PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2906696-7 1988 Thus, stimulation of this receptor reduces noradrenaline overflow, and hence diminishes beta-adrenoceptor mediated increases in renin. Norepinephrine 43-56 renin Homo sapiens 128-133 2679773-0 1989 Humoral effect of norepinephrine on renin release in humans. Norepinephrine 18-32 renin Homo sapiens 36-41 2528578-7 1989 Plasma renin activity (PRA) was assessed by radio-immunoassay of generated angiotensin I and arterial noradrenaline concentrations using high-performance liquid chromatography (HPLC). Norepinephrine 102-115 renin Homo sapiens 7-12 3071599-0 1988 Norepinephrine and calcium responses to altered sodium intake in modulating and non-modulating high-renin hypertension. Norepinephrine 0-14 renin Homo sapiens 100-105 2529058-9 1989 Direct correlations between the percent changes in forearm vascular resistance and those in plasma norepinephrine and plasma renin activity were found only in normal subjects in control conditions but were not observed after sympathetic blockade. Norepinephrine 99-113 renin Homo sapiens 125-130 2853744-1 1988 The relationship between changes in the pressor response to infused noradrenaline induced by intravenous injection of ouabain, an Na+,K+-ATPase inhibitor, and plasma renin activity and plasma ionized calcium was examined in 16 normotensive subjects and in 16 patients with essential hypertension. Norepinephrine 68-81 renin Homo sapiens 166-171 2853744-7 1988 The changes in the pressor response to noradrenaline induced by the injection of ouabain was significantly smaller in essential hypertensives, particularly in low-renin hypertensives, compared with normotensives. Norepinephrine 39-52 renin Homo sapiens 163-168 3394838-6 1988 Vasopressin increased from 1.2 +/- 0.3 to 137 +/- 45 pg/ml and renin activity increased from 1.45 +/- 4.0 to 3.80 +/- 1.0 ng.ml-1.h-1 with no further changes in epinephrine, norepinephrine, and vasoactive intestinal polypeptide. Norepinephrine 174-188 renin Homo sapiens 63-68 2848203-9 1988 Furthermore, the beta 2-adrenoceptor-induced facilitation of noradrenaline release may in part be mediated by local stimulation of angiotensin II synthesis, which may occur by increased formation or activation of renin and/or increased availability of angiotensinogen. Norepinephrine 61-74 renin Homo sapiens 213-218 2902135-3 1988 In all three situations, renin activity was closely correlated with noradrenaline levels in the phaeochromocytoma patients (r = 0.545, r = 0.600, and r = 0.739; P less than 0.01) but not in the subjects with primary hypertension or in the volunteers. Norepinephrine 68-81 renin Homo sapiens 25-30 3294177-7 1988 In patients with essential hypertension, intracellular sodium and free calcium concentrations were negatively correlated with plasma renin activity (r = -0.66, p less than 0.001; r = -0.60, p less than 0.001, plasma norepinephrine concentration. Norepinephrine 216-230 renin Homo sapiens 133-138 2902135-6 1988 These findings show that in phaeochromocytoma, hypertension is accompanied by high renin levels and that renin release is stimulated in response to noradrenaline overflow. Norepinephrine 148-161 renin Homo sapiens 105-110 2975466-6 1988 The increase in plasma renin activity that followed the reduction in central venous pressure was drastically attenuated in four patients who had undergone cardiac transplantation, along with other reflex effects (changes in forearm vascular resistance and plasma norepinephrine) of cardiopulmonary receptor manipulations. Norepinephrine 263-277 renin Homo sapiens 23-28 2850686-0 1988 [Beta adrenergic receptor-induced stimulation of the vascular renin-angiotensin system: significance for noradrenaline liberation and the mechanism of action of angiotensin-converting enzyme inhibitors]. Norepinephrine 105-118 renin Homo sapiens 62-67 2485066-4 1987 There was a slight but significant increase in plasma noradrenaline as renin became inhibited: plasma adrenaline was unchanged. Norepinephrine 54-67 renin Homo sapiens 71-76 3017854-0 1986 Vascular responses to ouabain and norepinephrine in low and normal renin hypertension. Norepinephrine 34-48 renin Homo sapiens 67-72 6356743-14 1983 There was a positive correlation