PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26004137-0	2015	CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and betaTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells.	cd166	0-5	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	82-90	
26004137-7	2015	Mechanically, CD166 down-regulated two ubiquitin E3 ligases, betaTrCP and Smurf1, which play critical roles in the destability of MCAM protein.	cd166	14-19	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	61-69	
26004137-10	2015	Taken together, we establish a model that CD166 regulates MCAM through a signaling flow from activation of PI3K/AKT and c-Raf/MEK/ERK signaling to the inhibition of potential MCAM ubiquitin E3 ligases, betaTrCP and Smurf1, blockage of this signaling cascade may be useful in the treatment of CD166 and MCAM-dependent HCC.	cd166	42-47	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	202-210