PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34413442-0 2021 A novel BMP-2-loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite for bone regeneration. beta-tricalcium phosphate 36-61 bone morphogenetic protein 2 Homo sapiens 8-13 31436137-0 2020 Dose-effects of Slow-released BMP-2 Functionalized beta-TCP in Repairing Critical-sized Bone Defects. beta-tricalcium phosphate 51-59 bone morphogenetic protein 2 Homo sapiens 30-35 33472600-4 2021 The present study aimed to induce and maintain new bone formation using the topical co-administration of recombinant human BMP-2 (rh-BMP-2) and zoledronate (ZOL) on beta-tricalcium phosphate (beta-TCP) composite. beta-tricalcium phosphate 165-190 bone morphogenetic protein 2 Homo sapiens 123-128 33472600-4 2021 The present study aimed to induce and maintain new bone formation using the topical co-administration of recombinant human BMP-2 (rh-BMP-2) and zoledronate (ZOL) on beta-tricalcium phosphate (beta-TCP) composite. beta-tricalcium phosphate 165-190 bone morphogenetic protein 2 Homo sapiens 133-138 33472600-4 2021 The present study aimed to induce and maintain new bone formation using the topical co-administration of recombinant human BMP-2 (rh-BMP-2) and zoledronate (ZOL) on beta-tricalcium phosphate (beta-TCP) composite. beta-tricalcium phosphate 192-200 bone morphogenetic protein 2 Homo sapiens 123-128 33472600-4 2021 The present study aimed to induce and maintain new bone formation using the topical co-administration of recombinant human BMP-2 (rh-BMP-2) and zoledronate (ZOL) on beta-tricalcium phosphate (beta-TCP) composite. beta-tricalcium phosphate 192-200 bone morphogenetic protein 2 Homo sapiens 133-138 32665018-0 2020 Anterior cervical discectomy and fusion with recombinant human bone morphogenetic protein-2-adsorbed beta-tricalcium phosphate granules: a preliminary report. beta-tricalcium phosphate 101-126 bone morphogenetic protein 2 Homo sapiens 63-91 32665018-2 2020 This study evaluated the clinical outcome of ACDF with BMP-2-adsorbed beta-tricalcium phosphate granules. beta-tricalcium phosphate 70-95 bone morphogenetic protein 2 Homo sapiens 55-60 32665018-3 2020 METHODS: Thirty-two patients with cervical spondylopathy received treatment of ACDF with BMP-2-adsorbed beta-tricalcium phosphate granules. beta-tricalcium phosphate 104-129 bone morphogenetic protein 2 Homo sapiens 89-94 32665018-12 2020 CONCLUSIONS: Our preliminary findings suggest that BMP-2-adsorbed beta-tricalcium phosphate granules will be an effective alternative to autogenous bone grafting for cervical fusion in treating cervical spondylopathy. beta-tricalcium phosphate 66-91 bone morphogenetic protein 2 Homo sapiens 51-56 31702866-0 2020 Local application of alendronate controls bone formation and beta-tricalcium phosphate resorption induced by recombinant human bone morphogenetic protein-2. beta-tricalcium phosphate 61-86 bone morphogenetic protein 2 Homo sapiens 127-155 31436137-1 2020 The aim of this study is to investigate the efficacy and the effect of the dosage of the slow-released Escherichia coli-derived recombinant human bone morphogenetic protein 2 (ErhBMP-2) functionalized beta-tricalcium phosphate (beta-TCP) in repairing critical-sized bone defects. beta-tricalcium phosphate 201-226 bone morphogenetic protein 2 Homo sapiens 146-174 31436137-1 2020 The aim of this study is to investigate the efficacy and the effect of the dosage of the slow-released Escherichia coli-derived recombinant human bone morphogenetic protein 2 (ErhBMP-2) functionalized beta-tricalcium phosphate (beta-TCP) in repairing critical-sized bone defects. beta-tricalcium phosphate 228-236 bone morphogenetic protein 2 Homo sapiens 146-174 29771832-6 2018 RESULTS: Comparison of the results obtained with those achieved for CGFs alone showed that BMP2 and BMP-7 release, significantly increased in CGFs mixed with Round-up and beta-TCP, TGF-beta1 release was similar to CGFs alone, whereas IG-1 release