between the mean increment in active renin and in norepinephrine levels in diabetic patients. Norepinephrine 83-97 renin Homo sapiens 70-75 3910726-4 1985 There was a slight but significant increase in plasma noradrenaline as renin became inhibited; plasma adrenaline was unchanged. Norepinephrine 54-67 renin Homo sapiens 71-76 3938249-7 1985 At variance with primary hypertensive and normal volunteers, renin was tightly correlated with noradrenaline in patients with phaeochromocytoma (r" = .54, r" = .60, and r" = .74 in supine position, after standing and after walking 1 h, p less than .01). Norepinephrine 95-108 renin Homo sapiens 61-66 6204165-2 1984 With a high salt intake, plasma catecholamine levels were lower at each grade of exercise; the norepinephrine-renin response curve was shifted to the right and the norepinephrine-heart rate response curve to the left. Norepinephrine 95-109 renin Homo sapiens 110-115 6681179-5 1983 Circulating norepinephrine correlated in a positive fashion with renin before and after operation. Norepinephrine 12-26 renin Homo sapiens 65-70 3514728-8 1986 Norepinephrine levels were elevated in all patients (694 +/- 110 pg/ml) and correlated with baseline stroke volume index (r = 0.75, p less than 0.025) and plasma renin activity (r = 0.67, p less than 0.05). Norepinephrine 0-14 renin Homo sapiens 162-167 7048470-0 1982 [Plasma noradrenaline concentration in essential hypertension-with particular references to age, plasma renin activity and spontaneous fall of blood pressure (author"s transl)]. Norepinephrine 8-21 renin Homo sapiens 104-109 6755251-3 1982 A positive correlation between plasma norepinephrine and plasma renin activity, as well as between norepinephrine and aldosterone, was observed. Norepinephrine 38-52 renin Homo sapiens 64-69 7176332-1 1982 The cardiovascular pressor responsiveness to infused norepinephrine (NE) or angiotensin II (AII) as related to endogenous plasma NE or renin levels was assessed in 20 patients with mild parenchymal kidney disease (plasma creatinine 2.20 +/- 0.58 mg/dl, +/- SEM) and in 20 normal subjects approximately matched for sex and age. Norepinephrine 53-67 renin Homo sapiens 135-140 6752473-4 1982 Plasma norepinephrine (P-NE) levels increased in proportion to the severity of CHF (p less than 0.001) and had a positive correlation with systemic vascular resistance (SVR) (p less than 0.01), VP (p less than 0.05), pulmonary artery wedge pressure (PWP) (p less than 0.01) and plasma renin activity (PRA) (p less than 0.01). Norepinephrine 7-21 renin Homo sapiens 285-290 6752474-5 1982 There is a positive correlation between plasma norepinephrine and active plasma renin during graded exercise (r = 0.916, p less than 0.01). Norepinephrine 47-61 renin Homo sapiens 80-85 6345203-4 1983 The renin increase was neurogenic because plasma norepinephrine increased, the response was abolished by beta blockade, and renin did not increase in patients with denervated transplanted kidneys. Norepinephrine 49-63 renin Homo sapiens 4-9 7030951-5 1981 There was a significant correlation between percent increments in plasma renin activity (PRA) and the rise in plasma norepinephrine (r = 0.68, p less than 0.05) and a close negative correlation between percent increase in PRA and the ratio of fall in mean blood pressure (MAP) per unit of weight loss (r = -0.73, p less than 0.005). Norepinephrine 117-131 renin Homo sapiens 73-78 7021039-6 1981 Mean plasma noradrenaline concentration was higher in initial hypertensive subjects with a high active renin concentration than in those with a normal renin concentration (442 +/- 70 vs 324 +/- 100 pg/ml). Norepinephrine 12-25 renin Homo sapiens 103-108 7021039-6 1981 Mean plasma noradrenaline concentration was higher in initial hypertensive subjects with a high active renin concentration than in those with a normal renin concentration (442 +/- 70 vs 324 +/- 100 pg/ml). Norepinephrine 12-25 renin Homo sapiens 151-156 7036720-0 1981 Sodium intake alters the effects of norepinephrine on the renin system and the kidney. Norepinephrine 36-50 renin Homo sapiens 58-63 6266691-7 1981 The plasma renin activity increased from 12.6 +/- 5.0 to 29.9 +/- 8.4 ng/ml/hr (p = 0.030) as plasma aldosterone concentration decreased