance its therapeutic potential, we have engineered HSV1716 to convey the noradrenaline transporter (NAT) gene (HSV1716/NAT), whose expression endows infected cells with the capacity to accumulate the noradrenaline analog metaiodobenzylguanidine (MIBG). Norepinephrine 79-92 solute carrier family 6 member 2 Homo sapiens 125-128 22311903-2 2012 Norepinephrine transporter blockade with atomoxetine raises blood pressure in autonomic failure by increasing synaptic norepinephrine concentrations in postganglionic sympathetic neurons. Norepinephrine 119-133 solute carrier family 6 member 2 Homo sapiens 0-26 21844155-9 2011 Subnormal norepinephrine spillover in low blood pressure phenotype was linked to low tyrosine hydroxylase (43.7% normal, P=0.001), rate-limiting in norepinephrine synthesis, and in normal blood pressure to increased levels of the norepinephrine transporter (135% normal, P=0.019), augmenting transmitter reuptake. Norepinephrine 10-24 solute carrier family 6 member 2 Homo sapiens 230-256 19564048-1 2009 The norepinephrine transporter (NET), which is involved in the neurotransmission of norepinephrine (NE), may play an important role in the development of major depressive disorder (MDD). Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 21885739-1 2011 The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor). Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 21885739-1 2011 The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor). Norepinephrine 48-62 solute carrier family 6 member 2 Homo sapiens 4-30 21885739-1 2011 The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor). Norepinephrine 48-62 solute carrier family 6 member 2 Homo sapiens 32-35 21416264-4 2011 The SLC6A2 gene is located on chromosome 16q12.2 and encodes the norepinephrine transporter (NET), responsible for the reuptake of norepinephrine into presynaptic nerve terminals. Norepinephrine 65-79 solute carrier family 6 member 2 Homo sapiens 4-10 21416264-4 2011 The SLC6A2 gene is located on chromosome 16q12.2 and encodes the norepinephrine transporter (NET), responsible for the reuptake of norepinephrine into presynaptic nerve terminals. Norepinephrine 65-79 solute carrier family 6 member 2 Homo sapiens 93-96 21412203-1 2011 BACKGROUND: The presynaptic norepinephrine transporter (NET) mediates synaptic clearance and recycling of norepinephrine. Norepinephrine 28-42 solute carrier family 6 member 2 Homo sapiens 56-59 20491280-3 2010 The purpose of this study was to determine whether norepinephrine transporter (NET) gene and serotonin transporter (5-HTT) gene polymorphisms are associated with the antidepressant response to milnacipran, a serotonin and norepinephrine reuptake inhibitor. Norepinephrine 51-65 solute carrier family 6 member 2 Homo sapiens 79-82 19573018-7 2009 Transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduced mRNA and protein levels of NET and DBH after shutdown of endogenous Phox2, which was accompanied by a decreased [(3)H]norepinephrine uptake. Norepinephrine 198-212 solute carrier family 6 member 2 Homo sapiens 107-110 19468717-2 2009 We aimed to determine the potential correlations of 5-HTT/NET gene polymorphisms with the susceptibility to depression and the antidepressant response to selective serotonin reuptake inhibitors (SSRIs) or dual selective serotonin/norepinephrine reuptake inhibitors (SNRIs). Norepinephrine 230-244 solute carrier family 6 member 2 Homo sapiens 58-61 19545450-1 2009 BACKGROUND: Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis. Norepinephrine 33-47 solute carrier family 6 member 2 Homo sapiens 86-100 19545450-1 2009 BACKGROUND: Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis. Norepinephrine 33-47 solute carrier family 6 member 2 Homo sapiens 102-105 17673606-1 2007 Desvenlafaxine succinate (DVS) is a recently introduced antagonist of the human norepinephrine and serotonin transporters (hNET and hSERT, respectively), currently in clinical development for use in the treatment of major depressive disorder and vasomotor symptoms associated with menopause. Norepinephrine 80-94 solute carrier family 6 member 2 Homo sapiens 123-127 19212675-2 2009 By microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower expression in unfavorable NB tumor types as compared to favorable