was lower compared with CGFs alone. beta-tricalcium phosphate 171-179 bone morphogenetic protein 2 Homo sapiens 91-95 31137998-0 2019 Analysis of sequential dual immobilization of type I collagen and BMP-2 short peptides on hydrolyzed poly(buthylene succinate)/beta-tricalcium phosphate composites for bone tissue engineering. beta-tricalcium phosphate 127-152 bone morphogenetic protein 2 Homo sapiens 66-71 30270749-10 2018 In groups receiving calcium phosphate implants loaded with 10 mug BMP2 and 1 mug BMP2/10 mug L51P, the volume of bone was increased and betaTCP was decreased compared to groups receiving implants with 1 mug BMP2 and 10 mug L51P. beta-tricalcium phosphate 136-143 bone morphogenetic protein 2 Homo sapiens 66-76 28888067-7 2018 A bone morphogenetic protein 2 (BMP-2)-loaded TSAH/beta-TCP hydrogel was injected as a control. beta-tricalcium phosphate 51-59 bone morphogenetic protein 2 Homo sapiens 2-30 28888067-7 2018 A bone morphogenetic protein 2 (BMP-2)-loaded TSAH/beta-TCP hydrogel was injected as a control. beta-tricalcium phosphate 51-59 bone morphogenetic protein 2 Homo sapiens 32-37 29396102-0 2018 The accelerated effect of recombinant human bone morphogenetic protein 2 delivered by beta-tricalcium phosphate on tendon-to-bone repair process in rabbit models. beta-tricalcium phosphate 86-111 bone morphogenetic protein 2 Homo sapiens 44-72 29396102-3 2018 The aim of this study was to investigate the accelerated effect of recombinant human BMP-2 (rhBMP-2) delivered by beta-TCP on the tendon-to-bone repair process. beta-tricalcium phosphate 114-122 bone morphogenetic protein 2 Homo sapiens 85-90 30270749-10 2018 In groups receiving calcium phosphate implants loaded with 10 mug BMP2 and 1 mug BMP2/10 mug L51P, the volume of bone was increased and betaTCP was decreased compared to groups receiving implants with 1 mug BMP2 and 10 mug L51P. beta-tricalcium phosphate 136-143 bone morphogenetic protein 2 Homo sapiens 66-70 30270749-10 2018 In groups receiving calcium phosphate implants loaded with 10 mug BMP2 and 1 mug BMP2/10 mug L51P, the volume of bone was increased and betaTCP was decreased compared to groups receiving implants with 1 mug BMP2 and 10 mug L51P. beta-tricalcium phosphate 136-143 bone morphogenetic protein 2 Homo sapiens 81-85 27746180-4 2016 The present study demonstrated that the local administration of ZOL with recombinant human BMP-2 (rh-BMP-2) using beta tricalcium phosphate (beta-TCP) as a carrier had superior efficacy not only to augment the BMP-induced new ectopic bone formation but to maintain the trabecular bone structure inside the new bone for long period. beta-tricalcium phosphate 114-139 bone morphogenetic protein 2 Homo sapiens 91-96 28024612-0 2017 Fabrication of a three-dimensional beta-tricalcium-phosphate/gelatin containing chitosan-based nanoparticles for sustained release of bone morphogenetic protein-2: Implication for bone tissue engineering. beta-tricalcium phosphate 35-60 bone morphogenetic protein 2 Homo sapiens 134-162 27746180-4 2016 The present study demonstrated that the local administration of ZOL with recombinant human BMP-2 (rh-BMP-2) using beta tricalcium phosphate (beta-TCP) as a carrier had superior efficacy not only to augment the BMP-induced new ectopic bone formation but to maintain the trabecular bone structure inside the new bone for long period. beta-tricalcium phosphate 114-139 bone morphogenetic protein 2 Homo sapiens 101-106 27746180-4 2016 The present study demonstrated that the local administration of ZOL with recombinant human BMP-2 (rh-BMP-2) using beta tricalcium phosphate (beta-TCP) as a carrier had superior efficacy not only to augment the BMP-induced new ectopic bone formation but to maintain the trabecular bone structure inside the new bone for long period. beta-tricalcium phosphate 141-149 bone morphogenetic protein 2 Homo sapiens 91-96 27746180-4 2016 The present study demonstrated that the local administration of ZOL with