from 30.5 +/- 6.5 to 11.3 4/- 1.2 ng/dl (p = 0.010) and norepinephrine concentrations decreased from 774 +/- 105 to 618 +/- 85 pg/ml (p = 0.020). Norepinephrine 193-207 renin Homo sapiens 11-16 282093-13 1978 In white hypertensives plasma noradrenaline and renin activity were significantly correlated. Norepinephrine 30-43 renin Homo sapiens 48-53 7020260-4 1981 Though absolutely normal, noradrenaline in high renin essential hypertension was significantly higher than in low renin essential hypertension; it correlated neither with age nor blood pressure. Norepinephrine 26-39 renin Homo sapiens 48-53 7204569-9 1981 Marked increases in epinephrine and slight increases in norepinephrine were associated with increases in plasma glucose and renin activity and decreases in plasma potassium. Norepinephrine 56-70 renin Homo sapiens 124-129 6998868-1 1980 The acute responsiveness of plasma catecholamine, renin (PRA), and aldosterone levels to exogenous norepinephrine was studied under placebo conditions and following renin (PRA), and aldosterone levels to exogenous norepinephrine was studied under placebo conditions and following renin-angiotensin activation by diuretic pretreatment in 25 normal subjects and 34 patients with borderline-to-moderate essential hypertension. Norepinephrine 99-113 renin Homo sapiens 50-55 6998868-8 1980 These findings demonstrate that an acute increase in the blood levels of the adrenergic neurotransmittor, norepinephrine, causes mild but distinct stimulation of plasma renin and aldosterone levels. Norepinephrine 106-120 renin Homo sapiens 169-174 6998868-9 1980 Renin release in response to exogenous norepinephrine is not enhanced following renin-angiotensin activation by diuretic pretreatment. Norepinephrine 39-53 renin Homo sapiens 0-5 6998868-10 1980 The responsiveness of the renin-angiotensin-aldosterone system to an acute norepinephrine input seems to be intact in essential hypertension. Norepinephrine 75-89 renin Homo sapiens 26-31 6997978-0 1980 Plasma noradrenaline concentration in hypertensive and normotensive forty-year-old individuals: relationship to plasma renin concentration. Norepinephrine 7-20 renin Homo sapiens 119-124 396070-0 1979 Plasma noradrenaline concentration in hypertensive and normotensive 40-year-old individuals: relationship to plasma renin concentration. Norepinephrine 7-20 renin Homo sapiens 116-121 396070-6 1979 In the hypertensive group a close correlation (r = 0.77, P less than 0.001) was found between plasma noradrenaline and plasma renin concentration after acute stimulation. Norepinephrine 101-114 renin Homo sapiens 126-131 399456-6 1979 Young white hypertensive patients (< 45 years) had higher plasma noradrenaline than controls, and in white hypertensives plasma noradrenaline was positively correlated with plasma renin. Norepinephrine 131-144 renin Homo sapiens 183-188 215376-0 1978 Plasma noradrenaline and adrenaline and beta-adrenoreceptor responsiveness in renin subgroups of essential hypertension. Norepinephrine 7-20 renin Homo sapiens 78-83 6987097-0 1980 [Studies on the blood pressure control mechanism in essential hypertension: the relation of plasma norepinephrine concentrations to plasma renin activity and haemodynamics (author"s transl)]. Norepinephrine 99-113 renin Homo sapiens 139-144 512062-0 1979 Blood pressure response to norepinephrine infusion in relationship to plasma catecholamines and renin activity in man. Norepinephrine 27-41 renin Homo sapiens 96-101 499312-2 1979 There was a significant fall (mean +/- SD) in the 24 h urinary excretion of vanillylmandelic acid (15.3 +/- 2.8 to 6.7 +/- 1.9 micronmol) noradrenaline (199.0 +/- 105.8 to 125.2 +/- 43.3 nmol) and plasma renin activity (0.71 +/- 0.47 to 0.40 +/- 0.20 pmol Angio I ml-1 h-1) while the urinary normetadrenaline/noradrenaline ratio increased (10.4 +/- 6.1 to 17.1 +/- 5.1). Norepinephrine 138-151 renin Homo sapiens 204-209 282107-0 1978 Relationship of basal plasma noradrenaline to blood pressure, age, sex, plasma renin activity and plasma volume in essential hypertension. Norepinephrine 29-42 renin Homo sapiens 79-84 282107-7 1978 Basal plasma noradrenaline concentration was significantly higher in high renin essential hypertensive subjects compared with