PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20406625-12	2010	PDE4, but not PDE3, controls the atrial inotropic and cAMP beta(1)-adrenoceptor-mediated responses to (-)-noradrenaline.	Norepinephrine	102-119	adrenoceptor beta 1	Homo sapiens	59-79	
15375008-4	2004	Short-term (10-minute) and sustained (24-hour) beta1AR stimulation with norepinephrine similarly enhanced cell contraction and Ca2+ transients, in contrast to anticipated receptor desensitization.	Norepinephrine	72-86	adrenoceptor beta 1	Homo sapiens	47-54	
16543734-6	2006	However, the visceral depot of women showed a higher maximal stimulation by noradrenaline than that of men, in accordance with higher beta1- and beta3-AR protein levels.	Norepinephrine	76-89	adrenoceptor beta 1	Homo sapiens	134-153	
15908512-7	2005	In the presence of alphaAR blockade, concentration-response curves for isoproterenol, norepinephrine, and epinephrine suggested that a beta1AR was involved in this response, and the rank order of potency was isoproterenol > norepinephrine = epinephrine.	Norepinephrine	86-100	adrenoceptor beta 1	Homo sapiens	135-142	
15908512-7	2005	In the presence of alphaAR blockade, concentration-response curves for isoproterenol, norepinephrine, and epinephrine suggested that a beta1AR was involved in this response, and the rank order of potency was isoproterenol > norepinephrine = epinephrine.	Norepinephrine	227-241	adrenoceptor beta 1	Homo sapiens	135-142	
15523499-1	2005	The beta-adrenergic receptors (beta-AR) are G protein-coupled receptors activated by epinephrine and norepinephrine and are involved in a variety of their physiological functions.	Norepinephrine	101-115	adrenoceptor beta 1	Homo sapiens	31-38	
12616336-1	2003	Two forms of the activated beta1-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists such as (-)-pindolol and (-)-CGP 12177 but is relatively insensitive to (-)-propranolol.	Norepinephrine	79-96	adrenoceptor beta 1	Homo sapiens	27-45	
9300318-1	1997	In this study we examined the effects of long-term treatment of 19 patients with primary hypertension with the beta 1-adrenoceptor antagonist atenolol on norepinephrine and epinephrine kinetics, at rest and during sympathoadrenal stimulation by lower body negative pressure.	Norepinephrine	154-168	adrenoceptor beta 1	Homo sapiens	111-130	
12383575-0	2002	Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro.	Norepinephrine	47-65	adrenoceptor beta 1	Homo sapiens	96-123	
12383575-1	2002	OBJECTIVE: The goal of this study was to determine whether the cardiostimulant effects of the endogenous beta(1)-adrenergic receptor (AR) agonist, (-)-norepinephrine are modified by polymorphic (Serine49Glycine [Ser49Gly], Glycine389Arginine [Gly389Arg]) variants of beta(1)-ARs in the nonfailing adult human heart.	Norepinephrine	147-165	adrenoceptor beta 1	Homo sapiens	105-132	
12383575-1	2002	OBJECTIVE: The goal of this study was to determine whether the cardiostimulant effects of the endogenous beta(1)-adrenergic receptor (AR) agonist, (-)-norepinephrine are modified by polymorphic (Serine49Glycine [Ser49Gly], Glycine389Arginine [Gly389Arg]) variants of beta(1)-ARs in the nonfailing adult human heart.	Norepinephrine	147-165	adrenoceptor beta 1	Homo sapiens	134-136	
10435003-7	1999	Noradrenaline (NA, 1 microM) was used to stimulate beta 1-AR and isoprenaline (ISO, 1 microM) in the presence of the beta 1-AR antagonist CGP 20712A (0.1 microM) to stimulate beta 2-AR.	Norepinephrine	0-13	adrenoceptor beta 1	Homo sapiens	51-60	
10435003-7	1999	Noradrenaline (NA, 1 microM) was used to stimulate beta 1-AR and isoprenaline (ISO, 1 microM) in the presence of the beta 1-AR antagonist CGP 20712A (0.1 microM) to stimulate beta 2-AR.	Norepinephrine	0-13	adrenoceptor beta 1	Homo sapiens	117-126	
9988105-15	1999	The increased responsiveness to norepinephrine may involve (i) a rapid up-regulation of cardiac beta1-adrenoceptors and cAMP signaling in cardiac pacemaker cells due to the loss of the inhibitory influence of cardiac NO, and (ii) the up-regulation of beta1-adrenoceptor-mediated signal transduction processes in response to the L-NAME-induced withdrawal of cardiac sympathetic nerve activity.	Norepinephrine	32-46	adrenoceptor beta 1	Homo sapiens	96-114	