recombinant human BMP-2 (rh-BMP-2) using beta tricalcium phosphate (beta-TCP) as a carrier had superior efficacy not only to augment the BMP-induced new ectopic bone formation but to maintain the trabecular bone structure inside the new bone for long period. beta-tricalcium phosphate 141-149 bone morphogenetic protein 2 Homo sapiens 101-106 25978116-7 2015 The mean value of the radiological score was significantly greater in the TCP/BMP2 loaded group at 12 weeks post-operation compared to those in the other groups. beta-tricalcium phosphate 74-77 bone morphogenetic protein 2 Homo sapiens 78-82 25978116-10 2015 Bone surface and bone volume, as quantitated through microCT, were higher in the TCP/BMP2 loaded group. beta-tricalcium phosphate 81-84 bone morphogenetic protein 2 Homo sapiens 85-89 24268199-0 2014 Osteogenic differentiation of bone marrow MSCs by beta-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. beta-tricalcium phosphate 50-75 bone morphogenetic protein 2 Homo sapiens 104-108 24571511-2 2014 The aim of the present study was to assess the strengthening effect of a beta-TCP microsphere-hydrogel composite containing recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone healing and implant osseointegration. beta-tricalcium phosphate 73-81 bone morphogenetic protein 2 Homo sapiens 142-170 25373389-5 2015 Three-dimensional (3-D) culturing on porous beta-tricalcium phosphate (TCP) scaffolds and co-culturing of hBMSCs and hPCs significantly promoted the osteogenic specific mRNA expression of COL1alpha1, BMP-2, osteopontin (OPN) and osteocalcin (OC). beta-tricalcium phosphate 71-74 bone morphogenetic protein 2 Homo sapiens 200-205 25017094-7 2014 VEGF and BMP2 were significantly upregulated in the macrophages exposed to Mg-beta-TCP scaffolds, indicating pro-osteogenic properties of macrophages in beta-TCP modified Mg scaffolds. beta-tricalcium phosphate 78-86 bone morphogenetic protein 2 Homo sapiens 9-13 24268199-7 2014 Bone morphogenetic protein 2 (BMP2) was also significantly upregulated by the beta-TCP stimulation, indicating that macrophage may participate in the beta-TCP stimulated osteogenesis. beta-tricalcium phosphate 78-86 bone morphogenetic protein 2 Homo sapiens 0-28 24268199-7 2014 Bone morphogenetic protein 2 (BMP2) was also significantly upregulated by the beta-TCP stimulation, indicating that macrophage may participate in the beta-TCP stimulated osteogenesis. beta-tricalcium phosphate 78-86 bone morphogenetic protein 2 Homo sapiens 30-34 24268199-7 2014 Bone morphogenetic protein 2 (BMP2) was also significantly upregulated by the beta-TCP stimulation, indicating that macrophage may participate in the beta-TCP stimulated osteogenesis. beta-tricalcium phosphate 150-158 bone morphogenetic protein 2 Homo sapiens 0-28 24268199-7 2014 Bone morphogenetic protein 2 (BMP2) was also significantly upregulated by the beta-TCP stimulation, indicating that macrophage may participate in the beta-TCP stimulated osteogenesis. beta-tricalcium phosphate 150-158 bone morphogenetic protein 2 Homo sapiens 30-34 19582858-0 2009 Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/beta-tricalcium phosphate porous ceramics. beta-tricalcium phosphate 94-119 bone morphogenetic protein 2 Homo sapiens 26-31 22524330-2 2013 The aim of this study is to evaluate the effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) associated with bone substitute materials beta-tricalcium phosphate (beta-TCP), biphasic calcium phosphate (BCP), and bovine bone mineral on vertical guided bone regeneration (GBR) in rabbit calvarium. beta-tricalcium phosphate 150-175 bone morphogenetic protein 2 Homo sapiens 69-97 22524330-2 2013 The aim of this study is to evaluate the effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) associated with bone substitute materials beta-tricalcium phosphate (beta-TCP), biphasic calcium phosphate (BCP), and bovine bone mineral on vertical guided bone regeneration (GBR) in rabbit