those with normal or low plasma renin activity. Norepinephrine 13-26 renin Homo sapiens 74-79 282107-9 1978 Plasma noradrenaline was reduced significantly in relatively young patients with low renin essential hypertension, but appeared to be normal in other low renin subjects. Norepinephrine 7-20 renin Homo sapiens 85-90 282107-11 1978 Basal plasma noradrenaline correlated significantly with blood pressure in patients with normal or low renin essential hypertension but the relationships were only significant in male patients. Norepinephrine 13-26 renin Homo sapiens 103-108 690418-4 1978 Significantly greater levels of plasma norepinephrine were present in patients with high plasma renin activity and lesser levels in patients with low renin activity than in normal renin or labile hypertensives. Norepinephrine 39-53 renin Homo sapiens 96-101 690418-4 1978 Significantly greater levels of plasma norepinephrine were present in patients with high plasma renin activity and lesser levels in patients with low renin activity than in normal renin or labile hypertensives. Norepinephrine 39-53 renin Homo sapiens 150-155 690418-4 1978 Significantly greater levels of plasma norepinephrine were present in patients with high plasma renin activity and lesser levels in patients with low renin activity than in normal renin or labile hypertensives. Norepinephrine 39-53 renin Homo sapiens 150-155 690418-5 1978 Blood pressure correlated significantly with plasma norepinephrine in male patients with normal renin essential hypertension but not in females. Norepinephrine 52-66 renin Homo sapiens 96-101 731871-2 1978 The urinary excretion of noradrenaline was increased in patients with elevated peripheral plasma renin activity and in those with elevated renal vein renin ratio in comparison with the patients with normal plasma renin activity. Norepinephrine 25-38 renin Homo sapiens 97-102 731871-2 1978 The urinary excretion of noradrenaline was increased in patients with elevated peripheral plasma renin activity and in those with elevated renal vein renin ratio in comparison with the patients with normal plasma renin activity. Norepinephrine 25-38 renin Homo sapiens 150-155 731871-2 1978 The urinary excretion of noradrenaline was increased in patients with elevated peripheral plasma renin activity and in those with elevated renal vein renin ratio in comparison with the patients with normal plasma renin activity. Norepinephrine 25-38 renin Homo sapiens 150-155 624999-4 1978 Noradrenaline elicited a marked increase in renin secretion in the absence of any discernible alterations in renal arterial pressure, and prolonged perfusion with Ca-free Locke solution failed to depress noradrenaline-evoked renin secretion. Norepinephrine 0-13 renin Homo sapiens 44-49 653304-0 1978 Renin stimulation by passive tilting: the influence of an anti-gravity suit on postural changes in plasma renin activity, plasma noradrenaline concentration and kidney function in normal man. Norepinephrine 129-142 renin Homo sapiens 0-5 624999-0 1978 Stimulation of renin secretion and calcium efflux from the isolated perfused cat kidney by noradrenaline after prolonged calcium deprivation. Norepinephrine 91-104 renin Homo sapiens 15-20 624999-7 1978 Increasing the noradrenaline concentration produced graded increases in 45Ca efflux and renin release, and the peak rise in efflux preceded or coincided with peak renin secretion. Norepinephrine 15-28 renin Homo sapiens 88-93 624999-2 1978 The effects of noradrenaline on the secretion of renin and on the efflux of Ca have been investigated in the isolated cat kidney perfused with Locke solution containing the alpha-adrenergic blocking agent, phenoxybenzamine, to block increases in renal vascular resistance. Norepinephrine 15-28 renin Homo sapiens 49-54 624999-7 1978 Increasing the noradrenaline concentration produced graded increases in 45Ca efflux and renin release, and the peak rise in efflux preceded or coincided with peak renin secretion. Norepinephrine 15-28 renin Homo sapiens 163-168 624999-9 1978 DL-Propranolol inhibited the increase in 45Ca efflux and renin release resulting from noradrenaline stimulation. Norepinephrine 86-99 renin Homo sapiens 57-62 865132-4 1977 When high-renin hypertensive