9884381-10	1999	CONCLUSIONS: Norepinephrine and epinephrine hasten human ventricular relaxation and promote phosphorylation of implicated proteins through both beta1- and beta2-adrenergic receptors, thereby potentially improving diastolic function.	Norepinephrine	13-27	adrenoceptor beta 1	Homo sapiens	144-181	
8097683-0	1993	Noradrenaline kinetics and coronary haemodynamics during acute beta 1-adrenoceptor blockade in man.	Norepinephrine	0-13	adrenoceptor beta 1	Homo sapiens	63-82	
8738299-1	1996	We have reported that chronic treatment of patients with beta 1-adrenoceptor blockers sensitises isolated atrial preparations to adrenaline, noradrenaline and 5-Ht.	Norepinephrine	141-154	adrenoceptor beta 1	Homo sapiens	57-76	
8697051-8	1995	When considering differential beta-AR recruitment by catecholamines, it is the beta 1-AR which is always activated at the lowest norepinephrine levels, whatever the species, while the activation of the beta 3-AR requires higher norepinephrine levels.	Norepinephrine	129-143	adrenoceptor beta 1	Homo sapiens	79-88	
8861784-9	1996	Isoprenaline, noradrenaline, and adrenaline were almost full agonists in both cell types (intrinsic activity from 74% or 95%) during combined beta 1, beta 2- and alpha 2-adrenoceptor blockade.	Norepinephrine	14-27	adrenoceptor beta 1	Homo sapiens	142-182	
7953289-2	1994	A proposed mechanism of ligand-activated trans-membrane proton transfer within alpha-helices III, IV, V, VI and VII of the beta 1-adrenoceptor involving activation of a Tyr377-Arg156-Tyr157 proton shuttle by two hydrogen bond proton donor interactions of the natural ligand, nor-adrenaline is found to have an equivalent representation in the m2-muscarinic receptor.	Norepinephrine	275-289	adrenoceptor beta 1	Homo sapiens	123-142	
8104641-6	1993	Following alpha-blockade with 10 microM phenoxybenzamine, both noradrenaline adrenaline produced concentration-dependent relaxations in both blood vessels, their effects being mediated predominantly through beta 2-adrenoceptors; a lesser beta 1-adrenoceptor component to relaxation was also found in internal mammary artery and a minor beta 1-adrenoceptor component was present in saphenous vein.	Norepinephrine	63-76	adrenoceptor beta 1	Homo sapiens	238-257	
8104641-6	1993	Following alpha-blockade with 10 microM phenoxybenzamine, both noradrenaline adrenaline produced concentration-dependent relaxations in both blood vessels, their effects being mediated predominantly through beta 2-adrenoceptors; a lesser beta 1-adrenoceptor component to relaxation was also found in internal mammary artery and a minor beta 1-adrenoceptor component was present in saphenous vein.	Norepinephrine	63-76	adrenoceptor beta 1	Homo sapiens	336-355	
1309447-8	1992	Decreased norepinephrine stores correlate weakly with beta 1-adrenergic receptor downregulation consistent with the hypothesis that norepinephrine depletion occurs in response to increased adrenergic drive.	Norepinephrine	10-24	adrenoceptor beta 1	Homo sapiens	54-80	
1279289-4	1992	beta 1-Adrenoceptor-mediated effects were isoprenaline (ISO) infusion-induced increase in systolic blood pressure (SBP) and bicycle exercise-induced increase in heart rate (HR); beta 2-adrenoceptor-mediated effects were ISO infusion-induced increase in plasma norepinephrine (NE) and decrease in diastolic blood pressure (DBP); ISO infusion-induced increase in HR was assessed as mixed beta 1- and beta 2-adrenoceptor-mediated effect.	Norepinephrine	260-274	adrenoceptor beta 1	Homo sapiens	0-19	
1309447-8	1992	Decreased norepinephrine stores correlate weakly with beta 1-adrenergic receptor downregulation consistent with the hypothesis that norepinephrine depletion occurs in response to increased adrenergic drive.	Norepinephrine	132-146	adrenoceptor beta 1	Homo sapiens	54-80	
