PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29986514-1 2018 The calcium-dependent β-propeller proteins mammalian serum paraoxonase 1 (PON1) and phosphotriesterase diisopropyl fluorophosphatase (DFPase) catalyze the hydrolysis of organophosphorus compounds and enhance hydrolysis of various nerve agents. Organophosphorus Compounds 178-204 paraoxonase 1 Homo sapiens 68-81 29986514-1 2018 The calcium-dependent β-propeller proteins mammalian serum paraoxonase 1 (PON1) and phosphotriesterase diisopropyl fluorophosphatase (DFPase) catalyze the hydrolysis of organophosphorus compounds and enhance hydrolysis of various nerve agents. Organophosphorus Compounds 178-204 paraoxonase 1 Homo sapiens 83-87 28223025-3 2017 Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs). Organophosphorus Compounds 71-97 paraoxonase 1 Homo sapiens 14-18 28223025-3 2017 Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs). Organophosphorus Compounds 99-102 paraoxonase 1 Homo sapiens 14-18 23625910-3 2015 The aim of this study was to determine the effects of PON1 gene polymorphism and its effects on PON and AChE enzyme activities in individuals who were exposed to organophosphorus insecticides due to occupational reasons, and to profile the probability of susceptibility to organophosphorus compounds. Organophosphorus Compounds 273-299 paraoxonase 1 Homo sapiens 54-58 26948828-2 2017 PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs) such as methyl parathion and chlorpyrifos. Organophosphorus Compounds 57-83 paraoxonase 1 Homo sapiens 0-4 26948828-2 2017 PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs) such as methyl parathion and chlorpyrifos. Organophosphorus Compounds 85-88 paraoxonase 1 Homo sapiens 0-4 23625910-3 2015 The aim of this study was to determine the effects of PON1 gene polymorphism and its effects on PON and AChE enzyme activities in individuals who were exposed to organophosphorus insecticides due to occupational reasons, and to profile the probability of susceptibility to organophosphorus compounds. Organophosphorus Compounds 273-299 paraoxonase 1 Homo sapiens 54-57 23201180-2 2013 The paraoxonase 1 from human serum (PON1) is a phosphotriesterase (PTE) that hydrolyses several xenobiotics including drugs and organophosphorus compounds (OPs). Organophosphorus Compounds 128-154 paraoxonase 1 Homo sapiens 4-17 23201180-2 2013 The paraoxonase 1 from human serum (PON1) is a phosphotriesterase (PTE) that hydrolyses several xenobiotics including drugs and organophosphorus compounds (OPs). Organophosphorus Compounds 128-154 paraoxonase 1 Homo sapiens 36-40 23201180-2 2013 The paraoxonase 1 from human serum (PON1) is a phosphotriesterase (PTE) that hydrolyses several xenobiotics including drugs and organophosphorus compounds (OPs). Organophosphorus Compounds 156-159 paraoxonase 1 Homo sapiens 4-17 23201180-2 2013 The paraoxonase 1 from human serum (PON1) is a phosphotriesterase (PTE) that hydrolyses several xenobiotics including drugs and organophosphorus compounds (OPs). Organophosphorus Compounds 156-159 paraoxonase 1 Homo sapiens 36-40 17532308-1 2007 Paraoxonase (PON1) plays an important role in mechanism of organophosphorus compound (OP) toxicity, as seen both in vitro and in vivo studies. Organophosphorus Compounds 59-84 paraoxonase 1 Homo sapiens 0-11 20338154-4 2010 Native, untagged engineered recombinant human PON1 (rHuPON1) expressed in Escherichia coli and purified by conventional column chromatographic purification is stable, active, and capable of protecting PON1 knockout mice (PON1(-/-)) from exposure to high levels of the OP compound diazoxon. Organophosphorus Compounds 268-279 paraoxonase 1 Homo sapiens 46-50 20338154-4 2010 Native, untagged engineered recombinant human PON1 (rHuPON1) expressed in Escherichia coli and purified by conventional column chromatographic purification is stable, active, and capable of protecting PON1 knockout mice (PON1(-/-)) from exposure to high levels of the OP compound diazoxon. Organophosphorus Compounds 268-279 paraoxonase 1 Homo sapiens 55-59 17532308-1 2007 Paraoxonase (PON1) plays an important role in mechanism of organophosphorus compound (OP) toxicity, as seen both in vitro and in vivo studies. Organophosphorus Compounds 59-84 paraoxonase 1 Homo sapiens 13-17 16007003-1 2005 OBJECTIVES: The Q192R polymorphism of paraoxonase (PON1) has been shown to affect hydrolysis of organophosphorus compounds. Organophosphorus Compounds 96-122 paraoxonase 1 Homo sapiens 38-49 12777966-1 2003 BACKGROUND: Paraoxonase (PON1), a HDL-associated enzyme, protects against toxicity from specific organophosphorus compounds and oxidized lipids. Organophosphorus Compounds 97-123 paraoxonase 1 Homo sapiens 12-23 12777966-1 2003 BACKGROUND: Paraoxonase (PON1), a HDL-associated enzyme, protects against toxicity from specific organophosphorus compounds and oxidized lipids. Organophosphorus Compounds 97-123 paraoxonase 1 Homo sapiens 25-29 33049692-4 2021 PON1 has a limited hydrolytic potential of the racemic OPs, while the bacterial PTE exhibits a significant catalytic activity on the less toxic isomers P(+) of the nerve agents. Organophosphorus Compounds 55-58 paraoxonase 1 Homo sapiens 0-4 31293901-3 2019 The susceptibility to exposure can be evaluated by studying the most common polymorphisms of genes involved in the metabolism of organophosphorus compounds (cytochrome P450, glutathione transferase, acetyltransferases or paraoxonase 1). Organophosphorus Compounds 129-155 paraoxonase 1 Homo sapiens 221-234