patients with increased levels of norepinephrine were compared with those having high renin and normal levels of norepinephrine, they showed a lesser decrease in mean arterial pressure--5 +/- 5% versus 14 +/- 4%, P less than 0.05--a decrease in plasma renin activity of 20 +/- 17% versus an increase of 77 +/- 24% (P less than 0.01), and a decrease in norepinephrine levels of 42 +/- 7% versus an increase of 10 +/- 23% (P less than 0.05) (means +/- SE). Norepinephrine 63-77 renin Homo sapiens 10-15 754399-4 1978 High renin patients had significantly elevated levels of basal plasma norepinephrine. Norepinephrine 70-84 renin Homo sapiens 5-10 754399-5 1978 In addition, a sub-group of the low renin population who were relatively young had reduced plasma norepinephrine conentration. Norepinephrine 98-112 renin Homo sapiens 36-41 754399-8 1978 Plasma norepinephrine correlated significantly with blood pressure in normal and low renin hypertensives, but the relationships were confined only to male subjects. Norepinephrine 7-21 renin Homo sapiens 85-90 588376-3 1977 In patients with high plasma renin activity the excretion of noradrenaline and adrenaline was relatively high while that of dopamine was low. Norepinephrine 61-74 renin Homo sapiens 29-34 696418-0 1978 Renin release in relation to plasma noradrenaline during supine exercise in cardiac patients. Norepinephrine 36-49 renin Homo sapiens 0-5 33240096-3 2020 Norepinephrine, the main sympathetic neurotransmitter, is released at prejunctional neuroeffector junctions in the kidney and modulates renin release, renal vascular resistance, sodium and water handling, and immune cell response. Norepinephrine 0-14 renin Homo sapiens 136-141 1168515-4 1975 2 Noradrenaline (1.18 times 10-minus 4M) and adrenaline (1.09 times 10-minus 4M) added to the incubation medium stimulated renin production by 45 and 34% respectively, compared with the incubated controls. Norepinephrine 2-15 renin Homo sapiens 123-128 4829861-0 1974 Comparison of the renin response to dopamine and noradrenaline in normal subjects and patients with autonomic insufficiency. Norepinephrine 49-62 renin Homo sapiens 18-23 4304350-0 1969 In vitro stimulation of renin production by epinephrine, norepinephrine, and cyclic AMP. Norepinephrine 57-71 renin Homo sapiens 24-29 6021207-2 1967 Despite concurrent increases in arterial blood pressure, the plasma renin activity of normal subjects increased both in response to the infusion of catecholamines (norepinephrine: epinephrine, 10:1) and in response to stimulation of the sympathetic nervous system by cold. Norepinephrine 164-178 renin Homo sapiens 68-73 1071602-2 1976 Patients with mild essential hypertension and elevated plasma renin activity, when compared with normal subjects and hypertensive subjects with normal plasma renin, demonstrated features of sympathetic nervous cardiovascular excitation, accompanied by a raised plasma noradrenaline concentration. Norepinephrine 268-281 renin Homo sapiens 62-67 1222215-3 1975 High norepinephrine concentration has an inhibitory effect on renin secretion which is reversed by phentolamine: activation of alpha receptors probably decreases renin release. Norepinephrine 5-19 renin Homo sapiens 62-67 1222215-3 1975 High norepinephrine concentration has an inhibitory effect on renin secretion which is reversed by phentolamine: activation of alpha receptors probably decreases renin release. Norepinephrine 5-19 renin Homo sapiens 162-167 1152295-12 1975 Norepinephrine induced significantly greater pressor effect in normal or high renin essential hypertension. Norepinephrine 0-14 renin Homo sapiens 78-83 1152295-13 1975 The adopted dose of norepinephrine suppressed both PRA and PAC and a tendency to the greater fall in PRA was observed in normal or high renin essential hypertension. Norepinephrine 20-34 renin Homo sapiens 136-141 4413101-0 1974 Effect of theophylline and adrenergic blocking drugs on the renin response to norepinephrine in vitro. Norepinephrine 78-92 renin Homo sapiens 60-65 28991825-8 2017 Total concomitant vasopressor requirements, based on norepinephrine equivalents excluding vasopressin, were significantly lower at 24 hours in the renin-angiotensin-aldosterone system inhibitor group versus the