PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25402186-4 2014 In the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in equine sperm. Norepinephrine 243-257 solute carrier family 6 member 3 Homo sapiens 216-219 26503701-1 2015 The transporters for norepinephrine and dopamine (NET and DAT, respectively) constitute the molecular targets for recreational drugs and therapeutics used in the treatment of psychiatric disorders. Norepinephrine 21-35 solute carrier family 6 member 3 Homo sapiens 58-61 26209364-8 2015 Together, these effects induced by psychostimulants, mediated through a non-dopamine transporter-mediated mechanism involving norepinephrine and the prefrontal cortex, may also contribute importantly to the reinforcing properties of these drugs. Norepinephrine 126-140 solute carrier family 6 member 3 Homo sapiens 76-96 23421681-4 2013 The 6-position of serotonin and the para-hydroxyl groups of dopamine and norepinephrine were found to face Ala173 in hSERT, Gly153 in hDAT, and Gly149 in hNET. Norepinephrine 73-87 solute carrier family 6 member 3 Homo sapiens 134-138 23421681-7 2013 Uptake experiments support that the 5-hydroxyl group of serotonin and the meta-hydroxyl group norepinephrine and dopamine are placed in the hydrophilic pocket around Ala173, Ser438, and Thr439 in hSERT corresponding to Gly149, Ser419, Ser420 in hNET and Gly153 Ser422 and Ala423 in hDAT. Norepinephrine 94-108 solute carrier family 6 member 3 Homo sapiens 282-286 19022290-1 2009 Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and DAT respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake. Norepinephrine 43-57 solute carrier family 6 member 3 Homo sapiens 86-89 19632110-2 2009 Synthesis of the two diastereomeric isomers of the molecule followed by chiral resolution of each enantiomer revealed the (2R,3S)-isomer to be a potent norepinephrine reuptake inhibitor (IC(50)=28 nM) with excellent selectivity over the dopamine transporter and 13-fold selectivity over the serotonin transporter. Norepinephrine 152-166 solute carrier family 6 member 3 Homo sapiens 237-257 18480676-3 2008 Among these are several genes associated with the catecholaminergic system including the dopamine receptor genes (DRD4 and DRD5), the dopamine transporter gene, and the gene for dopamine beta-hydroxylase, which catalyzes conversion of dopamine to norepinephrine. Norepinephrine 247-261 solute carrier family 6 member 3 Homo sapiens 134-154 16515684-2 2006 The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse. Norepinephrine 46-60 solute carrier family 6 member 3 Homo sapiens 77-80 17224717-3 2007 The current study measured SERT occupancy and modulation of DAT by the serotonin/norepinephrine reuptake inhibitor (SNRI) venlafaxine using [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane SPECT. Norepinephrine 81-95 solute carrier family 6 member 3 Homo sapiens 60-63 12837768-4 2003 Of 18 mutations where hNET amino acid residues were exchanged with those of the human dopamine transporter, MrIA had increased potency for inhibition of [3H]norepinephrine uptake for three mutations (in predicted extracellular loops 3 and 4 and transmembrane domain (TMD) 8) and decreased potency for one mutation (in TMD6 and intracellular loop (IL) 3). Norepinephrine 157-171 solute carrier family 6 member 3 Homo sapiens 86-106 16722229-3 2006 Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux. Norepinephrine 15-29 solute carrier family 6 member 3 Homo sapiens 67-70 15950014-6 2005 In brain regions expressing both the DAT and the norepinephrine transporter (NET), the relative contributions of dopamine and norepinephrine to ADHD pathophysiology and therapeutic response are obfuscated by the capacity of the NET to clear dopamine as well as norepinephrine. Norepinephrine 126-140 solute carrier family 6 member 3 Homo sapiens 37-40 17073682-3 2006 The fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (DAT, NET and SERT) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable NET ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific CNS disorders. Norepinephrine 45-59 solute carrier family 6 member 3 Homo sapiens 90-93 15763132-1 2005 Pre-synaptic norepinephrine (NE) and dopamine (DA) transporters (NET and DAT) terminate catecholamine synaptic transmission through reuptake of released neurotransmitter. Norepinephrine 13-27 solute carrier family 6 member 3 Homo sapiens 73-76 15763138-4 2005 Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent. Norepinephrine 13-27 solute carrier family 6 member 3 Homo sapiens 79-82 15164608-1 2004 Following exocytotic release of the biogenic amine neurotransmitters, norepinephrine and dopamine, are removed from the synaptic cleft by the respective transporter, norepinephrine transporter (NET) and dopamine transporter (DAT) located on the plasma membrane. Norepinephrine 70-84 solute carrier family 6 member 3 Homo sapiens 203-223 15164608-1 2004 Following exocytotic release of the biogenic amine neurotransmitters, norepinephrine and dopamine, are removed from the synaptic cleft by the respective transporter, norepinephrine transporter (NET) and dopamine transporter (DAT) located on the plasma membrane. Norepinephrine 70-84 solute carrier family 6 member 3 Homo sapiens 225-228 14499136-0 2003 Phenylephrine and norepinephrine increase dopamine transporter ligand binding in striatum. Norepinephrine 18-32 solute carrier family 6 member 3 Homo sapiens 42-62 12196911-1 2002 The norepinephrine, dopamine and serotonin transporters (NET, DAT and SERT, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology. Norepinephrine 4-18 solute carrier family 6 member 3 Homo sapiens 62-65 11092898-1 2001 The norepinephrine (NET) and dopamine (DAT) transporters are highly homologous proteins, displaying many pharmacological similarities. Norepinephrine 4-18 solute carrier family 6 member 3 Homo sapiens 39-42 11427501-0 2001 Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. Norepinephrine 41-55 solute carrier family 6 member 3 Homo sapiens 100-120 9154329-13 1997 In cross-loading experiments, 5 mM Na(+)- or 0 Cl(-)-induced efflux was much lower from [3H]-noradrenaline-loaded DAT, than NAT cells and was sensitive to mazindol, but not to desipramine. Norepinephrine 93-106 solute carrier family 6 member 3 Homo sapiens 114-117 30055194-4 2019 In contrast to NET, DAT and SERT, OCT3 has higher capacity and lower affinity for substrates, is sodium-independent, and is multi-specific, with the capacity to transport norepinephrine, dopamine, serotonin and histamine. Norepinephrine 171-185 solute carrier family 6 member 3 Homo sapiens 20-23 8667208-3 1996 In dopamine transporter expressing cells, the maximal transport rate (Vmax) of MPP+, dopamine and noradrenaline was the same, but in noradrenaline transporter expressing cells the Vmax of MPP+ and dopamine was only one-half of the Vmax of noradrenaline. Norepinephrine 98-111 solute carrier family 6 member 3 Homo sapiens 3-23 32956676-6 2021 The present studies focused on the initial characterization of a novel atypical DAT inhibitor, CT-005404, which binds to DAT with high selectivity relative to serotonin and norepinephrine transport, and produces long-term elevations of extracellular DA. Norepinephrine 173-187 solute carrier family 6 member 3 Homo sapiens 80-83 33551812-2 2020 Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). Norepinephrine 48-61 solute carrier family 6 member 3 Homo sapiens 106-109 9092590-1 1997 Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively. Norepinephrine 40-56 solute carrier family 6 member 3 Homo sapiens 178-181 9092590-1 1997 Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively. Norepinephrine 58-62 solute carrier family 6 member 3 Homo sapiens 178-181 34083626-3 2021 We found that senior investors display higher gray matter volume and increased structural brain connectivity in dopamine-related pathways, as well as a set of genes functionally associated with adrenaline and noradrenaline biosynthesis (SLC6A3, TH and SLC18A2), which is seemingly involved in reward processing and bodily stress responses during financial trading. Norepinephrine 209-222 solute carrier family 6 member 3 Homo sapiens 237-243 27190169-6 2016 Inasmuch as they increase synaptic dopamine levels, dopamine transporter (DAT) inhibitors, whether they are selective or have actions on noradrenaline or serotonin transporters, theoretically represent an attractive way to alleviate parkinsonism per se and potentially enhance l-DOPA antiparkinsonian action (provided that sufficient dopamine terminals remain within the striatum). Norepinephrine 137-150 solute carrier family 6 member 3 Homo sapiens 52-72 29329285-7 2018 We also provide evidence, from coarse grain MD simulations that the CHOL sites observed in the DAT crystal structures are preserved in all human monoamine transporters (dopamine, serotonin and norepinephrine), suggesting that our findings might extend to the entire family. Norepinephrine 193-207 solute carrier family 6 member 3 Homo sapiens 95-98 27190169-6 2016 Inasmuch as they increase synaptic dopamine levels, dopamine transporter (DAT) inhibitors, whether they are selective or have actions on noradrenaline or serotonin transporters, theoretically represent an attractive way to alleviate parkinsonism per se and potentially enhance l-DOPA antiparkinsonian action (provided that sufficient dopamine terminals remain within the striatum). Norepinephrine 137-150 solute carrier family 6 member 3 Homo sapiens 74-77