PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7623808-5	1995	DNA replication initiates within this region in the single-copy CAD gene in Syrian baby hamster kidney cells and in the large chromosomal amplicons that were generated after selection with N-phosphonacetyl-L-aspartate, a specific inhibitor of CAD.	sparfosic acid	189-217	CAD protein	Mesocricetus auratus	243-246	
8868464-1	1996	Cells often acquire resistance to the antiproliferative agents methotrexate (MTX) or N-phosphonacetyl-L-aspartate (PALA) through amplification of genes encoding the target enzymes dihydrofolate reductase or carbamylphosphate synthetase/aspartate transcarbamylase/dihydroorotase (CAD), respectively.	sparfosic acid	85-113	CAD protein	Mesocricetus auratus	207-283	
7623808-6	1995	DNA synthesis also initiates within this OBR in autonomously replicating extrachromosomal amplicons (CAD episomes) located in an N-phosphonacetyl-L-aspartate-resistant clone (5P20) of CHOK1 cells.	sparfosic acid	129-157	CAD protein	Mesocricetus auratus	101-104	
6180304-1	1982	Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional protein CAD, overproduce this protein as a result of amplification of the CAD gene.	sparfosic acid	34-64	CAD protein	Mesocricetus auratus	168-171	
6896736-1	1982	Mutant Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate, a potent and specific inhibitor of aspartate transcarbamylase, have amplified the gene coding for the multifunctional protein (CAD) that includes this activity.	sparfosic acid	46-76	CAD protein	Mesocricetus auratus	205-208	
6656763-1	1983	Syrian hamster cell lines selected in multiple steps for resistance to high levels of N-(phosphonacetyl)-L-aspartate (PALA) contain many copies of the gene coding for the pyrimidine pathway enzyme CAD.	sparfosic acid	86-116	CAD protein	Mesocricetus auratus	197-200	
6180304-1	1982	Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional protein CAD, overproduce this protein as a result of amplification of the CAD gene.	sparfosic acid	34-64	CAD protein	Mesocricetus auratus	234-237	
6180304-1	1982	Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional protein CAD, overproduce this protein as a result of amplification of the CAD gene.	sparfosic acid	66-70	CAD protein	Mesocricetus auratus	168-171	
6180304-1	1982	Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional protein CAD, overproduce this protein as a result of amplification of the CAD gene.	sparfosic acid	66-70	CAD protein	Mesocricetus auratus	234-237	
381311-1	1979	Mutant Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase, overproduce CAD, a multifunctional protein which catalyzes the first three reactions of de novo UMP biosynthesis.	sparfosic acid	41-71	CAD protein	Mesocricetus auratus	159-162