non-renin-angiotensin-aldosterone system inhibitor group (10.7 vs 18.1 microg/min, respectively; p = 0.007), but no significant differences were seen at the other time points assessed. Norepinephrine 53-67 renin Homo sapiens 147-152 18087164-2 2008 Ischemia/reperfusion releases this renin leading to local angiotensin formation and norepinephrine release. Norepinephrine 84-98 renin Homo sapiens 35-40 18087164-7 2008 Renin inhibition with BILA2157 did not affect mast cell degranulation, but attenuated norepinephrine release. Norepinephrine 86-100 renin Homo sapiens 0-5 18087164-8 2008 CONCLUSIONS: Our findings disclose that immediate-type hypersensitivity elicits renin release from mast cells, activating a local renin-angiotensin system, thereby promoting norepinephrine release. Norepinephrine 174-188 renin Homo sapiens 80-85 18087164-8 2008 CONCLUSIONS: Our findings disclose that immediate-type hypersensitivity elicits renin release from mast cells, activating a local renin-angiotensin system, thereby promoting norepinephrine release. Norepinephrine 174-188 renin Homo sapiens 130-135 18006623-1 2007 UNLABELLED: The activation of the renin-angiotensin-aldosterone system prevents the uptake of norepinephrine in the myocardium. Norepinephrine 94-108 renin Homo sapiens 34-39 15675318-6 2005 Also, norepinephrine increases sodium reabsorption in proximal tubules, and in part augments renin-aldosterone system that increases sodium reabsorption in distal nephron. Norepinephrine 6-20 renin Homo sapiens 93-98 16284232-1 2006 It has long been proposed that the renin-angiotensin system exerts a stimulatory influence on the sympathetic nervous system, including augmentation of central sympathetic outflow and presynaptic facilitation of norepinephrine release from sympathetic nerves. Norepinephrine 212-226 renin Homo sapiens 35-40 12184059-7 2002 In reality, renin-angiotensin actions on the sympathetic nervous system are probably much more circumscribed than this, with the case perhaps being strongest for a presynaptic action of angiotensin on sympathetic nerves, to augment noradrenaline release. Norepinephrine 232-245 renin Homo sapiens 12-17 12489810-0 2002 Activation of a renin-angiotensin system in ischemic cardiac sympathetic nerve endings and its association with norepinephrine release. Norepinephrine 112-126 renin Homo sapiens 16-21 12766641-12 2003 CONCLUSIONS: In patients who received long-term treatment with renin-angiotensin system inhibitors, intraoperative refractory arterial hypotension was corrected with both terlipressin and norepinephrine. Norepinephrine 188-202 renin Homo sapiens 63-68 12130713-7 2002 Thus, renin is rapidly activated during ischemia in cardiac sympathetic nerve terminals, and this process eventually culminates in angiotensin II formation, stimulation of AT(1) receptors, and carrier-mediated norepinephrine release. Norepinephrine 210-224 renin Homo sapiens 6-11 8682064-8 1995 A study in 804 men with congestive heart failure who received either enalapril or hydralazine plus isosorbide dinitrate showed the greatest reduction in mortality after 2 years in enalapril treated patients with plasma noradrenaline levels > 900 pg.ml-1 or plasma renin levels > 16 ng.ml-1.h-1. Norepinephrine 219-232 renin Homo sapiens 267-272 9915270-9 1999 In addition, sequential measurements of neurohormonal mediator levels in patients receiving calcitriol showed that plasma renin (18.5 +/- 12.7 v 12.3 +/- 11.0 pg/mL; P = 0.007), angiotensin II (AT II; 79.7 +/- 48.6 v 47.2 +/- 45.7 pg/mL; P = 0.001), and atrial natriuretic peptide (ANP; 16.6 +/- 9.7 v 12.2 +/- 4.4 pg/mL; P = 0.03) levels significantly decreased, whereas antidiuretic hormone (ADH), epinephrine, and norepinephrine levels did not change significantly. Norepinephrine 417-431 renin Homo sapiens 122-127 9711055-5 1998 Heart failure results in activation of the renin-angiotensin system as a compensatory mechanism with elevation of circulating angiotensin II, norepinephrine and vasopressin. Norepinephrine 142-156 renin Homo sapiens 43-48 9453523-8 1998 Among patients with cardioinhibitory syncope, norepinephrine concentration rose significantly from baseline to syncope (0.44 +/- 0.12 ng/ml versus 1.14 +/- 0.72 ng/ml; p < 0.05), whereas no