PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34185362-1 2021 Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms. Organophosphorus Compounds 29-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 34185362-1 2021 Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms. Organophosphorus Compounds 29-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 34185362-1 2021 Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms. Organophosphorus Compounds 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 34185362-1 2021 Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms. Organophosphorus Compounds 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 31138650-2 2019 OPs inactivate acetylcholinesterase (AChE) by covalently modifying its catalytic serine. Organophosphorus Compounds 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 3699334-0 1986 Kinetic studies and structure-activity relationships of bispyridinium oximes as reactivators of acetylcholinesterase inhibited by organophosphorus compounds. Organophosphorus Compounds 130-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 5315349-0 1971 Relationships between the structure of organophosphorus compounds and their activity as acetylcholinesterase inhibitors. Organophosphorus Compounds 39-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 33592259-1 2021 Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 33592259-1 2021 Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 33592259-1 2021 Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. Organophosphorus Compounds 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 33592259-1 2021 Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. Organophosphorus Compounds 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 32333945-2 2020 Poisonings by organophosphorus compounds (OP) that lead to life-threatening toxic manifestations require immediate treatment that combines administration of anticholinergic drugs and an aldoxime as a reactivator of AChE. Organophosphorus Compounds 14-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-219 31138650-2 2019 OPs inactivate acetylcholinesterase (AChE) by covalently modifying its catalytic serine. Organophosphorus Compounds 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 30950246-1 2019 Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE). Organophosphorus Compounds 24-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 30950246-1 2019 Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE). Organophosphorus Compounds 24-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 30950246-1 2019 Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE). Organophosphorus Compounds 52-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 30950246-1 2019 Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE). Organophosphorus Compounds 52-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 26851641-1 2016 Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE). Organophosphorus Compounds 33-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Organophosphorus Compounds 118-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Organophosphorus Compounds 118-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Organophosphorus Compounds 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Organophosphorus Compounds 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30027640-2 2019 Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard. Organophosphorus Compounds 28-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 30027640-2 2019 Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard. Organophosphorus Compounds 28-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 29772260-1 2018 The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Organophosphorus Compounds 119-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 29772260-1 2018 The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Organophosphorus Compounds 119-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 30938485-3 2019 3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds. Organophosphorus Compounds 241-267 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 30938485-3 2019 3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds. Organophosphorus Compounds 241-267 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 30027640-2 2019 Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 30027640-2 2019 Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 30312685-1 2018 Poisoning by organophosphorus compounds (OP) is characterized by inhibition of the key enzyme acetylcholinesterase (AChE) and potentially fatal outcomes in humans. Organophosphorus Compounds 13-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 30312685-1 2018 Poisoning by organophosphorus compounds (OP) is characterized by inhibition of the key enzyme acetylcholinesterase (AChE) and potentially fatal outcomes in humans. Organophosphorus Compounds 13-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 29024789-1 2018 The primary toxic mechanism of organophosphorus compounds, i.e. nerve agents or pesticides, is based on the irreversible inhibition of acetylcholinesterase. Organophosphorus Compounds 31-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 29180286-1 2018 Reactivation of acetylcholinesterase (AChE), an essential enzyme in neurotransmission, is a key point in the treatment of acute poisoning by nerve agents and pesticides, which structurally belong to organophosphorus compounds (OP). Organophosphorus Compounds 199-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 29180286-1 2018 Reactivation of acetylcholinesterase (AChE), an essential enzyme in neurotransmission, is a key point in the treatment of acute poisoning by nerve agents and pesticides, which structurally belong to organophosphorus compounds (OP). Organophosphorus Compounds 199-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 29248576-1 2018 Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP). Organophosphorus Compounds 191-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 29248576-1 2018 Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP). Organophosphorus Compounds 191-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 26851641-1 2016 Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE). Organophosphorus Compounds 33-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Organophosphorus Compounds 127-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Organophosphorus Compounds 127-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Organophosphorus Compounds 155-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Organophosphorus Compounds 155-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25522658-1 2015 Poisoning by organophosphorus compounds (OP) used as pesticides and nerve agents is due to irreversible inhibition of the enzyme acetylcholinesterase (AChE). Organophosphorus Compounds 13-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Organophosphorus Compounds 188-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Organophosphorus Compounds 188-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 25828536-2 2015 Similar to acetylcholinesterase, the enzyme reacts with organophosphorus compounds (OP) like nerve agents or pesticides that cause enzyme inhibition (BChE adducts). Organophosphorus Compounds 56-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 25522658-1 2015 Poisoning by organophosphorus compounds (OP) used as pesticides and nerve agents is due to irreversible inhibition of the enzyme acetylcholinesterase (AChE). Organophosphorus Compounds 13-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Organophosphorus Compounds 250-276 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Organophosphorus Compounds 250-276 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Organophosphorus Compounds 278-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Organophosphorus Compounds 278-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 22561105-1 2012 Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment. Organophosphorus Compounds 73-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 24057572-1 2014 Great efforts have been undertaken in the last decades to develop new oximes to reactivate acetylcholinesterase inhibited by organophosphorus compounds (OP). Organophosphorus Compounds 125-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 24413757-3 2014 Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 24413757-3 2014 Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited. Organophosphorus Compounds 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 23047024-1 2013 Organophosphorus compounds (OPs) and oximes may interfere with other molecules than AChE in the living systems, affecting in this way various cellular processes and underlying mechanisms. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 23047024-1 2013 Organophosphorus compounds (OPs) and oximes may interfere with other molecules than AChE in the living systems, affecting in this way various cellular processes and underlying mechanisms. Organophosphorus Compounds 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 22561105-1 2012 Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment. Organophosphorus Compounds 73-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 21998030-1 2012 Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach. Organophosphorus Compounds 77-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 21998030-1 2012 Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach. Organophosphorus Compounds 77-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 20807085-1 2011 The standard treatment of poisoning by organophosphorus compounds (OP) includes the reversible muscarine receptor antagonist atropine and oximes for the reactivation of OP-inhibited acetylcholinesterase (AChE). Organophosphorus Compounds 39-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 21470076-1 2011 For the diagnosis and therapy monitoring of intoxications with organophosphorus compounds, the determination of acetylcholinesterase (AChE) activity in whole blood is crucial. Organophosphorus Compounds 63-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 21470076-1 2011 For the diagnosis and therapy monitoring of intoxications with organophosphorus compounds, the determination of acetylcholinesterase (AChE) activity in whole blood is crucial. Organophosphorus Compounds 63-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 21930118-1 2011 Treatment of poisoning by highly toxic organophosphorus compounds (OP) with atropine and an acetylcholinesterase (AChE) reactivator (oxime) is of limited effectiveness in case of different nerve agents and pesticides. Organophosphorus Compounds 39-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 21144749-2 2011 They work by blocking acetylcholinesterase"s (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. Organophosphorus Compounds 125-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-43 21451868-1 2011 Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Organophosphorus Compounds 30-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 21451868-1 2011 Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Organophosphorus Compounds 30-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 20669006-1 2011 Acetylcholinesterase (AChE) is the primary target of organophosphorus compounds (OP). Organophosphorus Compounds 53-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20669006-1 2011 Acetylcholinesterase (AChE) is the primary target of organophosphorus compounds (OP). Organophosphorus Compounds 53-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21144749-2 2011 They work by blocking acetylcholinesterase"s (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. Organophosphorus Compounds 125-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 21144749-2 2011 They work by blocking acetylcholinesterase"s (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. Organophosphorus Compounds 125-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 20882513-1 2010 Poisoning with organophosphorus compounds (OP), e.g. pesticides and nerve agents, causes inhibition of acetylcholinesterase (AChE) by phosphylation of the active site serine residue. Organophosphorus Compounds 15-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 20882513-1 2010 Poisoning with organophosphorus compounds (OP), e.g. pesticides and nerve agents, causes inhibition of acetylcholinesterase (AChE) by phosphylation of the active site serine residue. Organophosphorus Compounds 15-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 19883634-1 2010 It is generally accepted that inhibition of acetylcholinesterase (AChE) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. Organophosphorus Compounds 116-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 19883634-1 2010 It is generally accepted that inhibition of acetylcholinesterase (AChE) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. Organophosphorus Compounds 116-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Organophosphorus Compounds 119-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Organophosphorus Compounds 119-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Organophosphorus Compounds 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Organophosphorus Compounds 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 20156534-1 2010 Standard treatment of acute poisoning by organophosphorus compounds (OP) includes administration of an antimuscarinic (e.g. atropine) and of an oxime-based reactivator of OP-inhibited acetylcholinesterase (AChE). Organophosphorus Compounds 41-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 11679273-1 2001 The fiber-optic biosensor consisting of an acetylcholinesterase (AChE)-immobilized Langmuir-Blodgett (LB) film was developed to detect organophosphorus compounds in contaminated water. Organophosphorus Compounds 135-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 17913691-0 2007 Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds. Organophosphorus Compounds 140-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 17913691-1 2007 Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosphorus compounds (OP). Organophosphorus Compounds 88-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 17913691-1 2007 Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosphorus compounds (OP). Organophosphorus Compounds 88-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 16780806-0 2006 Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds. Organophosphorus Compounds 141-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 16266695-1 2005 Standard treatment of poisoning by organophosphorus compounds (OP) includes the administration of an anti-muscarinic, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). Organophosphorus Compounds 35-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 16119193-1 2005 Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are able to treat intoxication by organophosphorus compounds, especially with pesticides or nerve agents. Organophosphorus Compounds 90-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 16119193-1 2005 Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are able to treat intoxication by organophosphorus compounds, especially with pesticides or nerve agents. Organophosphorus Compounds 90-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 12706567-1 2003 The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water. Organophosphorus Compounds 128-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 12706567-1 2003 The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water. Organophosphorus Compounds 128-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). Organophosphorus Compounds 216-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). Organophosphorus Compounds 216-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). Organophosphorus Compounds 244-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). Organophosphorus Compounds 244-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 17456837-2 2007 Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 17456837-2 2007 Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Organophosphorus Compounds 22-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Organophosphorus Compounds 22-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Organophosphorus Compounds 22-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 416-420 15762562-3 2005 The molecular recognition agent for the sensor is the enzyme acetylcholinesterase (AChE), which binds organophosphorus compounds irreversibly, creating an anionic phosphonyl species. Organophosphorus Compounds 102-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 15762562-3 2005 The molecular recognition agent for the sensor is the enzyme acetylcholinesterase (AChE), which binds organophosphorus compounds irreversibly, creating an anionic phosphonyl species. Organophosphorus Compounds 102-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 9587020-0 1998 Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Organophosphorus Compounds 131-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 9268605-0 1997 Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Organophosphorus Compounds 102-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9268605-1 1997 The differential inhibition of the target esterases acetylcholinesterase (AChE) and neuropathy target esterase (NTE, neurotoxic esterase) by organophosphorus compounds (OPs) is followed by distinct neurological consequences in exposed subjects. Organophosphorus Compounds 141-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 9268605-1 1997 The differential inhibition of the target esterases acetylcholinesterase (AChE) and neuropathy target esterase (NTE, neurotoxic esterase) by organophosphorus compounds (OPs) is followed by distinct neurological consequences in exposed subjects. Organophosphorus Compounds 141-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78