calvarium. beta-tricalcium phosphate 177-185 bone morphogenetic protein 2 Homo sapiens 69-97 22454365-7 2012 Accordingly, pure CS and CS/beta-TCP composites stimulated osteoblast-like cells to express BMP-2/TGF-beta gene and proteins, and further regulate the expression of Runx2 gene and protein, and ultimately affect the ALP activity and OCN deposition. beta-tricalcium phosphate 28-36 bone morphogenetic protein 2 Homo sapiens 92-97 22045631-4 2012 The growth factor bone morphogenetic protein 2 (BMP-2) was highly expressed in SaOS-2 cultured with the beta-TCP coated Mg alloy by Western blot analysis (p < 0.05). beta-tricalcium phosphate 104-112 bone morphogenetic protein 2 Homo sapiens 18-46 22045631-4 2012 The growth factor bone morphogenetic protein 2 (BMP-2) was highly expressed in SaOS-2 cultured with the beta-TCP coated Mg alloy by Western blot analysis (p < 0.05). beta-tricalcium phosphate 104-112 bone morphogenetic protein 2 Homo sapiens 48-53 22045631-8 2012 Immunohistochemical analysis of the experiment results demonstrated that the beta-TCP coated Mg alloy implants provided a high BMP-2 expression during the first 4 weeks postimplantation. beta-tricalcium phosphate 77-85 bone morphogenetic protein 2 Homo sapiens 127-132 21632105-6 2011 BMP-2 was loaded onto the beta-TCP with and without ECM by immersing the scaffolds in the BMP-2 solution. beta-tricalcium phosphate 26-34 bone morphogenetic protein 2 Homo sapiens 0-5 21632105-7 2011 The loading and release kinetics of the BMP-2 on the beta-TCP/ECM were significantly slower than those on the beta-TCP. beta-tricalcium phosphate 53-61 bone morphogenetic protein 2 Homo sapiens 40-45 21632105-11 2011 Furthermore, the BMP-2-loaded beta-TCP/ECM stimulated reorganization of the actin cytoskeleton, increased expression of alkaline phosphatase and calcium deposition by the cells compared to those without BMP-2 loading and the beta-TCP with BMP-2 loading. beta-tricalcium phosphate 30-38 bone morphogenetic protein 2 Homo sapiens 17-22 21632105-11 2011 Furthermore, the BMP-2-loaded beta-TCP/ECM stimulated reorganization of the actin cytoskeleton, increased expression of alkaline phosphatase and calcium deposition by the cells compared to those without BMP-2 loading and the beta-TCP with BMP-2 loading. beta-tricalcium phosphate 30-38 bone morphogenetic protein 2 Homo sapiens 203-208 21632105-11 2011 Furthermore, the BMP-2-loaded beta-TCP/ECM stimulated reorganization of the actin cytoskeleton, increased expression of alkaline phosphatase and calcium deposition by the cells compared to those without BMP-2 loading and the beta-TCP with BMP-2 loading. beta-tricalcium phosphate 30-38 bone morphogenetic protein 2 Homo sapiens 203-208 21427841-0 2011 [Preparation of recombinant human bone morphogenetic protein 2 decorated beta tricalcium phosphate/collagen and preliminary studies on its properties of inducing tooth formation]. beta-tricalcium phosphate 73-98 bone morphogenetic protein 2 Homo sapiens 34-62 21427841-2 2011 METHODS: The scaffold for tooth tissue engineering containing recombinant human bone morphogenetic protein 2 (rhBMP-2) was prepared by mixing nanoscale I tricalcium phosphate (beta-TCP)/collagen particles. beta-tricalcium phosphate 176-184 bone morphogenetic protein 2 Homo sapiens 80-108 25614023-0 2014 Efficient bone formation in a swine socket lift model using Escherichia coli-derived recombinant human bone morphogenetic protein-2 adsorbed in beta-tricalcium phosphate. beta-tricalcium phosphate 144-169 bone morphogenetic protein 2 Homo sapiens 103-131 21632105-3 2011 More specifically, we investigated whether the ECM produced by bone marrow-derived mesenchymal stem cells (hBMSC) on a beta-TCP scaffold can bind bone morphogenetic protein-2 (BMP-2) and control its release in a sustained manner, and further examined the effect of ECM and the BMP-2 released from ECM on cell behaviors. beta-tricalcium phosphate 119-127 bone morphogenetic protein 2 Homo sapiens 