significant change was observed in epinephrine (0.08 +/- 0.03 ng/ml versus 2.74 +/- 2.85 ng/ml; p = not significant [NS]), renin (5.68 +/- 3.03 pg/ml versus 19.58 +/- 11.47 pg/ml; p = NS), or aldosterone concentration (66.60 +/- 16.10 ng/ml versus 109.00 +/- 44.70 ng/ml; p = NS). Norepinephrine 46-60 renin Homo sapiens 316-321 9453523-9 1998 Patients with vasodepressor syncope had a significant rise in renin (9.03 +/- 4.56 pg/ml versus 52.53 +/- 41.63 pg/ml; p < 0.05) and aldosterone concentration (95.43 +/- 103.03 ng/ml versus 249.57 +/- 191.54 ng/ml; p < 0.05), whereas no change in level of epinephrine (0.12 +/- 0.12 ng/ml versus 0.28 +/- 0.33 ng/ml; p = NS) or norepinephrine (0.60 +/- 0.26 ng/ml versus 0.86 +/- 0.53 ng/ml; p = NS) was detected. Norepinephrine 334-348 renin Homo sapiens 62-67 9170549-6 1997 Recent studies of the hyperadrenergic (elevated plasma norepinephrine) subgroup of orthostatic intolerance is documenting a clinical spectrum including attenuated plasma renin activity and aldosterone, reduced supine blood volume coupled with dynamic orthostatic hypovolemia, elevated plasma norepinephrine and epinephrine, impaired clearance of norepinephrine from the circulation and evidence of partial dysautonomia. Norepinephrine 55-69 renin Homo sapiens 170-175 8621214-3 1996 A decrease in plasma norepinephrine (from 208 +/- 74 to 142 +/- 52 pg/mL, P < .01) was associated with decreases in plasma renin activity (from 1.06 +/- 0.98 to 0.62 +/- 0.63 ng/mL per hour, P < .01) and serum aldosterone (from 70 +/- 28 to 57 +/- 24 pg/mL, P < .05). Norepinephrine 21-35 renin Homo sapiens 126-131 1418846-7 1992 Plasma renin activity was positively correlated to plasma norepinephrine in the hypertensive women only (r = 0.41, P less than .05). Norepinephrine 58-72 renin Homo sapiens 7-12 8529037-1 1995 Close relations exist between the peripheral dopaminergic system, and the sympathetic nervous and renin-angiotensin-aldosterone system: D1 dopamine receptor stimulation-induced vasodilation may activate the sympathetic nervous and renin-angiotensin system in vivo, presynaptic D2 dopamine receptor stimulation is known to inhibit stimulated norepinephrine release from sympathetic nerve terminals, in experimental conditions both in vitro and in vivo. Norepinephrine 341-355 renin Homo sapiens 98-103 7954098-1 1994 In heart failure, both the sympathetic nervous system and the renin angiotensin system play important pathophysiological roles, and the two systems may interact with each other, e.g., angiotensin II facilitating noradrenaline release. Norepinephrine 212-225 renin Homo sapiens 62-67 15278468-5 1993 There was a significant positive correlation between plasma renin and aldosterone (r = 0.56, P < 0.01) levels in non-cirrhotics, but no correlation was observed in cirrhotics; and there was a significant positive correlation between plasma norepinephrine and arginine vasopressin (r = 0.45, P < 0.05) levels in non-cirrhotics, but no correlation in cirrhotics. Norepinephrine 243-257 renin Homo sapiens 60-65 8489125-2 1993 In patients with low renin essential hypertension, plasma and urinary norepinephrine levels, plasma renin activity and fractional excretion of sodium were significantly lower, while plasma volume, extracellular fluid volume and exchangeable sodium were higher than in normal renin essential hypertension. Norepinephrine 70-84 renin Homo sapiens 21-26 8582385-10 1995 Impairment of left ventricular systolic function was confirmed in 38 of the 50 symptomatic patients (76%) and was associated with increases in plasma concentrations of active renin (58 +/- 8 IU.mol-1, P < 0.001 compared to healthy elderly subjects), angiotensin II (23 +/- 5 pg.ml-1, P < 0.008), noradrenaline (7.7 +/- 1.2 nmol.l-1, P < 0.01) and atrial natriuretic peptide (121 +/- 18 pg.ml-1, P < 0.002). Norepinephrine 302-315 renin Homo sapiens 175-180 8529037-1 1995 Close relations exist between the peripheral dopaminergic system, and the sympathetic nervous and renin-angiotensin-aldosterone system: D1 dopamine receptor stimulation-induced vasodilation may activate the sympathetic nervous and renin-angiotensin system in vivo, presynaptic D2 dopamine receptor stimulation is known to inhibit stimulated norepinephrine release