1363262-5	1992	On the other hand, noradrenaline induces its positive inotropic effect on atrial and ventricular preparations solely via beta 1-adrenoceptor stimulation.	Norepinephrine	19-32	adrenoceptor beta 1	Homo sapiens	121-140	
1685558-14	1991	Consistent with this finding, around 80% of the adenylyl cyclase stimulation by both (-)-noradrenaline and (-)-adrenaline was mediated through beta 1AR, around 20% through beta 2AR.	Norepinephrine	85-102	adrenoceptor beta 1	Homo sapiens	143-151	
1687117-7	1991	On the other hand, for long-term treatment selective beta 1-adrenoceptor antagonists may be beneficial since they protect the heart from the deleterious effects of chronic exposure to high (cardiac derived) noradrenaline and simultaneously may restore the previously reduced beta-adrenoceptor function.	Norepinephrine	207-220	adrenoceptor beta 1	Homo sapiens	53-72	
1685558-15	1991	The positive inotropic effects of (-)-noradrenaline appeared to be nearly exclusively mediated through beta 1AR in right ventricular papillary muscles.	Norepinephrine	34-51	adrenoceptor beta 1	Homo sapiens	103-111	
1968697-4	1990	Noradrenaline, on the other hand, caused a positive inotropic effect nearly exclusively via atrial and ventricular beta-1 adrenoceptor stimulation.	Norepinephrine	0-13	adrenoceptor beta 1	Homo sapiens	115-134	
1685558-7	1991	In the sinoatrial pacemaker (-)-adrenaline caused positive chronotropic effects through both beta 1AR and beta 2AR while (-)-noradrenaline does so predominantly through beta 1AR.	Norepinephrine	121-138	adrenoceptor beta 1	Homo sapiens	169-177	
1685558-8	1991	During beta 1AR blockade (-)-adrenaline did cause the same maximum effects through beta 2AR as (-)-noradrenaline did through beta 1AR.	Norepinephrine	95-112	adrenoceptor beta 1	Homo sapiens	125-133	
1851566-4	1991	The IgG against the beta 1-adrenoceptor inhibited the action of norepinephrine on the contractility of atria.	Norepinephrine	64-78	adrenoceptor beta 1	Homo sapiens	20-39	
1652275-1	1991	Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR).	Norepinephrine	41-54	adrenoceptor beta 1	Homo sapiens	103-123	
1652275-1	1991	Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR).	Norepinephrine	41-54	adrenoceptor beta 1	Homo sapiens	125-133	
1978979-12	1990	The beneficial effects of xamoterol in patients with heart failure could be due to prevention of the detrimental effects of norepinephrine such as beta 1-adrenoceptor downregulation of an increase of Gi (inhibitory guanine-nucleotide binding protein).	Norepinephrine	124-138	adrenoceptor beta 1	Homo sapiens	147-166	
1979509-8	1990	On isolated, electrically driven right atria the beta 1-adrenoceptor-mediated positive inotropic effect of noradrenaline was - even with beta 1-adrenoceptor number increased - not altered, while the beta 2-adrenoceptor-mediated effect of procaterol was markedly enhanced.	Norepinephrine	107-120	adrenoceptor beta 1	Homo sapiens	49-68	
11527117-5	1990	On the other hand, norepinephrine induces its positive inotropic effect on atrial and ventricular preparations solely via beta1-adrenoceptor stimulation.	Norepinephrine	19-33	adrenoceptor beta 1	Homo sapiens	122-140	
1980074-2	1990	Concomitantly, the M2-receptor-mediated negative inotropic effect of carbachol was reduced, while the beta 1-adrenoceptor-mediated positive inotropic effect of noradrenaline was not altered.	Norepinephrine	160-173	adrenoceptor beta 1	Homo sapiens	102-121	
2829863-0	1987	Adrenaline and noradrenaline increase contractile force of human ventricle through both beta 1- and beta 2-adrenoceptors.	Norepinephrine	15-28	adrenoceptor beta 1	Homo sapiens	88-120	
2542808-20	1989	The more efficient activation of contractile force by (-)-noradrenaline in cat, compared to man, appears to be related to a 2-fold higher density of beta 1-adrenoceptors, a 6-fold higher production of cyclic AMP per beta 1-adrenoceptor and possibly to a more effective use of cyclic AMP for contraction.	Norepinephrine	54-71	adrenoceptor beta 1	Homo sapiens	149-168	