ones. Norepinephrine 79-91 solute carrier family 6 member 2 Homo sapiens 154-160 19120127-13 2008 We have demonstrated that the reduced neuronal noradrenaline reuptake present in both disorders does have an epigenetic mechanism, with demonstrable reduction in the abundance of the transporter protein, the NET gene silencing being associated with DNA binding by the methylation-related inhibitory transcription factor MeCP2. Norepinephrine 47-60 solute carrier family 6 member 2 Homo sapiens 208-211 18308800-11 2008 Reversal of impaired executive function by a NET inhibitor implicates the NET and norepinephrine in MDMA-induced cognitive impairment and may be relevant to therapeutic strategies. Norepinephrine 82-96 solute carrier family 6 member 2 Homo sapiens 45-48 16539676-1 2006 For many years, the norepinephrine transporter (NET) was considered a "static" protein that contributed to the termination of the action of norepinephrine in the synapse of noradrenergic neurons. Norepinephrine 20-34 solute carrier family 6 member 2 Homo sapiens 48-51 17379857-1 2007 The noradrenaline transporter (NET) is a Na(+)/Cl(-) dependent monoamine transporter that mediates rapid clearance of noradrenaline from the synaptic cleft, thereby terminating neuronal signaling. Norepinephrine 4-17 solute carrier family 6 member 2 Homo sapiens 31-34 16989291-3 2006 For the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [SERT] or the norepinephrine transporter [NET]). Norepinephrine 109-123 solute carrier family 6 member 2 Homo sapiens 219-245 16515684-2 2006 The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse. Norepinephrine 46-60 solute carrier family 6 member 2 Homo sapiens 82-85 17073682-3 2006 The fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (DAT, NET and SERT) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable NET ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific CNS disorders. Norepinephrine 45-59 solute carrier family 6 member 2 Homo sapiens 219-222 12791828-7 2003 RESULTS: hNET-expressing hepatoma cell lines accumulated up to 36 times more norepinephrine than did wild-type cells and 8 times more than did hNET-expressing neuroblastoma cell line SK-N-SH. Norepinephrine 77-91 solute carrier family 6 member 2 Homo sapiens 9-13 17124432-1 2006 BACKGROUND: Norepinephrine transporter (NET) is involved in the regulation of norepinephrine (NE) turnover and metabolism. Norepinephrine 78-92 solute carrier family 6 member 2 Homo sapiens 12-38 17124432-1 2006 BACKGROUND: Norepinephrine transporter (NET) is involved in the regulation of norepinephrine (NE) turnover and metabolism. Norepinephrine 78-92 solute carrier family 6 member 2 Homo sapiens 40-43 15950014-6 2005 In brain regions expressing both the DAT and the norepinephrine transporter (NET), the relative contributions of dopamine and norepinephrine to ADHD pathophysiology and therapeutic response are obfuscated by the capacity of the NET to clear dopamine as well as norepinephrine. Norepinephrine 49-63 solute carrier family 6 member 2 Homo sapiens 77-80 15950014-6 2005 In brain regions expressing both the DAT and the norepinephrine transporter (NET), the relative contributions of dopamine and norepinephrine to ADHD pathophysiology and therapeutic response are obfuscated by the capacity of the NET to clear dopamine as well as norepinephrine. Norepinephrine 49-63 solute carrier family 6 member 2 Homo sapiens 228-231 15950014-6 2005 In brain regions expressing both the DAT and the norepinephrine transporter (NET), the relative contributions of dopamine and norepinephrine to ADHD pathophysiology and therapeutic response are obfuscated by the capacity of the NET to clear dopamine as well as norepinephrine. Norepinephrine 126-140 solute carrier family 6 member 2 Homo sapiens 77-80 15763139-1 2005 The norepinephrine transporter (NET) is a membrane protein responsible for transporting extracellular norepinephrine. Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 12837768-4 2003 Of 18 mutations where hNET amino acid residues were exchanged with those of the human dopamine transporter, MrIA had increased potency for inhibition of [3H]norepinephrine uptake for three mutations (in predicted extracellular loops 3 and 4 and transmembrane domain (TMD) 8) and decreased potency for one mutation (in TMD6 and intracellular loop (IL) 3). Norepinephrine 157-171 solute carrier family 6 member 2 Homo sapiens 22-26 12837768-7 2003 A comparison of the results with previous data for desipramine and cocaine inhibition of norepinephrine uptake by the mutant hNETs reveals that MrIA binding to hNET occurs at a site that is distinct from but overlaps with the binding sites for tricyclic antidepressants and cocaine. Norepinephrine 89-103 solute carrier family 6 member 2 Homo sapiens 125-129 16722247-1 2006 The norepinephrine transporter (NET) terminates noradrenergic signalling by rapid re-uptake of neuronally released norepinephrine (NE) into presynaptic terminals. Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 16449406-8 2006 Noradrenaline and adrenaline plasma clearance and plasma tritiated noradrenaline and adrenaline extraction in transit through the heart, all dependent on the noradrenaline transporter (NET), were reduced in PD. Norepinephrine 0-13 solute carrier family 6 member 2 Homo sapiens 158-183 16449406-8 2006 Noradrenaline and adrenaline plasma clearance and plasma tritiated noradrenaline and adrenaline extraction in transit through the heart, all dependent on the noradrenaline transporter (NET), were reduced in PD. Norepinephrine 0-13 solute carrier family 6 member 2 Homo sapiens 185-188 15763139-3 2005 The regional distribution of the NET has been defined by synaptosomal uptake of norepinephrine and by autoradiographic approaches in rodent and primate brain. Norepinephrine 80-94 solute carrier family 6 member 2 Homo sapiens 33-36 15763140-1 2005 Binding assays for the norepinephrine (NE) transporter (NET) with [3H]nisoxetine have generally yielded weak potencies for compounds related to cocaine and 1-(2-(di(4-fluorophenyl)-methoxy)-ethyl)-4-(3-phenylpropyl)piperazine (GBR 12909), as compared with their functional activity in inhibiting NE uptake. Norepinephrine 23-37 solute carrier family 6 member 2 Homo sapiens 56-59 16871320-1 2004 The norepinephrine transporter (NET) is located in the plasma membrane of noradrenergic neurons, where it functions to take up synaptically released norepinephrine (NE). Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 15337646-2 2004 The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and serotonin transporter gene (5-HTT) polymorphisms are associated with the antidepressant response to milnacipran, a dual serotonin/norepinephrine reuptake inhibitor. Norepinephrine 58-72 solute carrier family 6 member 2 Homo sapiens 91-94 14726430-1 2004 Norepinephrine transporter (NET) function has a central role in the regulation of synaptic norepinephrine concentrations. Norepinephrine 91-105 solute carrier family 6 member 2 Homo sapiens 0-26 14726430-1 2004 Norepinephrine transporter (NET) function has a central role in the regulation of synaptic norepinephrine concentrations. Norepinephrine 91-105 solute carrier family 6 member 2 Homo sapiens 28-31 14726430-10 2004 In contrast, NET inhibition resulted in a similar suppression in the cold pressor and handgrip response, low-frequency blood pressure oscillations, and venous norepinephrine in the supine position. Norepinephrine 159-173 solute carrier family 6 member 2 Homo sapiens 13-16 14726430-13 2004 Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. Norepinephrine 62-76 solute carrier family 6 member 2 Homo sapiens 34-37 15164608-1 2004 Following exocytotic release of the biogenic amine neurotransmitters, norepinephrine and dopamine, are removed from the synaptic cleft by the respective transporter, norepinephrine transporter (NET) and dopamine transporter (DAT) located on the plasma membrane. Norepinephrine 70-84 solute carrier family 6 member 2 Homo sapiens 166-192 12791828-12 2003 CONCLUSION: Transduction of the hNET gene enables Morris hepatoma cells to accumulate norepinephrine and MIBG. Norepinephrine 86-100 solute carrier family 6 member 2 Homo sapiens 32-36 12805287-1 2003 The norepinephrine transporter (NET) mediates reuptake of norepinephrine released from neurons, and, as such, it is an important regulator of noradrenergic neurotransmission. Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 12401556-2 2002 At the cellular level, functional noradrenergic neurotransmission depends on synaptic reuptake of norepinephrine as mediated by the norepinephrine transporter (NET). Norepinephrine 98-112 solute carrier family 6 member 2 Homo sapiens 132-158 12401556-2 2002 At the cellular level, functional noradrenergic neurotransmission depends on synaptic reuptake of norepinephrine as mediated by the norepinephrine transporter (NET). Norepinephrine 98-112 solute carrier family 6 member 2 Homo sapiens 160-163 11919656-5 2002 The K(m) of noradrenaline was lower for hNET, rK7D, rE62K and rK375N than for rNET or rR612Q. Norepinephrine 12-25 solute carrier family 6 member 2 Homo sapiens 40-44 11923423-1 2002 Expression of the norepinephrine transporter (NET), which mediates the reuptake of norepinephrine into presynaptic nerve terminals, is restricted to noradrenergic (NA) neurons. Norepinephrine 18-32 solute carrier family 6 member 2 Homo sapiens 46-49 9928902-1 1998 The norepinephrine transporter (NET) plays a critical role in brain norepinephrine homeostasis and is a target for antidepressants and drugs of abuse. Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 11804991-1 2002 BACKGROUND: Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance. Norepinephrine 70-84 solute carrier family 6 member 2 Homo sapiens 98-101 11082428-1 2000 Certain antidepressant and psychostimulant drugs block the uptake of norepinephrine from the synaptic cleft by inhibiting norepinephrine transporter (NET) function. Norepinephrine 69-83 solute carrier family 6 member 2 Homo sapiens 122-148 11082428-1 2000 Certain antidepressant and psychostimulant drugs block the uptake of norepinephrine from the synaptic cleft by inhibiting norepinephrine transporter (NET) function. Norepinephrine 69-83 solute carrier family 6 member 2 Homo sapiens 150-153 11082428-9 2000 [(3)H]Nisoxetine binding to NET and NET protein levels were also reduced by exposure of cells to high concentrations of norepinephrine, although norepinephrine exposures were accompanied by changes indicative of cellular toxicity. Norepinephrine 120-134 solute carrier family 6 member 2 Homo sapiens 28-31 11082428-9 2000 [(3)H]Nisoxetine binding to NET and NET protein levels were also reduced by exposure of cells to high concentrations of norepinephrine, although norepinephrine exposures were accompanied by changes indicative of cellular toxicity. Norepinephrine 120-134 solute carrier family 6 member 2 Homo sapiens 36-39 10037744-1 1999 The synaptic action of norepinephrine is terminated by NaCl-dependent uptake into presynaptic noradrenergic nerve endings, mediated by the norepinephrine transporter (NET). Norepinephrine 23-37 solute carrier family 6 member 2 Homo sapiens 139-165 10037744-1 1999 The synaptic action of norepinephrine is terminated by NaCl-dependent uptake into presynaptic noradrenergic nerve endings, mediated by the norepinephrine transporter (NET). Norepinephrine 23-37 solute carrier family 6 member 2 Homo sapiens 167-170 10037744-2 1999 NET is expressed only in neuronal tissues that synthesize and secrete norepinephrine and in most cases is co-expressed with the norepinephrine-synthetic enzyme dopamine beta-hydroxylase (DBH). Norepinephrine 70-84 solute carrier family 6 member 2 Homo sapiens 0-3 10037744-2 1999 NET is expressed only in neuronal tissues that synthesize and secrete norepinephrine and in most cases is co-expressed with the norepinephrine-synthetic enzyme dopamine beta-hydroxylase (DBH). Norepinephrine 128-142 solute carrier family 6 member 2 Homo sapiens 0-3 9676821-7 1998 The results suggest that SERT and NET genotypes may participate differentially in the regulation of the norepinephrine turnover rate under presumed steady-state conditions in the central nervous system. Norepinephrine 104-118 solute carrier family 6 member 2 Homo sapiens 34-37 11875370-6 2002 Compared with the wild-type hNET, the maximum rate (V(max)) of norepinephrine uptake by the Ala(457)Pro variant was slightly reduced, whereas the turnover number (calculated from V(max)/B(max)) was approximately two-fold higher. Norepinephrine 63-77 solute carrier family 6 member 2 Homo sapiens 28-32 11875370-7 2002 However, the Ala(457)Pro variant exhibited a 50-fold higher K(m) (i.e. lower apparent affinity) for norepinephrine than the wild-type hNET. Norepinephrine 100-114 solute carrier family 6 member 2 Homo sapiens 134-138 11333263-1 2001 The norepinephrine transporter (NET) is responsible for the rapid NaCl-dependent uptake of norepinephrine into presynaptic noradrenergic nerve endings. Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 10898109-5 2000 However, COS-7 cells expressing the hNET variant Gly478Ser displayed an approximately four-fold increase in the Km for norepinephrine, while the Vmax was unaffected. Norepinephrine 119-133 solute carrier family 6 member 2 Homo sapiens 36-40 10898109-6 2000 The increase in the Km, which is equivalent to a four-fold reduction in the affinity of the variant hNET for its natural substrate norepinephrine, indicates that the glycine in position 478 is part of a substrate recognition domain. Norepinephrine 131-145 solute carrier family 6 member 2 Homo sapiens 100-104 7500004-1 1995 Transport of norepinephrine (NE+) by cocaine- and antidepressant-sensitive transporters in presynaptic terminals is predicted to involve the cotransport of Na+ and Cl-, resulting in a net movement of charge per transport cycle. Norepinephrine 13-27 solute carrier family 6 member 2 Homo sapiens 184-187 9334417-1 1997 The norepinephrine transporter (NET) is a membrane protein responsible for termination of the action of synaptic norepinephrine and is a site of action of many drugs used to treat major depression. Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 32-35 9092590-1 1997 Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively. Norepinephrine 40-56 solute carrier family 6 member 2 Homo sapiens 205-208 9092590-1 1997 Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively. Norepinephrine 58-62 solute carrier family 6 member 2 Homo sapiens 205-208 8794928-1 1996 Rotating disk electrode (RDE) voltammetry is applied to the measurement of the transport of the catecholamine neurotransmitters norepinephrine (4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, NE) and dopamine (3,4-dihydroxyphenethylamine, DA) in suspensions of LLC-NET cells, a line of porcine kidney cells expressing the human norepinephrine transporter (hNET). Norepinephrine 128-142 solute carrier family 6 member 2 Homo sapiens 261-264 8794928-1 1996 Rotating disk electrode (RDE) voltammetry is applied to the measurement of the transport of the catecholamine neurotransmitters norepinephrine (4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, NE) and dopamine (3,4-dihydroxyphenethylamine, DA) in suspensions of LLC-NET cells, a line of porcine kidney cells expressing the human norepinephrine transporter (hNET). Norepinephrine 128-142 solute carrier family 6 member 2 Homo sapiens 324-350 8794928-1 1996 Rotating disk electrode (RDE) voltammetry is applied to the measurement of the transport of the catecholamine neurotransmitters norepinephrine (4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, NE) and dopamine (3,4-dihydroxyphenethylamine, DA) in suspensions of LLC-NET cells, a line of porcine kidney cells expressing the human norepinephrine transporter (hNET). Norepinephrine 128-142 solute carrier family 6 member 2 Homo sapiens 352-356 8710929-5 1996 Here we report channel-like events from a presumably fixed stoichiometry [norepinephrine (NE)+, Na+, and Cl-], human NE (hNET) in the gamma-aminobutyric acid transporter gene family. Norepinephrine 74-88 solute carrier family 6 member 2 Homo sapiens 121-125 8667208-8 1996 In contradistinction, the toxicity of MPTP at the noradrenaline neurons in the primate cerebral cortex (Pifl et al., 1991) may involve the higher affinity of MPP+ for the noradrenaline transporter. Norepinephrine 50-63 solute carrier family 6 member 2 Homo sapiens 171-196 7905857-1 1993 The norepinephrine transporter protein (NET) is the presynaptic reuptake site for norepinephrine and a site of action for several drugs with CNS effects, some of which are therapeutically useful and some of which are drugs of abuse. Norepinephrine 4-18 solute carrier family 6 member 2 Homo sapiens 40-43 8315492-6 1993 MIBG uptake in hNET transfected cells is inhibited by 3 x 10(-6) M norepinephrine (87% inhibition) and by hNET transport inhibitors: 10(-7) M desipramine (94% inhibition) and 10(-7) M mazindol (97% inhibition). Norepinephrine 67-81 solute carrier family 6 member 2 Homo sapiens 15-19