from sympathetic nerve terminals, in experimental conditions both in vitro and in vivo. Norepinephrine 341-355 renin Homo sapiens 231-236 8222516-14 1993 The renin-angiotensin-aldosterone axis was stimulated by noradrenaline in both euhydrated and overhydrated subjects. Norepinephrine 57-70 renin Homo sapiens 4-9 2365484-6 1990 Plasma renin release showed a significant correlation with noradrenaline release in the patients with MVD (r = 0.47, p less than 0.01); but this relationship was lost in the patients with the CAD, due to an excessive noradrenaline release. Norepinephrine 59-72 renin Homo sapiens 7-12 1382170-2 1992 One of the main stimuli for the secretion of renin present in the renal juxtamedullary cells, but also in some other tissues, is provided by the sympathetic nervous system via the action of norepinephrine on beta 1-adrenoceptors. Norepinephrine 190-204 renin Homo sapiens 45-50 1646164-6 1991 After enalaprilat, norepinephrine venoarterial difference increased in the renin-secreting kidney (from 264 to 396, SED = 57 pg/ml, p less than 0.05), whereas it increased only slightly in the contralateral kidney (from 149 to 256, SED = 72 pg/ml, NS). Norepinephrine 19-33 renin Homo sapiens 75-80 1542835-1 1992 Correlation between increased cranial and peripheral norepinephrines and increased cranial to systemic renin ratio has been observed in a small number of patients with postcarotid endarterectomy hypertension. Norepinephrine 53-68 renin Homo sapiens 103-108 1425633-9 1992 The similarity between the changes in concentration of active renin and noradrenaline would suggest that sympathetic nerve activity may have been responsible either for the release of active renin or for the conversion of inactive renin to its active form in the kidney. Norepinephrine 72-85 renin Homo sapiens 191-196 1425633-9 1992 The similarity between the changes in concentration of active renin and noradrenaline would suggest that sympathetic nerve activity may have been responsible either for the release of active renin or for the conversion of inactive renin to its active form in the kidney. Norepinephrine 72-85 renin Homo sapiens 191-196 1576090-8 1992 The norepinephrine/epinephrine ratio decreases as epinephrine, prolactin, renin and fatty acids rise. Norepinephrine 4-18 renin Homo sapiens 74-79 1653766-7 1991 Our data indicate the existence in hypertensive individuals of a vascular renin-angiotensin system that seems to modulate sympathetic activity through the presynaptic facilitation of norepinephrine release. Norepinephrine 183-197 renin Homo sapiens 74-79 1760896-5 1991 The data indicate that a reduction in the activity of the renin-angiotensin-aldosterone system, modulated by circulating norepinephrine and plasma renin substrate, may significantly contribute to the fall in blood pressure associated with weight loss. Norepinephrine 121-135 renin Homo sapiens 58-63 2365484-6 1990 Plasma renin release showed a significant correlation with noradrenaline release in the patients with MVD (r = 0.47, p less than 0.01); but this relationship was lost in the patients with the CAD, due to an excessive noradrenaline release. Norepinephrine 217-230 renin Homo sapiens 7-12 2184065-3 1990 During exercise, increments (increase from the resting value to the value at 80% of maximal working capacity) in renin (1.5 +/- 0.4 nmol.l-1.h-1 and 3.7 +/- 0.5 nmol.l-1.h-1; p less than 0.001), angiotensin II (28 +/- 8 nmol/l and 60 +/- 8 nmol/l; p less than 0.001), aldosterone (0.16 +/- 0.04 nmol/l and 0.25 +/- 0.05 nmol/l; p less than 0.05), adrenaline (1.96 +/- 0.49 nmol/l and 2.92 +/- 0.51 nmol/l; p less than 0.05), and noradrenaline (12.01 +/- 1.25 nmol/l and 18.74 +/- 1.45 nmol/l; p less than 0.01) were significantly lower in the patients than in control subjects. Norepinephrine 429-442 renin Homo sapiens 113-118 2406102-0 1990 Plasma noradrenaline and dopamine in renin-mediated hypertension. Norepinephrine 7-20 renin Homo sapiens 37-42 1670902-4 1991 Plasma renin decreased with bucindolol therapy, from 11.6 +/- 13.4 to 4.3 +/- 4.1 ng/ml/hour (mean +/- standard deviation; p less than 0.05), whereas plasma norepinephrine was unchanged, from 403 +/- 231 to 408 +/- 217 pg/ml. Norepinephrine 157-171 renin Homo sapiens 7-12