2900601-4	1988	Norepinephrine, however, increased contractile force solely via beta 1-adrenoceptor stimulation.	Norepinephrine	0-14	adrenoceptor beta 1	Homo sapiens	64-83	
2878742-0	1987	Hemodynamic effects of the beta 1-adrenoceptor partial agonist xamoterol in relation to plasma norepinephrine levels during exercise in patients with left ventricular dysfunction.	Norepinephrine	95-109	adrenoceptor beta 1	Homo sapiens	27-46	
33093660-0	2021	Binding pathway determines norepinephrine selectivity for the human beta1AR over beta2AR.	Norepinephrine	27-41	adrenoceptor beta 1	Homo sapiens	68-75	
2434752-6	1986	In addition, on atria and on ventricles, adenylate cyclase was activated by norepinephrine (presumably by beta 1- and beta 2-adrenoceptor stimulation) and by procaterol (by beta 2-adrenoceptor stimulation).	Norepinephrine	76-90	adrenoceptor beta 1	Homo sapiens	106-137	
2439795-5	1986	On isolated electrically driven human right atria, (+/-)-bisoprolol was approximately 30 times more potent in antagonizing the beta 1-adrenoceptor-mediated positive inotropic effect of noradrenaline (pA2-value, 8.42) than the beta 2-adrenoceptor-mediated positive inotropic effect of procaterol (pA2-value, 6.99).	Norepinephrine	185-198	adrenoceptor beta 1	Homo sapiens	127-146	
6170594-8	1981	The amylase release induced by norepinephrine, mediated via beta1-adrenoceptor, is depressed by DSCG.	Norepinephrine	31-45	adrenoceptor beta 1	Homo sapiens	60-78	
33677066-11	2021	beta1-AR were stimulated with the physiological agonist norepinephrine (100 muM).	Norepinephrine	56-70	adrenoceptor beta 1	Homo sapiens	0-8	
33093660-3	2021	To understand the structural basis for this physiologically important selectivity, we solved the crystal structures of the human beta1AR bound to an antagonist carazolol and different agonists including norepinephrine, epinephrine and BI-167107.	Norepinephrine	203-217	adrenoceptor beta 1	Homo sapiens	129-136	
33093660-2	2021	While the hormone epinephrine binds beta1AR and beta2AR with similar affinity, the smaller neurotransmitter norepinephrine is approximately tenfold selective for the beta1AR.	Norepinephrine	108-122	adrenoceptor beta 1	Homo sapiens	166-173	
31810852-7	2020	The Molecular Docking and afterward Molecular Dynamics calculations of formed complexes between octopamine/norepinephrine with beta1- and beta2- adrenergic receptors examined in details the interactions that lead to the formation of stable complexes.	Norepinephrine	107-121	adrenoceptor beta 1	Homo sapiens	127-165	
33481407-17	2021	Our studies suggest that both beta1- and beta2-adrenergic receptor mediate the stabilizing effects of epinephrine and norepinephrine on the endothelial barrier.	Norepinephrine	118-132	adrenoceptor beta 1	Homo sapiens	30-66	
28522796-11	2017	CONCLUSIONS These data show that the beta1-adrenoceptor polymorphisms, together with the COMT polymorphism, affect norepinephrine consumption and stay in hospital in a situation of enhanced cardiovascular stress, reflected here by the postoperative period after cardiac surgery.	Norepinephrine	115-129	adrenoceptor beta 1	Homo sapiens	37-55	
32743496-11	2019	Conclusions: The co-presence of norepinephrine in serum samples can artifactually elevate alpha1AR and beta1AR activity, which can be avoided by serum pre-treatment with MAO.	Norepinephrine	32-46	adrenoceptor beta 1	Homo sapiens	103-110	
25451930-4	2015	Despite its hyperfunctionality, we found the Arg-389 variant of ADRB1 to be hyperphosphorylated upon continuous stimulation with norepinephrine compared with the Gly-389 variant.	Norepinephrine	129-143	adrenoceptor beta 1	Homo sapiens	64-69	
24663151-1	2014	The beta1-adrenoceptor (beta1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline.	Norepinephrine	132-145	adrenoceptor beta 1	Homo sapiens	4-22	
24663151-1	2014	The beta1-adrenoceptor (beta1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline.	Norepinephrine	132-145	adrenoceptor beta 1	Homo sapiens	24-31	
24982877-1	2014	Human cardiac beta 1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine.	Norepinephrine	93-107	adrenoceptor beta 1	Homo sapiens	14-23