PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10480302-5	1999	RESULTS: PTX treatment induced incremental increases in the levels of IL-4 and IL-10 in both sera and CSF of 6 HAM patients.	Pentoxifylline	9-12	interleukin 10	Homo sapiens	79-84	
11121122-7	2000	An inhibitory effect on interleukin-10 mRNA was likewise seen after thalidomide and pentoxifylline, but not subsequent to prednisone treatment.	Pentoxifylline	84-98	interleukin 10	Homo sapiens	24-38	
8574830-1	1995	The present study concerns the release of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha and of the anti-inflammatory cytokine IL-10 by human leukocytes in whole blood during stimulation with Streptococcus pneumoniae and the effects of various xanthine derivates, i.e., pentoxifylline (PTX), caffeine, and theofylline, and of dexamethasone (DXM).	Pentoxifylline	316-330	interleukin 10	Homo sapiens	173-178	
9172017-0	1996	Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline.	Pentoxifylline	84-98	interleukin 10	Homo sapiens	75-80	
9172017-3	1996	We investigated PTX effects on production and mRNA expression of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta and IL-10.	Pentoxifylline	16-19	interleukin 10	Homo sapiens	112-117	
9172017-8	1996	We also noted that the effects of PTX on IL-6, IL-8 and IL-10 production were different in WB and in PBMC culture.	Pentoxifylline	34-37	interleukin 10	Homo sapiens	56-61	
9227317-4	1997	In these same experiments, tumour necrosis factor-alpha (TNF-alpha) production was inhibited and IL-10 and prostaglandin E2 (PGE2) production was enhanced by treatment with pentoxifylline.	Pentoxifylline	173-187	interleukin 10	Homo sapiens	97-102	
8724037-5	1996	Moreover, PTX reduced TNF-alpha, IFN-gamma and IL-10 production and NF-kappa B activation.	Pentoxifylline	10-13	interleukin 10	Homo sapiens	47-52	
8724037-7	1996	However, the inhibition of p24 release and specially of IL-10 production required significantly lower doses of PTX.	Pentoxifylline	111-114	interleukin 10	Homo sapiens	56-61	
8632062-5	1996	PTX significantly decreased TNF-alpha and interleukin-12 (IL-12), whereas it increased IL-4 and IL-10 production.	Pentoxifylline	0-3	interleukin 10	Homo sapiens	96-101	
8632062-7	1996	Increasing doses of PTX significantly reduced TNF-alpha and IL-12 mRNA expression of blood mononuclear cells, but increased IL-4 and IL-10 expression in eight patients with relapsing-remitting multiple sclerosis.	Pentoxifylline	20-23	interleukin 10	Homo sapiens	133-138	
8574830-1	1995	The present study concerns the release of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha and of the anti-inflammatory cytokine IL-10 by human leukocytes in whole blood during stimulation with Streptococcus pneumoniae and the effects of various xanthine derivates, i.e., pentoxifylline (PTX), caffeine, and theofylline, and of dexamethasone (DXM).	Pentoxifylline	332-335	interleukin 10	Homo sapiens	173-178	
8574830-4	1995	The release of IL-10 was significantly reduced by PTX at 24 h and by caffeine at 48 h, but DXM increased the release of this cytokine.	Pentoxifylline	50-53	interleukin 10	Homo sapiens	15-20	
31219000-10	2019	Our data suggest that treatment with Sbv + PTX acts in CD68+ cells reducing the expression of TNF-alpha but not IL-10, resulting in more efficient modulation of the inflammatory response, accelerating the healing process.	Pentoxifylline	43-46	interleukin 10	Homo sapiens	112-117	
9227316-4	1997	However, incubation of leucocytes with S. pneumoniae in the presence of LSF or PTX stimulated the production of IL-10 about four- and twofold at 24 hr and 48 hr, respectively.	Pentoxifylline	79-82	interleukin 10	Homo sapiens	112-117	