146-174 21632105-3 2011 More specifically, we investigated whether the ECM produced by bone marrow-derived mesenchymal stem cells (hBMSC) on a beta-TCP scaffold can bind bone morphogenetic protein-2 (BMP-2) and control its release in a sustained manner, and further examined the effect of ECM and the BMP-2 released from ECM on cell behaviors. beta-tricalcium phosphate 119-127 bone morphogenetic protein 2 Homo sapiens 176-181 20725979-9 2010 When loaded with BMP2 and VEGF and implanted in the quadriceps muscle, PLA/beta-TCP scaffolds did not induce ectopic mineralization but induced a significant 1.8-fold increase in neo vessel formation. beta-tricalcium phosphate 75-83 bone morphogenetic protein 2 Homo sapiens 17-21 20575676-4 2010 Culturing human osteoblasts on beta-TCP scaffold for 1 and 7 days induced gene expression of bone morphogenetic protein 2 (BMP2) and its receptors and activated its downstream Smad1/5 signaling pathway, which were orchastrated with induced osteoblastic differentiation. beta-tricalcium phosphate 31-39 bone morphogenetic protein 2 Homo sapiens 93-121 20575676-4 2010 Culturing human osteoblasts on beta-TCP scaffold for 1 and 7 days induced gene expression of bone morphogenetic protein 2 (BMP2) and its receptors and activated its downstream Smad1/5 signaling pathway, which were orchastrated with induced osteoblastic differentiation. beta-tricalcium phosphate 31-39 bone morphogenetic protein 2 Homo sapiens 123-127 20575676-7 2010 We concluded that beta-TCP scaffold promotes osteoblastic differentiation by a BMP2 autocrine loop, a process involving alpha2beta1 integrin and mitogen-activated protein kinase/extracellular related kinase signaling pathways. beta-tricalcium phosphate 18-26 bone morphogenetic protein 2 Homo sapiens 79-83 18563826-0 2009 Repair of long intercalated rib defects in dogs using recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and beta-tricalcium phosphate. beta-tricalcium phosphate 138-163 bone morphogenetic protein 2 Homo sapiens 72-100 18991087-3 2008 The objective of the present study was to determine whether adenoviral delivery of modified human BMP2 gene (AdBMP2) using beta tricalcium phosphate (ss-TCP) as a carrier could promote osteoblastic differentiation of bone marrow mesenchymal stem cells (BMSCs) and ectopic bone formation. beta-tricalcium phosphate 123-148 bone morphogenetic protein 2 Homo sapiens 98-102 15293319-1 2004 A new type of degradable biomaterial with bone-inducing capacity was made by combining porous beta-tricalcium phosphate (beta-TCP) with a delivery system for recombinant human bone morphogenetic protein-2 (rhBMP-2). beta-tricalcium phosphate 121-129 bone morphogenetic protein 2 Homo sapiens 176-204 12181665-3 2002 First, bone tissue is induced in muscle by bone morphogenetic protein-2 (BMP-2) with beta-tricalcium phosphate as a carrier to maintain its form in the muscle. beta-tricalcium phosphate 85-110 bone morphogenetic protein 2 Homo sapiens 73-78 10397918-1 1999 A beta-tricalcium phosphate-monocalcium phosphate monohydrate (beta-TCP-MCPM) cement was evaluated as an effective carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) in rat femoral critical-size defects. beta-tricalcium phosphate 63-71 bone morphogenetic protein 2 Homo sapiens 144-172 15683650-0 2005 Ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2-loaded porous beta-tricalcium phosphate in mice. beta-tricalcium phosphate 109-134 bone morphogenetic protein 2 Homo sapiens 66-94 15683650-1 2005 The present study investigated the ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded porous beta-tricalcium phosphate (beta-TCP) in mice. beta-tricalcium phosphate 154-179 bone morphogenetic protein 2 Homo sapiens 101-129 15683650-1 2005 The present study investigated the ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded porous beta-tricalcium phosphate (beta-TCP) in mice. beta-tricalcium phosphate 181-189 bone morphogenetic protein 2 Homo sapiens 101-129