8699867-4	1995	Using sensitive RT-PCR assays, data show that at this same PTX concentration (5 x 10(-4) M), these cells also exhibited inhibition in the expression of IL-4 and IL-10 mRNA, together with inhibition of IL-2 and IFN-gamma mRNA expression.	Pentoxifylline	59-62	interleukin 10	Homo sapiens	161-166	
8699868-7	1995	Finally, IL-10 was also influenced by PTX (65% of baseline).	Pentoxifylline	38-41	interleukin 10	Homo sapiens	9-14	
29715306-12	2018	Synergistic inhibition of TNF production by (PTX+DEX) was especially pronounced in newborn vs. adult blood and was accompanied by reduction of TNF mRNA and enhancement of IL10 mRNA.	Pentoxifylline	45-48	interleukin 10	Homo sapiens	171-175	
17196208-8	2008	The levels of the anti-inflammatory cytokine, IL-10, also declined significantly less in the pentoxifylline group compared to placebo (P<0.01) with a trend towards a higher increase of TGF-beta1 in the former group (P=0.16).	Pentoxifylline	93-107	interleukin 10	Homo sapiens	46-51	
30205379-10	2018	Moreover, the PTX group showed a statistically significantly greater reduction in the serum levels of TNF-alpha, IL-6, IL-10, and 8-OHdG along with a statistically significant increase in the levels of BDNF and serotonin in comparison with the control group after the treatment.	Pentoxifylline	14-17	interleukin 10	Homo sapiens	119-124	
28072760-5	2017	RESULTS: Whether added 2 h pre-, simultaneously to, or 2 h post-TLR stimulation, PTX inhibited TLR-mediated cytokine production in a concentration-dependent manner, with greater efficacy and potency in newborn blood, decreasing intracellular TNF and IL-1beta with relative preservation of IL-10 and IL-6.	Pentoxifylline	81-84	interleukin 10	Homo sapiens	289-294	
28072760-6	2017	PTX decreased TLR-mediated TNF mRNA while increasing IL-10 mRNA.	Pentoxifylline	0-3	interleukin 10	Homo sapiens	53-58	
28288151-6	2017	Early IL-10 production was significantly downregulated by PTX in term and preterm neonates, while remaining unchanged in adults.	Pentoxifylline	58-61	interleukin 10	Homo sapiens	6-11	
17178383-7	2007	PTX-treated MDDCs which were induced to mature with LPS produced lower levels of TNF-alpha, IL-12 and IL-18 and higher levels of IL-10 than corresponding control MDDCs.	Pentoxifylline	0-3	interleukin 10	Homo sapiens	129-134	
16361898-11	2005	IL-10 levels at 4 hours were up-regulated in both LPS and PTX + LPS-treated animals; however, levels were higher in the LPS groups, which paralleled high TNF-alpha levels.	Pentoxifylline	58-61	interleukin 10	Homo sapiens	0-5	
17112855-1	2006	Pentoxifylline (PTX) is a nonselective phosphodiesterase inhibitor that inhibits the production of TNFalpha and IL6 and IL-10 cytokines.	Pentoxifylline	0-14	interleukin 10	Homo sapiens	120-125	
17112855-1	2006	Pentoxifylline (PTX) is a nonselective phosphodiesterase inhibitor that inhibits the production of TNFalpha and IL6 and IL-10 cytokines.	Pentoxifylline	16-19	interleukin 10	Homo sapiens	120-125	
17112855-8	2006	In summary IL-10 and TNF-alpha levels decreased in stable recipients treated with PTx.	Pentoxifylline	82-85	interleukin 10	Homo sapiens	11-16	
16361898-12	2005	In contrast, IL-10 levels at 4 and 24 hours in PTX + LPS-treated animals remained constant, whereas in LPS-treated animals, IL-10 levels at 24 hours were markedly decreased.	Pentoxifylline	47-50	interleukin 10	Homo sapiens	13-18	
14989392-7	2004	RESULTS: Pentoxifylline induced a dose-dependent suppression of spontaneous TNF-alpha and IL-10 release from AMs in EAA.	Pentoxifylline	9-23	interleukin 10	Homo sapiens	90-95